3α-Hydroxy-5α-pregnan-20-one exposure reduces GABA(A) receptor α4 subunit mRNA levels

European Journal of Pharmacology

Volumn 409, Issue 2, 2000, Pages

  Grobin, A Chistina ^a   Morrow, A Leslie ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Development; Neurosteroid; P19 cell

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; MESSENGER RNA; NEUROSTEROID; RECEPTOR SUBUNIT; ELTANOLONE; PROTEIN SUBUNIT;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENT; GENE EXPRESSION; NERVE CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; PREGNANOLONE; PROTEIN SUBUNITS; RECEPTORS, GABA-A; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0034624255     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00797-4     Document Type: Article

References (8)

1. GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms
2. Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery
3. - in P19-N cells reveals unique pharmacological properties
4. Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in male and female rats
5. Endogenous levels of 5 alpha-reduced progestins and androgens in fetal vs. adult rat brains
6. GABA(A) receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
7. Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABA(A)-gated current and increases the GABA(A) receptor α4 subunit in association with increased anxiety
8. Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment