New complexities for BRCA1 and BRCA2

Current Biology

Volumn 11, Issue 16, 2001, Pages

  Kerr, Peter ^a   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035928799     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00389-X     Document Type: Article

References (77)

1. The genetics of breast cancer susceptibility
2. BRCA1 and BRCA2
3. BRCA1 required for transcription-coupled repair of oxidative DNA damage
4. In search of the tumour-suppressor functions of BRCA1 and BRCA2
5. DNA double strand break repair in mammalian cells
6. DNA double-strand breaks: Signaling, repair and the cancer connection
7. RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein
8. Association of BRCA1 with Rad51 in mitotic and meiotic cells
9. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
10. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
11. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
12. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations
13. BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability
14. Involvement of Brca2 in DNA repair
15. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
16. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
17. Chromosomal instability in BRCA1- or BRCA2-defective human cancer cells detected by spontaneous micronucleus assay
18. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability
19. Genetic analysis of BRCA1 function in a defined tumor cell line
20. Caretaker Brca1: Keeping the genome in the straight and narrow
21. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2
22. Double-strand-break-induced homologous recombination in mammalian cells
23. Brca1 controls homology-directed DNA repair
24. BRCA2 is required for homology-directed repair of chromosomal breaks
25. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
26. ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3
27. Mammalian nucleotide excision repair and syndromes
28. Ten years of TFIIH
29. How many more breast cancer predisposition genes are there?
30. Molecular biology of Fanconi anemia: Implications for diagnosis and therapy
31. Positional cloning of a novel Fanconi anemia gene, FANCD2
32. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
33. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
34. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
35. Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
36. The ubiquitin system
37. SCF and APC: The Yin and Yang of cell cycle regulated proteolysis
38. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
39. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
40. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
41. Identification of a RING protein that can interact in vivo with the BRCA1 gene product
42. Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers
43. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50
44. The BARD1-CstF-50 interaction links mRNA 3′ end formation to DNA damage and tumor suppression
45. Cell-cycle related regulation of poly(A) polymerase by phosphorylation
46. Deregulation of poly(A) polymerase interferes with cell growth
47. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
48. BRCA1 is a component of the RNA polymerase II holoenzyme
49. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
50. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
51. Gene-expression profiles in hereditary breast cancer
52. Profiling familial breast cancer
53. BRCA1: Exploring the links to transcription
54. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
55. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes
56. Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells
57. Molecular portraits of human breast tumours
58. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
59. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
60. BRCA1 inhibition of estrogen receptor signaling in transfected cells
61. Breast cancer susceptibility gene 1 (BRCA1) is a coactivator of the androgen receptor
62. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells
63. Direct DNA binding by Brca1
64. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis
65. BRCA1 at a branch point
66. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
67. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
68. Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
69. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
70. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
71. Involvement of Brca1 in S-Phase and G2-Phase checkpoints after ionizing irradiation
72. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
73. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
74. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
75. Specific recognition of cruciform DNA by nuclear protein HMG1
76. DNA double-strand breaks: Signaling, repair and the cancer connection
77. Themes and variations on ubiquitylation