Constitutive endocytosis of GABA(A) receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons

Journal of Neuroscience

Volumn 20, Issue 21, 2000, Pages 7972-7977

  Kittler, J T ^a   Delmas, P ^a   Jovanovic, J N ^a   Brown, D A ^a   Smart, T G ^a   Moss, S J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Adaptin; AP2; Clathrin; Dynamin; Endocytosis; GABA(A) receptor; mIPSC

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CLATHRIN; DYNAMIN; RECEPTOR SUBUNIT; 4 AMINOBUTYRIC ACID A RECEPTOR; ADAPTOR PROTEIN; ALPHA ADAPTIN; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE; HYBRID PROTEIN; MEMBRANE PROTEIN; PEPTIDE; PROTEIN KINASE C; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; COATED PIT; COMPLEX FORMATION; ENDOCYTOSIS; EPILEPTOGENESIS; HIPPOCAMPUS; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR BLOCKING; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MOUSE; NERVE CELL; NERVE CELL INHIBITION; PATCH CLAMP; PHYSIOLOGY; SERODIAGNOSIS;

ADAPTOR PROTEIN COMPLEX 2; ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELLS, CULTURED; CLATHRIN; COATED PITS, CELL-MEMBRANE; DYNAMINS; ENDOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; GLUTATHIONE TRANSFERASE; GTP PHOSPHOHYDROLASES; HIPPOCAMPUS; MEMBRANE PROTEINS; MICE; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDES; PRECIPITIN TESTS; PROTEIN KINASE C; RECEPTORS, GABA-A; RECOMBINANT FUSION PROTEINS; SYNAPTIC TRANSMISSION;

EID: 0034310719     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-21-07972.2000     Document Type: Article

References (40)

1. Use dependent regulation of GABA(A) receptors
2. The distribution, prevalence and drug binding profile of GABA(A) receptor subtypes differing in the β subunit variant
3. Theta, a novel gamma-aminobutyric acid type A receptor subunit
4. Subunit specific association of protein kinase C and the receptor for activated C kinase with γ-aminobutyric acid type A receptors
5. Dynamin-dependent endocytosis of ionotropic glutamate receptors
6. Activation of protein kinase C induces gamma-aminobutyric acid type A receptor internalization in Xenopus oocytes
7. Delta and kappa opioid receptors are differentially regulated by dynamin dependent endocytosis when activated by the same alkaloid
8. Opioid inhibition of GABA release from presynaptic terminals of the rat hippocampus
9. Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors
10. Subcellular localization and endocytosis of homomeric gamma2 subunit splice variants of gamma-aminobutyric acid type A receptors
11. Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition
12. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit
13. Assembly of GABA(A) receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts
14. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation
15. Analysis of GABA(A) receptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras
16. Activation of a postsynaptically silent synapses during pairing-induced LTP in a CA1 region of a hippocampal slice
17. Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP
18. Role of AMPA receptor cycling in synaptic transmission and plasticity
19. GABA(A) receptor channels
20. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization
21. Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
22. The structural era of endocytosis
23. Adjacent phosphorylation sites on GABA(A) receptor beta subunits determine regulation by cAMP-dependent protein kinase
24. Modulation of amino acid activated ligand gated ion channels by protein phosphorylation
25. Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses
26. G-protein-coupled receptor kinases
27. From ion currents to genomic analysis: Recent advances in GABA(A) receptor research
28. Clathrin-coated vesicle formation and protein sorting: An integrated process
29. Single step purification of polypeptides expressed in E. coli as fusions with glutathione S-transferase
30. Identification of residues with GABA(A) receptor a subunits that mediate specific assembly with receptor β subunits
31. Identification of GABAA/benzodiazepine receptors on clathrin-coated vesicles from rat brain
32. Sequestration of gamma-aminobutyric acid A receptors on clathrin-coated vesicles during chronic benzodiazepine administration in vivo
33. Clathrin-coated vesicles from bovine brain contain uncoupled GABA(A) receptors
34. Presynaptic inhibition in the hippocampus
35. Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin
36. The amphiphysin family of proteins and their role in endocytosis at the synapse
37. Amphiphysin heterodimers: Potential role in clathrin-mediated endocytosis
38. The distribution of 13 GABA(A) receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon