Involvement of Brca2 in DNA repair

Molecular Cell

Volumn 1, Issue 3, 1998, Pages 347-357

  Patel, Ketan J ^a   Yu, Veronica P C C ^a   Lee, Hyunsook ^a   Corcoran, Anne ^a   Thistlethwaite, Fiona C ^d   Evans, Martin J ^d   Colledge, William H ^b   Friedman, Lori S ^c   Ponder, Bruce A J ^c   Venkitaraman, Ashok R ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DNA; DNA POLYMERASE; PROTEIN P53; RECOMBINASE; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL DIVISION; CHROMOSOME ABERRATION; CHROMOSOME DISORDER; CYTOLOGY; DNA DAMAGE; DNA REPAIR; ENZYMOLOGY; FETUS; FIBROBLAST; GENE EXPRESSION; GENETIC RECOMBINATION; GENETICS; LIVER; METABOLISM; MOUSE; MUTAGENESIS; PHYSIOLOGY; RADIATION EXPOSURE;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BRCA2 PROTEIN; CELL DIVISION; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DNA DAMAGE; DNA NUCLEOTIDYLTRANSFERASES; DNA REPAIR; FETUS; FIBROBLASTS; GENE EXPRESSION; LIVER; MICE; MUTAGENESIS; NEOPLASM PROTEINS; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; VDJ RECOMBINASES;

EID: 0031990269     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80035-0     Document Type: Article

References (63)

1. Agarwal, M., Agarwal, A., Taylor, W.R., and Stark, G.R. (1995). p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA 92, 8493-8497.
2. Auerbach, A.D., and Wolman, S.R. (1976). Susceptibility of Fanconi's anemia fibroblasts to chromosome damage by carcinogens. Nature 261, 494-496.
3. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J.N., Ried, T., Tagle, D., et al. (1996). Atm-deficient mice, a paradigm of ataxia-telangiectasia. Cell 86, 159-171.
4. Baumann, P., Benson, F.E., and West, S.C. (1997). Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87, 757-766.
5. Brugarolas, J., Chandrasekaran, C., Gordon, J.I., Beach, D., Jacks, T., and Hannon, G.J. (1995). Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557.
6. Brugarolas, J., and Jacks, T. (1997). Double indemnity: p53, BRCA and cancer. Nature Med. 3, 721-722.
7. Cohen, M., Shaham, M., Dagan, J., Shmueli, E., and Kohn, G. (1975). Cytogenetic investigations in families with ataxiatelangiectasia. Cytogenet. Cell Genet. 15, 338-356.
8. Collins, N., McManus, R., Wooster, R., Mangion, J., Seal, S., Lakhani, S., Ormiston, W., and Daly, P.A. (1995). Consistent loss of the wild-type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13. Oncogene 10, 1673-1675.
9. de Vries, A., van Oostrom, C.T.M., Hofhuis, F.M.A., Dornant, P.M., Berg, R.J.W., and de Gruijl, F. (1995). Increased susceptibility to ultraviolet B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377, 169-173.
10. Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. (1995). Mice lacking p21 undergo normal development but are defective in G1 checkpoint control. Cell 82, 675-684.
11. Doroshow, J.H. (1992). Reductive activation of mitomycin C: a delicate balance. J. Natl. Cancer Inst. 84, 1138-1139.
12. Ehlich, A., Martin, V., Muller, W., and Rajewsky, K. (1994). Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4, 573-584.
13. Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672.
14. Friedberg, E.C., Walker, G.C., and Siede, W. (1995). DNA Repair and Mutagenesis. (Washington, D.C.: ASM).
15. German, J. (1993). Bloom syndrome: a Mendelian prototype of somatic mutational disease. Medicine 72, 393-406.
16. Giaccia, A., Weinstein, R., Hu, J., and Stamato, T.D. (1985). Cell-cycle dependent repair of double-strand DNA breaks in a gamma-ray sensitive Chinese hamster cell. Som. Cell Mol. Genet. 11, 485-491.
17. Griffiths, S.D., Goodhead, D.T., Marsden, S.J., Wright, E., Krajewski, S., Reed, J.C., Korsmeyer, S.J., and Greaves, M. (1994). Interleukin 7-dependent B lymphocyte precursors are ultrasensitive to apoptosis. J. Exp. Med. 179, 1789-1797.
18. Gudmundsson, J., Johannesdottir, G., Bergthorsson, J., Arason, A., Ingvarsson, S., Egilsson, V., and Barkardottir, R. (1995). Different tumour types from BRCA2 carriers show wild-type chromosome deletions on 13q12q13. Cancer Res. 55, 4830-4832.
19. Hayashi, S., Kunisada, T., Ogawa, M., Sudo, T., Kodama, H., Suda, T., Nishikawa, S., and Nishikawa, S.-I. (1990). Stepwise progression of B-lineage differentiation supported by interleukin 7 and other stromal cell molecules. J. Exp. Med. 171, 1683-1687.
20. Jeggo, P.A. (1990). Studies on mammalian mutants defective in rejoining double-strand breaks in DNA. Mutat. Res. 239, 1-16.
21. Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R.W. (1991). Participation of p53 in the cellular response to DNA damage. Cancer Res. 51, 6304-6311.
22. Kastan, M.B., Zhan, Q., el-Deiry, W.S., Carrier, F., Jacks, T., Walsh, V., Plunkett, B.S., Vogelstein, B., and Fornace, A.J.J. (1992). A mammalian cell cycle checkpoint pathway utilising p53 and GADD45 is defective in ataxia telangiectasia. Cell 71, 587-597.
23. Kinzler, K.W., and Vogelstein, B. (1997). Cancer-susceptibility genes: gatekeepers and caretakers. Nature 386, 761-762.
24. Ko, L.J., and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
25. Kuerbitz, S.J., Plunkett, B.S., Walsh, W.V., and Kastan, M.B. (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89, 7491-7495.
26. Lansford, R., Okada, A., Chen, J., Oltz, E.M., Blackwell, T.K., Alt, F.W., and Rathbun, G. (1996). Mechanism and control of immunoglobulin gene rearrangement. In Molecular Immunology, Second Edition, B.D. Hames and D.M. Glover, eds. (Oxford: IRL), pp. 1-64.
27. Lin, W.-C., and Desiderio, S. (1995). V(D)J recombination and the cell cycle. Immunol. Today 16, 279-289.
28. Lindahl, T. (1993). Instability and decay of the primary structure of DNA. Nature 362, 709-715.
29. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-852.
30. Lu, X., and Lane, D.P. (1993). Differential induction of transcriptionally active p53 following UV or ionising radiation: defects in chromosomal instability syndromes? Cell 75, 765-778.
31. Ludwig, T., Chapman, D., Papaioannou, V., and Efstratiadis, A. (1997). Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brcal, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226-1241.
32. McWhir, J., Selfridge, J., Harrison, D.J., Squires, S., and Melton, D.W. (1993). Mice with DNA repair gene (ERCC1) deficiency have elevated levels of p53, liver abnormalities and die before weaning. Nature Genet. 5, 217-224.
33. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P., Harshmann, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L.M., and Ding, W. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71.
34. Milner, J., Ponder, B.A.J., Hughes-Davies, L., Seltmann, M., and Kouzarides, T. (1997). Transcriptional activation functions in Brca2. (scientific correspondence). Nature 386, 772-773.
35. Mizuta, R., LaSalle, J.M., Cheng, H., Shinohara, A., Ogawa, H., Copeland, N., Jenkins, N.A., Lalande, M., and Alt, F.W. (1997). RAB22 and RAB163/mouse BRCA2: proteins that interact specifically with the RAD51 protein. Proc. Natl. Acad. Sci. USA 94, 6927-6932.
36. Murray, A.W. (1995). The genetics of cell cycle checkpoints. Curr. Opin. Genet. Dev. 5, 5-11.
37. Nakane, H., Takeuchi, S., Yuba, S., Siajo, M., Nkatsu, Y., and Murai, H. (1995). High incidence of ultraviolet B or chemical carcinogen induced skin tumours in mice lacking the XPA gene. Nature 377, 165-168.
38. Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. (1990). Rag-1 and Rag-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1521.
39. Painter, R.B., and Young, B.R. (1980). Radiosensitivity in ataxia telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77, 7315-7317.
40. Parrington, J.M., Delhanty, J., and Baden, H. (1971). Unscheduled DNA synthesis, UV-induced chromosome aberrations and SV40 transformation in cultured cells from xeroderma pigmentosum. Ann. Hum. Genet. 35, 149-160.
41. Paulovich, A.G., Toczyski, D.P., and Hartwell, L.H. (1997). When checkpoints fail. Cell 88, 315-321.
42. Ramsden, D.A., Paull, T.T., and Gellert, M. (1997). Cell-free V(D)J recombination. Nature 388, 488-491.
43. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. (1996). Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
44. Sands, A.T., Sanchez, A., Conti, C.J., and Bradley, A. (1995). High susceptibility to ultaviolet light induced carcinogenesis in mice lacking XPC. Nature 377, 162-165.
45. Savage, J.R.K. (1975). Classification and relationships of induced chromosomal structural changes. J. Med. Genet. 12, 103-122.
46. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D.A., Smith, S., Uziel, T., and Sfez, S. (1995). A single ataxia-telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753.
47. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D.M. (1997). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275.
48. Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., and Bradley, A. (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804-810.
49. Shinohara, A., Ogawa, H., and Ogawa, T. (1992). Rad51 protein involved in repair and recombination in S. cerevesiae is a RecA-like protein. Cell 69, 457-470.
50. Sobol, R.W., Horton, J.K., Kuhn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. (1997). Requirement of mammalian DNA polymerase β in base excision repair. Nature 379, 183-186.
51. Stewart, N., Hicks, G.G., Paraskevas, F., and Mowat, M. (1995). Evidence for a second cell cycle block at G2/M by p53. Oncogene 10, 1053-1059.
52. Sun, Z., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F. (1996). Spk1/ Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10, 395-406.
53. Suzuki, A., Pompa, J.-L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., and Wakeham, A. (1997). Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 11, 1242-1252.
54. Tavtigian, S.V., Simard, J., Rommens, J., Couch, F., Shattuckeidens, D., Neuhausen, S., Merajver, S., and Thorlacius, S. (1996). The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333-337.
55. ten Boekel, E., Melchers, F., and Rolink, A. (1995). The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7, 1013-1019.
56. Todaro, G.J., and Green, H. (1963). Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell. Biol. 17, 299-313.
57. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. (1995). A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.J. Immunol. Meth. 184, 39-51.
58. Weaver, D.T., and Alt, F.W. (1997). From RAGs to stitches. Nature 388, 428-429.
59. Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R., Vissers, C.J., Nigg, A., van Steeg, H., Bootsma, D., and Hoeijmakers, J.H.J. (1997). Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 7, 427-439.
60. Weemaes, C.M., Hustinx, T.W., Scheres, J., van Munster, P., Bakkeren, J., and Taalman, R.D. (1981). A new chromosomal instability disorder: the Njimegen breakage syndrome. Acta. Paediat. Scand. 70, 557-564.
61. Wooster, R., Bignell, J., Lancaster, S., Swift, S., Seal, S., Mangion, N., Collins, S., Gregory, C., Gumbs, G., and Micklem, R. (1995). Identification of the breast-cancer susceptibility gene BRCA2. Nature 378, 789-792.
62. Xu, Y., and Baltimore, D. (1996). Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410.
63. Zampetti-Bossler, F., and Scott, D. (1981). Cell death, chromosome damage and mitotic delay in normal human, ataxia-telangiectasia and retinoblastoma fibroblasts after x-irradiation. Int. J. Rad. Biol. 39, 5829-5842.