δ subunit inhibits neurosteroid modulation of GABA(A) receptors

Journal of Neuroscience

Volumn 16, Issue 21, 1996, Pages 6648-6656

  Zhu, Wei Jian ^a   Wang, Jian Feng ^a   Krueger, Karl E ^a   Vicini, Stefano ^a,b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

allopregnenolone; cDNA transfection; GABA(A) receptor subunit; patch clamp; single cell RT PCR; aminobutyric acid

Indexed keywords

3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL; ION CHANNEL; MESSENGER RNA; PREGNENOLONE; PROTEIN SUBUNIT;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GRANULE CELL; HUMAN; HUMAN CELL; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPSE;

EID: 0000808114     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-21-06648.1996     Document Type: Article

References (40)

1. A receptor subunit mRNA in rat cerebellar granule neurons: importance of environmental cues. J Neurochem 66:1347-1353.
2. A receptor subtypes containing the S subunit in rat brain. FEBS Lett 283:145-149.
3. A receptor subunit mRNAs in vivo and in vitro. J Neurochem 59:62-72.
4. Chen C, Okayama H (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
5. Cooper EJ, Johnston GAR, Edwards FA (1995) Differential sensitivity of synaptic GABAergic currents to a neuroactive steroid in brain slices from male rats. Soc Neurosci Abstr 21:1345.
6. A receptors. J Pharmacol Exp Ther 272:438-445.
7. A receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
8. A receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci 14:5302-5324.
9. A receptor complexes in rat cortex and spinal cord show differential responses to steroid modulation. Mol Pharmacol 40:995-999.
10. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS (1988) Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther 246:803-812.
11. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp technique for high-resolution current recording from cell and cell-free membrane patches. Pflügers Arch 391:85-91.
12. Kofuji P, Wang JB, Moss SJ, Huganir RL, Burt DR (1991) Generation of two forms of the gamma-aminobutyric acid A receptor γ2 subunit in mice by alternative splicing. J Neurochem 56:713-715.
13. A receptor a subunit. Mol Pharmacol 44:87-92.
14. A receptor function. Trends Pharmacol 16:295-303.
15. A receptors to neurosteroids. J Neurochem 57:1818-1821.
16. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
17. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 12:4151-4172.
18. A/benzodiazepine receptor heterogeneity: neurophysiological implications. Neuropharmacology 34:245-254.
19. A receptor channels. Annu Rev Neurosci 17:569-602.
20. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007.
21. Majewska MD, Mienville JM, Vicini S (1988) Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett 90:279-284.
22. A receptor structure and physiological properties in cultured cerebellar granule neurons. Neuron 13:149-158.
23. A receptor subtypes really occur in the brain. Trends Neurosci 19:139-143.
24. A receptor subunit for benzodiazepine pharmacology. Nature 338:582-584.
25. A receptor. Neuron 4:759-765.
26. A receptor subunit composition? Receptors Channels 1:135-142.
27. Quirk K, Gillard NP, Ragan I, Whiting PJ, McKernan RM (1994) Model of subunit composition of γ-aminobutyric acid receptor subtypes expressed in rat cerebellum with respect to their a and γ/δ subunits. J Biol Chem 269:16020-16028.
28. A receptors from rat brain. Eur J Pharmacol 290:175-181.
29. A receptors in rat brain. J Pharmacol Exp Ther 262:801-806.
30. A receptor subunit: role of the S subunit. J Neurosci 14:7077-7086.
31. Saxena NC, MacDonald RL (1996) Properties of putative cerebellar γ-aminobutyric acid (A) receptor isoforms. Mol Pharmacol 49:567-579.
32. A receptor on the response on the response to a steroid. Eur J Pharmacol 206:77-88.
33. A receptor subunits exist in distinct neuronal sub-populations. Neuron 3:327-337.
34. A receptors on channel function. Neuron 5:703-711.
35. Turner DM, Ransom RW, Yang JS-J, Olsen EW (1989) Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther 248:960-966.
36. A receptor subtypes. Int Rev Neurobiol 38:95-139.
37. A receptor: is there hope? J Neurosci Res 41:567-571.
38. Zhao Z, Joho RH (1990) Isolation of distantly related members in a multigene family using the polymerase chain reaction technique. Biochem Biophys Res Commun 167:174-182.
39. A receptor occurs only after cerebellar granule cell migration. Brain Res Dev Brain Res 75:91-103.
40. Zheng T, Zhu WJ, Puia G, Vicini S, Grayson DR, Costa E, Caruncho HJ (1995) Changes in γ-aminobutyrate type A receptor subunits mRNAs, translation product expression, and receptor function during neuronal maturation in vitro. Proc Natl Acad Sci USA 91:10952-10956.