Ligand-gated ion channel subunit partnerships: GABA(A) receptor α6 subunit gene inactivation inhibits δ subunit expression

Journal of Neuroscience

Volumn 17, Issue 4, 1997, Pages 1350-1362

  Jones, A ^a   Korpi, E R ^b,c   McKernan, R M ^d   Pelz, R ^e   Nusser, Z ^f   Makela R ^b,c   Mellor, J R ^a   Pollard, S ^g   Bahn, S ^a   Stephenson, F A ^g   Randall, A D ^a   Sieghart, W ^e   Somogyi, P ^f   Smith, A J H ^a   Wisden, W ^a,h  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF TURKU   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF LONDON   (United Kingdom)

^h MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

cerebellum; dicistronic mRNA; flunitrazepam; GABA(A) receptor; gene targeting; granule cell; homologous recombination; internal ribosome entry site; knockout mice; ligand gated ion channel; muscimol; Ro 15 4513; SR95531; subunit assembly; subunit sorting; transgenic mice; 6 subunit

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; FLUNITRAZEPAM; ION CHANNEL; MESSENGER RNA; MUSCIMOL; RADIOLIGAND; RECEPTOR SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENE TARGETING; GENETIC RECOMBINATION; GRANULE CELL; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 16944366300     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-04-01350.1997     Document Type: Article

References (23)

1. 6 subunit gene expression in cere-bellar granule cells. J Neurochem 66:1810-1818.
2. A receptor subtypes containing the δ subunit in rat brain. FEBS Lett 283:145-149.
3. Bonnerot C, Nicolas J-F (1993) Application of LacZ gene fusions to postimplantation development. Methods Enzymol 225:451-469.
4. A receptor subunits in label-fracture replicas of cultured rat cerebellar granule cells. Receptors Channels 2:143-153.
5. A receptor subunits in primary cultures of rat cerebellar granule cells. Neuroscience 67:583-593.
6. Connolly CN, Krishek BJ, McDonald BJ, Smart TG, Moss SJ (1996) Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J Biol Chem 271:89-96.
7. A receptors. J Pharmacol Exp Ther 272:438-445.
8. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
9. A-receptor subunit expression. Dev Brain Res 88:1-16.
10. A receptor gating kinetics on the α-subunit isoform: implications for structure-function relations and synaptic transmission. J Physiol (Lond) 489:529-543.
11. Green WN, Claudio T (1993) Acetylcholine receptor assembly: subunit folding and oligomerization occur sequentially. Cell 74:57-69.
12. 2 subunit gene of γ-aminobutyric acid type A receptors. Proc Natl Acad Sci USA 92:7749-7753.
13. A receptor in the rat nervous system. J Comp Neurol 365:504-510.
14. 6-containing receptors. Mol Pharmacol 49:253-259.
15. 6 subunit. J Neurochem 67:907-916.
16. A/benzodiazepine receptor from rat cerebellum. J Neurochem 63:371-374.
17. A receptor maintaining their individual benzodiazepine-binding specificities. J Neurochem 66:685-691.
18. A receptor a subunit. Mol Pharmacol 44:87-92.
19. 3H]Ro 15-4513 binding sites. Neuroscience 53:483-488.
20. Korpi ER, Kuner T, Seeburg PH, Lüddens H (1995) Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol Pharmacol 47:283-289.
21. Kreienkamp H-J, Maeda RK, Sine SM, Taylor P (1995) Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron 14:635-644.
22. Wong G, Sarviharju M, Toropainen M, Matecka D, Korpi ER (1996) Pharmacological actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol. Pharmacol Biochem Behav 53:723-730.
23. A-benzodiazepine receptors by immunoafflnity chromatography. FEBS Lett 284:15-18.