Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: The membrane activation model

Trends in Neurosciences

Volumn 23, Issue 9, 2000, Pages 429-435

  Kneussel, Matthias ^a   Betz, Heinrich ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACTIN BINDING PROTEIN; GEPHYRIN; GLYCINE RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LIPID BINDING PROTEIN; NEUROTRANSMITTER RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROFILIN; RAC PROTEIN; RHO FACTOR; TUBULIN;

CYTOSKELETON; ENZYME ACTIVATION; INHIBITORY POSTSYNAPTIC POTENTIAL; NEUROTRANSMISSION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SIGNAL PROCESSING; TRANSLATION REGULATION;

EID: 0034284148     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01627-1     Document Type: Review

References (71)

1. Sheng, M. (1996) PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron 17, 575-578
2. Craven, S.E. and Bredt, D.S. (1998) PDZ proteins organize synaptic signaling pathways. Cell 93, 495-498
3. Kirsch, J. (1999) Assembly of signaling machinery at the postsynaptic membrane. Curr. Opin. Neurobiol. 9, 329-335
4. Kirsch, J. et al. (1993) Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature 266, 745-748
5. Feng, G. et al. (1998) Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282, 1321-1324
6. A receptor subtypes requires the γ2 subunit and gephyrin. Nat. Neurosci. 7, 563-571
7. A receptor clustering in gephyrin-deficient mice. J. Neurosci. 19, 9289-9297
8. Kirsch, J. and Betz, H. (1995) The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J. Neurosci. 15, 4148-4156
9. Kirsch, J. et al. (1991) The 93-kDa glycine receptor associated protein binds to tubulin. J. Biol. Chem. 266, 22242-22245
10. Stallmeyer, B. et al. (1999) The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96, 1333-1338
11. Kins, S. et al. (2000) Collybistin, a novel brain specific GEF, induces submembrane clustering of gephyrin. Nat. Neurosci. 3, 22-29
12. Reid, T. et al. (1999) Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. J. Biol. Chem. 274, 33587-33593
13. Mammoto, A. et al. (1998) Interactions of drebrin and gephyrin with profilin. Biochem. Biophys. Res. Commun. 243, 86-89
14. Finkel, T. et al. (1994) Dynamic actin structures stabilized by profilin. Proc. Natl. Acad. Sci. U. S. A. 91, 1510-1514
15. Johnson, J.L. and Wadman, S.K. (1995) Molybdenum cofactor deficiency and isolated sulfite oxidase deficiency. In The Metabolic and Molecular Bases of Inherited Disease (Scriver, C.R. et al., eds), pp. 2271-2283, McGraw-Hill
16. Sabatini, D.M. et al. (1999) Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science 284, 1161-1164
17. A receptors and the cytoskeleton. Nature 397, 69-72
18. Wang, H. and Olsen, R.W. (2000) Binding of GABARAP to microtubules and microfilaments suggests involvement of the J. Neurochem. 75, 644-655
19. C receptors to the cytoskeleton at retinal synapses. Nature 397, 66-69
20. A receptors in mice lacking dystrophin (mdx mice). Eur. J. Neurosci. 11, 4457-4462
21. Blake, D.J. and Kröger, S. (2000) The neurobiology of Duchenne muscular dystrophy: learning lessons from muscle? Trends Neurosci. 23, 92-99
22. Prior, P. et al. (1992) Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8, 1161-1170
23. Schmitt, B. et al. (1987) The Mr 93 000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein. Biochemistry 26, 805-811
24. Pfeiffer, F. et al. (1982) Purification by affinity chromatography of the glycine receptor of rat spinal cord. J. Biol. Chem. 257, 9389-9393
25. Graham, D. et al. (1985) Purification and characterization of the glycine receptor of pig spinal cord. Biochemistry 12, 990-994
26. Triller, A. et al. (1985) Distribution of glycine receptors at central synapses: an immunoelectron microscopy study. J. Cell Biol. 101, 683-688
27. Altschuler, R. et al. (1986) Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor. Brain Res. 369, 316-320
28. Meyer, G. et al. (1995) Identification of a gephyrin binding motif on the glycine receptor β subunit. Neuron 15, 563-572
29. Kneussel, M. et al. (1999) Hydrophobic interactions mediate binding of the glycine receptor β-subunit to gephyrin. J. Neurochem. 72, 1323-1326
30. Bechade, C. et al. (1996) Expression of glycine receptor α subunits and gephyrin in cultured spinal neurons. Eur. J. Neurosci. 8, 429-435
31. Kirsch, J. et al. (1996) Synaptic targeting of ionotropic neurotransmitter receptors. Mol. Cell. Neurosci. 8, 93-98
32. Kirsch, J. et al. (1995) Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol. Cell. Neurosci. 6, 450-461
33. Becker, C.M. et al. (1988) Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J. 7, 3717-3726
34. Hoch, W. et al. (1989) Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor. Neuron 3, 339-348
35. Kins, S. et al. (1999) Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK293 cells. Eur. J. Neurosci. 11, 740-744
36. Triller, A. et al. (1987) Gamma-aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses. J. CellBiol. 104, 947-956
37. A-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining. Brain Res. 642, 59-69
38. Cabot, J.B. et al. (1995) Postsynaptic gephyrin immunoreactivity exhibits a nearly one-to-one correspondence with γ-aminobutyric acid-like immunogold-labeled synaptic inputs to sympathetic preganglionic neurons. J. Comp. Neurol. 356, 418-432
39. Todd, A.J. et al. (1996) Colocalization of GABA, glycine and their receptors at synapses in the rat spinal cord. J. Neurosci. 16, 974-982
40. A receptor subunits in the rat retina. J. Comp. Neurol. 357, 1-14
41. Giustetto, M. et al. (1998) Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat. J. Comp. Neurol. 395, 231-244
42. Craig, A.M. et al. (1996) Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons. J. Neurosci. 16, 3166-3177
43. Betz, H. (1998) Gephyrin, a major player in GABAergic postsynaptic membrane assembly? Nat. Neurosci. 7, 541-543
44. A receptor associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc. Natl. Acad. Sci. U. S. A. 97, 8594-8599
45. A receptors and gephyrin expression in cultured motoneurons. J. Neurosci. 19, 7434-7449
46. Kirsch, J. and Betz, H. (1998) Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392, 717-720
47. Jonas, P. et al. (1998) Co-release of two fast neurotransmitters at a central synapse. Science 281, 419-424
48. Ramming, M. et al. Diversity and phylogeny of gephyrin: novel tissue-specific splice variants, gene structure and homologies to molybdenum cofactor synthesizing and cytoskeleton-associated proteins. Proc. Natl. Acad. Sci. U. S. A. (in press)
49. Liu, M.T.W. et al. (2000) Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. J. Biol Chem. 275, 1814-1822
50. Lemmon, M.A. et al. (1996) PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624
51. Kavran, J.M. et al. (1998) Specificity and promiscuity in phosphoinositide binding by pleckstrin homology (PH) domains. J. Biol. Chem. 273, 30497-30508
52. Mackay, D.J.G. and Hall, A. (1998) Rho GTPases. J. Biol Chem. 273, 20685-20688
53. Schlüter, K. et al. (1997) Profilins as regulators of actin dynamics. Biochim. Biophys. Acta 1359, 97-109
54. Witke, W. et al. (1998) In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. EMBO J. 17, 967-976
55. Duclert, A. and Changeux, J.P. (1995) Acetylcholine receptor gene expression at the developing neuromuscular junction. Physiol. Rev. 75, 339-368
56. Levi, S. et al. (1998) Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J. Cell Sci. 111, 335-345
57. Boehm, S. et al. (1998) Glycine receptors in cultured chick sympathetic neurons are excitatory and trigger neurotransmitter release. J. Physiol. 504, 683-694
58. Craig, A.M. and Banker, G. (1994) Neuronal polarity. Annu. Rev. Neurosci. 17, 267-310
59. 2+ transients in embryonic rat dorsal horn neurons in culture. Eur. J. Neurosci. 6, 1275-1280
60. Reichling, D.B. et al. (1994) Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons. J. Physiol. 476, 411-421
61. Maier, U. et al. (1999) Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J. Biol. Chem. 274, 29311-29317
62. Hoch, W. (1999) Formation of the neuromuscular junction. Agrin and its unusual receptors. Eur. J. Biochem. 265, 1-10
63. Abbott, M.A. et al. (1999) The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J. Neurosci. 19, 7300-7308
64. A receptors to postsynaptic domains by insulin. Nature 388, 686-690
65. Chou, M.M. and Blenis, J. (1996) The 70kDa S6 kinase complexes with and is activated by the Rho family G proteins cdc42 and Rac1. Cell 85, 573-583
66. Racca, C. et al. (1997) Dendritic and postsynaptic localizations of glycine receptor α subunit mRNAs. J. Neurosci. 17, 1691-1700
67. Fanger, G.R. (1999) Regulation of the MAPK family members: role of subcellular localization and architectural organization. Histol. Histopathol. 14, 887-894
68. Daniels, R.H. and Bokoch, G.M. (1999) p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem. Sci. 24, 350-355
69. Altiok, N. et al. (1997) Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity. EMBO J. 16, 717-725
70. Allison, D.W. et al. (2000) Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J. Neurosci. 20, 4545-4554
71. Sabatini, D.M. et al. (1997) Neural roles of immunophilins and their ligands. Mol. Neurobiol. 15, 223-235