Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABA(A)-gated current and increases the GABA(A) receptor α4 subunit in association with increased anxiety

Journal of Neuroscience

Volumn 18, Issue 14, 1998, Pages 5275-5284

  Smith, Sheryl S ^a   Gong, Qi H ^a   Li, Xinshe ^a   Moran, Maria H ^a   Bitran, Daniel ^b   Frye, Cheryl A ^c   Hsu, Fu Chun ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Center for Interdisciplinary Studies   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Allopregnanolone; Decay time constant; Elevated plus maze; GABA(A) receptor; GABA(A) gated current; Kinetics; Progesterone; Rat; 4 subunit

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; PROGESTERONE; RECEPTOR SUBTYPE; STEROID 5ALPHA REDUCTASE INHIBITOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; ELTANOLONE; PEPTIDE FRAGMENT;

AFFECTIVE NEUROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; MAZE TEST; NONHUMAN; OVARIECTOMY; PATCH CLAMP; PREMENSTRUAL SYNDROME; PRIORITY JOURNAL; PSEUDOPREGNANCY; PUERPERAL DEPRESSION; RAT; ANIMAL; CHANNEL GATING; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; HIPPOCAMPUS; KINETICS; METABOLISM; PHYSIOLOGY; WITHDRAWAL SYNDROME;

ANIMALS; ANXIETY; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; GABA MODULATORS; HIPPOCAMPUS; ION CHANNEL GATING; KINETICS; MAZE LEARNING; PEPTIDE FRAGMENTS; PREGNANOLONE; PROGESTERONE; PSEUDOPREGNANCY; RATS; RECEPTORS, GABA-A; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0032527128     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-14-05275.1998     Document Type: Article

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