The GABA-A receptor gene family: New targets for therapeutic intervention

Neurochemistry International

Volumn 34, Issue 5, 1999, Pages 387-390

  Whiting, Paul J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; COMPLEMENTARY DNA; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

BRAIN; DNA DETERMINATION; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SHORT SURVEY;

ANIMALS; BENZODIAZEPINES; BINDING SITES; BRAIN CHEMISTRY; GAMMA-AMINOBUTYRIC ACID; HUMANS; RECEPTORS, GABA-A; THERAPEUTICS;

EID: 0033046508     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00048-0     Document Type: Short Survey

References (38)

1. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. Backus K.H., Arigoni M., Drescher U., Scheurer L., Matherbe P., Mohler H., Benson J.A. Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification. NeuroReport. 5:1993;285-288.
3. Belelli D., Lambert J.J., Peters J.A., Wafford K.A., Whiting P.J. The interaction of the general anethsetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc. Natl. Acad. Sci. USA. 9:1997;11031-11036.
4. Borboni P., Porzio O., Fusco A., Sesti G., Lauro R., Marlier L.N. Molecular and cellular characterization of the GABAA receptor in the rat pancreas. Mol. Cell Endocrinol. 103:1994;157-163.
5. Brooks-Kayal A.R., Shumate M.D., Jin H., Rikhter T.Y., Coulter D.A. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat. Med. 10:1998;1166-1172.
6. Chang Y., Wang R., Barot S., Weiss D.S. Stoichiometry of a recombinant GABAA receptor. J. Neurosci. 16:1996;5415-5424.
7. Connolly C.N., Wooltorton J.R., Smart T.G., Moss S.J. Subcellular localization of gamma-aminobutyric acid type A receptors is determined by receptor beta subunits. Proc. Natl. Acad. Sci. USA. 93:1996;9899-9904.
8. Davies P.A., Hanna M.C., Hales T.G., Kirkness E.F. Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit. Nature. 385:1997;820-823.
9. Fisher J.L., Macdonald R.L. Single channel properties of recombinant GABAA receptors containing gamma 2 or delta subtypes expressed with alpha 1 and beta 3 subtypes in mouse L929 cells. J. Physiol. (Lond.). 505:1997;283-297.
10. Fritschy J.-M., Kiener T., Bouilleret V., Loup F. GABAergic neurons and GABA-A receptors in temporal lobe epilepsy. Neurochem. Int. 34:1999;435-445.
11. Garret M., Bascles L., Boue-Grabot E., Sartor P., Charron G., Bloch B., Margolskee R.F. An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system. J. Neurochem. 68:1997;1382-1389.
12. A receptors. Molec. Pharmacol. 43:1993;970-975.
13. A receptors containing γ3 subunits. Eur. J. Pharmacol. Molec. Pharmacol. Sect. 291:1996;301-309.
14. Hadingham K.L., Garrett E.M., Wafford K.A., Bain C., Heavens R.P., Sirinathsinghji D.J.S., Whiting P.J. Cloning of cDNAs encoding the human γ-aminobutyric acid type A receptor α6 subunit and characterisation of the pharmacology of α6-containing receptors. Molec. Pharmacol. 49:1996;253-259.
15. Hedblom E., Kirkness E.F. A novel class of GABAA receptor subunit in tissues of the reproductive system. J. Biol. Chem. 272:1997;15346-15350.
16. Johnston G.A. GABAc receptors: relatively simple transmitter-gated ion channels? Trends Pharmacol. Sci. 17:1996;319-323.
17. B receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
18. Lambert J.J., Belilli D., Hill-Venning C., Peters J.A. Neurosteroids and GABA-A receptor function. Tr. Pharmacol. Sci. 16:1995;295-303.
19. Levin M.L., Chatterjee A., Pragliola A., Worley K.C., Wehnert M., Zhuchenko O., Smith R.F., Lee C.C., Herman G.E. A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28. Genome Res. 6:1996;465-477.
20. Lindstrom J., Anand R., Peng X., Gerzanich V., Wang F., Li Y. Neuronal nicotinic receptor subtypes. Ann. NY Acad. Sci. 757:1995;100-116.
21. Maricq A.V., Peterson A.S., Brake A.J., Myers R.M., Julius D. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 254:1991;432-437.
22. McKernan R.M., Whiting P.J. Which GABA-A receptor subtypes really occur in the brain? Tr. in Neurosci. 19:1996;139-143.
23. Mihic S.J., Ye Q., Wick M.J., Koltchine V.V., Krasowski M.D., Finn S.E., Mascia M.P., Valenzuela C.F., Hanson K.K., Greenblatt E.P., Harris R.A., Harrison N.L. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature. 389:1997;385-389.
24. Pritchett D.B., Sontheimer H., Shivers B.H., Ymer S., Kettenmann H., Schofield P.R., Seeburg pH. Importance of a novel GABA-A receptor subunit for benzodiazepine pharmacology. Nature. 338:1989;582-585.
25. Schmid G., Chittolini R., Raiteri R., Bonanno G. Differential effects of zinc on native GABA-A receptor function in rat hippocampus and cerebellum. Neurochem. Int. 34:1999;399-405.
26. Sieghart W. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
27. Smart T.G., Moss S.J., Xie X., Huganir R.L. GABAA receptors are differentially sensitive to zinc: dependence on subunit composition. Br. J. Pharmacol. 103:1991;1837-1839.
28. Smith S.S., Gong Q.H., Hsu F.C., Markowitz R.S., ffrench-Mullen J.M., Li X. GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature. 392:1998;926-930.
29. Thompson S.A., Whiting P.J., Wafford K.A. Alpha subunits influence the action of pentobarbital on recombinant GABA-A receptors. Br. J. Pharmacol. 117:1996;521-527.
30. Tretter V., Ehya N., Fuchs K., Sieghart W. Stoichiometry and assembly of a recombinant GABAA receptor subtype. J. Neurosci. 17:1997;2728-2737.
31. Vannier C., Triller A. Biology of the postsynaptic glycine receptor. Int. Rev. Cytol. 176:1997;201-244.
32. Wafford K.A., Burnett D.M., Leidenheimer N.J., Burt D.R., Wang J.B., Kofuji P., Dunwiddie T.V., Harris R.A., Sikela J.M. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron. 7:1991;27-33.
33. Wagner S., Castel M., Gainer H., Yarom Y. GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity. Nature. 387:1997;598-603.
34. Whiting P.J., McKernan R.M., Wafford K.A. Structure and pharmacology of vertebrate GABA-A receptor subtypes. Int. Rev. Neurobiol. 38:1995;95-138.
35. Whiting P.J., McAllister G., Vasilatis D., Bonnert T.P., Heavens R.P., Smith D.W., Hewson L., O'Donnell R., Rigby M.R., Sirinathsinghji D.J., Marshall G., Thompson S.A., Wafford K.A. Neuronal restricted RNA splicing regulates the expression of a novel GABA-A receptor subunit conferring atypical functional properties. J. Neurosci. 17:1997;5027-5037.
36. Wilke K., Gaul R., Klauck S.M., Poustka A. A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor. Genomics. 45:1997;1-10.
37. Wingrove P.B., Wafford K.A., Bain C., Whiting P.J. The modulatory action of loreclezole at the GABA type A receptor is determined by a single amino acid in the β2 and β3 subunit. Proc. Natl. Acad. Sci. USA. 91:1994;4569-4573.
38. Yang W., Reyes A.A., Lan N.C. Identification of the GABAA receptor subtype mRNA in human pancreatic tissue. FEBS Lett. 346:1994;257-262.