Low brain GABA level is associated with poor seizure control

Annals of Neurology

Volumn 40, Issue 6, 1996, Pages 908-911

  Petroff, Ognen A C ^a   Rothman, Douglas L ^b   Behar, Kevin L ^a   Mattson, Richard H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ADULT; ARTICLE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DISEASE CONTROL; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTIC FOCUS; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL LOBE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADULT; ANTICONVULSANTS; BRAIN; EPILEPSY; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED;

EID: 0030483254     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410400613     Document Type: Article

References (28)

1. Roberts E. The establishment of GABA as a neurotransmitter. In: Squires RF, ed. GABA and benzodiazepines receptors, vol 1. Boca Raton, FL: CRC Press, 1988:1-21
2. Lambert N, Grover L. The mechanism of biphasic GABA responses. Science 1995;269:928-929
3. Tasker JG, Dudek FE. Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy. Neurochem Res 1991;16:251-262
4. Roberts E. Failure of GABAergic inhibition: a key to local and global seizures. Adv Neurol 1986;44:319-341
5. Meldrum BS. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br J Clin Pharmacol 1989;27(suppl 1): 3S-11S
6. DeDeyn PP, D'Hooge R, Marescau B, Pei Y-Q. Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants. Epilepsy Res 1992;12: 87-110
7. During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 1993;341:1607-1613
8. Fountain NB, Lothman EW. Pathophysiology of status epilepticus. J Clin Neurophysiol 1995;12:326-342
9. Löscher W, Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 1994;17:95-134
10. Heinemann U, Draguhn A, Ficker E, et al. Strategies for the development of drugs for pharmacoresistant epilepsies. Epilepsia 1994;35(suppl 5):S10-S21
11. Wood JH, Hare TA, Glaeser BS, et al. Low cerebrospinal fluid γ-aminobutyric acid content in seizure patients. Neurology 1979;29:1203-1208
12. Böhlen P, Huot S, Palfreyman MG. The relationship between GABA concentrations in brain and cerebrospinal fluid. Brain Res 1979;167:297-305
13. Schechter PJ, Sjoerdsma A. Clinical relevance of measuring GABA concentrations in cerebrospinal fluid. Neurochem Res 1990;15:419-423
14. Kuzniecky RI, Jackson GD. Magnetic resonance in epilepsy. New York: Raven, 1995
15. Petroff OAC, Pleban LA, Spencer DD. Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetyl-aspartate, glutamate, and GABA content of epileptic human brain. Magn Reson Imaging 1995;13:1197-1211
16. 1H-double resonance difference spectroscopy of the rat brain in vivo. Proc Natl Acad Sci USA 1984;81:6330-6334
17. 1H NMR measurements of GABA levels in human brain in vivo. Proc Natl Acad Sci USA 1993;90:5662-5666
18. 31P NMR spectroscopic study of rat brain in vivo. Magn Reson Med 1994;31:660-667
19. Mattson RH, Petroff O, Rothman D, Behar K. Vigabatrin: effects on human brain GABA levels by nuclear magnetic resonance spectroscopy. Epilepsia 1994;53(suppl 5):S29-S32
20. 1H spectroscopic measurements of GABA, glutamate, and glutamine in human brain. Epilepsia 1995;36:457-464
21. Mattson RH, Petroff OAC, Rothman DL, Behar KL. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurol Scand Suppl 1995;162: 27-30
22. Petroff OAC, Rothman DL, Behar KL, et al. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 1996;39:95-99
23. 1H NMR spectra of human brain. Magn Reson Med 1994;32:294-302
24. Petroff OAC, Spencer D, Alger JR, Prichard JW. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 1989;39: 1197-1202
25. Gardner MJ, Altman DG. Statistics with confidence. London: British Medical Journal, 1989
26. During MJ. Dynamic neurochemical alterations in human temporal lobe epilepsy. Clin Neurosci 1994;2:53-63
27. During MJ, Ryder KM, Spencer DD. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature 1995; 376:174-177
28. van Donselaar CA, Schimsheimer R, Geerts AT, Declerck AC. Value of the electroencephalogram in adult patients with untreated first seizure. Arch Neurol 1992;49:231-237