Activation of mammalian Chk1 during DNA replication arrest: A role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Journal of Cell Biology

Volumn 154, Issue 5, 2001, Pages 913-923

  Feijoo, Carmen ^a   Hall Jackson, Clare ^a   Wu, Rong ^b   Jenkins, David ^a   Leitch, Jane ^a   Gilbert, David M ^b   Smythe, Carl ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Cancer; Checkpoint; Kinase; Origins; S phase

Indexed keywords

CHK1 PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALKALOIDS; ANIMALS; APHIDICOLIN; ATAXIA TELANGIECTASIA; CAFFEINE; CELL FRACTIONATION; CELL LINE; CELL SEPARATION; DNA REPLICATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; HYDROXYUREA; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; NUCLEIC ACID SYNTHESIS INHIBITORS; PHOSPHODIESTERASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; REPLICATION ORIGIN; S PHASE; STAUROSPORINE;

ANIMALIA; MAMMALIA;

EID: 0035802112     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200104099     Document Type: Article

References (52)

1. Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
2. The Schizosaccharomyces pombe rad3 checkpoint gene
3. Caffeine inhibits the checkpoint kinase ATM
4. Replication checkpoint enforced by kinases Cds1 and Chk1
5. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
6. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
7. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
8. The action of caffeine on X-irradiated HeLa cells. III. Enhancement of X-ray-induced killing during G2 arrest
9. Autoradiography of HeLa cell DNA
10. Mammalian Chk2 is a downstream effecror of the ATM-dependent DNA damage checkpoint pathway
11. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells
12. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: Implications for Chk1 regulation
13. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
14. PD 98059 prevents establishment of the spindle assembly checkpoint and inhibits the G2-M transition in meiotic but not mitotic cell cycles in Xenopus
15. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus
16. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
17. Replication control: Choreographing replication origins
18. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
19. The ATM Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
20. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase
21. Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in somatic cells
22. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
23. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
24. Effect of damage to early, middle, and late-replicating DNA on progress through the S period in Chinese hamster ovary cells
25. Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells
26. On the mechanism of DNA replication in mammalian chromosomes
27. The synchronisation of mammalian cells
28. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
29. Spatial and temporal dynamics of DNA replication sites in mammalian cells
30. Rapid destruction of human Cdc25A in response to DNA damage
31. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
32. A kinase from fission yeast responsible for blocking mitosis in S phase
33. Checkpoint pathways come of age
34. Radiosensitivity in ataxia-telangiectasia: A new explanation
35. Application of the baculoviral expression system to signal transduction
36. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
37. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
38. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
39. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
40. Activation of dormant origins of DNA replication in budding yeast
41. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
42. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells
43. Regulation of DNA-replication origins during cell-cycle progression
44. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
45. Rad-dependent response of the chk1 encoded protein kinase at the DNA damage checkpoint
46. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2
47. DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair
48. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
49. Origin-specific initiation of mammalian nuclear DNA replication in a Xenopus cell-free system
50. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
51. Atr-mediated checkpoint pathways regulate phosphorylation and activation of human chk1
52. Recombinant ATM protein complements the cellular A-T phenotype