Mice lacking the β3 subunit of the GABA(A) receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome

Journal of Neuroscience

Volumn 18, Issue 20, 1998, Pages 8505-8514

  DeLorey, T M ^a,e   Handforth, A ^c   Anagnostaras, S G ^b   Homanics, G E ^d   Minassian, B A ^c,f   Asatourian, A ^c   Fanselow, M S ^b   Delgado Escueta, A ^b   Ellison, G D ^b   Olsen, R W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Division of Pediatric Neurology   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e MOLECULAR RESEARCH INSTITUTE   (United States)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Angelman syndrome; Epilepsy; GABA(A) receptor; GABRB3; Hyperactivity; Learning and memory; Motor coordination; Mouse model; Seizure; Sleep

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLONAZEPAM; ETHOSUXIMIDE; GABOXADOL; PLACEBO; RECEPTOR SUBUNIT; UBIQUITIN PROTEIN LIGASE; VALPROIC ACID;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 15Q; CONTROLLED STUDY; EPILEPSY; FEMALE; GENE DELETION; GENE DISRUPTION; GENE MUTATION; HAPPY PUPPET SYNDROME; HYPERACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LEARNING DISORDER; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REST; SEIZURE; AGE; ANIMAL; AVOIDANCE BEHAVIOR; C57BL MOUSE; CHROMOSOME 15; CHROMOSOME MAP; CONDITIONING; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; FEAR; GENETICS; GENOTYPE; HUMAN; HYPERKINESIA; MEMORY; MOTOR ACTIVITY; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY; SLEEP; VOCALIZATION;

AGE FACTORS; ANGELMAN SYNDROME; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 15; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEAR; GENOTYPE; HUMANS; HYPERKINESIS; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PHENOTYPE; RECEPTORS, GABA-A; SLEEP; VOCALIZATION, ANIMAL;

EID: 0032531430     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-20-08505.1998     Document Type: Article

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