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A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
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The S. pombe rad3 checkpoint gene
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A human homologue of the Schizosaccharomyces pombe rad9+ checkpoint control gene
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sp is identified by sequence similarity. This gene can complement some, but not all, of the defects associated with S. pombe rad9 mutants.
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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
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of special interest. Mec1 and Tel1 proteins have overlapping functions. Here, the authors specifically measure the phosphorylation status of Rad53 protein, which is shown to be phosphorylated in a Mec1-dependent manner.
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Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. of special interest Science. 271:1996;357-360 Mec1 and Tel1 proteins have overlapping functions. Here, the authors specifically measure the phosphorylation status of Rad53 protein, which is shown to be phosphorylated in a Mec1-dependent manner.
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Sanchez, Y.1
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0029156599
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DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
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cs, a large protein kinase with a kinase domain showing specific homology to P13-kinase and the inability to identify associated lipid kinase activity.
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Hartley, K.O.1
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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
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cs complemented a relevant defective cell line.
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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
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A meiotic recombination checkpoint controlled by mitotic checkpoint genes
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of outstanding interest. Preventing the 'repair' of the double strand breaks introduced during meiosis arrests progress through meiosis. S. cerevisiae Mec1 and other checkpoint proteins, but not Rad9, are shown to be required to prevent progress through meiosis when recombination-induced double strand breaks are not rejoined, establishing significant overlap between meiotic and mitotic DNA structure checkpoints.
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Lydall D, Nikolsky Y, Bishop DK, Weinert T. A meiotic recombination checkpoint controlled by mitotic checkpoint genes. of outstanding interest Nature. 383:1996;840-843 Preventing the 'repair' of the double strand breaks introduced during meiosis arrests progress through meiosis. S. cerevisiae Mec1 and other checkpoint proteins, but not Rad9, are shown to be required to prevent progress through meiosis when recombination-induced double strand breaks are not rejoined, establishing significant overlap between meiotic and mitotic DNA structure checkpoints.
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Lydall, D.1
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0028882869
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Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
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of outstanding interest. Rad17 is required for the DNA processing events at telomeres that occur in cdc13 mutant cells at the restrictive temperature. Rad17 sequence shows homology to the Rec1 nuclease and S. pombe Rad 1. It is not established that Rad17 processes DNA directly.
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Lydall D, Weinert T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. of outstanding interest Science. 270:1995;1488-1491 Rad17 is required for the DNA processing events at telomeres that occur in cdc13 mutant cells at the restrictive temperature. Rad17 sequence shows homology to the Rec1 nuclease and S. pombe Rad 1. It is not established that Rad17 processes DNA directly.
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Lydall, D.1
Weinert, T.2
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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects and thymic lymphomas
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Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects and thymic lymphomas. of outstanding interest Genes Dev. 10:1996;2411-2422 In this work, mice are deleted for ATM. Together with [23,26], this suggests a direct role in the meiotic checkpoints in mammalian cells.
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Xu, Y.1
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26
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10244227923
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The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes
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of outstanding interest. Antibodies to Atm and Atr proteins are used to stain synapsing meiotic mouse chromosomes. The two proteins show complementary staining patterns, Atr is located on asynaptic chromosome arms during pachytene whereas Atm is located on synapsed chromosomes.
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Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. of outstanding interest Genes Dev. 10:1996;2423-2437 Antibodies to Atm and Atr proteins are used to stain synapsing meiotic mouse chromosomes. The two proteins show complementary staining patterns, Atr is located on asynaptic chromosome arms during pachytene whereas Atm is located on synapsed chromosomes.
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Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
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cdc2, inhibit NIMA and prevent premature mitosis
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