Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 9896-9902

  Li, Baomin ^b   Comai, Lucio ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSAYS; DISEASES; DNA; GENES; SUBSTRATES;

GENOMIC INSTABILITY;

PROTEINS;

AMINO ACID; DIMER; DOUBLE STRANDED DNA; EXONUCLEASE; GENE PRODUCT; HELICASE; KU ANTIGEN; PROTEIN KU80; UNCLASSIFIED DRUG; WERNER SYNDROME PROTEIN; ADENOSINE TRIPHOSPHATE; CELL NUCLEUS ANTIGEN; COMPLEMENTARY DNA; DNA; DNA BINDING PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; NUCLEAR PROTEIN; RECOMBINANT PROTEIN; RECQ HELICASE; WRN PROTEIN, HUMAN; XRCC5 PROTEIN, HUMAN;

AGING; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER SUSCEPTIBILITY; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; DNA DEGRADATION; DNA METABOLISM; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC STABILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; WERNER SYNDROME; ANIMAL; CELL LINE; CELL NUCLEUS; CHEMISTRY; GENE DELETION; GENETICS; INSECT; METABOLISM; MOLECULAR CLONING; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS; ANIMALS; ANTIGENS, NUCLEAR; CELL LINE; CELL NUCLEUS; CLONING, MOLECULAR; DNA; DNA HELICASES; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EXONUCLEASES; GENE DELETION; GLUTATHIONE TRANSFERASE; HUMANS; INSECTS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RECQ HELICASES; WERNER SYNDROME;

EID: 0035971076     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008575200     Document Type: Article

References (52)

1. Epstein, C. J., Martin, G. M., Schultz, A. L., and Motulsky, A. G. (1966) Medicine 45, 177-221
2. Dyer, C., and Sinclair, A. (1998) Age Ageing 27, 73-80
3. Martin, G. M. (1978) Birth Defects Orig. Artic. Ser. 14, 5-39
4. Goto, M., Miller, R. W., Ishikawa, Y., and Sugano, H. (1996) Cancer Epidemiol. Biomark. Prev. 5, 239-246
5. Fukuchi, K., Martin, G. M., and Monnat, R. J. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 5893-5897
6. Salk, D., Au, K., Hoehn, H., and Martin, G. M. (1985) Adv. Exp. Med. Biol. 190, 541-550
7. Yu, C. E., Oshima, J., Fu, Y. H., Wijsman, E., Hisama, F., Alisch, R., Matthews, S., Nakura, J., Miki, T., Ouais, S., Martin, G., Mulligan, J., and Schellenberg, G. (1996) Science 272, 258-262
8. Matsumoto, T., Shimamoto, A., Goto, M., and Furuichi, Y. (1997) Nat. Genet. 16, 885-886
9. Ellis, N. A., Groden, T. Z., Ye, J., and Straughen, D. J. (1995) Cell 83, 655-666
10. Puranam, K. L., and Blackshear, P. J. (1994) J. Biol. Chem. 269, 29838-29845
11. Mushegian, A. R., Bassett, D. E., Boguski, M. S., Bork, P., and Koonin, E. V. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5831-5836
12. Moser, M. J., Holley, W. R., Chatterjee, A., and Mian, I. S. (1997) Nucleic Acids Res. 25, 5110-5118
13. Huang, S., Li, B., Gray, M., Oshima, J., Mian, I. S., and Campisi, J. (1998) Nat. Genet. 20, 114-116
14. Shen, J. C., Gray, M., Oshima, J., and Loeb, L. (1998) Nucleic Acids Res. 26, 2879-2885
15. Shen, J. C., Gray, M., Oshima, J., Kamath-Loeb, A., Fry, M., and Loeb, L. (1998) J. Biol. Chem. 273, 34139-34144
16. Li, B., and Comai, L. (2000) J. Biol. Chem. 275, 28349-28352
17. Devries, E. W., Vandriel, W. C., Bergsma, A. C., and Vandervliet, P. C. (1989) J. Mol. Biol. 208, 65-78
18. Mimori, T., and Hardin, J. A. (1986) J. Biol. Chem. 261, 375-379
19. Ochem, A. E., Skopac, D., Costa, M., Rabilloud, T., Vuillard, L., Simoncsits, A., Giacca, M., and Falaschi, A. (1997) J. Bicl. Chem. 272, 29919-29926
20. Pailard, S., and Strauss, F. (1991) Nucleic Acids Res. 19, 5619-5624
21. Karran, P. (2000) Curr. Opin. Genet. Dev. 10, 144-150
22. Kanaar, R., Hoeijmakers, J., and van Gent, D. C. (1998) Cell Biol. 8, 483-491
23. Gottlieb, T. M., and Jackson, S. P. (1993) Cell 72, 131-142
24. Hammarsten, O., and Chu, G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 525-530
25. Baumann, P., and West, S. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 14066-14070
26. Bailey, S. M., Meyne, J., Chen, D., J., Kurimasa, A., Li, G. C., Lehnert, B. E., and Goodwin, E. H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 14899-14904
27. Critchlow, S., and Jackson, S. P. (1998) Trends Biochem. Sci. 23, 394-398
28. Ramsden, D. A., and Gellert, M. (1998) EMBO J. 17, 609-614
29. Kamath-Loeb, A., Shen, J. C., Loeb, L., and Fry, M. (1998) J. Biol. Chem. 273, 34145-34150
30. Gray, M., Shen, J. C., Kamath-Loeb, A., Blank, A., Sopher, B., Martin, G., Oshima, J., and Loeb, L. (1997) Nat. Genet. 17, 100-103
31. Jin, S., and Weaver, D. V. (1997) EMBO J. 16, 6874-6885
32. Orren, D. K., Brosh, R. M., Nehlin, J. O., Machwe, A., Gray, M. D., and Bohr, V. A. (1999) Nucleic Acids Res. 27, 3557-3566
33. Shen, J.-C., and Loeb, L. A. (2000) Nucleic Acids Res. 28, 3260-3268
34. Cooper, M. P., Machwe, A., D. K., O., Brosh, R. M., Ramsden, D., and Bohr, V. A. (2000) Genes Dev. 14, 907-912
35. Wu, X., and Lieber, M. R. (1996) Mol. Cell. Biol. 16, 5186-5193
36. Gell, D., and Jackson, S. P. (1999) Nucleic Acids Res. 27, 3494-3502
37. Singleton, B. K., Torres-Arzayus, M. I., Rottinghaus, S. T., Taccioli, G. E., and Jeggo, P. A. (1999) Mol. Cell. Biol. 19, 3267-3277
38. Dynan, W. S., and Yoo, S. (1998) Nucleic Acids Res. 26, 1551-1559
39. Grawunder, U., Wilm, M., Wu, X., Kulesza, P., Wilson, T. E., Mann, M., and Lieber, M. R. (1997) Nature 388, 492-494
40. Karanjawala, Z., Grawunder, U., Hsieh, C. L., and Lieber, M. (1999) Curr. Biol. 9, 1501-1504
41. Paull, T. T., and Gellert, M. (1998) Mol. Cell 1, 969-979
42. Paull, T. T., and Gellert, M. (1999) Genes Dev. 13, 1276-1288
43. Paull, T. T., and Gellert, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6409-6414
44. Fujiwara, Y., Higashikawa, T., and Tatsumi, M. (1977) J. Cell. Physiol. 92, 365-374
45. Stefanini, M., Scappaticca, S., Lagomarsini, P., Borroni, G., Berardesca, E., and Nuzzo, F. (1989) Mutant Res. 219, 179-181
46. Runger, T. M., Bauer, C., Dekant, B., Moller, K., Sobotta, P., Czerny, C., Poot, M., and Martin, G. M. (1994) J. Invest. Dermatol. 102, 45-48
47. Gebhart, E., Bauer, R., Raub, U., Schinzel, M., Ruprecht, K. W., and Jonas, J. B. (1988) Human Genet. 80, 135-139
48. Vogel, H., Lim, D. S., Karsenty, G., Finegold, M., and Hasty, P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10770-10775
49. DiFilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., and Nussenzweig, A. (2000) Nature 404, 510-514
50. Marciniak, R. A., Lombard, D. B., Johnson, F. B., and Guarente, L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6887-6892
51. Gray, M. D., Wang, L., Youssoufian, H., Martin, G. M., and Oshima, J. (1998) Exp. Cell Res. 242, 487-494
52. Bachant, J. B., and Elledge, S. J. (1999) Nature 398, 757-758