RecQ family helicases: Roles in cancer and aging

Current Opinion in Genetics and Development

Volumn 10, Issue 1, 2000, Pages 32-38

  Karow, Julia K ^a   Wu, Leonard ^a   Hickson, Ian D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HELICASE;

AGING; CANCER; CANCER SUSCEPTIBILITY; CHROMOSOME SEGREGATION; DNA DENATURATION; DNA REPLICATION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENETIC RECOMBINATION; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0034001767     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00039-8     Document Type: Review

References (59)

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20. ••] showed that the RECQ4 gene is mutated in Rothmund-Thomson syndrome.
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22. ••].
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34. •], can disrupt G-quadruplex DNA.
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36. •]) describing an exonuclease activity which resides in the amino-terminal domain of WRN. These authors find that this exonuclease proceeds in a 3′→5′ direction.
37. •].
38. •].
39. •]. These authors found that the exonuclease activity of WRN proceeds in a 5′→3′ direction, which contradicts the other reports on the WRN exonuclease activity.
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45. + gene and show that it is essential for cell viability. Moreover, they show that deletion of rqh1 in fission yeast suppresses the lethality of top3 mutants. This indicates that the genetic interaction between RecQ helicases and topo III is conserved amongst different yeast species.
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