Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

Nucleic Acids Research

Volumn 29, Issue 21, 2001, Pages 4378-4386

  Pedrazzi, Graziella ^a   Perrera, Claudia ^a   Blaser, Heiko ^a   Kuster, Patrick ^a   Marra, Giancarlo ^a   Davies, Sally L ^b   Ryu, Gi Hyuck ^a,d   Freire, Raimundo ^c   Hickson, Ian D ^b   Jiricny, Josef ^a   Stagljar, Igor ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; GENE PRODUCT; HELICASE;

ARTICLE; BASE MISPAIRING; BLOOM SYNDROME; CANCER SUSCEPTIBILITY; CELL NUCLEUS; CONTROLLED STUDY; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; EVOLUTION; GENE MUTATION; GENETIC CONSERVATION; GENETIC DISORDER; GENETIC RECOMBINATION; GENETIC STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 0035504589     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.21.4378     Document Type: Article

References (41)

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2. The Bloom's syndrome gene product is homologous to RecQ helicases
3. The recQ gene of Escherichia coli K12: Molecular cloning and isolation of insertion mutants
4. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
5. +, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
6. Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ
7. Positional cloning of the Werner's syndrome gene
8. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
9. Cloning of two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
10. Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder
11. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
12. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination
13. Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae
14. The Bloom's syndrome gene product promotes branch migration of holliday junctions
15. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
16. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homologous recombination
17. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
18. The Bloom's syndrome gene product interacts with topoisomerase III
19. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
20. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
21. Eukaryotic mismatch repair: An update
22. Eukaryotic DNA mismatch repair
23. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
24. The Bloom's syndrome gene product is a 3′-5′ DNA helicase
25. Identification of hMutLβ, a heterodimer of hMLH1 and hPMS1
26. Mammalian Ras interacts directly with the serine-threonine kinase Raf
27. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines
28. Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription
29. DNA mismatch correction in a defined system
30. Methyl-directed repair of DNA base-pair mismatches in vitro
31. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
32. Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast
33. The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2
34. Mediating mismatch repair
35. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
36. DNA polymerase delta is required for human mismatch repair in vitro
37. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair
38. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction
39. Saccharomyces cerevisiae Msh2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA
40. Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes
41. The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair