DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 451, Issue 1-2, 2000, Pages 187-196

  Foiani, Marco ^a   Pellicioli, Achille ^a   Lopes, Massimo ^a   Lucca, Chiara ^a   Ferrari, Marina ^a   Liberi, Giordano ^a   Muzi Falconi, Marco ^a   Plevani, Paolo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Budding yeast; Cell cycle; Checkpoints; DNA damage; DNA replication

Indexed keywords

CELL CYCLE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENOTOXICITY; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

CELL CYCLE; DNA DAMAGE; DNA REPLICATION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0034733495     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00049-X     Document Type: Review

References (61)

1. Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1996;1664-1672.
2. Paulovich A.G., Toczyski D.P., Hartwell L.H. When checkpoints fail. Cell. 88:1997;315-321.
3. Weinert T. DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev. 8:1998;185-193.
4. Amon A. The spindle checkpoint. Curr. Opin. Genet. Dev. 9:1999;69-75.
5. Vinella D., D'Ari R. Overview of controls in the Escherichia coli cell cycle. BioEssays. 17:1995;527-536.
6. Shiloh Y. Ataxia telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Ann. Rev. Genet. 31:1997;635-662.
7. Weinert T.A., Hartwell L.H. The RAD9 gene controls the cell cycle response to DNA in Saccharomyces cerevisiae. Science. 241:1988;317-322.
8. Sherr C.Y. Cancer cell cycles. Science. 274:1996;1672-1677.
9. Haber J.E. Exploring the pathways of homologous recombination. Curr. Opin. Cell Biol. 4:1992;401-412.
10. Lydall D., Weinert T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science. 270:1995;1488-1491.
11. Paciotti V., Lucchini G., Plevani P., Longhese M.P. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J. 17:1998;4199-4209.
12. Longhese M.P., Foiani M., Muzi-Falconi M., Lucchini G., Plevani P. DNA damage checkpoint in budding yeast. EMBO J. 17:1998;5525-5528.
13. Onel K., Koff A., Bennett R.L., Unrau P., Holloman W.K. The REC1 gene of Ustilago maydis, which encodes a 3′-5′ exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint. Genetics. 143:1996;165-174.
14. Lydall D., Weinert T. G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair. Mol. Gen. Genet. 256:1997;638-651.
15. Waga S., Stillman B. The DNA replication fork in eukaryotic cells. Ann. Rev. Biochem. 67:1998;721-751.
16. Shimomura T., Ando S., Matsumoto K., Sugimoto K. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Mol. Cell. Biol. 18:1998;5485-5491.
17. Kondo T., Matsumoto K., Sugimoto K. Role of a complex containing Rad17, Mec3 and Ddc1 in the yeast DNA damage checkpoint pathway. Mol. Cell. Biol. 19:1999;1136-1143.
18. Thelen M.P., Venclovas C., Fidelis K. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell. 96:1999;769-770.
19. Emili A. MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol. Cell. 2:1998;183-189.
20. Sun Z., Hsiao J., Fay D.S., Stern D.F. Rad53 FHA domain is associated with phosphorylated Rad9 in the DNA damage checkpoint. Science. 281:1998;272-274.
21. Vialard J.E., Gilbert C.S., Green C.M., Lowndes N.F. The budding yeast rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with rad53 after DNA damage. EMBO J. 17:1998;2687-2698.
22. Soulier J., Lowndes N.F. The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage. Curr. Biol. 9:1999;551-554.
23. Sun Z., Fay D.S., Marini F., Foiani M., Stern D.F. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:1996;395-406.
24. Sanchez Y., Desany B.A., Jones W.J., Liu Q., Wang B., Elledge S.J. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science. 271:1996;357-360.
25. Cohen-Fix O., Koshland D. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc. Natl. Acad. Sci. U. S. A. 94:1997;14361-14366.
26. Zhou Z., Elledge S. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell. 75:1993;1119-1127.
27. Brush G., Morrow D.M., Heiter P., Kelly T.J. The ATM homolog MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. U. S. A. 93:1996;15075-15080.
28. Smith G.C.M., Jackson S.P. The DNA-dependent protein kinase. Genes Dev. 13:1999;916-934.
29. Pellicioli A., Lucca C., Liberi G., Marini F., Lopes M., Plevani P., Romano A., Di Fiore P.P., Foiani M. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J. 18:1999;6561-6572.
30. Foiani M., Ferrari M., Liberi G., Lopes M., Lucca C., Marini F., Pellicioli A., Muzi-Falconi M., Plevani P. S-phase DNA damage checkpoint in budding yeast. Biol. Chem. 379:1998;1019-1023.
31. Gardner R., Putnam C.W., Weinert T. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast. EMBO J. 18:1999;3173-3185.
32. Friedberg E.C., Walker G.C., Siede W. DNA Repair and Mutagenesis. 1995;ASM Press, Washington, DC.
33. de la Torre Ruiz M.-A., Green C.M., Lowndes N.F. RAD9 and RAD24 define two addittive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J. 17:1998;2687-2698.
34. Huang M., Zhou Z., Elledge S.J. The DNA replication and DNA damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell. 94:1998;595-605.
35. Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387:1997;296-299.
36. Nurse P. Checkpoint pathways come of age. Cell. 91:1997;865-867.
37. Pines J. Checkpoint on the nuclear frontier. Nature. 397:1999;104-105.
38. Li X., Cai M. Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:1997;2723-2734.
39. Sidorova J.M., Breeden L.L. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev. 11:1997;3032-3045.
40. Cohen-Fix O., Peters J.M., Kirschner M.W., Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10:1996;3081-3093.
41. Yamamoto A., Guacci V., Koshland D. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133:1996;99-110.
42. Paulovich A.G., Hartwell L.H. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell. 82:1995;841-847.
43. Santocanale C., Diffley J.F.X. A Mec1- and Rad53-dependent checkpoint controls late-origin firing origins of DNA replication. Nature. 395:1998;615-618.
44. Shiraige K., Hori Y., Shiraishi K., Yamashita M., Takahashi K., Obuse C., Tsurimoto T., Yoshikawa H. Regulation of DNA-replication origins during cell-cycle progression. Nature. 395:1998;618-621.
45. Dohrmann P.R., Oshiro G., Tecklenburg M., Sclafani R.A. RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae. Genetics. 151:1999;965-977.
46. Cheng L., Collyer T., Hardy C.F.J. Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol. Cell. Biol. 19:1999;4270-4278.
47. Longhese M.P., Neecke H., Paciotti V., Lucchini G., Plevani P. The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast. Nucleic Acids Res. 24:1996;3533-3537.
48. Marini F., Pellicioli A., Paciotti V., Lucchini G., Plevani P., Stern D.F., Foiani M. A role for DNA primase in coupling DNA replication to DNA damage response. EMBO J. 16:1997;639-650.
49. Foiani M., Lucchini G., Plevani P. The DNA polymerase α-primase complex couples DNA replication, cell cycle progression and DNA-damage response. Trends Biochem. Sci. 22:1997;424-427.
50. Desany B.A., Alcasabas A.A., Bachant J.B., Elledge S.J. Recovery from DNA replication stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12:1998;2956-2970.
51. Enoch T., Gould K.L., Nurse P. Mitotic checkpoint control in fission yeast. Cold Spring Harbor Symp. Quant. Biol. 56:1991;408-416.
52. Al-Khodairy F., Fotou F., Sheldrick K.S., Griffiths D.J.F., Lehmann A.R., Carr A.M. Identification and characterization of new elements involved in checkpoint controls in fission yeast. Mol. Biol. Cell. 5:1994;147-160.
53. Stewart E., Riley Chapman C., Al-Khodairy F., Carr A.M., Enoch T. Rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16:1997;2682-2692.
54. Chakraverty R.K., Hickson I.D. Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. BioEssays. 21:1999;286-294.
55. Gangloff S., McDonald J.P., Bendixen C., Arthur L., Rothstein R. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol. 14:1994;8391-8398.
56. Watt P.M., Louis E.J., Borts R.H., Hickson I.D. Sgs1: a homolog of E. coli RecQ that interacts with topoisomerase II in vivo is required for faithful chromosome segregation. Cell. 81:1995;253-260.
57. Seigneur M., Bidnenko V., Ehrlich S.D., Michel B. RuvAB acts at arrested replication forks. Cell. 95:1998;419-430.
58. Zou H., Rothstein R. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell. 90:1997;87-96.
59. Kogoma T. Stable DNA replication: interplay between DNA replication, homologous recombination and transcription. Mol. Biol. Rev. 61:1997;212-238.
60. Malkova A., Ivanov E.L., Haber J.E. Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc. Natl. Acad. Sci. U. S. A. 93:1996;7131-7136.
61. Holmes A.M., Haber J.E. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell. 96:1999;415-424.