Blunted furosemide action on cerebellar GABA(A) receptors in ANT rats selectively bred for high alcohol sensitivity

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1493-1502

  Makela R ^a,b   Lehtonen, M ^a   Wisden, W ^c   Luddens H ^d   Korpi, E R ^a,e  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e UNIVERSITY OF TURKU   (Finland)

Author keywords

Cerebellum; Furosemide; GABA(A) receptor; GABA(A) receptor antagonists; Receptor subtypes; Selected rat lines

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; CLOZAPINE; FLUMAZENIL; FUROSEMIDE; MUSCIMOL; PICROTOXININ; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SULFUR 35; TERT BUTYLBICYCLOPHOSPHOROTHIOATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; GENETIC SELECTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY CELL; MALE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

ANIMALS; AUTORADIOGRAPHY; CELL LINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBELLUM; DIURETICS; ETHANOL; FEMALE; FUROSEMIDE; GABA AGONISTS; HUMANS; IN SITU HYBRIDIZATION; LIGANDS; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0030472310     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00073-1     Document Type: Article

References (30)

1. Chen C., Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:1987;2745-2752.
2. Eriksson, K. and Rusi, M. (1981) Finnish selection studies on alcohol-related behaviors: general outline. In: Development of Animal Models as Pharmacogenetic Tools, (McClearn G.E., Deitrich R.A. and Erwin G., Eds), pp. 87-117. NIAAA Research Monograph No. 6, U.S. Government Printing Office, Washington, DC, U.S.A.
3. Farrant, M. and Webster, R.A. (1989) GABA antagonists - their use and mechanisms of action. In: Neuromethods, Vol. 12, Drugs As Tools in Neurotransmitter Research, (Boulton, A.B., Baker G.B. and Juorio A.V., Eds), pp. 161-219. Humana Press, Clifton, NJ, U.S.A.
4. A receptor site. Brain Res. 384:1986;224-231.
5. Hellevuo K., Kiianmaa K., Korpi E.R. Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 34:1989;399-404.
6. A/benzodiazepine receptor from rat cerebellum. J. Neurochem. 63:1994;371-374.
7. A receptor. Nature. 361:1993;356-359.
8. A receptor function. J. Neurochem. 63:1994;1167-1170.
9. Korpi E.R., Kuner T., Seeburg P.H., Lüddens H. Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol. Pharmacol. 47:1995;283-289.
10. Korpi E.R., Wong G., Lüddens H. Subtype specificity of γ-aminobutyric acid type A receptor antagonism by clozapine. Naynyn Schmiedeberg's Arch. Pharmacol. 352:1995;365-373.
11. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum J. Neurosci. 12:1992;1063-1076.
12. A benzodiazepine receptor complex. J. Receptor Res. 11:1991;535-551.
13. A receptor selective for a behavioural alcohol antagonist. Nature. 346:1990;648-651.
14. A/benzodiazepine receptor subtypes. J. Neurosci. 15:1995;6957-6962.
15. A receptor channels. Annu. Rev. Neurosci. 17:1994;569-602.
16. Malminen O., Korpi E.R. GABA/benzodiazepine receptor/chloride ionophore complex in brains of rat lines selectively bred for differences in ethanol-induced motor impairment. Alcohol. 5:1988;239-249.
17. A receptors composed from mutant and wild-type α6 subunits. J. Neurochem. 65:1995;2401-2408.
18. Olsen R.W. Drug interactions at the GABA receptor-ionophore complex. Annu. Rev. Pharmacol. Toxicol. 22:1982;245-277.
19. A receptors of adult rat cerebellum demonstrates two α subunit per receptor oligomer. J. Biol. Chem. 270:1995;21285-21290.
20. A receptor subunit for benzodiazepine pharmacology. Nature. 338:1989;582-585.
21. Quirk K., Gillard N.P., Ragan C.I., Whiting P.J., McKernan R.M. Model of subunit composition of γ-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J. Biol. Chem. 269:1994;16020-16028.
22. A receptor subtypes. Pharmacol. Revs. 47:1995;181-234.
23. 35S]TBPS binding. Brain Res. 414:1987;357-364.
24. A receptor binding and function in vitro in two rat lines developed for high and low alcohol sensitivity. Neurochem. Res. 14:1989;733-739.
25. 3H]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity. J. Neurochem. 54:1990;1980-1987.
26. A receptors of an alcohol-sensitive ANT rat line. Alcohol. Clin. Exp. Res. 15:1991;241-248.
27. Wisden, W. and Morris, B.J., In situ hybridization with synthetic oligonucleotide probes. In: In Situ Hybridization Protocols for the Brain (Wisden W. and Morris B.J., Eds), 1994, pp. 9-34. Academic Press, London, U.K.
28. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon J. Neurosci. 12:1992;1040-1062.
29. Wong G., Sarviharju M., Toropainen M., Matecka D., Korpi E.R. Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 53:1996;723-730.
30. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 8:1989;1665-1670.