Fragile and unstable chromosomes in cancer: Causes and consequences

Trends in Genetics

Volumn 17, Issue 6, 2001, Pages 339-345

  Richards, Robert I ^a  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN;

ADENOCARCINOMA; ANEUPLOIDY; APOPTOSIS; CANCER; CANCER CELL; CANCER RISK; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME FRAGILE SITE; CHROMOSOME FRAGILITY; CHROMOSOME MUTATION; CHROMOSOME NUMBER; CHROMOSOME TRANSLOCATION; CLINICAL FEATURE; DNA REPLICATION; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC DISORDER; HETEROZYGOSITY LOSS; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; REVIEW; TUMOR CELL; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME FRAGILE SITES; CHROMOSOME FRAGILITY; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; HUMANS; MUTATION; NEOPLASMS;

EID: 0035369401     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02303-4     Document Type: Review

References (49)

1. Fragile sites still breaking
2. Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2
3. Human chromosomal fragile site FRA16B is an amplified minisatellite repeat
4. FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis
5. Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B
6. Sequence of the FRA3B common fragile site: Implications for the mechanism of FHIT deletion
7. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
8. Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACs spanning FRA7G within the common region of LOH in breast and prostate cancer
9. FRA7G extends over a broad region: Coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites
10. Molecular characterisation of a common fragile site (FRA7H) on human chromosome 7 by the cloning of an SV40 integration site
11. Constitutive fragile sites and cancer
12. Variation in the expression of aphidicolin-induced fragile sites in human lymphocyte cultures
13. Allele specific late replication and fragility of the most active common fragile site, FRA3B
14. The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives
15. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
16. Common chromosomal fragile site FRA16D DNA sequence: Identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells
17. The tumour-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
18. Muir-Torre-like syndrome in Fhit-deficient mice
19. Hyaluronidase induction of a novel WW domain-containing oxidoreductase that enhances tumour necrosis factor cytotoxicity
20. Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy
21. Deregulated cyclin E induces chromosome instability
22. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
23. A new role for hypoxia in tumour progression: Induction of fragile site triggering genomic rearrangements and formation of complex Dms and HSRs
24. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
25. A genome-wide map showing common regions of loss of heterozygosity/allelic imbalance in breast cancer
26. Chromosomal fragile site FRA16D and DNA instability in cancer
27. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
28. Unusual behaviour of a human autosome having two rare folate sensitive fragile sites
29. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
30. Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma
31. Frequent dysregulation of the c-MAF proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
32. A 700 kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D
33. The characterisation of the common fragile site FRA16D and its involvement in multiple myeloma translocations
34. Human papillomavirus type 16 integrations in cervical tumours frequently occur in common fragile sites
35. The role of the FHIT/FRA3B locus in cancer
36. Structure and expression of the FHIT in cancer cells
37. An FHIT tumour suppressor gene?
38. FHIT, a putative tumour suppressor in humans, is a dinucleotide 5′,5‴-P1,P3-triphosphate hydrolase
39. The timing of cell division: Ap4A as a signal
40. Replacement of Fhit in cancer cells suppresses tumorigenicity
41. The tumour-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
42. Muir-Torre-like syndrome in Fhit-deficient mice
43. The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region
44. FHIT gene therapy prevents tumor development in Fhit-deficient mice
45. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer
46. Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: Implications for replicon mapping and chromosome fragility
47. Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia
48. DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
49. Fragile sites