Cerebellar γ-aminobutyric acid type A receptors: Pharmacological subtypes revealed by mutant mouse lines

Molecular Pharmacology

Volumn 52, Issue 3, 1997, Pages 380-388

  Mäkelä, Riikka ^a,b   Uusi Oukari, Mikko ^e   Homanics, Gregg E ^c   Quinlan, Joseph J ^c   Firestone, Leonard L ^c   Wisden, William ^d   Korpi, Esa R ^a,e  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; DIAZEPAM; FLUMAZENIL; FUROSEMIDE; MUSCIMOL; PICROTOXIN; RECEPTOR SUBTYPE; TRITIUM; ZOLPIDEM;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CEREBELLUM; DRUG RECEPTOR BINDING; GABAERGIC TRANSMISSION; GRANULE CELL; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

EID: 1842290971     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.3.380     Document Type: Article

References (40)

1. A receptor subtypes. Pharmacol. Rev. 47:181-234 (1995).
2. A receptor subtypes really occur in the brain? Trends Neurosci. 19:139-143 (1996).
3. A receptor subunit. Nature (Lond.) 385:820-823 (1997).
4. A receptor selective for a behavioural alcohol antagonist. Nature (Lond.) 346:648-651 (1990).
5. A/benzodiazepine receptor 06 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice. J. Comp. Neural. 339:341-352 (1994).
6. A receptor diversity. Neuropharmacology 35:1139-1160 (1996).
7. 3H]Ro 15-4513: a biochemical and autoradiographic study. J. Neurochem. 48:46-52 (1987).
8. 3H]Ro 15-4513 binding in intact cultured cerebellar granule cells. Eur. J. Pharmacol. 169:53-60 (1989).
9. A receptor a subunit. Mol. Pharmacol. 44:87-92 (1993).
10. Korpi, E. R., T. Kuner, P. H. Seeburg, and H. Lüddens. Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol. Pharmacol. 47:283-289 (1995).
11. A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J. Neurosci. 16:103-114 (1996).
12. Zhu, W. J., J. F. Wang, S. Vicini, and D. R. Grayson. α6 and γ2 subunit antisense oligodeoxynucleotides alter γ-aminobutyric acid receptor pharmacology in cerebellar neurons. Mol. Pharmacol. 50:23-33 (1996).
13. A receptors. J. Neurosci. 16:6648-6656 (1996).
14. A receptor 06 subunit gene inactivation inhibits δ subunit expression. J. Neurosci. 17:1350-1362 (1997).
15. Homanics, G. E., C. Ferguson, J. J. Quinlan, J. Daggett, K. Snyder, C. Lagenaur, Z.-P. Mi, X.-H. Wang, D. R. Grayson, and L. L. Firestone. Gene knockout of the α6 subunit of the γ-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol. Pharmacol. 51:588-596 (1997).
16. A receptor subtype that is insensitive to diazepam. J. Pharmacol. Exp. Ther. 257:1236-1242 (1991).
17. Bahn, S., R. J. Harvey, M. G. Darlison, and Wisden W. Conservation of γ-aminobutyric acid type A receptor α6 subunit gene expression in cerebellar granule cells. J. Neurochem. 66:1810-1818 (1996).
18. Hadingham, K. L., E. M. Garrett, K. A. Wafford, C. Bain, R. P. Heavens, D. J. S. Sirinathsinghji, and PJ. Whiting. Cloning of cDNAs encoding the human γ-aminobutyric acid type A receptor α6 subunit and characterization of the pharmacology of α6-containing receptors. Mol. Pharmacol. 49:253-259. (1996).
19. 35S]butylbicyclophosphorothionate binding by antagonists: relationship to patterns of subunit expression. J. Neurochem. 66:2179-2187 (1996).
20. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat. 3:59-76 (1990).
21. Wong, G., M. Sarviharju, M. Toropainen, D. Matecka, and E. R. Korpi. Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 53:723-730 (1996).
22. A receptor antagonist SR 95531 is a substrate inhibitor of MAO-A in the rat and human locus coeruleus. Eur. J. Neurosci. 6:1038-1049 (1994).
23. A receptor subunits. Trends Pharmacol. Sci. 12:49-51 (1991).
24. Olsen, R. W. Drug interactions at the GABA receptor-ionophore complex. Annu. Rev. Pharmacol. Toxicol. 22:245-277 (1982).
25. A receptor site. Brain Res. 384:224-231 (1986).
26. A receptors from rat brain. Eur. J. Pharmacol. 290:175-181 (1995).
27. 2+. Neuron 5:781-788 (1990).
28. A receptor isoforms. Mol. Pharmacol. 49:567-579 (1996).
29. A receptor complex. J. Neurochem. 62:602-607 (1994).
30. Wingrove, P. B., K. A. Wafford, C. Bain, and P. J. Whiting. The modulatory action of loreclezole at the γ-aminobutyric acid type A receptor is determined by a single amino acid in the β2 and β3 subunit. Proc. Natl. Acad. Sci. USA 91:4569-4573 (1994).
31. A receptor inverse agonists modulate γ-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site. Mol. Pharmacol. 48:965-969 (1995).
32. A receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267:1426-1429 (1992).
33. A receptors. J. Pharmacol. Exp. Ther. 272:438-445 (1995).
34. A receptor maintaining their individual benzodiazepine-binding specificities. J. Neurochem. 66:685-691 (1996).
35. Quirk, K., N. P. Gillard, C. I. Ragan, P. J. Whiting, and R, M. McKernan. Model of subunit composition of γ-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J. Biol. Chem. 269:16020-16028 (1994).
36. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12:1040-1062 (1992).
37. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12:1063-1076 (1992).
38. A receptor is concentrated in synaptic junctions containing the α1 and β2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology 35:1425-1444 (1996).
39. A receptors. Eur. J. Pharmacol. 244:29-35 (1993).
40. A receptor expression in Bergmann glial cells. J. Neurosci. 14:2503-2514 (1994).