Cerebellar granule-cell-specific GABAa receptors attenuate benzodiazepine-induced ataxia: Evidence from α6-subunit-deficient mice

European Journal of Neuroscience

Volumn 11, Issue 1, 1999, Pages 233-240

  Korpi, Esa R ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Alcohol sensitivity; Benzodiazepines; Genetic redundancy; Motor coordination

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BRAIN RECEPTOR; DIAZEPAM; FLUMAZENIL; INTRALIPID; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CEREBELLUM; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GRANULE CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MALE; MOTOR PERFORMANCE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SYNAPSE;

ANIMALS; ATAXIA; BENZODIAZEPINES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIAZEPAM; ETHANOL; GABA MODULATORS; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NERVE FIBERS; PSYCHOMOTOR PERFORMANCE; PURKINJE CELLS; RECEPTORS, GABA-A; SYNAPSES;

EID: 0032898674     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00421.x     Document Type: Article

References (3)

1. Bahn, S., Harvey, R.J., Darlison, M.G. & Wisden, W. (1996) Conservation of γ-aminobutyric acid type A receptor α6 subunit gene expression in cerebellar granule cells. J. Neurochem., 66, 1810-1818.
2. Bonetti, E.P., Burkard, W.P., Gabi, M., Hunkeler, W., Lorez, H.-P., Martin, J.R., Möhler, H., Osterrieder, W., Pieri, L., Polc, P., Richards, J.G., Schaffner, R., Scherschlicht, R., Schoch, P. & Haefely, W.E. (1989) Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol. Pharmacol. Biochem. Behav., 31, 733-749.
3. A receptors. J. Physiol., 497, 753-759.