Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

Molecular Cell

Volumn 2, Issue 3, 1998, Pages 317-328

  Chen, Junjie ^a   Silver, Daniel P ^a   Walpita, Deepika ^b   Cantor, Sharon B ^a   Gazdar, Adi F ^c   Tomlinson, Gail ^c   Couch, Fergus J ^e   Weber, Barbara L ^d   Ashley, Terry ^b   Livingston, David M ^a   Scully, Ralph ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA BINDING PROTEIN; MONOCLONAL ANTIBODY; RAD51 PROTEIN; RAD51 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ARTICLE; BREAST TUMOR; CELL CULTURE; CELL LINE; CELL NUCLEUS; CHROMOSOME MAP; CYTOLOGY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FEMALE; GENETIC TRANSFECTION; GENETICS; HUMAN; MEIOSIS; METABOLISM; MITOSIS; OVARY TUMOR; PATHOLOGY; TUMOR SUPPRESSOR GENE; ULTRASTRUCTURE; ZYGOTE;

ANTIBODIES, MONOCLONAL; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL LINE; CELL NUCLEUS; CHROMOSOME MAPPING; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; FEMALE; GENES, BRCA1; GENES, TUMOR SUPPRESSOR; HUMANS; MEIOSIS; MITOSIS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; RAD51 RECOMBINASE; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; ZYGOTE;

EID: 0032159062     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80276-2     Document Type: Article

References (65)

1. Baumann, P., Benson, F.E., and West, S.C. (1996). Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87, 757-766.
2. Beckmann, M.W., Picard, F., An, H.X., Van Roeyen, C.R.C., Dominik, S.I., et al. (1996). Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA1 markers in sporadic breast cancer. Br. J. Cancer 73, 1220-1226.
3. Bertwistle, D., Swift, S., Marston, N.J., Jackson, L.E., Crossland, S., et al. (1997). Nuclear location and cell cycle regulation of the BRCA2 protein. Cancer Res. 57, 5485-5488.
4. Bieche, I., Nogues, C., Rivoilan, S., Khodja, A., Latil, A., and Lidereau, R. (1997). Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma. Br. J. Cancer 76, 1416-1418.
5. Blackshear, P.E., Goldsworthy, S.M., Foley, J.F., McAllister, K.A., Bennett, L.M., et al. (1998). Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene 16, 61-68.
6. Bork, P., Hofmann, K., Bucher, P., Neuwald, A.F., Altschul, S.F., and Koonin, E.V. (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68-76.
7. Callebaut, I., and Mornon, J.P. (1997). From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30.
8. Chapman, M.S., and Verma, I.M. (1996). Transcriptional activation by BRCA1. Nature 382, 678-679.
9. Chen, F., Nastasi, A., Shen, Z., Brenneman, M., Crissman, H., and Chen, D.J. (1997). Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52. Mutat. Res. 384, 205-211.
10. Chen, P.L., Chen, C.F., Chen, Y., Xiao, J., Sharp, Z.D., and Lee, W.H. (1998). The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl. Acad. Sci. USA 95, 5287-5292.
11. Claus, E.B., Risch, N., and Thompson, W.D. (1991). Genetic analysis of breast cancer in the cancer and steroid hormone study. Am. J. Hum. Genet. 48, 232-241.
12. Cleton-Jansen, A.M., Collins, N., Lakhani, S.R., Weissenbach, J., Devilee, P., et al. (1995). Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13. Br. J. Cancer 72, 1241-1244.
13. Connor, F., Bertwistle, D., Mee, P.J., Ross, G.M., Swift, S., et al. (1997). Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat. Genet. 17, 423-430.
14. Fishman, J., Osborne, M.P., and Telang, N.T. (1995). The role of estrogen in mammary carcinogenesis. Ann. N Y Acad. Sci. 768, 91-100.
15. Friedberg, E.C., Walker, G.C., and Siede, W. (1995). DNA repair and mutagenesis. (Washington, DC: ASM Press).
16. Futreal, P.A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshmann, K., et al. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122.
17. Goggins, M., Schutte, M., Lu, J., Moskaluk, C.A., Weinstein, C.L., et al. (1996). Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 56, 5360-5364.
18. Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K., and Koller, B.H. (1996). BRCA1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet. 12, 191-194.
19. Gudas, J.M., Nguyen, H., Li, T., and Cowan, K. (1995). Hormone-dependent regulation of BRCA1 inhuman breast cancer cells. Cancer Res. 55, 4561-4565.
20. Gudas, J.M., Li, T., Nguyen, H., Jensen, D., Rauscher, F.J.I., and Cowan, K.H. (1996). Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ. 7, 717-723.
21. Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996). The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023.
22. Hakem, R., de la Pompa, J.L., Elia, A., Potter, J., and Mak, T.W. (1997). Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat. Genet. 16, 298-302.
23. Hall, J.M., Lee, M.K., and Newmann, B. (1990). Linkage of early-onset breast cancer to chromosome 17q21. Science 250, 1684-1689.
24. Hanawalt, P.C., Cooper, P.K., Ganesan, A., and Smith, C.A. (1979). DNA repair in bacteria and mammalian cells. Annu. Rev. Biochem. 48, 783-836.
25. Kelsell, D.P., Spurr, N.K., Barnes, D.M., Gusterson, B., and Bishop, D.T. (1996). Combined loss of BRCA1/BRCA2 in grade 3 breast carcinomas. Lancet 347, 1554-1555.
26. Kerangueven, F., Eisinger, F., Noguchi, T., Allione, F., Wargniez, V., et al. (1997). Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions. Oncogene 14, 339-347.
27. Koonin, V.F., Altschul, S.F., and Bork, P. (1996). BRCA1 protein products: functional motifs. Nat. Genet. 13, 266-267.
28. Lancaster, J.M., Wooster, R., Mangion, J., Phelan, C.M., Cochran, C., et al. (1996). BRCA2 mutations in primary breast and ovarian cancers. Nat. Genet. 13, 238-240.
29. Lane, T.F., Deng, C., Elson, A., Lyu, M.S., Kozak, C.A., and Leder, P. (1995). Expression of BRCA1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 9, 2712-2722.
30. Liehr, J.G., Avitts, T.A., Randerath, E., and Randerath, K. (1986). Estrogen-induced endogenous DNA adduction: possible mechanism of hormonal cancer. Proc. Natl. Acad. Sci. USA 83, 5301-5305.
31. Lim, D.S., and Hasty, P. (1996). A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16, 7133-7143.
32. Liu, C.Y., Flesken-Nikitin, A., Li, S., Zeng, Y., and Lee, W.-H. (1996). Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843.
33. Ludwig, T., Chapman, D.L., Papaioannou, V.E., and Efstratiadis, A. (1997). Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226-1241.
34. Makela, T.P., Parvin, J.D., Kim, J., Huber, L.J., Sharp, P.A., and Weinberg, R.A. (1995). A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription. Proc. Natl. Acad. Sci. USA 92, 5174-5178.
35. Marcus, J.N., Watson, P., Page, D.L., Narod, S.A., Lenoir, G., et al. (1996). Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77, 697-709.
36. Marquis, S.T., Rajan, J.V., Wynshaw-Boris, A., Xu, J.,and Yin, G.-Y. (1995). The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues. Nat. Genet. 11, 17-26.
37. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P.A., Harshman, K., et al. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71.
38. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T., and Nakamura, Y. (1996). Mutation analysis in the BRCA2 gene in primary breast cancers. Nat. Genet. 13, 245-247.
39. Monteiro, A.N.A., August, A., and Hanafusa, H. (1996). Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA 93, 13595-13599.
40. Narod, S.A., Feunteun, J., Lynch, H.T., Watson, P., Conway, T., Lynch, J., and Lenoir, G. (1991). Familial breast-ovarian cancer locus on chromosome 17q12-23. Lancet 338, 82-83.
41. Neuhausen, S.L., and Marshall, C.J. (1994). Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res. 54, 6069-6072.
42. Newman, B., Austin, M.A., Lee, M., and King, M.-C. (1988). Inheritance of breast cancer: evidence for autosomal dominant transmission in high risk families. Proc. Natl. Acad. Sci. USA 85, 1-5.
43. Patel, K.J., Yu, V.P.C.C., Lee, H., Corcoran, A., Thistlethwaite, F.C., Evans, M.J., Colledge, W.H., Friedman, L.S., Ponder, B.A.J., and Venkitaraman, A.R. (1998). Involvement of Brca2 in DNA repair. Mol. Cell 1, 347-357.
44. Radding, C.M. (1991). Helical interactions in homologous pairing and strand exchange driven by RecA protein. J. Biol. Chem. 266, 5355-5358.
45. Rajan, J.V., Wang, M., Marquis, S.T., and Chodosh, L.A. (1996). Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc. Natl. Acad. Sci. USA 93, 13078-13083.
46. Rajan, J.V., Marquis, S.T., Gardner, H.P., and Chodosh, L.A. (1997). Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev. Biol. 184, 385-401.
47. Rupp, W.D., and Howard-Flanders, P. (1968). Discontinuities in the DNA synthesised in an excision-defective strain of Escherichia coli following ultraviolet irradiation. J. Mol. Biol. 31, 291-304.
48. Scully, R., Ganesan, S., Brown, M., DeCaprio, J.A., Cannistra, S.A., Feunteun, J., Schnitt, S., and Livingston, D.M. (1996). Location of BRCA1 in human breast and ovarian cell lines. Science 272, 123-125.
49. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D.M. (1997a). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275.
50. Scully, R., Anderson, S.F., Chao, D.M., Wei, W., Ye, L., Young, R.A., Livingston, D.M., and Parvin, J.D. (1997b). BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 94, 5605-5610.
51. Scully, R., Chen, J., Ochs, R.L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D.M. (1997c). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435.
52. Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.-S., Regel, E., et al. (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking BRCA2. Nature 386, 804-810.
53. Shinohara, A., Ogawa, H., and Ogawa, T. (1992). Rad51 protein involved in repair and recombination in Saccharomyces cerevisiae is a RecA-like protein. Cell 69, 457-470.
54. Sung, P. (1994). Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein. Science 265, 1241-1243.
55. Sung, P., and Robberson, D.L. (1995). DNA strand exchange mediated by a Rad51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82, 453-461.
56. Suzuki, A., de la Pompa, J.L., Hakem, R., Elia, A., Yoshida, R., et al. (1997). Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 11, 1242-1252.
57. Tavtigian, S.V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., et al. (1996). The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat. Genet. 12, 333-337.
58. Teng, D.H., Bogden, R., Mitchell, J., Baumgard, M., Bell, R., et al. (1996). Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nat. Genet. 13, 241-244.
59. Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., et al. (1996). Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. USA 93, 6236-6240.
60. Vaughn, J.P., Davis, P.L., Jarboe, M.D., Huper, G., Evans, A.C., et al. (1996). BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells. Cell Growth Differ. 7, 711-715.
61. Wessel, G.M., and McClay, D.R. (1986). Two embryonic, tissue-specific molecules identified by adouble-label immunofluorescence technique for monoclonal antibodies. J. Histochem. Cytochem. 34, 703-706.
62. Wooster, R., Neuhausen, S.L., Mangion, J., Quirk, Y., Ford, D., et al. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 265, 2088-2090.
63. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., et al. (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792.
64. Xia, S.J., Shammas, M.A., and Reis, R.J. (1997). Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol. Cell. Biol. 17, 7151-7158.
65. Zhang, H., Tombline, G., and Weber, B.L. (1998). BRCA1, BRCA2, and DNA damage response: collision or collusion? Cell 92, 433-436.