Decreased GABA(A)-receptor clustering results in enhanced anxiety and a bias for threat cues

Nature Neuroscience

Volumn 2, Issue 9, 1999, Pages 833-839

  Crestani, Florence ^c   Lorez, Matthias ^c   Baer, Kristin ^c   Essrich, Christian ^c   Benke, Dietmar ^c   Laurent, Jean Paul ^c   Belzung, Catherine ^a,c   Fritschy, Jean Marc ^c   Lüscher, Bernhard ^b,c   Mohler, Hanns ^c  

^a UNIVERSITÉ DE TOURS   (France)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; GABAERGIC SYSTEM; HIPPOCAMPUS; LONG TERM POTENTIATION; MOUSE; NONHUMAN; ORBITAL CORTEX; PANIC; PRIORITY JOURNAL; RECEPTOR DENSITY; SPATIAL MEMORY; STATE DEPENDENT LEARNING; ANIMAL; ANXIETY DISORDER; ASSOCIATION; C57BL MOUSE; DRUG EFFECT; FEAR; GENETICS; HETEROZYGOTE; INSTRUMENTAL CONDITIONING; MAZE TEST; MEMORY; MOUSE STRAIN; NERVE CELL; PATCH CLAMP; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ANIMALS; ANXIETY; ANXIETY DISORDERS; AVOIDANCE LEARNING; CONDITIONING, OPERANT; CUES; FEAR; GAMMA-AMINOBUTYRIC ACID; HETEROZYGOTE; HIPPOCAMPUS; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A;

EID: 0033237836     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/12207     Document Type: Article

References (39)

1. Eysenck, M. W. in Handbook of Individual Differences: Biological Perspectives (eds. Gale, A. & Eysenck, M. W.) 157-178 (Wiley, New York, 1992).
2. McNally, R. J. in Nebraska Symposium on Motivation Vol. 43 (eds. Dienstbier, R. A. & Hope, D. A.) 211-250 (Univ. Nebraska Press, London, 1996).
3. Gray, J. A. & McNaughton, N. in Nebraska Symposium on Motivation Vol. 43 (eds. Dienstbier, R. A. & Hope, D. A.) 61-134 (Univ. Nebraska Press, London, 1996).
4. Rogan, M. T. & LeDoux, J. E. Emotion: systems, cells, synaptic plasticity. Cell 85, 469-475 (1996).
5. Phillips, R. G. & LeDoux, J. E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106, 274-285 (1992).
6. LeDoux, J. E. in The Cognitive Neurosciences (ed. Gazzaniga, M.) 1049-1062 (MIT Press, Cambridge, Massachusetts, 1995).
7. Schlegel, S. et al. Decreased benzodiazepine receptor binding in panic disorder measured by iomazenil SPECT. Eur. Arch. Psychiatry Clin. Neurosci. 244, 49-51 (1994).
8. Kaschka, W., Feistel, H. & Ebert, D. Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECT. J. Psychiatr. Res. 29, 427-434 (1995).
9. A-benzodiazepine receptor binding in panic disorder. Arch. Gen. Psychiatry 55, 715-720 (1998).
10. Tiihonen, J. et al. Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis. Mol. Psychiatry. 2, 463-471 (1997).
11. Abadie, P. et al. Relationships between trait and state anxiety and the central benzodiazepine receptor: a PET study. Eur. J. Neurosci. 11, 1470-1478 (1999).
12. Günther, U. et al. Benzodiazepine-insensitive mice generated by targeted disruption of the γ2 subunit gene of γ-aminobutyric acid type A receptors. Proc. Natl. Acad. Sci. USA 92, 7749-7753 (1995).
13. A-receptor subtypes requires the γ2 subunit and gephyrin. Nat. Neurosci. 1, 563-571 (1998).
14. A-receptor subunits revealed by antigen-retrieval immunohistochemistry. J. Comp. Neurol. 390, 194-210 (1998).
15. A-receptor channels. Annu. Rev. Neurosci. 17, 569-602 (1994).
16. Griebel, G., Belzung, C., Misslin, R. & Vogel, E. The free-exploratory paradigm: an effective method for measuring neophobic behavior in mice and testing neophobia-reducing drugs. Behav. Pharmacol. 4, 637-644 (1993).
17. Lister, R. G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92, 180-185 (1987).
18. Misslin, R., Belzung, C. & Vogel, E. Behavioral validation of a light/dark choice procedure. Behav. Proc. 18, 119-132 (1989).
19. Blanchard, D. C. & Blanchard, R. J. Ethopharmacological approaches to the biology of emotion. Annu. Rev. Psychol. 39, 43-68 (1988).
20. Knight, R. T. Contribution of human hippocampal region to novelty detection. Nature 383, 256-259 (1996).
21. Haefely, W. in The Challenge of Neuropharmacology (eds. Mohler, H. & DaPrada, M.) 15-40 (Roche, Basel, Switzerland, 1994).
22. Abeliovich, A. et al. PKCγ mutant mice exhibit mild deficits in spatial and contextual learning. Cell 75, 1263-1271 (1993).
23. Beuzen, A. & Belzung, C. Link between emotional memory and anxiety states: a study by principal component analysis. Physiol. Behav. 58, 111-118 (1995).
24. Mc Gaugh, J. L. Significance and remembrance: The role of neuromodulatory systems. Psychol. Sci. 1, 15-25 (1990).
25. Panksepp, J., Sacks, D. S. & Crepeau, L. J. in Fear, Avoidance and Phobias (ed. Denny, M. R.) 7-59 (Erlbaum, Hillsdale, New Jersey, 1991).
26. Kim, J. J., Clark, R. E. Thompson, R.F. Hippocampectomy impairs the memory of recently, but not remotely acquired trace eyeblink conditioned responses. Behav. Neurosci. 109, 195-203 (1995).
27. Holland, P.C. in Quantitative Analyses of Behavior: Discrimination Processes (eds. Commons, M. L. et al.) 183-206 (Ballinger, New York, 1983).
28. McNaughton, N. Cognitive dysfunction resulting from hippocampal hyperactivity - A possible cause of anxiety disorder? Pharmacol. Biochem. Behav. 56, 603-611 (1997).
29. Büeler, H. et al. Normal development and behavior of mice lacking the neuronal cell-surface PrP protein. Nature 356, 577-582 (1992).
30. Beracochea, D. J. & Jaffard, R. Effects of ibotenic lesions of mammillary bodies on spontaneous and rewarded spatial alternation in mice. J. Cogn. Neurosci. 2, 133-140 (1990).
31. Reiman, E. M. et al. A focal brain abnormality in panic disorder, a severe form of anxiety. Nature 310, 683-685 (1984).
32. Nordahl, T. E. et al. Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology 3, 261-272 (1990).
33. O'Boyle, C. A., Harris, D., Barry, H. & Cullen, J. H. Differential effects of benzodiazepine sedation in high and low anxious patients in a real life stress setting. Psychopharmacology 88, 226-229 (1986).
34. Glue, P., Wilson, S., Coupland, N., Ball, D. & Nutt, D. The relationship between benzodiazepine receptor sensitivity and neuroticism. J. Anxiety Disord. 9, 33-45 (1995).
35. Holland, P.C. Brain mechanisms for changes in processing of conditional stimuli in Pavlovian conditioning: implications for behavior theory. Animal Learn. Behav. 25, 373-399 (1997).
36. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H. & Lindholm, D. Activity-dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J. 9, 3545-3550 (1990).
37. Lüthi, A. et al. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372, 777-779 (1994).
38. Carlson, S. & Willot, J. F. The behavioral salience of tones as indicated by prepulse inhibition of the startle response: relationship to hearing loss and central neural plasticity in C57BL/6J mice. Hear. Res. 99, 168-175 (1996).
39. A-receptors. Mol. Neurobiol. 18, 35-86 (1998).