Identification of amino acid residues responsible for the α5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABAA receptor

Journal of Neurochemistry

Volumn 77, Issue 2, 2001, Pages 445-451

  Anna Casula, M ^a,b   Bromidge, Frances A ^a   Pillai, Gopalan V ^a   Wingrove, Peter B ^a   Martin, Karine ^a   Maubach, Karen ^a   Seabrook, Guy R ^a   Whiting, Paul J ^a   Hadingham, Karen L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Benzodiazepine binding site; GABAA receptor; Site directed mutagenesis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID; BENZODIAZEPINE; L 655 708; LIGAND; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR BIOLOGY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTI-ANXIETY AGENTS; AZIDES; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CARBOLINES; DNA, COMPLEMENTARY; FEMALE; FLUMAZENIL; FLUNITRAZEPAM; HUMANS; IMIDAZOLES; ISOLEUCINE; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PYRIDAZINES; PYRIDINES; RECEPTORS, GABA-A; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; TRANSFECTION; XENOPUS LAEVIS;

EID: 0035044472     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00289.x     Document Type: Article

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