Subtle changes in residue 77 of the γ subunit of α1β2γ2 GABA(A) receptors drastically alter the affinity for ligands of the benzodiazepine binding site

Journal of Biological Chemistry

Volumn 272, Issue 18, 1997, Pages 11799-11804

  Buhr, Andreas ^a   Baur, Roland ^a   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLUMAZENIL; ZOLPIDEM;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; XENOPUS LAEVIS;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELL LINE; DIAZEPAM; FEMALE; FLUMAZENIL; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHENYLALANINE; POINT MUTATION; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION; XENOPUS LAEVIS;

EID: 0030959309     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.18.11799     Document Type: Article

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