The main determinant of furosemide inhibition on GABA(A) receptors is located close to the first transmembrane domain

European Journal of Pharmacology

Volumn 357, Issue 2-3, 1998, Pages 251-256

  Jackel, Carolin ^a   Kleinz, Raymonde ^a   Mäkelä, Riikka ^b   Hevers, Wulf ^a   Jezequel, Sylvie ^d   Korpi, Esa R ^c   Lüddens, Hartmut ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Subunit; Functional domain; Furosemide; GABA(A) receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FUROSEMIDE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHIMERA; DRUG MECHANISM; GABAERGIC TRANSMISSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; XENOPUS;

ALLOSTERIC REGULATION; ANIMALS; BASE SEQUENCE; CELL MEMBRANE; FUROSEMIDE; GABA ANTAGONISTS; MOLECULAR SEQUENCE DATA; OOCYTES; RECEPTORS, GABA-A; XENOPUS;

EID: 0032544760     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00576-7     Document Type: Article

References (14)

1. Bahn S., Jones A., Wisden W. Directing gene expression to cerebellar granule cells using γ-aminobutyric acid type A receptor α6 subunit transgenes. Proc. Natl. Acad. Sci. USA. 94:1997;9417-9421.
2. A receptors. Mol. Pharmacol. 52:1997;714-724.
3. A channel subtypes. Mol. Neurobiol., in press.
4. Kleingoor C., Wieland H.A., Korpi E.R., Seeburg P.H., Kettenmann H. Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue. Neuroreport. 4:1993;187-190.
5. A receptors α4β2γ2 and α6β2γ2. Mol. Pharmacol. 50:1996;1253-1261.
6. A receptors. Br. J. Pharmacol. 120:1997;741-748.
7. Korpi E.R., Kuner T., Seeburg P.H., Lüddens H. Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol. Pharmacol. 47:1995;283-289.
8. Kuner T., Schoepfer R., Korpi E.R. Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. NeuroReport. 5:1993;297-300.
9. A receptor subunit mRNAs in the rat brain: II. Olfactory bulb and cerebellum. J. Neurosci. 12:1992;1063.
10. A receptors. Trends Pharmacol. Sci. 12:1991;49-51.
11. A receptor selective for a behavioural alcohol antagonist. Nature. 346:1990;648.
12. A receptors containing the α4 subunit. Mol. Pharmacol. 50:1996;670-678.
13. A receptors is essential for benzodiazepine receptor agonist binding. J. Biol. Chem. 267:1991;1426-1429.
14. A receptor α4 subunit. FEBS Lett. 289:1991;227.