Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor α1 subtype

Nature Neuroscience

Volumn 3, Issue 6, 2000, Pages 587-592

  McKernan, R M ^a   Rosahl, T W ^a   Reynolds, D S ^a   Sur, C ^a   Wafford, K A ^a   Atack, J R ^a   Farrar, S ^a   Myers, J ^a   Cook, G ^a   Ferris, P ^a   Garrett, L ^a   Bristow, L ^a   Marshall, G ^a   Macaulay, A ^a   Brown, N ^a   Howell, O ^a   Moore, K W ^a   Carling, R W ^a   Street, L J ^a   Castro, J L ^a   Ragan, C I ^a   Dawson, G R ^a   Whiting, P J ^a   more..

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 7 TERT BUTYL 3 (2,5 DIFLUOROPHENYL) 6 (2 METHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; SEDATIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG BINDING; GENE TARGETING; GENETIC RECOMBINATION; LONG TERM POTENTIATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; TRANQUILIZING ACTIVITY;

ALLOSTERIC SITE; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; AZIDES; BENZODIAZEPINES; BINDING, COMPETITIVE; BRAIN; CELL LINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; FLUOROBENZENES; HYPNOTICS AND SEDATIVES; LIGANDS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOTOR ACTIVITY; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A; STARTLE REACTION; TRIAZOLES;

EID: 0034108997     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/75761     Document Type: Article

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