p53-Mediated apoptosis is attenuated in Werner syndrome cells

Genes and Development

Volumn 13, Issue 11, 1999, Pages 1355-1360

  Spillare, Elisa A ^a   Robles, Ana I ^a   Wang, Xin Wei ^a   Shen, Jiang Cheng ^b   Yu, Chang Eu ^c   Schellenberg, Gerard D ^c   Harris, Curtis C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

DNA helicase; P53 carboxy terminal domain; XPB; XPD

Indexed keywords

HELICASE; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; PREMATURE AGING; PRIORITY JOURNAL; PROMOTER REGION; VERNER MORRISON SYNDROME;

EID: 0033151615     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.11.1355     Document Type: Article

References (29)

1. Clarke, A.R., C.A. Purdie, D.J. Harrison, R.G. Morris, C.C. Bird, M.L. Hooper, and A.M. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849-852.
2. Dimri, G.P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. 92: 9363-9367.
3. Ellis, N.A. 1997. DNA helicases in inherited human disorders. Curr. Opin. Genet. Dev. 7: 354-363.
4. Elmore, L.W., A.R. Hancock, S.F. Chang, X.W. Wang, S. Chang, C.P. Callahan, D.A. Geller, H. Will, and C.C. Harris. 1997. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci. 94: 14707-14712.
5. Epstein, C.J., G.M. Martin, A.L. Schultz, and A.G. Motulsky. 1966. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltim.). 45: 177-221.
6. Goto, M., R.W. Miller, Y. Ishikawa, and H. Sugano. 1996. Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol. Biomarkers Prev. 5: 239-246.
7. Goto, M., O. Imamura, J. Kuromitsu, T. Matsumoto, Y. Yamabe, Y. Tokutake, N. Suzuki, B. Mason, D. Drayna, M. Sugawara, M. Sugimoto, and Y. Furuichi. 1997. Analysis of helicase gene mutations in Japanese Werner's syndrome patients. Hum. Genet. 99: 191-193.
8. Gray, M.D., J.-C. Shen, A.S. Kamath-Loeb, A. Blank, B.L. Sopher, G.M. Martin, J. Oshima, and L.A. Loeb. 1997. The Werner syndrome protein is a DNA helicase. Nat. Genet. 17: 100-103.
9. Hollstein, M., D. Sidransky, B. Vogelstein, and C.C. Harris. 1991. p53 mutations in human cancers. Science 253: 49-53.
10. Huang, S., B. Li, M.D. Gray, J. Oshima, I.S. Mian, and J. Campisi. 1998. The premature aging syndrome protein, WRN, is a 3′ → 5′ exonuclease. Nat. Genet. 20: 114-116.
11. Lane, D.P. 1992. Cancer. p53, guardian of the genome. Nature 358: 15-16.
12. Lebel, M. and P. Leder. 1998. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. 95: 13097-13102.
13. Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
14. Lowe, S.W., E.M. Schmitt, S.W. Smith, B.A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849.
15. Marciniak, R.A., D.B. Lombard, F.B. Johnson, and L. Guarente. 1998. Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. 95: 6887-6892.
16. Matsumoto, T., A. Shimamoto, M. Goto, and Y. Furuichi. 1997. Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat. Genet. 16: 335-336.
17. Shen, J.-C., M.D. Gray, J. Oshima, A.S. Kamath-Loeb, M. Fry, and L.A. Loeb. 1998. Werner syndrome protein. J. Biol. Chem. 273: 34139-34144.
18. Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and T. Van Dyke. 1994. p53-Dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711.
19. Thweatt, R. and S. Goldstein. 1993. Werner syndrome and biological ageing: A molecular genetic hypothesis. BioEssays 15: 421-426.
20. Wang, X.W. and C.C. Harris. 1996. TP53 tumour suppressor gene: Clues to molecular carcinogenesis and cancer therapy. Cancer Surv. 28: 169-196.
21. Wang, L., M. Miura, L. Bergeron, H. Zhu, and J. Yuan. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78: 739-750.
22. Wang, X.W., H. Yeh, L. Schaeffer, R. Roy, V. Moncollin, J.M. Egly, Z. Wang, E.C. Friedberg, M.K. Evans, E.G. Taffe, V.A. Bohr, J.H. Hoeijmakers, K. Forrester, and C.C. Harris. 1995. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat. Genet. 10: 188-195.
23. Wang, X.W., W. Vermeulen, J.D. Coursen, M. Gibson, S.E. Lupold, K. Forrester, G. Xu, L. Elmore, H. Yeh, J.H.J. Hoeijmakers, and C.C. Harris. 1996. The XPB and XPD helicases are components of the p53-mediated apoptosis pathway. Genes & Dev. 10: 1219-1232.
24. Watt, P.M., I.D. Hickson, R.H. Borts, and E.J. Louis. 1996. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Genetics 144: 935-945.
25. Yamabe, Y., A. Shimamoto, M. Goto, J. Yokota, M. Sugawara, and Y. Furuichi. 1998. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53. Mol. Cell. Biol. 18: 6191-6200.
26. Yamagata, K., J.-I. Kato, A. Shimamoto, M. Goto, Y. Furuichi, and H. Ikeda. 1998. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases. Proc. Natl Acad. Sci. 95: 8733-8738.
27. Yan, H., C.Y. Chen, R. Kobayashi, and J. Newport. 1998. Replication focus-forming activity 1 and the Werner syndrome gene product. Nat. Genet. 19: 375-378.
28. Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347.
29. Yu, C.E., J. Oshima, E.M. Wijsman, J. Nakura, T. Miki, C. Piussan, S. Matthews, Y.H. Fu, J. Mulligan, G.M. Martin, and G.D. Schellenberg. 1997. Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am. J. Hum. Genet. 60: 330-341.