Properties of putative cerebellar γ-aminobutyric acidA receptor isoforms

Molecular Pharmacology

Volumn 49, Issue 3, 1996, Pages 567-579

  Saxena, Nina C ^a   Macdonald, Robert L ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Neuroscience Laboratory Building   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; DIAZEPAM; PENTOBARBITAL; PICROTOXIN; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CELL STRAIN L 929; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MEMBRANE CURRENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; CARBOLINES; CEREBELLUM; CONVULSANTS; DIAZEPAM; GABA ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; ION CHANNELS; ISOMERISM; MEMBRANE POTENTIALS; MICE; PENTOBARBITAL; PICROTOXIN; RATS; RECEPTORS, GABA-A; TRANSFECTION;

EID: 0029967726     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. A receptor subtypes: from pharmacology to molecular biology. FASEB J. 5:2916-2923 (1991).
2. A receptor structure and function. J. Biol. Chem. 267:16747-16750 (1992).
3. A receptor channels. Annu. Rev. Neurosci. 17:569-602 (1994)
4. A receptor: a chemically gated ion channel. Biochem. J. 249:21-32 (1988)
5. A receptor determined by electron microscopic image analysis. J. Neurochem. 62:815-818 (1994).
6. Ragan, C. I., R. M. McKernan, K. Wafford, and P. J. Whiting. γ-Aminobutyric acid-A (GABA-A) receptor/ion channel complex. Biochem. Soc. Trans. 21:622-626 (1993).
7. Quirk, K., N. P. Gillard, C. I. Ragan, P. J. Whiting, and R. M. McKernan. Model of subunit composition of γ-aminobutyric acid-A receptor subtypes expressed in rat cerebellum with respect to their α and δ subunits. J. Biol. Chem. 269:16020-16028 (1994).
8. Laurie, D. J., P. H. Seeburg, and W. Wisden. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci 12:1063-1076 (1992).
9. A receptor. FESS Lett. 258:17-21 (1989).
10. A receptor subunits in the rat CNS. J. Comp. Neurol. 326:193-216 (1992).
11. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 8:1665-1670 (1989).
12. A receptor subpopulations. J. Biol. Chem 268:3753-3757 (1993).
13. A/benzodiazepine receptor from rat cerebellum. J. Neurochem. 63:371-374 (1994).
14. Kozak, M. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res. 9:5233-5262 (1981).
15. Kozak, M. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12:857-872 (1984).
16. Hugenvik, J. I., M. W. Collard, R. E. Stofko, A. P. Seasholtz, and M. D. Uhler. Regulation of the human enkephalin promoter by the two isoforms of the catalytic subunit of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase. Mol. Endocrinol. 5:921-930 (1991).
17. Hall, C. V., P. E. Jacob, G. M. Ringold, and F. Lee. Expression and regulation of Escherichia coli lac Z gene fusions in mammalian cells. J. Mol. Appl. Genet. 2:101-109 (1983).
18. Chen, C., and H. Okayama. High efficiency transformation of mammalian cells by plasmid DNA. Mol Cell. Biol. 7:2745-2752 (1987).
19. Sanes, J. R., J. L. R. Rubenstein, and J. F. Nicolas. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 5:3133-3142 (1986).
20. Nolan, G P., S. Fiering, J. F. Nicolas, and L. A. Herzenberg. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transduction of Escherichia coli lacZ. Proc. Natl. Acad. Sci. USA 85:2603-2607 (1988).
21. A receptor main conductance state of mouse spinal cord neurones in culture. J. Physiol (Lond.) 410:479-499 (1989).
22. A receptor current in mouse spinal cord neurons. Neuron 5:789-796 (1990).
23. Home, A. L., P. C. Harkness, K. L. Hadingham, P. J. Whiting, and J. A. Kemp. The influence of the γ2L subunit on the modulation of responses to GABAA receptor activation. Br. J. Pharmacol. 108:711-716 (1993).
24. A receptor channels of mouse spinal neurones in culture. J. Physiol. (Lond.) 475:69-82 (1994).
25. A receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267:1426-1429 (1992).
26. A receptor channel of mouse spinal neurones in culture. J. Phsiol. (Lond.) 417:483-500 (1989).
27. Macdonald, R. L., and J. L. Barker. Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian neurons: a common mode of anti-convulsant action Neurology 28:325-330 (1978).
28. - channels. Neurosci. Lett 96:89-95 (1989).
29. A receptor currents by opposite mechanisms Soc. Neurosci. Abstr. 15:1150 (1989).
30. A receptor selective for a behavioural alcohol antagonist. Nature (Lond.) 346:648-651 (1990).
31. Angelotti, T. P., F. Tan, K. G. Chahine, and R. L. Macdonald. Molecular and electrophysiological characterization of a allelic variant of the rat α6 GABA receptor subunit. Mol. Brain Res 16:173-178 (1992).
32. A receptor complex in cultured rat neurones. J. Physiol. 447:587-625 (1992).
33. 2-. Neuron 5:781-788 (1990).
34. A receptor. Neuroreport 6:1313-1316 (1995).
35. A receptor subunits: role of the S subunit. J. Neurosci. 14:7077-7086 (1994).
36. A receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique. J. Neurosci. 13:1418-1428 (1993).
37. A receptor subunits: α1β1 and α1β1γ2S subunits produce unique ion channels with dissimilar single-channel properties. J. Neurosci. 13:1429-1440 (1993).
38. Hartnett, C., J. Yu, M. Brown, K. Gerber, R. Primus, T. V. Ramabhadran, and D. Gallagher. Effect of subunit composition on GABA/benzodiazepine receptor binding characteristics in a baculovirus expression system. Soc. Neurosci. Abstr. 19:477 (1993).
39. Celentano, J. J., M. Gyenes, T. T. Gibbs, and D. H. Farb. Negative modulation of the γ-aminobutyric acid response by extracellular zinc. Mol. Pharmacol. 40:766-773 (1991).
40. Xie, X., and T. G. Smart. A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission. Nature (Lond.) 349:521-524 (1991).
41. A-receptor complex. Br. J. Pharmacol. 99:643-654 (1990).
42. A receptors are differentially sensitive to zinc: dependence on subunit composition. Br. J. Pharmacol. 103:1837-1839 (1991).
43. A receptor currents. Neuroreport 6:461-464 (1995).
44. Frederickson C. J. Neurobiology of zinc-containing neurons. Int. Rev. Neurobiol. 31:145-238 (1989).
45. Faber H., K. Braun, W. Zuschratter, and H. Scheich. System-specific distribution of zinc in the chick brain. Cell Tissue Res. 25:247-257 (1989).
46. Davies M. F., P. A. Maguire, and G. H. Loew. Zinc selectively inhibits flux through benzodiazepine-insensitive γ-aminobutyric acid chloride channels in cortical and cerebellar microsacs. Mol. Pharmacol. 44:876-881 (1993).
47. 2+ in cerebellar granule cells in culture. Eur. J. Neurosci. 5:65-72 (1993).
48. Henkin R. I., B. M. Patten, P. K. Re, and D. Bronzert. A syndrome of acute zinc loss. Arch. Neurol. 32:745-751 (1975).