Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function

Genes and Development

Volumn 15, Issue 11, 2001, Pages 1361-1372

  Wang, Hong ^a   Liu, Dou ^a   Wang, Yanchang ^a   Qin, Jun ^a   Elledge, Stephen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Anaphase promoting complex; Chk1; DNA damage checkpoint; Pds1; Phosphorylation

Indexed keywords

DNA;

ANAPHASE; ARTICLE; CELL CYCLE; DNA DAMAGE; GENOTYPE; IMMUNOBLOTTING; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; YEAST;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FUNGAL PROTEINS; GENES, CDC; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PLASMIDS; PROTEIN KINASES; PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0034991258     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.893201     Document Type: Article

References (69)

1. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
2. The spindle checkpoint
3. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisae
4. Association of Chk1 with 3 proteins is stimulated by DNA damage
5. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
6. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
7. Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control
8. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
9. Pds1p of budding yeast has dual roles: Inhibition of anaphase initiation and regulation of mitotic exit
10. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
11. Cell cycle checkpoints: Preventing an identity crisis
12. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
13. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
14. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes
15. Cut2 proteolysis required for sister-chromatid separation in fission yeast
16. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase
17. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
18. RAD53 DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
19. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
20. DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae
21. Cell cycle. The only way out of mitosis
22. Roles of ubiquitin-mediated proteolysis in cell cycle control
23. Substrate specificity determinants of the checkpoint protein kinase Chk1
24. Budding yeast Cdc20: A target of the spindle checkpoint
25. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation. Evidence that proper spindle association of esp1 is regulated by pds1
26. Phosphorylation meets ubiquitination: The control of NF-[κ]B activity
27. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
28. Dynamic localization of the nuclear import receptor and its interactions with transport factors
29. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
30. Proteolysis and the G1-S transition: The SCF connection
31. Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase
32. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
33. The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast
34. Sensing and responding to DNA damage
35. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
36. Regulation of the APC and the exit from mitosis
37. Cyclin ubiquitination: The destructive end of mitosis
38. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1
39. Chk1 is a weel kinase in the G2 DNA damage check-point inhibiting cdc2 by Y15 phosphorylation
40. The G2-phase DNA-damage checkpoint
41. Mitotic and G2 checkpoint control: Regulation of -3 protein binding by phosphorylation of Cdc25C on serine-216
42. Chk1 and cds1: Linchpins of the DNA damage and replication checkpoint pathways
43. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
44. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
45. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
46. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
47. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
48. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
49. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
50. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
51. SCF(β-TRCP) and phosphorylation dependent ubiquitination of IκBα catalyzed by Ubc3 and Ubc4
52. Cell cycle: Checkpoint proteins and kinetochores
53. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
54. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
55. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition
56. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Sccl
57. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
58. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
59. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
60. DRC1, DNA replication and checkpoint protein 1, functions with DPBl1 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
61. A DNA damage checkpoint meets the cell cycle engine
62. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
63. The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
64. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in pathway(s)
65. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
66. TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast
67. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
68. The DNA damage response: Putting checkpoints in perspective
69. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis