Evaluation of [methyl-3H]L655,708 and [ethyl-3H]RY80 as putative PET ligands for central GABA(A) receptors containing α5 subunit

Nuclear Medicine and Biology

Volumn 26, Issue 7, 1999, Pages 743-748

  Opacka Juffry, J ^a   Hirani, E ^a   Dawson, G R ^b   Luthra, S K ^a   Hume, S P ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Brain uptake; Positron emission tomography; Radioligands; Rat brain

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUNITRAZEPAM; L 655708; RADIOLIGAND; RY 80; TRACER; UNCLASSIFIED DRUG; ZOLPIDEM; ALKYNE; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAGNOSTIC AGENT; IMIDAZOLE DERIVATIVE; L 655,708; LIGAND; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CINGULATE GYRUS; CONTROLLED STUDY; DRUG BRAIN LEVEL; HIPPOCAMPUS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEDULLA OBLONGATA; MUSCLE RELAXATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; THALAMUS; TRANQUILIZING ACTIVITY; ANIMAL; BLOOD; BRAIN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ENZYME SPECIFICITY; METABOLISM; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ALKYNES; ANIMALS; BENZODIAZEPINES; BRAIN; FLUNITRAZEPAM; GABA MODULATORS; IMIDAZOLES; LIGANDS; MALE; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032585785     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(99)00053-0     Document Type: Article

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