Effects of propofol and pentobarbital on ligand binding to GABA(A) receptors suggest a similar mechanism of action

Canadian Journal of Physiology and Pharmacology

Volumn 76, Issue 1, 1998, Pages 46-52

  Davies, Martin ^a   Thuynsma, Rick P ^a   Dunn, Susan M J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Allosterism; Barbitur5ate; GABA(A) receptor; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; FLUNITRAZEPAM; MUSCIMOL; PENTOBARBITAL; PROPOFOL; RECEPTOR SUBTYPE;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN MEMBRANE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ALLOSTERIC SITE; ANESTHETICS, INTRAVENOUS; ANIMALS; AZIDES; BENZODIAZEPINES; BRAIN; CATTLE; FLUNITRAZEPAM; GABA AGONISTS; LIGANDS; MEMBRANES; MUSCIMOL; PENTOBARBITAL; PROPOFOL; RECEPTORS, GABA-A;

EID: 0031892222     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-76-1-46     Document Type: Article

References (31)

1. A receptors of clonal murine hypothalmic GT1-7 neurones by propofol. Br. J. Pharmacol. 115: 953-960.
2. A receptor in bovine brain membranes. Biochemistry, 29: 4200-4208.
3. Concas, A., Santoro, G., Mascia, M.P., Serra, M., Sanna, E., and Biggio, G. 1990. The general anesthetic propofol enhances the function of γ-aminobutyric acid-coupled chloride channel in the rat cerebral cortex. J. Neurochem. 55: 2135-2138.
4. 35S]butylbicyclophorothionate binding in rat cerebral cortex. Eur. J. Pharmacol. 267: 207-213.
5. A receptor subtype. Can. J. Physiol. Pharmacol. 72 (Suppl. 1) : 337.
6. A receptors: ligand binding and chloride transporting properties. Biochemistry, 33: 755-763.
7. A receptor. Int. Rev. Neurobiol. 36: 51-96.
8. Fischer, J.B., and Olsen, R.W. 1986. Biochemical aspects of GABA/benzodiazepine receptor function. In Benzodiazepine/GABA receptors and chloride channels: structural and functional properties. Edited by R.W. Olsen and J.C. Venter. Alan R. Liss Inc., New York. pp. 241-259.
9. Franks, N.P., and Lieb, W.R. 1994. Molecular and cellular mechanisms of general anaesthesia. Nature (London), 367: 607-614.
10. Hales, T.G., and Lambert, J.J. 1991. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br. J. Pharmacol. 104: 619-628.
11. A receptor. Br. J. Pharmacol. 112: 906-910.
12. Hara, M., Yoshihisa, K., and Ikemoto, Y. 1994. Enhancement by propofol of the γ-aminobutyric acid A response in dissociated hippocampal pyramidal neurons of the rat. Anesthesiology, 81: 988-994.
13. Harris, B.D., Wong, G., Moody, E.G., and Skolnick, P. 1995a. Different subunit requirements for volatile and nonvolatile anesthetics at γ-aminobutyric acid type A receptors. Mol. Pharmacol. 47: 363-367.
14. Harris, R.A., Mihic, S.J., Dildy-Mayfield, J.E., and Machu, T.K. 1995b. Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition. FASEB J. 9: 1454-1462.
15. Harrison, N.L., Kugler, J.L., Jones, M.V., Greenblatt, E.P., and Pritchett, D.B. 1993. Positive modulation of human γ-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol. Pharmacol. 44: 628-632.
16. A receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium. J. Pharmacol. Exp. Ther. 263: 569-578.
17. Longoni, B., Demontis, G.C., and Olsen, R.W. 1993. Enhancement of γ-aminobutyric acid A receptor function and binding by the volatile anesthetic halothane. J. Pharmacol. Exp. Ther. 266: 153-159.
18. A receptor channel of mouse spinal neurones in culture. J. Physiol. (London), 417: 483-500.
19. Mihic, S.J., McQuilkin, S.J., Eger, E.I., Ionescu, P., and Harris, R.A. 1994. Potentiation of γ-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds corresponds to their abilities to induce general anesthesia. Mol. Pharmacol. 46:851-857.
20. Miller, K. 1986. Are lipids or proteins the target of general anaesthetic action? Trends Neurosci. 9: 49-51.
21. Moody, E.J., Suzdak, P.D., Paul, S.M., and Skolnick, P. 1988. Modulation of the benzodiazepine/γ-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J. Neurochem. 5: 1386-1393.
22. A receptor determined by electron microscopic image analysis. J. Neurochem. 62: 815-818.
23. Olsen, R.W., and Snowman, A.M. 1982. Chloride-dependent enhancement by barbiturates of γ-aminobutyric acid receptor binding. J. Neurosci. 2: 1812-1823.
24. A receptors in cultured murine hippocampal neurons. J. Neurosci. 14: 7747-7760.
25. A receptor complex. Brain Res. 596: 238-242.
26. Quinlan, J.J., Gallaher, E.J., and Firestone, L.L. 1993. Halothanes's effects on GABA-gated chloride flux in mice bred for sensitivity or resistance to diazepam. Brain Res. 610: 224-228.
27. Rodbard, D., and Feldman, H.A. 1975. Theory of protein-ligand interaction. Methods Enzymol. 36: 3-16.
28. A receptor subtypes. Pharmacol. Rev. 47: 182-234.
29. A receptor: dependence on receptor subunit combination. Br. J. Pharmacol. 117: 521-527.
30. A receptor channels. Neurosci. Lett. 96: 89-95.
31. 1- current correlates with in vivo anesthetic potency. J. Pharmacol. Exp. Ther. 270: 987-991.