Modulation of amino acid-gated ion channels by protein phosphorylation

International Review of Neurobiology

Volumn 39, Issue 39, 1996, Pages 1-52

  Moss, Stephen J ^a   Smart, Trevor G ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTAMATE RECEPTOR; NERVE PROTEIN; NEUROTRANSMITTER RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL; CHANNEL GATING; CONSENSUS SEQUENCE; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; REVIEW;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CONSENSUS SEQUENCE; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHOSPHORYLATION; RECEPTORS, GLUTAMATE; RECEPTORS, NEUROTRANSMITTER;

EID: 0030332789     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (190)

1. Agopyan, N., Tokutomi, N., and Akaike, N. (1993). Protein kinase A-mediated phosphor)lation reduces only the fast desensitizing glycine current in acutely dissociated ventromedial hypothalamic neurons. Neurosnence 56, 605-615.
2. Akagi, H., Hirai, K., and Hishinuma, F. (1991). Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development. FEBS Lett. 281, 160-166.
3. Amador, M., and Dani, J. A. (1991). Protein kinase inhibitor, 11-7, directly affects N-methylD-aspartate receptor channels. Neurosci. I-elt. 124, 251-255.
4. A receptor subunits: α1/β1 and al/31y2S subunits produce unique ion channels with dissimilar single-channel properties./ Neurosci. 13, 1429-1440.
5. Angelotti, T. P., Uhler, M. D., and Macdonald R. L. (1993). Enhancement of recombinant γaminobutyric acid type A receptor currents by chronic activation of cAMP-dependent protein kinase. AM Phannacol 44, 1202-1210.
6. Aniksztejn, L., Otani, S., and Ben-Ari, Y. (1992). Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term protentiation through protein kinase C. Eur. J. Neurosci. 4, 500-505.
7. Amvyl, R. (1991). Modulation of vertebrate neuronal calcium channels by transmitters. Brain Res. Rev. 16, 265-281.
8. Bading, H., and Greenberg, M. E. (1991). Stimulation of protein tyrosine phosphor)lation by NMDA receptor activation. Science 253, 912-914.
9. A receptor: The receptor channel superfamily. Trends Neurosci. 10, 502-509.
10. Bateson, A. N., Lasham, A., and Darlison, M. G. (1991). γAminobutyric acidA receptor heterogeneity is increased by alternative splicing of a novel β subunit gene transcript. / Neurochem. 56, 1437-1440.
11. Ben-Ari, Y., Aniksztejn, L., and Bregestovski, P. (1992). Protein kinase C modulation of NMDA currents: an important link for LTP induction. Trends Neurosci. 15, 333-339.
12. Betz, H., Kuhse, J., Fischer, M., Schmieden, V., Laube, B., Kuryatov, A., Langosch, D., Meyer, G., Bormann, J., and Rundstrom, N. (1994). Structure, diversity and synaptic localization of inhibitory glycine receptors. J. Physiol. (Paris) 88, 243-248.
13. Bialojian, C., and Takai, A. (1988). Inhibitory effects of a marine-sponge toxin okadaic acid on protein phosphatases: Specificity and kinetics. Biochemical J. 256, 283-290.
14. Blackstone, C., Murphy, T. H., Moss, S. J., Baraban.J. M., and Huganir, R. L. (1994). CyclicAMP and synaptic activitγdependent phosphor)lation of AMPA-preferring glutamate receptors, y. Neurosci. 14, 7585-7593.
15. A receptor form ion channels with properties of the native receptor. Science 242, 577-579.
16. Bliss, T. V. P., and Collingridge, G. L. (1993). A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361, 31-39.
17. Bormann.J., Rundstrom, N., Betz, IL, and Langosch, D. (1993). Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and heterooligomers. EMBOJ. 12, 3729-3737.
18. Browning, M. D., Bureau, M., Dudek, E. M., and Olsen, R. W. (1990). Protein kinase C and cAMP-dependent protein kinase phosphorylate the β subunit on the purified γ-aminobutyric acid receptor. Proc. Natl. Acad. Sti. USA 87, 1315-1318.
19. A receptor by cAMP-dependent protein kinase and by protein kinase C: Analysis of the substrate domain. Neurochem. Res. 1, 95-100.
20. A receptor polypeptides by SER/THR and TYR kinase activities associated with the purified receptor. J. Biol. Chem. 270, 26482-26487.
21. Chen, L., and Huang, L.-Y. M. (1991). Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid. Neuron 7, 319-326.
22. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356, 521-523.
23. A receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea pig./ Physiol. 482.2, 353-362.
24. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones. / Physiol. 420, 207-221.
25. Clipstone, N. A, and Crabtree, G. R. (1992). Identification of calcineurin as a key signalling enzyme in lymphocyte-T activation. Nature 357, 695-697.
26. Collingridge, G. L., and Lester, R. A.J. (1989). Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacological. Rev. 40, 143-210.
27. A receptors. J. Biol. Chem. 271, 89-97.
28. Crepel, F., and Knipa, M. (1988). Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells: An in vitro study. Brain Res. 458, 397-401.
29. Cutting, G. R., Lu, L., O'Hara, B. F., Kasch, L. M., Montrose-Rafizadeh, C., Donovan, D. M., Shimada, S., Antonarais, S. E., Guggino, W. B., and Uhl, G. R. (1991). Cloning of the γ-aminobutyric acid (GABA) pi cDNA: A GABA receptor subunit highly expressed in the retina. Proc. Natl. Acad. Sci.USA, 88, 2673-2677.
30. 2+. Neuron 5, 781-788.
31. DildγMayfield.J. E., and Harris, R. A. (1994). Activation of protein kinase C inhibits kainate-induced currents in oocytes expressing glutamate receptor subunits. / Neurochem. 62, 1639-1642.
32. Durand, G. M., Gregor, P., Zheng, X., Bennett, M. V. L., Uhl, G. R., and Zukin, R. S. (1992). Cloning of an apparent splice variant of the rat Aï-methyl-D-aspartate receptor NMDAR1 with an altered sensitivity to polyamines and activators of protein kinase C. Proc. Natl. Acad. Sci.USA 89, 9359-9363.
33. Durand, G. M., Bennett, M. V. L., and Zukin, R. S. (1993). Splice variants of the N-methylD-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc. Nail. Acad. Sci.USA 90, 6731-6735.
34. Egebjerg, J., Bettler, B., Hermans-Borgmeyer, I., and Heinemann, S. (1991). Cloning of a cDN'A for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351, 745-748.
35. 2+/CaM-dependent protein kinase in rat brain./ Neurosci. 5, 3270-3277.
36. Feigenspan, A., and Bormann, J. (1994a). Modulation of GABAc receptors in rat retinal bipolar cells by protein kinase C./ Physiol 481, 325-330.
37. Feigenspan, A., and Bormann.J. (1994b). Facilitation of GABAergic signaling in the retina by receptors stimulating adenylate cyclase. Prof. Natl. Acad. Sci.USA, 91, 10893-10897.
38. Figurov, A., Boddeke, H., and Muller, D. (1993). Enhancement of AMPA-mediated S)Tiaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices. Eur.J. ffeurosci. 5, 1035-1041.
39. Fritschy, J. M., Benke, D., Mertens, S., Oenel, W. H., Bachi, T., and Mohler, H. (1992). Five subtypes of type A γaminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. Natl. Acad. Sci. USA, 89, 6726-6730.
40. Gallo, V., Upson, L. M., Hayes, W. P., Vyklicky, L., Jr., Winters, C. A., and Buonanno, A. (1992). Molecular cloning and developmental analysis of a new glutamate receptor subunit isoform in cerebellum./ Neurosci. 12, 1010-1023.
41. Gerber, G., Kangrga, I., Ryu, P. D., Larew.J. S. A., and Randic, M. (1989). Multiple effects of phorbol esters in the rat spinal dorsal horn./ Neurosd. 9, 3606-3617.
42. Gillette, M. A., and Dacheux, R. (1995). GABA- and glycine-activated currents in the rod bipolar cell of the rabbit retina. / Neurophysiol. 74, 856-875.
43. A currents in retinal bipolar cells./ Neurophysiot. (in press).
44. Glaum, S. R., and Miller, R.J. (1993). Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat./ Neurosci. 13, 1636-1641.
45. Greengard, P.,Jen,J., Nairn, A. C., and Stevens, C. F. (1991). Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253, 1135-1138.
46. Greeningloh, G., Schieden, V. Schofeild, P. R., Seeburg, P. H., Siddique, T., Mohandas, T. K-, Becker, C. M., and Betz, H. (1990a). Alpha subunits of the human glycine receptor: primary structures, functional expression and chomosomal localisation of the corresponding genes. EMBOJ. 9, 771-776.
47. Grenningloh, G., Pribilla, I., Prior, P., Multhaup, G., Beyreuther, K., Taleb, O., and Betz, H. (1990b). Cloning and expression of the 58 kD subunit of the inhibitory glycine receptor. Neuron 4, 963-970.
48. Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen, M., Beyreuther, K., Gundelfinger, E. D., and Betz, H. (1987). The Strychnine binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328, 215-220.
49. Gyenes, M., Farrant, M., and Färb, D. H. (1988). "Run-down" of γaminobutyric acidA receptor function during whole-cell recording: A possible role for phosphorylation. AM. Phannacol. 34, 719-723.
50. Gyenes, M., Wang, Q., Gibbs, T. T., and Färb, D. H. (1994). Phosphorylation factors control neurotransmitter and neuromodulator actions at the γaminobutyric acid type A receptor. Mol. Phannacol. 46, 542-549.
51. A receptor function by an analog of cyclic AMP. Neurosci. Lett. 105, 137-142.
52. Harvey, R. J., Chinchetru, M. A., and Darlison, M. G. (1994). Alternative splicing of a 51-nucleotide exon that encodes a putative protein kinase C phosphorylation site generates two forms of the chicken γaminobutyric acid-A receptor /32 subunit. / Neurochem. 62, 10-16.
53. A receptor subunit which can form a chimeric receptorwith a vertebrate a subunit. EAIBOJ. 11,3239-3245.
54. Hemmings, H. C., Nairn, A. C., McGuinness, T. L., Huganir, R. L., and Greengard, P. (1989). The role of protein phosphorylation in neuronal signal transduction. FASEBJ. 3, 1583-1592.
55. Heuschneider, G., and Schwartz, R. D. (1989). cAMP and forskolin decrease γaminobutyric acid-gated chloride flux in rat brain synaptoneurosomes. Proc. Nail. Acad. Sci.USA 86, 2938-2942.
56. Hidaka, H., and Kobayoshi, R. (1992). Pharmacology of protein kinase inhibitors. Ann. Rev. Toxicol Pharmacol. 32, 377-397.
57. Hollmann, M., and Heinemann, S. (1994). Cloned glutamate receptors. Ann. Rev. Neurosti. 17, 31-108.
58. Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., and Heinemann, S. (1989). Cloning by functional expression of a member of the glutamate receptor family. A'a(ur342,643-648.
59. Hollmann, M., Maron, C., and Heinemann, S. (1994). N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluRl. Neuron 13, 1331-1343.
60. Inomata, H., Nabekura,J., and Akaike, N. (1993). Suppression of taurine response in acutely dissociated substantia nigra neurons by intracellular cyclic AMP. Brain Res. 615, 347-350.
61. Ishihara, H., Martin, B. L., Brautigan, D. L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K., Uemura, D., and Hartshorne, D. J. (1989). Calyculin-A and okadaic acid inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun. 159, 871-877.
62. Kano, M., and Konnerth, A. (1992). Potentiation of GABA-mediated currents by cAMP-dependent protein kinase. Neuroreport 3, 563-566.
63. Kano, M., Rexhausen, U., Dreessen,J., and Konnerth, A. (1992). Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells. Nature 356, 601-604.
64. A receptor-activated current in cultured rat suprachiasmatic neurones. J. Physiol. 478, 67-73.
65. Keinanen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoom, T. A., Sakmann, B., and Seeburg, P. H. (1990). A family of AMPA-selective glutamate receptors. Science 249, 556-560.
66. Kellenberger, S., Malherbe, P., and Sigel, E. (1992). Function of the α1/β2γ2S γ-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. J. Biol. Chem. 267, 25660-25663.
67. Keller, B. U., Hollmann, M., Heinemann, S., and Konnerth, A. (1992). Calcium influx through subunits GluRl/GluRS of kainate/AMPA receptor channels is regulated by cAMP dependent protein kinase. EMBOJ. 11, 891-896.
68. Kelso, S. R., Nelson, T. E., and Leonard.J. P. (1992). Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes. / Physiol. 449, 705-718.
69. Kennedy, M. B., Bennett, M. K., and Erondu, N. G. (1983). Biochemical and immunochemical evidence that the 'major postsynaptic density protein' is a subunit of a calmodulindependent protein kinase. Proc. Nail. Acad. Sci.USA 80, 7357-7361
70. Kennelly, P.J., and Krebs, E. G . (1991). Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266, 15555-15558.
71. Kirkness, E. F., Bovenkerk, C. F., Ueda, T., and Turner, A. J. (1989). Phosphorylation of γaminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase. Biochem. J. 259, 613-616.
72. Knapp, A. G., and Dowling, J. E. (1987). Dopamine enhances excitatory amino acid-gated conductances in cultured retinal horizontal cells. Nature 325, 437-439.
73. Knapp, A. G., Schmidt, K. F., and Dowling, J. E. (1990). Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells. Proc. Nail. Acad. Sci.USA 87, 767-771.
74. Kofuji, P., Wang.J. B., Moss, S.J., Huganir, R. L., and Burt, D. R. (1991). Generation of two forms of the γaminobutyric acidA receptor yZ-subunit in mice by alternative splicing. J. Neurochem. 56, 713-715.
75. Kolaj, M., Cerne, R., Cheng, G., Brickey, D. A., and Randic, M. (1994). Alpha subunit of calcium/calmodulin-dependent protein kinase enhances excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons.J. Neurophysiol. 72, 2525-2531.
76. A receptor function. J. Neurochem. 63, 1167-1170.
77. A receptor function by protein kinase C phosphor) lation. Neuron 5, 1081-1095.
78. Kuhse, J., Kurvatov, A., Maulet, Y., Malosio, M. L., Schmieden, V., and Betz, H. (1991). Alternative splicing generates 2 isoforms of the α2 subunit of the inhibitory glycine receptor. FEES Lett. 283, 73-77.
79. Kuhse, J., Schmeiden, V'., and Betz, H. (1990). Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor./ Biol. Chem. 265, 22317-22320.
80. Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Masaki, H., Kumanishi, T., Arakawa, M., and Mishina, M. (1992). Molecular diversity of the NMDA receptor. Nature 358, 36-41.
81. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosci. 12, 4151-4172.
82. A receptor phosphorylation: multiple sites, actions and artifacts. Trends Phannacol. Sci.12, 84-87.
83. Leidenheimer, N. J., Machu, T. K., Endo, S., Olsen, R. W., Harris, R. A., and Browning, M. D. (1991b). Cyclic AMP-dependent protein kinase decreases γaminobutyric acidA receptor-mediated Cl" uptake by brain microsacs.J. Neurochem., 57, 722-725.
84. Leidenheimer, N.J., McQuilkin, S.J., Hahner, L. D., Whiting, P., and Harris, R. A. (1992). Activation of protein kinase C selectively inhibits the γ-aminobutyric acidA receptor: Role of desensitization. Mol. Phannacol. 41, 1116-1123.
85. A receptor.J. Neurochem. 60, 1972-1975.
86. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376, 737-745.
87. A receptor heterogeneity. Nature 335, 76-79.
88. 2+-dependent phosphatase. Nature 369, 235-239.
89. Liman, E. R., Knapp, A. G., and Dowling.J. E. (1989). Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase. Brain Res. 481,399-402.
90. A, receptor \vhole
91. Linden, D.J., and Connor.J. A. (1991). Participation of postsynaptic PKC in cerebellar longterm depression in culture. Science 254, 1656-1659.
92. Lozovaya, N. A., and Klee, M. R. (1995). Phorbol diacetate differentially regulates the N-methyl-r>aspartate (NMDA) and non-NMDA receptor-mediated components of the rat hippocampal excitatory postsynaptic currents. Neurosd. Lett. 189, 101-104.
93. A receptor selective for a behavioural alcohol antagonist. Nature 346, 648-651.
94. A receptor channels. Ann. Rev. Neurosd. 17, 569-602.
95. A receptor. J. Neurochem. 61, 375-377.
96. Maguire, G., and Werblin, F. (1994). Dopamine enhances a glutamate-gated ionic current in OFF bipolar cells of the tiger salamander retina.J. Neurosci. 14, 6094-6101.
97. Malenka, R. C., Madison, D. V., and Nicoll, R. A. (1986). Potentiation of synaptic transmission in the hippocampus by phorbol esters. Nature 321, 175-177.
98. Malosio, M. L., Grenningloh, G., Kuhse.J., Schmieden, V., Schmitt, B., Prior, P., and Betz, H. (1991a). Alternative splicing generates 2 variants of the al subunit of the inhibitory glycine receptor. / Biol. Chem. 266, 2048-2053.
99. Malosio, M. L., Marquez-Pouey, M., Kuhse, J., and Betz, H. (1991b). Widespread existance of glycine receptor subunit mRNAs in the adult and developing rat brain. EAIBO J. 10, 2401-2409.
100. Markham, H., and Segal, M. (1992a). The inositol 1,4,5-triphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA. J. Physiol. 447, 513-533.
101. Markham, H., and Segal, M. (1992b). Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones./ Physiol. 457, 491-501.
102. Matzenbach, B., Maulet, Y., Sefton, L., Courtier, B., Avner, P., Guenet, J. L., and Betz, H. (1994). Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. / Biol. Chem. 269, 2607-2612.
103. A) receptors by protein phosphorylation. Soc. Neurosci. Abs. 21, 723.18.
104. McDonald, B.J., and Moss, S.J. (1994). Differential phosphorylation of intracellular domains of γaminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase.J. Biol. Chem. 269, 18111-18117.
105. McGlade-McCulloh, E., Yamamoto, H., Tan, S-T., Brickey, D. A., and Soderling, T. R. (1993). Phosphorylation and regulation of glutamate receptors by calcium/calmodulindependent protein kinase II. Nature 362, 640-642.
106. Mcllroy, B. K., Walters, J. D., Blackshear, P. J., and Johnson, J. D. (1991). Phosphorylationdependent binding of a synthetic MARCKS peptide to calmodulin./ Biol. Chem. 266,4959-4964.
107. A receptor. Mol. Brain. lies. 28, 175-179.
108. Meguro, H., Mori, H., Araki, K., Kushi)-a, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., and Mishina, M. (1992). Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357, 70-74.
109. Moran, O., and Dascal, N. (1989). Protein kinase C modulates neurotransmitter responses in Xenopus oocytes injected wiht rat brain RNA. Brain lies. 5, 193-202.
110. Mori, H., Yamakura, T., Masaki, H., and Mishina, M. (1993). Involvement of the carboxγ terminal region in modulation by TPA of the NMDA receptor channel. Neuroreport 4, 519-522.
111. Moriyoshi, K., Masu, M., Ischii, T., Shigemoto, R., Mizuno, N., and Nakanishi, S. (1991). Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
112. Moss, S.J., Doherty, C. A., and Huganir, R. L. (1992a). Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the /81, y2S and y2L subunits of the γaminobutyric acid type A receptor. J. Biol Chem. 267, 14470-14476.
113. A receptors by cAMP-dependent protein phosphorylation. Science 257, 661-665.
114. Moss, S.J., Blackstone, C. D., and Huganir, R. L. (1993). Phosphorylation of recombinant non-NMDA glutamate receptors on serine and tyrosine residues. Neurochem. Res. 18, 105-110.
115. A receptors by tyrosine phosphorylation. Nature 377, 344-348.
116. Mulkey, R. M., Herron, C. E., and Malenka, R. C. (1993). An essential role for protein phosphatases in hippocampal long-term depression. Science 261, 1051-1055.
117. Nakanishi, S. (1994). Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity. Neuron 13, 1031-1037.
118. Nakanishi, S., and Masu, M. (1994). Molecular diversity and functions of glutamate receptors. Ann. Rev. Biophys. Biomol. Struct. 23, 319-348.
119. A receptors. FASEB J. 4, 1469-1480.
120. Parfitt, K. D., Hoffer, B. J., Bickford, C. D., and Wimer, P. C. (1990). Potentiation of γ aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: Receptor specificity. Neurophannacol. 29, 909-916.
121. Pearson, R. C., and Kemp, B. E. (1991). Protein kinases phosphorylation site sequences and consensus specificity motifs: Tabulations Meth. Enzymol. 200, 63-81.
122. Pereda, A., Triller, A., Korn, H., and Faber, D. S. (1992). Dopamine enhances both electrotonic coupling and chemical excitatory postsynaptic potentials at mixed synapses. Proc. Natl. Acad. Sci.USA 89, 12088-12092.
123. Pin, J.-P., and Duvoisin, R. (1995). the metabotropic glutamate receptors: Structure and functions. Neurojiharmacol. 34, 1-26.
124. A receptor current in mouse spinal neurons. Neuron 5, 789-796.
125. Pribilla, I., Takagi, T., Langosch, D., Bormann, J., and Betz, H. (1992). The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBOJ. 11, 4305-4311.
126. Pritchett, D. B., and Seeburg, P. H. (1990). γaminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 54, 1802-1804.
127. A receptor subunit for benzodiazepine pharmacology. Nature 338, 582-585.
128. A-benzodiazepine receptors produced in transfected cells. Science 245, 1389-1392.
129. Ragozzino, D., and Eusebi, F. (1993). Inhibition of GABA and glycine responses by glutamate in rat hippocampal neurons. Brain Res. 628, 115-120.
130. Raymond, L. A, Blackstone, C. D., and Huganir, R. L. (1993). Phosphorylation and modulation of recombinant GluRG glutamate receptors by cAMP-dependent protein kinase. Nature 361, 637-641.
131. A receptor in cerebellar granule cells in culture: Differential involvement of kinase activities. Neuroscience 3, 131-138.
132. Ruiz-Gomez, A., Vaello, M. L., Valdivieso, F., and Mayor, F., Jr. (1991). Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.J. BioL Chem. 266,559-566.
133. Sasaki, H., Nagura, K, Ishino, M., Tobioka, H., Kotani, K., and Sasaki, T. (1995). Cloning and characterisation of cell adhesion kinase β , a novel protein tyrosine kinase of the focal adhesion kinase subfamily./ EM. Chem. 270, 21206-21219.
134. Schmidt, K.-F., Kruse, M., and Halt, H. (1994). Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis). Proc. Natl. Acad. Sa. USA 91, 8288-8291.
135. Schmieden, V., Grenningloh, G., Schofield, P. R., and Betz, H. (1989). Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor. EAWOJ. 8, 695-700.
136. A receptor shows a ligandgated receptor super-family. A'a/ure328, 221-227.
137. Schonrock, B., and Bormann.J. (1995). Modulation of hippocampal glycine receptor channels by protein kinase C. Neuroreport 6, 301-304.
138. Schwartz, R. D., Heuschneider, G., Edgar, P. P., and Cohn, J. A. (1991). cAMP analogs inhibit γaminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes. Mol. Pharmacol. 39, 370-375.
139. Shenolikar, S. (1994). Protein serine/threonine phosphatases: New avenues for cell regulation. Ann. Rev. Cell Biol. 10, 55-86.
140. A receptor subunits exist in distinct neuronal subpopulations. Neuron 3, 327-337.
141. 2+, and -γaminobutyrate type A channels. Proc. Acad. Nail. Sci.USA 85, 6192-6196.
142. A receptors on channel function. Neuron 5, 703-711.
143. A-channels. FEBS. Lett. 291, 150-152.
144. A receptor function and ethanol. FEBS. Lett. 324, 140-142.
145. Sigel, E., Baur, R, and Malherbe, P. (1994). Protein kinase C transiently activates heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites. J. Biol. Chem. 269, 8204-8208.
146. A receptors are differentially sensitive to zinc: Dependence on subunit composition. Br.J. Phannacol. 103, 1837-1839.
147. Smith, D. B., and Johnson, K. S. (1988). The expression of heterologous proteins in E. coli as soluble glutathione-S-transferase fusion proteins. Gène 67, 31-40.
148. Snell, L. D., lorio, K. R., Tabakoff, B., and Hoffman, P. L. (1994). Protein kinase C activation attenuates Ar-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule neurones./ Neurochem. 62, 1783-1789.
149. Sommer, B., Keinanen, K., Verdoorn, T. A-, Wisden, W., Burnashev, N., Herb, A., Kohler, M., Takagi, T., Sakmann, B., and Seeburg, P. H. (1990). Flip and flop: A cell-specific functional switch in glutamate-operated channels of the CN'S. Science 249, 1580-1585.
150. Song, Y. M., and Huang, L. Y. (1990). Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons. Nature 348, 242-245.
151. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., and Cantley, L. C. (1994). Use of an orientated peptide library to determine the optimal substrates of protein kinases. Curr. Biol. 4, 973-982.
152. Songyang, Z., Carraway, K. L., Eck, M. J., Harrison, S. C., Fcldman, R. A., Mohammadi, M., Schlesinger,J., Hubbard, S. R., Smith, D. P., Eng, C. Lorenzo, M.J., Ponder, B. A., Mayer, B. J., and Cantley, L. C. (1995). Catalytic specificity of protein tyrosine kinases is critical for selective signalling. Nature 373, 536-539.
153. Sontheimer, H., Becker, C. M., Pritchett, D. B., Schofield, P. R., Grenningloh, G., Kettenmann, H., Betz, H., and Seeburg, P. H. (1989). Functional chloride channels by mammalian cell expression of rat glycine receptor subunit. Neuron 2, 1491-1497.
154. A receptor function In "Ion Channels" (vol 3) (T. Narahashi, ed.), pp 83-136. Plenum Press, New York.
155. A receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cells. Neiiroscience 62, 813-828.
156. A responses in hippocampal neurons are potentiated by glutamate. Nature 337, 170-173.
157. A-receptor function in hippocampal cells is maintained by phosphor) lation factors. Science 241, 339-341.
158. A/benzodiazcpine receptor α subunit by a receptor-associated protein kinase.J. Neurochem. 51, 1274-1284.
159. Tan, S.-E., Wenthold, R. J., and Soderling, T. R. (1994). Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin-dependent protein kinase II and protein kinase C in cultured hippocampal neurons./ Neurosci. 14, 1123-1129.
160. A receptors in mouse cortical homogenates are phosphorylated by endogenous protein kinase A. Mol. Brain. Kes. 4, 55-64.
161. A receptor desensitization in chick cortical neurons. Synapse 4, 126-131.
162. Ticku, M. K., and Mehta, A. K. (1990). γAminobutyric acidA receptor desensitization in mice spinal cord cultured neurons: Lack of involvement of protein kinases A and C. Mol. Phannacol. 38, 719-724.
163. Tingley, W. G., Röche, K. W., Thompson, A. K., and Huganir, R. L. (1993). Regulation of NMDA receptor phosphor)lation by alternative splicing of the C-terminal domain. Nature 364, 70-73.
164. Tong, G., Shepherd, D., and Jahr, C. E. (1995). Synaptic desensitization of NMDA receptors by calcineurin. Science 267, 1510-1512.
165. Uchiyama M., Keiko, H., Hishinuma, F., and Akagi, H. (1994). Down regulation of glycine receptor channels by protein kinase C in Xenopus oocytes injected with synthetic RNA. Mol. Brain Res. 24, 295-300.
166. Unwin, N. (1993). Neurotransmitter action: Opening of ligand gated ion channels. Neuron 10, 31-41.
167. Vaello, M. L., Ruiz-Gomez, A., and Mayor, F., Jr. (1992). Glycinergic ligands modulate the rate of phosphorylation of the glycine receptor by protein kinase C. Kochern. Biophys. Res. Commun. 188, 813-819.
168. Vaello, M. L., Ruiz-Gomez, A., Lerma.J., and Mayor, F., Jr. (1994). Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase./ Biol. Chem. 269, 2002-2008.
169. A receptors. Mot. Brain. Res. 31, 165-172.
170. A receptor function in bipolar cells and ganglion cells of the rat retina. / Neurophysiol. 67, 791-797.
171. A receptor function through activation of cyclic AMP. Vis. Neurosd. 11, 899-908.
172. A receptors requires phosphorylation of the alternatively spliced variant of the y2 subunit. FEES. Lett. 313, 113-117.
173. A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron 7, 27-33.
174. Wagner, K. R., Mei, L., and Huganir, R. L. (1991). Protein tyrosine kinases and phosphatases in the nervous system. Curr. Opin. Neurobiol. 1, 65-73
175. Wang, Y. T., and Salter, M. W. (1995). Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369, 233-235.
176. Wang, L.-Y., Slater, M. W., and MacDonald.J. F. (1991). Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science 253, 1132-1135.
177. Wang, L.-Y, Dudek, E. M., Browning, M. D., and MacDonald.J. F. (1994a). Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.J. Physiol. 475.3, 431-437.
178. Wang, L.-Y, Orser, B. A., Brautigan, D. L., and MacDonald.J. F. (1994b). Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature 369, 230-232.
179. Wang, L.-Y, Taverna, F. A., Huang, X.-P., MacDonald.J. F., and Hampson, D. R. (1993). Phosphorylation and modulation of a kainate receptor (GIuR6) by cAMP-dependent protein kinase. Science 259, 1173-1175.
180. Wang, R. A., Cheng, G., Kolaj, M., and Randic, M. (1995). Alpha-subunit of calcium/ calmodulin-dependent protein kinase II enhances γaminobutyric acid and inhibitory synaptic responses of rat neurons in vitro. J. Neurophysiol. 73, 2099-2106.
181. A-mediated synaptic current by ethanol in hippocampal CA1 neurons: Possible role of protein kinase C. / Pharmacol. Exp. Ther. 268, 1388-1395.
182. \Vhite, G., Li, C., and Ishac, E. (1992). 1,9-Dideoxyforskolin does not mimic all cAMP and protein kinase A independent effects of forskolin on GABA activated ion currents in adult rat sensory neurons. Brain. Res. 586, 157-161.
183. Whiting, P., McKeman, R. M., and Iversen, L. L. (1990). Another mechanism for creating diversity in γ-aminobutyrate type A receptors: RNA splicing directs expression of two forms of-y2 phosphorylation site. Proc. Natl. Acad. Sci.USA 87, 9966-9970.
184. A receptor channels: From subunits to functional entities. Cun. Opin. Neurobiol. 2, 263-269.
185. Wylie, D. J. A., and Nicoll, R. A. (1994). A role for protein kinases and phosphatases in the Ca2t-induced enhancement of hippocarnpal AMPA receptor-mediated S)Tiaptic responses. Neuron 13, 635-643.
186. Yakel, J. L., Vissavajjhala, P., Derkach, V. A., Brickey, D. A., and Soderling, T. R. (1995). Identification of a Ca2t/calmodulin-dependent protein kinase II regulatory phosphorylauon site in non-W-methyl-D-aspartate glutamate receptors. Proc. Natl. Acad. Sci.USA 92, 1376-1380.
187. Yamakura, T., Mori, H., Shimoji, K., and Mishina, M. (1993). Phosphorylation of the carboxγ terminal domain of the fl subunit is not responsible for potentiation by TPA of the NMDA receptor channel. Biochem. Biophys. Res. Commun. 196, 1537-1544.
188. Yamazaki, M., Mori, H., Araki, K., Mori, K.J., and Mishina7'M. (1992). Cloning expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300, 39-45.
189. 2+/calmodulindependent kinase II and phosphorylation of intermediate filament proteins by stimulation of glutamate receptors in cultured rat cortical astrocytes. J. Bid. Chem. 269, 5428-5439.
190. A receptor β subunit heterogeneity: Functional expression of cloned cDNAs. EMBO J. 8, 1665-1670.