메뉴 건너뛰기




Volumn 1, Issue 7, 1998, Pages 563-571

Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARRIER PROTEIN; GEPHYRIN; MEMBRANE PROTEIN;

EID: 33644665247     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/2798     Document Type: Article
Times cited : (736)

References (48)
  • 1
    • 0030221844 scopus 로고    scopus 로고
    • Synaptic targeting of ionotropic neurotransmitter receptors
    • Kirsch, J., Meyer, G. & Betz, H. Synaptic targeting of ionotropic neurotransmitter receptors. Mol. Cell Neurosci. 8, 93-98 (1996).
    • (1996) Mol. Cell Neurosci. , vol.8 , pp. 93-98
    • Kirsch, J.1    Meyer, G.2    Betz, H.3
  • 2
    • 0032584072 scopus 로고    scopus 로고
    • To muster a cluster: Anchoring neuro-transmitter receptors at synapses
    • Colledge, M. & Froehner, S. C. To muster a cluster: anchoring neuro-transmitter receptors at synapses. Proc. Natl. Acad. Sci. USA 95, 3341-3343 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3341-3343
    • Colledge, M.1    Froehner, S.C.2
  • 3
    • 0032524629 scopus 로고    scopus 로고
    • PDZ proteins organize synaptic signaling pathways
    • Craven, S. E. & Bredt, D. S. PDZ proteins organize synaptic signaling pathways. Cell 93, 495-498 (1998).
    • (1998) Cell , vol.93 , pp. 495-498
    • Craven, S.E.1    Bredt, D.S.2
  • 4
    • 0027723681 scopus 로고
    • Gephyrin antisense oligo-nucleotides prevent glycine receptor clustering in spinal neurons
    • Kirsch, J., Wolters, I., Triller, A. & Betz, H. Gephyrin antisense oligo-nucleotides prevent glycine receptor clustering in spinal neurons. Nature 366, 745-748 (1993).
    • (1993) Nature , vol.366 , pp. 745-748
    • Kirsch, J.1    Wolters, I.2    Triller, A.3    Betz, H.4
  • 5
    • 0028848501 scopus 로고
    • Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells
    • Kirsch, J., Kushe, J. & Betz, H. Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol. Cell. Neurosci. 6, 450-461 (1995).
    • (1995) Mol. Cell. Neurosci. , vol.6 , pp. 450-461
    • Kirsch, J.1    Kushe, J.2    Betz, H.3
  • 6
    • 0029124881 scopus 로고
    • Identification of a gephyrin binding motif on the glycine receptor β subunit
    • Meyer, G., Kirsch, J., Betz, H. & Langosch, D. Identification of a gephyrin binding motif on the glycine receptor β subunit. Neuron 15, 563-572 (1995).
    • (1995) Neuron , vol.15 , pp. 563-572
    • Meyer, G.1    Kirsch, J.2    Betz, H.3    Langosch, D.4
  • 7
    • 0028979105 scopus 로고
    • A-receptor subunits in the rat retina
    • A-receptor subunits in the rat retina. J. Comp. Neurol. 357, 1-14 (1995).
    • (1995) J. Comp. Neurol. , vol.357 , pp. 1-14
    • Sassoé-Pognetto, M.1
  • 9
    • 0032103933 scopus 로고    scopus 로고
    • Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat
    • Giusetto, M., Kirsch, J., Fritschy, J.-M., Cantino, D. & Sassoé-Pognetto, M. Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat. J. Comp. Neurol. 395, 231-244 (1998).
    • (1998) J. Comp. Neurol. , vol.395 , pp. 231-244
    • Giusetto, M.1    Kirsch, J.2    Fritschy, J.-M.3    Cantino, D.4    Sassoé-Pognetto, M.5
  • 10
    • 0028210635 scopus 로고
    • A-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining
    • A-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining. Brain Res. 642, 59-69 (1994).
    • (1994) Brain Res. , vol.642 , pp. 59-69
    • Bohlhalter, S.1    Mohler, H.2    Fritschy, J.M.3
  • 11
    • 0029054571 scopus 로고
    • Postsynaptic gephyrin immunoreactivity exhibits a nearly one-to-one correspondence with γ-aminobutyric acid-like immunogold-labeled synaptic inputs to sympathetic preganglionic neurons
    • Cabot, J. B., Bushnell, A., Alessi, V. & Mendell, N. R. Postsynaptic gephyrin immunoreactivity exhibits a nearly one-to-one correspondence with γ-aminobutyric acid-like immunogold-labeled synaptic inputs to sympathetic preganglionic neurons. J. Comp. Neurol. 356, 418-432 (1995).
    • (1995) J. Comp. Neurol. , vol.356 , pp. 418-432
    • Cabot, J.B.1    Bushnell, A.2    Alessi, V.3    Mendell, N.R.4
  • 12
    • 0028801734 scopus 로고
    • The relationship between glycine and gephyrin in synapses of the rat spinal cord
    • Todd, A. J., Spike, R. C., Chong, D. & Neilson, M. The relationship between glycine and gephyrin in synapses of the rat spinal cord. Eur. J. Neurosci. 7, 1-11 (1995).
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1-11
    • Todd, A.J.1    Spike, R.C.2    Chong, D.3    Neilson, M.4
  • 13
    • 0029927346 scopus 로고    scopus 로고
    • Colocalization of GABA, glycine and their receptors at synapses in the rat spinal cord
    • Todd, A. J., Watt, C., Spike, R. C. & Sieghart, W. Colocalization of GABA, glycine and their receptors at synapses in the rat spinal cord. J. Neurosci. 16, 974-982 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 974-982
    • Todd, A.J.1    Watt, C.2    Spike, R.C.3    Sieghart, W.4
  • 14
    • 0029968898 scopus 로고    scopus 로고
    • Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons
    • Craig, A. M., Banker, G., Chang, W., McGrath, M. E. & Serpinskaya, A. S. Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons. J. Neurosci. 16, 3166-3177 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 3166-3177
    • Craig, A.M.1    Banker, G.2    Chang, W.3    McGrath, M.E.4    Serpinskaya, A.S.5
  • 18
    • 0028981088 scopus 로고
    • Structure and pharmacology of γ-aminobutyric acid a receptor subtypes
    • Sieghart, W. Structure and pharmacology of γ-aminobutyric acid A receptor subtypes. Pharmacol. Rev. 47, 181-234 (1995).
    • (1995) Pharmacol. Rev. , vol.47 , pp. 181-234
    • Sieghart, W.1
  • 19
    • 0029687964 scopus 로고    scopus 로고
    • (ed. Narahashi, T.) Plenum Press, New York
    • Mohler, H. et al in Ion Channels (ed. Narahashi, T.) 89-113 (Plenum Press, New York, 1996).
    • (1996) Ion Channels , pp. 89-113
    • Mohler, H.1
  • 20
    • 0031052341 scopus 로고    scopus 로고
    • Insensitivity to anaesthetic agents conferred by a class of GABAa receptor subunit
    • Davies, P. A., Hanna, M. C., Hales, T. G. & Kirkness, E. F. Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit. Nature 385,820-823(1997).
    • (1997) Nature , vol.385 , pp. 820-823
    • Davies, P.A.1    Hanna, M.C.2    Hales, T.G.3    Kirkness, E.F.4
  • 21
    • 0030609903 scopus 로고    scopus 로고
    • A novel class of GABAA receptor subunits in tissues of the reproductive systems
    • Hedblom, E. & Kirkness, E. A novel class of GABAA receptor subunits in tissues of the reproductive systems. J. Biol. Chem. 272, 15346-15350 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 15346-15350
    • Hedblom, E.1    Kirkness, E.2
  • 22
    • 16944362407 scopus 로고    scopus 로고
    • Neuronally restricted RNa splicing regulates the expression of a novel GABAa receptor subunit conferring atypical functional properties
    • Whiting, P. J. et al. Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties. J. Neurosci. 17, 5027-5037 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 5027-5037
    • Whiting, P.J.1
  • 23
    • 0030851870 scopus 로고    scopus 로고
    • y-Aminobutyric acid type a receptor subunit assembly and sorting: Gene targeting and cell biology approaches
    • Wisden, W. & Moss, S. J. y-aminobutyric acid type A receptor subunit assembly and sorting: gene targeting and cell biology approaches. Biochem. Soc. Trans. 25, 820-824 (1997).
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 820-824
    • Wisden, W.1    Moss, S.J.2
  • 24
    • 0032571274 scopus 로고    scopus 로고
    • GABAA-receptor assembly in vivo - Lessons from subunit mutant mice
    • Mohler, H. et al. GABAA-receptor assembly in vivo - lessons from subunit mutant mice. Life Sci. 62,1611-1615(1998).
    • (1998) Life Sci. , vol.62 , pp. 1611-1615
    • Mohler, H.1
  • 25
    • 0029097465 scopus 로고
    • Benzodiazepine-insensitive mice generated by targeted disruption of the y2 subunit gene of GABAA receptors
    • Günther, U. et al. Benzodiazepine-insensitive mice generated by targeted disruption of the y2 subunit gene of GABAA receptors. Proc. Natl. Acad. Sci. USA 92, 7749-7753 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7749-7753
    • Günther, U.1
  • 26
    • 0030043594 scopus 로고    scopus 로고
    • Assembly and cell surface expression of heteromeric and homomeric y-aminobutyric acid type a receptors
    • Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G. & Moss, S. J. Assembly and cell surface expression of heteromeric and homomeric y-aminobutyric acid type A receptors. J. Biol. Chem. 271, 89-96 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 89-96
    • Connolly, C.N.1    Krishek, B.J.2    McDonald, B.J.3    Smart, T.G.4    Moss, S.J.5
  • 27
    • 0030611247 scopus 로고    scopus 로고
    • Assembly of GABAA receptors composed of Xl and ß2 subunits in both neurons and fibroblasts
    • Gorrie, G. H. et al. Assembly of GABAA receptors composed of (Xl and ß2 subunits in both neurons and fibroblasts. J. Neurosci. 17, 6587-6596 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 6587-6596
    • Gorrie, G.H.1
  • 28
    • 0028977843 scopus 로고
    • GABAA receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
    • Fritschy, J.-M. & Mohler, H. GABAA receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol 359,154-194 (1995).
    • (1995) J. Comp. Neurol , vol.359 , pp. 154-194
    • Fritschy, J.-M.1    Mohler, H.2
  • 29
    • 0031975271 scopus 로고    scopus 로고
    • Synapse-specific localization of NMDA- And GABAA-receptor subunits revealed by antigen-retrieval immunohistochemistry
    • Fritschy, J.-M., Weinmann, O., Wenzel, A. & Senke, D. Synapse-specific localization of NMDA- and GABAA-receptor subunits revealed by antigen-retrieval immunohistochemistry. J. Comp. Neurol. 390,194-210 (1998).
    • (1998) J. Comp. Neurol. , vol.390 , pp. 194-210
    • Fritschy, J.-M.1    Weinmann, O.2    Wenzel, A.3    Senke, D.4
  • 30
    • 0026612362 scopus 로고
    • The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum
    • Laurie, D. J., Seeburg, P. H. & Wisden, W. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12, 1063-1076 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 1063-1076
    • Laurie, D.J.1    Seeburg, P.H.2    Wisden, W.3
  • 31
    • 0032537056 scopus 로고    scopus 로고
    • Glycine-receptor activation is required for receptor clustering in spinal neurons
    • Kirsch, J. & Betz, H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392, 717-720 (1998).
    • (1998) Nature , vol.392 , pp. 717-720
    • Kirsch, J.1    Betz, H.2
  • 32
    • 2642625663 scopus 로고    scopus 로고
    • Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters
    • Levi, S., Vannier, C. & Triller, A. Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J. Cell Sci. 111, 335-345 (1998).
    • (1998) J. Cell Sci. , vol.111 , pp. 335-345
    • Levi, S.1    Vannier, C.2    Triller, A.3
  • 33
    • 0028574167 scopus 로고
    • Selective clustering of glutamate and y-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters
    • Craig, A. M., Blackstone, C. D., Huganir, R. L. & Banker, G. Selective clustering of glutamate and y-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters. Proc. Natl. Acad. Sci. USA 91,12373-12377 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12373-12377
    • Craig, A.M.1    Blackstone, C.D.2    Huganir, R.L.3    Banker, G.4
  • 34
    • 0029056356 scopus 로고
    • GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro
    • Berninger, B. et al GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro. Development 121, 2327-2335 (1995).
    • (1995) Development , vol.121 , pp. 2327-2335
    • Berninger, B.1
  • 35
    • 0031448738 scopus 로고    scopus 로고
    • GABAA-receptor oc-subunit is an essential prerequisite for receptor formation in vivo
    • Fritschy, J.-M., Benke, D., Johnson, D. K., Mohler, H. & Rudolph, U. GABAA-receptor oc-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience 81,1043-1053 (1997).
    • (1997) Neuroscience , vol.81 , pp. 1043-1053
    • Fritschy, J.-M.1    Benke, D.2    Johnson, D.K.3    Mohler, H.4    Rudolph, U.5
  • 36
    • 16944366300 scopus 로고    scopus 로고
    • Ligand-gated ion channel subunit partnership: GABAA receptor cx6 subunit gene inactivation inhibits 5 subunit expression
    • Jones, A. et al. Ligand-gated ion channel subunit partnership: GABAA receptor cx6 subunit gene inactivation inhibits 5 subunit expression. J. Neurosci. 17,1350-1362 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 1350-1362
    • Jones, A.1
  • 37
    • 12644290240 scopus 로고    scopus 로고
    • Mice devoid of y-aminobutyrate type a receptor ß3 subunit have epilepsy, cleft palate, and hypersensitive behavior
    • Homanics, G. E. et al. Mice devoid of y-aminobutyrate type A receptor ß3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc. Natl. Acad. Sci. USA 94, 4143-4148 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4143-4148
    • Homanics, G.E.1
  • 38
    • 0029909204 scopus 로고    scopus 로고
    • Differential synaptic localization of two major y-aminobutyric acid type a receptor a subunits on hippocampal pyramidal cells
    • Nusser, Z., Sieghart, W., Benke, D., Fritschy, J.-M. & Somogyi, P. Differential synaptic localization of two major y-aminobutyric acid type A receptor a subunits on hippocampal pyramidal cells. Proc. Natl Acad. Sci. USA 93, 11939-11944(1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11939-11944
    • Nusser, Z.1    Sieghart, W.2    Benke, D.3    Fritschy, J.-M.4    Somogyi, P.5
  • 39
    • 0029862916 scopus 로고    scopus 로고
    • Selective clustering of GABAA and glycine receptors in the mammalian retina
    • Koulen, P., Sassoé-Pognetto, M., Griinert, U. & Wässle, H. Selective clustering of GABAA and glycine receptors in the mammalian retina. J. Neurosci. 16, 2127-2140 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 2127-2140
    • Koulen, P.1    Sassoé-Pognetto, M.2    Griinert, U.3    Wässle, H.4
  • 40
    • 0032008543 scopus 로고    scopus 로고
    • Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
    • Nusser, Z., Sieghart, W. 8; Somogyi, P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18, 1693-1703 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 1693-1703
    • Nusser, Z.1    Sieghart, W.2    Somogyi, P.3
  • 41
    • 0025050847 scopus 로고
    • Structural and functional characterization of the yl subunit of GABAA/benzodiazepine receptors
    • Ymer, S. et al Structural and functional characterization of the yl subunit of GABAA/benzodiazepine receptors. EMBO J. 9, 3261-3267 (1990).
    • (1990) EMBO J. , vol.9 , pp. 3261-3267
    • Ymer, S.1
  • 42
    • 0025942562 scopus 로고
    • The y3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands
    • Knoflach, F. et al. The y3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. FEBS Lett. 293,191-194 (1991).
    • (1991) FEBS Lett. , vol.293 , pp. 191-194
    • Knoflach, F.1
  • 43
    • 0026515774 scopus 로고
    • The third y subunit of the y-aminobutyric acid type a receptor family
    • Herb, A. et al The third y subunit of the y-aminobutyric acid type A receptor family. Proc. Natl. Acad. Sci. USA 89,1433-1437 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1433-1437
    • Herb, A.1
  • 44
    • 0030299873 scopus 로고    scopus 로고
    • GABAA receptor subtypes differentiated by their y-subunit variants: Prevalence, pharmacology and subunit architecture
    • Benke, D., Honer, M., Michel, C. & Mohler, H. GABAA receptor subtypes differentiated by their y-subunit variants: prevalence, pharmacology and subunit architecture. Neuropharmacology 35, 1413-1423 (1996).
    • (1996) Neuropharmacology , vol.35 , pp. 1413-1423
    • Benke, D.1    Honer, M.2    Michel, C.3    Mohler, H.4
  • 45
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
    • Brewer, G. J., Torricelli, J. R., Evege, E. K. 8; Price, P. J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576 (1993).
    • (1993) J. Neurosci. Res. , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4
  • 46
    • 0021751227 scopus 로고
    • Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord
    • Pfeiffer, F., Simler, R., Grenningloh, G. & Betz, H. Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord. Proc. Natl. Acad. Sci. USA 81, 7224-7227(1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 7224-7227
    • Pfeiffer, F.1    Simler, R.2    Grenningloh, G.3    Betz, H.4
  • 47
    • 0027414642 scopus 로고
    • Cloned transcription factor MTF-I activates the mouse metallothionein I promoter
    • Radtke, F. et al Cloned transcription factor MTF-I activates the mouse metallothionein I promoter. EMBO J. 12, 1355-1362 (1993).
    • (1993) EMBO J. , vol.12 , pp. 1355-1362
    • Radtke, F.1
  • 48
    • 0023356876 scopus 로고
    • RNa 3' processing regulates histone mRNa levels in a mammalian cell cycle mutant. A processing factor becomes limiting in Gl-arrested cells
    • Luscher, B. & Schumperli, D. RNA 3' processing regulates histone mRNA levels in a mammalian cell cycle mutant. A processing factor becomes limiting in Gl-arrested cells. EMBO J. 6, 1721-1726(1987).
    • (1987) EMBO J. , vol.6 , pp. 1721-1726
    • Luscher, B.1    Schumperli, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.