From DNA damage to cell cycle arrest and suicide: A budding yeast perspective

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 4-11

  Lydall, David ^a   Weinert, Ted ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN;

CELL CYCLE; CELL CYCLE G2 PHASE; CELL DEATH; DNA DAMAGE; DNA METABOLISM; DNA REPAIR; FUNGAL GENETICS; MAMMAL CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; YEAST;

EUKARYOTA; MAMMALIA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0030052137     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90003-9     Document Type: Article

References (14)

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3. Paulovich AG, Hartwell LH: A Checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 1995, 82:841-847. This paper shows that Med and Rad53 are required to slow DNA replication down while DNA is being chronically alkylated by methyl methane sulphonate.
4. Painter RB, Young RB: Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc Natl Acad Sci USA 1980, 77:7315-7317.
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7. Lydall D, Weinert T: Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest Science 1995, 270:1488-1491. This paper shows that checkpoint control genes affect DNA damage processing as well as cell cycle arrest. Using an assay that measured DNA damage processing in vivo, the checkpoint gene RAD24 (and by inference RAD17 and MEC3) was shown to activate an exonuclease that degrades DNA in vivo. The degradation is probably a direct consequence of checkpoint protein function because RAD17 was shown to encode a putative 3′-5′ DNA exonuclease. Another checkpoint gene, RAD9, was shown to have a different role, inhibiting the degradation by RAD17, RAD24 and MEC3.
8. Garvik B, Carson M, Hartwell L: Single-stranded DNA arising at telomeres in cdc13 mutants may consistitue a specific signal for the RAD9 checkpoint Mol Cell Biol 1995, 15:6128-6138.
9. Weinert TA, Hartwell LH: Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint Genetics 1993, 134:63-80.
10. Weinert TA, Kiser GL, Hartwell LH: Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 1994, 8:652-665.
11. Friedberg EC, Walker GC, Siede W: DNA Repair and Mutagenesis. Washington DC: ASM Press; 1995.
12. Navas TA, Zhou Z, Elledge SJ: DNA polymerase e links the DNA replication machinery to the S phase checkpoint Cell 1995, 80:29-39. This paper shows that certain mutations in pole specifically cause defects in cell cycle arrest after inhibition of DNA synthesis and the transcriptional induction of the RNR3 gene.
13. 2/M checkpoints.
14. Nurse P: Universal control mechanism regulating onset of M-phase. Nature 1990, 344:503-508.