GABAA-receptor expression in glioma cells is triggered by contact with neuronal cells

European Journal of Neuroscience

Volumn 14, Issue 8, 2001, Pages 1294-1302

  Synowitz, Michael ^a,b   Ahmann, Petra ^a   Matyash, Marina ^a   Kuhn, Susanne A ^a   Hofmann, Birte ^c   Zimmer, Claus ^d   Kirchhoff, Frank ^a   Kiwit, Jürgen C W ^b   Kettenmann, Helmut ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Hospital Buch   (Germany)

^c Institute of Diagnostic Research   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cerebellar granule cells; Cl channels; Enhanced green fluorescent protein; GABA; Patch clamp

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; GREEN FLUORESCENT PROTEIN; MUSCIMOL; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN SLICE; CANCER CELL CULTURE; CELL ACTIVITY; CELL CONTACT; CELL INTERACTION; CELL METABOLISM; COCULTURE; CONTROLLED STUDY; CORRELATION FUNCTION; GLIOMA CELL; MICROGLIA; NERVE CELL; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; RECEPTOR BLOCKING; TUMOR GROWTH;

EID: 0035783708     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01764.x     Document Type: Article

References (39)

1. Ambar, B.B., Frei, K., Malipiero, U., Morelli, A.E., Castro, M.G., Lowenstein, P.R. & Fontana, A. (1999) Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand. Hum. Gene Ther., 10, 1641-1648.
2. A receptor inhibits the proliferative effects of bFGF in cortical progenitor cells. Eur. J. Neurosci., 9, 291-298.
3. Barth, R.F. (1998) Rat brain tumor models in experimental neurooncology: The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas. J. Neurooncol., 36, 91-102.
4. von Blankenfeld, G., Turner, J., Ahnert-Hilger, G., John, M., Enkvist, M.O., Stephenson, F., Kettenmann, H. & Wiedenmann, B. (1995) Expression of functional (GABA)A receptors in neuroendocrine gastropancreatic cells. Pflugers Arch., 430, 381-388.
5. Bottenstein, J.E. & Sato, G.H. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA, 76, 514-517.
6. Chicoine, M.R. & Silbergeld, D.L. (1995) Invading C6 glioma cells maintaining tumorigenicity. J. Neurosurg., 83, 665-671.
7. Drejer, J., Larsson, O.M., Kvamme, E., Svenneby, G., Hertz, L. & Schousboe, A. (1985) Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo. Neurochem. Res., 10, 49-62.
8. 3H]thymidine incorporation in cultured rat astrocytes. Neuropharmacology, 38, 725-732.
9. Giulian, D. & Baker, T.J. (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci., 6, 2163-2178.
10. A mRNAs have functional receptors. J. Neurosci., 14, 5429-5436.
11. Hamill, O., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. (1981) Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflugers Arch., 391, 85-100.
12. Hatten, M.E. (1987) Neuronal inhibition of astroglial cell proliferation is membrane mediated. J. Cell Biol., 104, 1353-1360.
13. Hatten, M.E. & Shelanski, M.L. (1988) Mouse cerebellar granule neurons arrest the proliferation of human and rodent astrocytoma cells in vitro. J. Neurosci., 8, 1447-1453.
14. Herschman, H. (1978) Characteristics of cell culture lines derived from chemically-induced neural tumors. In Laerum, O.D., Bigner, D.D. & Rajewsky, M.F. (eds), Biology of Brain Tumors, UICC, Geneva, pp. 172-183.
15. Jussofie, A., Reinhardt, V. & Kalff, R. (1994) GABA binding sites: Their density, their affinity to muscimol and their behaviour against neuroactive steroids in human gliomas of different degrees of malignancy. J. Neural Transm. Gen. Sect., 96, 233-241.
16. Ko, L., Koestner, A. & Wechsler, W. (1980) Morphological characterization of nitrosourea-induced glioma cell lines and clones. Acta Neuropathol. (Berl)., 51, 23-31.
17. Kobayashi, N., Allen, N., Clendenon, N. & Ko, L. (1980) An improved rat brain-tumor model. J. Neurosurg., 53, 808-815.
18. - conductance increase and a K+ channel blockade in cerebellar granule cells. Neuroscience, 79, 177-189.
19. A receptors on human glioma cells. Eur. J. Neurosci., 10, 231-238.
20. Labrakakis, C., Patt, S., Hartmann, J. & Kettenmann, H. (1998b) Glutamate receptor activation can trigger electrical activity in human glioma cells. Eur. J. Neurosci., 10, 2153-2162.
21. Labrakakis, C., Patt, S., Weydt, P., Cervos Navarro, J., Meyer, R. & Kettenmann, H. (1997b) Action potential-generating cells in human glioblastomas. J. Neuropathol. Exp. Neurol., 56, 243-254.
22. A receptors mediate trophic effects of GABA on embryonic brainstem monoamine neurons. J. Neurosci., 17, 2420-2428.
23. - channels in vitro. J. Neurobiol., 35, 277-286.
24. McCarthy, K.D. & de Vellis, J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol., 85, 890-902.
25. Miettinen, H., Kononen, J., Haapasalo, H., Helen, P., Sallinen, P., Harjuntausta, T., Helin, H. & Alho, H. (1995) Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: Relationship to cell. Cancer Res., 55, 2691-2695.
26. Mokry, J., Nemecek, S., Adler, J. & Dedic, K. (1993) Inoculation of C6 cell suspension into the brain of adult rats: Immunohistochemical study. Funct. Dev. Morph., 3, 175-180.
27. A receptor expression in Bergmann glial cells. J. Neurosci., 14, 2503-2514.
28. Olivi, A., Ewend, M.G., Utsuki, T., Tyler, B., Domb, A.J., Brat, D.J. & Brem, H. (1996) Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat. Cancer Chemother. Pharmacol., 39, 90-96.
29. Pastor, A., Chvatal, A., Sykova, E. & Kettenmann, H. (1995) Glycine- and GABA-activated currents in identified glial cells of the developing rat spinal cord slice. Eur. J. Neurosci., 7, 1188-1198.
30. Peterson, D.L., Sheridan, P.J. & Brown, W.E. Jr (1994) Animal models for brain tumors: Historical perspectives and future directions. J. Neurosurg., 80, 865-876.
31. Reifenberger, G., Bilzer, T., Seitz, R. & Wechsler, W. (1989) Expression of vimentin and glial fubrillary acidic protein in ethylnitrosourea-induced rat gliomas and glioma cell lines. Acta Neuropathol. (Berl)., 78, 270-282.
32. A receptors mediate inhibition of T cell responses. J. Neuroimmunol., 96, 21-28.
33. Tseng, S., Hwang, L. & Lin, S. (1997) Induction of antitumor immunity by intracerebrally implanted rat C6 glioma cells genetically engineered to secrete cytokines. J. Immunother., 20, 334-342.
34. A receptor subunit mRNAs in 13 cell lines. J. Neurosci., 14, 5417-5428.
35. Tzeng, J.J., Barth, R.F., Orosz, C.G. & James, S.M. (1991) Phenotype and functional activity of tumor-infiltrating lymphocytes isolated from immunogenic and nonimmunogenic rat brain tumors. Cancer Res., 51, 2373-2378.
36. Whittle, I.R., Macarthur, D.C., Malcolm, G.P., Li, M., Washington, K. & Ironside, J.W. (1998) Can experimental models of rodent implantation glioma be improved? J. Neurooncol., 36, 231-242.
37. Yang, W., Barth, R.F., Rotaru, J.H., Joel, D.D., Nawrocky, B.A. & Goodman, J. (1997) Enhanced survival of glioma bearing rats following boron neutron capture therapy with osmotic blood-brain barrier disruption and intracarotid injection of boronophenylalanine. J. Neurooncol., 33, 59-70.
38. A receptor alpha2 subunit is upregulated by testosterone in rat cerebral cortex. Neurosci. Lett., 265, 25-28.
39. Zhang, M., Gong, Y., Assy, N. & Minuk, G.Y. (2000) Increased GABAergic activity inhibits alpha-fetoprotein mRNA expression and the proliferative activity of the HepG2 human hepatocellular carcinoma cell line. J. Hepatol., 32, 85-91.