Sensing and responding to DNA damage

Current Opinion in Genetics and Development

Volumn 10, Issue 1, 2000, Pages 17-25

  Lowndes, Noel F ^a   Murguia, Jose R ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRUCTURE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034003395     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00050-7     Document Type: Review

References (76)

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45. ••], these studies describe a mechanism whereby either inhibition of DNA synthesis or DNA damage during S phase prevent late origin firing. Thus, regulation of late origin firing is an important component of the 'intra-S-phase' checkpoint.
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63. ••].
64. ••].
65. ••], a clear demonstration of the role of the checkpoint pathway in regulation of DSB repair. It is unlikely that checkpoint proteins play a direct role on the enzymology of DSB repair.
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