Drug interactions at GABAA receptors

Progress in Neurobiology

Volumn 67, Issue 2, 2002, Pages 113-159

  Korpi, Esa R ^a   Gründer, Gerhard ^b   Lüddens, Hartmut ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALCOHOL; ANION CHANNEL; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BICUCULLINE; CATION; CLOZAPINE; DIAZEPAM; ETOMIDATE; FUROSEMIDE; INHALATION ANESTHETIC AGENT; ION; ION CHANNEL; LIGAND; NEUROSTEROID; NEUROTRANSMITTER RECEPTOR; PICROTOXININ; PROPOFOL; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; ZOLPIDEM;

AUTORADIOGRAPHY; BEHAVIOR; BINDING SITE; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; DRUG RESEARCH; FISH; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; KNOCKOUT GENE; LIGAND BINDING; MEMBRANE BIOLOGY; MOLECULAR BIOLOGY; MOLECULAR CLONING; MOLECULAR EVOLUTION; NEUROPSYCHIATRY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; REVIEW; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANIMALS; DRUG INTERACTIONS; GABA AGONISTS; GABA ANTAGONISTS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, GABA-A;

EID: 0036064978     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(02)00013-8     Document Type: Review

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314. A receptor at sites on the N-terminal side of the middle of TM2
315. A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder
316. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
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318. A receptor subtypes: Dissecting their pharmacological functions
319. Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice: Comparison of diazepam, bretazenil and abecarnil, bretazenil and abecarnil
320. A α6 receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line
321. Radioiodinated 2′-iododiazepam: A potential imaging agent for SPECT investigations of benzodiazepine receptors
322. 11C]RO 15-1788 a benzodiazepine antagonist, studied in human brain in vivo by positron tomography
323. Novel properties of homomeric β1 γ-aminobutyric acid type A receptors: Actions of the anesthetics propofol and pentobarbital
324. A receptors: Influence of receptor subunits
325. Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at γ-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes
326. A receptors in rat brain
327. Ethanol sensitivity and consumption in F2 hybrid crosses of ANT and AT rats
328. In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci
329. 18F]FDG as PET markers of epileptic foci
330. In vivo demonstration of altered benzodiazepine receptor density in patients with generalised epilepsy
331. A receptor subnits: Role of the δ subunit
332. A receptor isoforms
333. Contrasting actions of lanthanum on different recombinant γ-aminobutyric acid receptor isoforms expressed in L929 fibroblasts
334. Effect of 'high ceiling' diuretics on active salt transport in the cortical thick ascending limb of Henle's loop of rabbit kidney
335. Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT: A preliminary report
336. A receptor shows a ligand-gated receptor super-family
337. Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA α6 receptors and the serotonin transporter in the level of response to alcohol: A pilot study
338. 2+
339. A receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat
340. Synaptic and extrasynaptic γ-aminobutyric acid type A receptor clusters in rat hippocampal cultures during development
341. A receptor β3 subunit involved in the actions of pentobarbital
342. A receptor desensitization
343. Changes in benzodiazepine receptors in Alzheimer-type dementia
344. A receptor on the response to a neurosteroid
345. Visualization of specific binding sites of benzodiazepine in human brain
346. A receptor subtypes
347. A receptors
348. A receptors
349. A γ-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex
350. A receptors on channel function
351. A receptor channels
352. A receptor function and ethanol
353. A receptor ε and θ subunits display unusual structural variation between species and are enriched in the rat locus ceruleus
354. Characterization of γ-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions
355. Altered atypical coupling of γ-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines
356. A receptors are differentially sensitive to zinc: Dependence on subunit composition
357. A glia-derived acetylcholine-binding protein that modulates synaptic transmission
358. A receptor α subunit
359. A receptor α4 subunit in association with increased anxiety
360. A receptor complex in experimental absence seizures in rat: An autoradiographic study
361. A-gated chloride ion channel blockers: Substituted 5-tert-butyl-2-phenyl-1,3-dithianes and -dithiane oxides
362. 35S]TBPS binding
363. A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: More support for a continuum hypothesis of "functional" psychosis
364. 35S]t-Butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to γ-aminobutyric acid-A and ion recognition sites
365. A receptors
366. A receptor inverse agonists modulate γ-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site
367. A receptor subtype in the brain is not lethal in mice
368. 123I]Iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain
369. A receptor expression in glioma cells is triggered by contact with neuronal cells
370. Anion permeability of the inhibitory post-synaptic membrane of the crayfish neuromuscular junction
371. A receptor α subunits that mediate specific assembly with receptor β subunits
372. Relative contributions of passive equilibrium and active transport to the distribution of chloride in mammalian cortical neurons
373. A receptor: Dependence on receptor subunit combination
374. Residues in transmembrane domains I and II determine γ-aminobutyric acid type A receptor subtype-selective antagonism by furosemide
375. Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: A fractal analysis
376. A receptor subtype
377. Stereoselective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals
378. Behavioral sensitivity and ethanol potentiation of the N-methyl-D-aspartate receptor antagonist MK-801 in a rat line selected for high ethanol sensitivity
379. A receptor subtype
380. A receptor δ subunit gene leads to an up-regulation of γ2 subunit-containing receptors in cerebellar granule cells
381. A receptors by aluminum
382. A receptor γ2 subunit messenger RNA by tolerance to and withdrawal from pentobarbital - An in situ hybridization study
383. A receptor channels
384. Differential regulation of γ-aminobutyric acid receptor channels by diazepam and phenobarbital
385. A receptor gated current depends on the subunit composition
386. A receptor α1 subunit N-terminal extracellular domain in propofol potentiation of chloride current
387. A receptors expressed in Xenopus oocytes
388. The structure of ion channels in membranes of excitable cells
389. Nicotinic acetylcholine receptor at 9 Å resolution
390. Acetylcholine receptor channel imaged in the open state
391. A receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity
392. 3H]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity
393. A receptors of an alcohol-sensitive ANT rat line
394. A receptors in two rat lines selected for high and low alcohol sensitivity
395. A receptor β2α6α1γ2 subunit gene cluster
396. A receptors in brain sections of AT and ANT rats
397. A receptors and anxiolytic action of diazepam
398. 123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia
399. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons
400. Decreased cerebral response to inhibitory neurotransmission in alcoholics
401. Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification
402. A receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit
403. A receptor expressed in Xenopus oocytes requires eight amino acids contained in the γ2L subunit
404. A/benzodiazepine receptors
405. A receptor β subunit
406. A receptors containing the α4 subunit
407. Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation
408. Benzodiazepine and GABA receptors in early Huntington's disease
409. A receptors via two distinct and separable mechanisms
410. A receptor interaction
411. A receptors and the cytoskeleton
412. Loreclezole (R 72063): An anticonvulsant chemically unrelated to prototype antiepileptic drugs
413. Distribution of GABA receptor ρ subunit transcripts in the rat brain
414. A receptors in rat hippocampal CA1 pyramidal neurons
415. 2+ antagonize NMDA and GABA responses of hippocampal neurons
416. A receptor α1, subunit is essential for GABA binding and chloride ion current gating
417. A receptor currents
418. Topiramate modulates GABA-evoked currents in murine cortical neurons by a non-benzodiazepine mechanism
419. A receptor gene family: New targets for therapeutic intervention
420. Another mechanism for creating diversity in γ-aminobutyrate type A receptors: RNA splicing directs expression of two forms of γ2 phosphorylation site
421. Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
422. A receptor
423. A receptors is essential for benzodiazepine agonist binding
424. The modulatory action of loreclezole at the γ-aminobutyric acid type A receptor is determined by a single amino acid in the β2 and β3 subunit
425. A receptor that determine ligand binding and modulation at the benzodiazepine site
426. A receptor channels: From subunits to functional entities
427. A receptor α4 subunit
428. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
429. A agonists
430. High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors
431. Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol
432. A receptors
433. A receptor complex: Dependence on the second transmembrane domain of β subunits
434. A receptor α1 subunit
435. A receptor channel-lining residues probed in cysteine mutants
436. Propofol-induced ataxia and hypnosis in rat lines selected for differential alcohol sensitivity
437. A/benzodiazepine receptors
438. A receptor-regulated chloride flux in rat cortical synaptoneurosomes
439. Propagating conformational changes over long (and short) distances in proteins
440. A receptor on the response to a neurosteroid
441. A receptors containing one, two, or three different subunits
442. Development of GABA-mediated, chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices
443. A receptors
444. A receptor deactivation, desensitization and inhibitory synaptic currents in rat cerebellar neurons