Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation

Journal of Neuroscience

Volumn 21, Issue 1, 2001, Pages 67-74

  Wagner, David A ^a   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Agonist efficacy; Binding site; Cysteine mutagenesis; GABA; GABAA receptor; Protein structure; Substituted cysteine accessibility method

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID; BIOTIN DERIVATIVE; CYSTEINE; ION CHANNEL; LIGAND; PENTOBARBITAL; RECEPTOR SUBUNIT; WATER;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CHANNEL GATING; CHEMICAL REACTION KINETICS; COMPETITIVE INHIBITION; CONTROLLED STUDY; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

EID: 0035141668     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-01-00067.2001     Document Type: Article

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