-
1
-
-
77953993819
-
-
New York: Executive Enterprises Publication.
-
Conner, J.D., L.S. Ebner, C.A. O'Connor, C. Volz, and K.W. Weinstein. 1987. Pesticide Regulation Handbook. New York: Executive Enterprises Publication.
-
(1987)
Pesticide Regulation Handbook
-
-
Conner, J.D.1
Ebner, L.S.2
O'Connor, C.A.3
Volz, C.4
Weinstein, K.W.5
-
2
-
-
0003672077
-
-
EPA/630/R-95/002F. Risk Assessment Forum, U.S. Environmental Protection Agency, [accessed March 29, 2007].
-
EPA (U.S. Environmental Protection Agency). 1998. Guidelines for Ecological Risk Assessment. EPA/630/R-95/002F. Risk Assessment Forum, U.S. Environmental Protection Agency. [online]. Available: oaspub.epa.gov/eims/ eimscomm.getfile?p_download_id=36512. [accessed March 29, 2007].
-
(1998)
Guidelines for Ecological Risk Assessment
-
-
-
3
-
-
0141480662
-
-
Final Report. EPA/630/P- 02/002F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC, [accessed March 11, 2005].
-
EPA (U.S. Environmental Protection Agency). 2002. A Review of the Reference Dose and Reference Concentration Processes. Final Report. EPA/630/P- 02/002F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/iris/RFD_ FINAL%5B1%5D.pdf [accessed March 11, 2005].
-
(2002)
A Review of the Reference Dose and Reference Concentration Processes
-
-
-
4
-
-
77953996328
-
-
U.S. Environmental Protection Agency, [accessed February 22, 2006].
-
EPA (U.S. Environmental Protection Agency). 2005. EPA Commemorates its History and Celebrates its 35th Anniversary. U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/history/ [accessed February 22, 2006].
-
(2005)
EPA Commemorates its History and Celebrates its 35th Anniversary
-
-
-
5
-
-
77954001283
-
Food Quality Protection Act (FQPA) of 1996
-
U.S. Environmental Protection Agency, [accessed February 23, 2006].
-
EPA (U.S. Environmental Protection Agency). 2005. Food Quality Protection Act (FQPA) of 1996. Office of Pesticides, U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/opppsps1/fqpa/ [accessed February 23, 2006].
-
(2005)
Office of Pesticides
-
-
-
6
-
-
84989226732
-
Highlights of the Food Quality Protection Act of 1996
-
U.S. Environmental Protection Agency, [accessed February 23, 2007].
-
EPA (U.S. Environmental Protection Agency). 2006. Highlights of the Food Quality Protection Act of 1996. Office of Pesticides, U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/oppfead1/fqpa/ fqpahigh.htm [accessed February 23, 2007].
-
(2006)
Office of Pesticides
-
-
-
7
-
-
84989270858
-
Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics
-
Austin, TX: The Association of Food and Drug Officials of the United States.
-
FDA (Food and Drug Administration). 1959. Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Staff of the Division of Pharmacology, Food and Drug Administration, Department of Health, Education and Welfare. Austin, TX: The Association of Food and Drug Officials of the United States.
-
(1959)
Staff of the Division of Pharmacology, Food and Drug Administration, Department of Health, Education and Welfare
-
-
-
8
-
-
77954026868
-
Food additives and nutrition supplements
-
2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
Frankos, V.H., and J.V. Rodricks. 2001. Food additives and nutrition supplements. Pp. 133-166 in Regulatory Toxicology, 2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
(2001)
Regulatory Toxicology
, pp. 133-166
-
-
Frankos, V.H.1
Rodricks, J.V.2
-
9
-
-
2342583132
-
Human pharmaceutical products
-
2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
Gad, S.C., and C.P. Chengelis. 2001. Human pharmaceutical products. Pp. 9-69 in Regulatory Toxicology, 2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
(2001)
Regulatory Toxicology
, pp. 9-69
-
-
Gad, S.C.1
Chengelis, C.P.2
-
12
-
-
77953983251
-
-
ADME Task Force, Technical Committee on Agricultural Chemical Safety Assessment, ILSI Health Sciences Institute, Washington, DC. November 2, 2004.
-
ILSI HESI (International Life Sciences Institute Health and Environmental Sciences Institute). 2004. The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments. ADME Task Force, Technical Committee on Agricultural Chemical Safety Assessment, ILSI Health Sciences Institute, Washington, DC. November 2, 2004.
-
(2004)
The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments
-
-
-
13
-
-
77954013741
-
Industrial chemicals: Regulation of new and existing chemicals (The Toxic Substances Control Act and similar worldwide chemical control laws)
-
2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
Kraska, R.C. 2001. Industrial chemicals: Regulation of new and existing chemicals (The Toxic Substances Control Act and similar worldwide chemical control laws). Pp. 244-276 in Regulatory Toxicology, 2nd Ed., S.C. Gad, ed. London: Taylor and Francis.
-
(2001)
Regulatory Toxicology
, pp. 244-276
-
-
Kraska, R.C.1
-
14
-
-
84966057454
-
Risk Assessment in the Federal Government: Managing the Process
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1983. Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Academy Press.
-
(1983)
-
-
-
15
-
-
0004155434
-
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1993. Issues in Risk Assessment. Washington, DC: National Academy Press.
-
(1993)
Issues in Risk Assessment
-
-
-
16
-
-
0003762673
-
Understanding Risk: Informing Decisions in a Democratic Society
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1996. Understanding Risk: Informing Decisions in a Democratic Society. Washington, DC: National Academy Press.
-
(1996)
-
-
-
17
-
-
34250205752
-
Toxicity Testing for Assessment of Environmental Agents: Interim Report
-
Washington, DC: The National Academies Press.
-
NRC (National Research Council). 2006. Toxicity Testing for Assessment of Environmental Agents: Interim Report. Washington, DC: The National Academies Press.
-
(2006)
-
-
-
18
-
-
84988938853
-
-
National Toxicology Program, National Institute for Environmental Health, Research Triangle Park, NC, [accessed March 11, 2005].
-
NTP (National Toxicology Program). 2004. The NTP Vision for the 21st Century. National Toxicology Program, National Institute for Environmental Health, Research Triangle Park, NC [online]. Available: http://ntpserver. niehs.nih.gov/ntp/main_pages/-NTPVision.pdf [accessed March 11, 2005].
-
(2004)
The NTP Vision for the 21st Century
-
-
-
19
-
-
84989221159
-
History of NTP
-
[accessed February 24, 2007].
-
NTP (National Toxicology Program). 2005. History of NTP. National Toxicology Program [online]. Available: http://ntp-server.niehs.nih.gov/ [accessed February 24, 2007].
-
(2005)
National Toxicology Program
-
-
-
20
-
-
0007129868
-
The OECD: Organization for Economic Co-operation and Development
-
[accessed March 7, 2007].
-
OECD (Organization of Economic Co-operation and Development). 2006. The OECD: Organization for Economic Co-operation and Development [online]. Available: http://www.oecd.org/dataoecd/15/33/34011915.pdf [accessed March 7, 2007].
-
(2006)
-
-
-
21
-
-
13944283866
-
New directions in incidence-dose modeling
-
Andersen, M.E., J.E. Dennison, R.S. Thomas, and R.B. Conolly. 2005. New directions in incidence-dose modeling. Trends Biotechnol. 23(3):122-127.
-
(2005)
Trends Biotechnol
, vol.23
, Issue.3
, pp. 122-127
-
-
Andersen, M.E.1
Dennison, J.E.2
Thomas, R.S.3
Conolly, R.B.4
-
22
-
-
27144534545
-
Toxicity assessment of industrial chemicals and airborne contaminants: Transition from in vivo to in vitro test methods
-
Bakand, S., C. Winder, C. Khalil, and A. Hayes. 2005. Toxicity assessment of industrial chemicals and airborne contaminants: Transition from in vivo to in vitro test methods: A review. Inhal. Toxicol. 17(13):775-787.
-
(2005)
A review. Inhal. Toxicol.
, vol.17
, Issue.13
, pp. 775-787
-
-
Bakand, S.1
Winder, C.2
Khalil, C.3
Hayes, A.4
-
23
-
-
33644864928
-
Agricultural chemical safety assessment: A multisector approach to the modernization of human safety requirements
-
Carmichael, N.G., H.A. Barton, A.R. Boobis, R.L. Cooper, V.L. Dellarco, N.G. Doerrer, P.A. Fenner-Crisp, J.E. Doe, J.C. Lamb IV, and T.P. Pastor. 2006. Agricultural chemical safety assessment: A multisector approach to the modernization of human safety requirements. Crit. Rev. Toxicol. 36(1):1-7.
-
(2006)
Crit. Rev. Toxicol.
, vol.36
, Issue.1
, pp. 1-7
-
-
Carmichael, N.G.1
Barton, H.A.2
Boobis, A.R.3
Cooper, R.L.4
Dellarco, V.L.5
Doerrer, N.G.6
Fenner-Crisp, P.A.7
Doe, J.E.8
Lamb, J.C.9
Pastor, T.P.10
-
24
-
-
0031886290
-
Toxicological evaluation and risk assessment of chemical mixtures
-
Cassee, F.R., J.P. Groten, P.J. van Bladeren, and V.J. Feron. 1998. Toxicological evaluation and risk assessment of chemical mixtures. Crit. Rev. Toxicol. 28(1):73-101.
-
(1998)
Crit. Rev. Toxicol.
, vol.28
, Issue.1
, pp. 73-101
-
-
Cassee, F.R.1
Groten, J.P.2
van Bladeren, P.J.3
Feron, V.J.4
-
25
-
-
21644477459
-
In vitro models in endocrine disruptor screening
-
Charles, G.D. 2004. In vitro models in endocrine disruptor screening. ILAR J. 45(4):494-501.
-
(2004)
ILAR J
, vol.45
, Issue.4
, pp. 494-501
-
-
Charles, G.D.1
-
26
-
-
33644865820
-
A tiered approach to systemic toxicity testing for agricultural chemical safety assessment
-
Doe, J.E., A.R. Boobis, A. Blacker, V. Dellarco, N.G. Doerrer, C. Franklin, J.I. Goodman, J.M. Kronenberg, R. Lewis, E.E. Mcconnell, T. Mercier, A. Moretto, C. Nolan, S. Padilla, W. Phang, R. Solecki, L. Tilbury, B. van Ravenzwaay, and D.C. Wolf. 2006. A tiered approach to systemic toxicity testing for agricultural chemical safety assessment. Crit. Rev. Toxicol. 36(1):37-68.
-
(2006)
Crit. Rev. Toxicol.
, vol.36
, Issue.1
, pp. 37-68
-
-
Doe, J.E.1
Boobis, A.R.2
Blacker, A.3
Dellarco, V.4
Doerrer, N.G.5
Franklin, C.6
Goodman, J.I.7
Kronenberg, J.M.8
Lewis, R.9
Mcconnell, E.E.10
Mercier, T.11
Moretto, A.12
Nolan, C.13
Padilla, S.14
Phang, W.15
Solecki, R.16
Tilbury, L.17
van Ravenzwaay, B.18
Wolf, D.C.19
-
27
-
-
0029618087
-
Toxicology of chemical mixtures: Challenges for today and the future
-
Feron, V.J., J.P. Groten, D. Jonker, F.R. Cassee, and P.J. van Bladeren. 1995. Toxicology of chemical mixtures: Challenges for today and the future. Toxicology 105(2-3):415-427.
-
(1995)
Toxicology
, vol.105
, Issue.2-3
, pp. 415-427
-
-
Feron, V.J.1
Groten, J.P.2
Jonker, D.3
Cassee, F.R.4
van Bladeren, P.J.5
-
28
-
-
0141785350
-
Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
-
Frasor, J., J.M. Danes, B. Komm, K.C.N. Chang, C.R. Lyttle, and B.S. Katzenellenbogen. 2003. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144(10):4562-4574.
-
(2003)
Endocrinology
, vol.144
, Issue.10
, pp. 4562-4574
-
-
Frasor, J.1
Danes, J.M.2
Komm, B.3
Chang, K.C.N.4
Lyttle, C.R.5
Katzenellenbogen, B.S.6
-
29
-
-
27744559796
-
Chemical Regulation: Options Exist to Improve EPA's Ability to Assess Health Risks and Manage its Chemical Review Program
-
GAO-05-458. U.S. Government Accounting Office, Washington, DC. June 2005, [accessed March 8, 2007].
-
GAO (U.S. Government Accounting Office). 2005. Chemical Regulation: Options Exist to Improve EPA's Ability to Assess Health Risks and Manage its Chemical Review Program. GAO-05-458. U.S. Government Accounting Office, Washington, DC. June 2005 [online]. Available: http://www.gao. gov/new.items/d05458.pdf [accessed March 8, 2007].
-
(2005)
-
-
-
30
-
-
19944430842
-
Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50
-
Gennari, A., C. van den Berghe, S. Casati, J. Castell, C. Clemedson, S. Coecke, A. Colombo, R. Curren, G. Dal Negro, A. Goldberg, C. Gosmore, T. Hartung, I. Langezaal, I. Lessigiarska, W. Maas, I. Mangelsdorf, R. Parchment, P. Prieto, J.R. Sintes, M. Ryan, G. Schmuck, K. Stitzel, W. Stokes, J.A. Vericat, L. Gribaldo. 2004. Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50. Altern. Lab. Anim. 32(4):437-459.
-
(2004)
Altern. Lab. Anim.
, vol.32
, Issue.4
, pp. 437-459
-
-
Gennari, A.1
van den Berghe, C.2
Casati, S.3
Castell, J.4
Clemedson, C.5
Coecke, S.6
Colombo, A.7
Curren, R.8
Dal Negro, G.9
Goldberg, A.10
Gosmore, C.11
Hartung, T.12
Langezaal, I.13
Lessigiarska, I.14
Maas, W.15
Mangelsdorf, I.16
Parchment, R.17
Prieto, P.18
Sintes, J.R.19
Ryan, M.20
Schmuck, G.21
Stitzel, K.22
Stokes, W.23
Vericat, J.A.24
Gribaldo, L.25
more..
-
31
-
-
33748742351
-
High-content screening moves to the front of the line
-
Haney, S.A., P. LaPan, J. Pan, and J. Zhang. 2006. High-content screening moves to the front of the line. Drug Discov. Today 11(19-20):889-894.
-
(2006)
Drug Discov. Today
, vol.11
, Issue.19-20
, pp. 889-894
-
-
Haney, S.A.1
LaPan, P.2
Pan, J.3
Zhang, J.4
-
32
-
-
0037107022
-
Expanding the HTS paradigm
-
Inglese, J. 2002. Expanding the HTS paradigm. Drug Discov. Today 7(Suppl. 18):S105-S106.
-
(2002)
Drug Discov. Today
, vol.7
, pp. S105-S106
-
-
Inglese, J.1
-
33
-
-
33746789921
-
Quantitative high-throughput screening: A titrationbased approach that efficiently identifies biological activities in large chemical libraries
-
Inglese, J., D.S. Auld, A. Jadhav, R.L. Johnson, A. Simeonov, A. Yasgar, W. Zheng, and C.P. Austin. 2006. Quantitative high-throughput screening: A titrationbased approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. U.S.A. 103(31):11473-11478.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, Issue.31
, pp. 11473-11478
-
-
Inglese, J.1
Auld, D.S.2
Jadhav, A.3
Johnson, R.L.4
Simeonov, A.5
Yasgar, A.6
Zheng, W.7
Austin, C.P.8
-
34
-
-
0026516625
-
New concepts in steroid hormone action: Transcription factors, proto-oncogenes, and the cascade model for steroid regulation of gene expression
-
Landers, J.P., and T.C. Spelsberg. 1992. New concepts in steroid hormone action: Transcription factors, proto-oncogenes, and the cascade model for steroid regulation of gene expression. Crit. Rev. Eukaryot. Gene Expr. 2(1):19-63.
-
(1992)
Crit. Rev. Eukaryot. Gene Expr.
, vol.2
, Issue.1
, pp. 19-63
-
-
Landers, J.P.1
Spelsberg, T.C.2
-
35
-
-
26444551993
-
Challenges in regulating pesticide mixtures
-
Lydy, M., J. Belden, C. Wheelock, B. Hammock, and D. Denton. 2004. Challenges in regulating pesticide mixtures. Ecology and Society 9(6):1-6.
-
(2004)
Ecology and Society
, vol.9
, Issue.6
, pp. 1-6
-
-
Lydy, M.1
Belden, J.2
Wheelock, C.3
Hammock, B.4
Denton, D.5
-
36
-
-
31944451232
-
Toxic potential of materials at the nanolevel
-
Nel, A., T. Xia, L. Madler, and N. Li. 2006. Toxic potential of materials at the nanolevel. Science 311(5761):622-627.
-
(2006)
Science
, vol.311
, Issue.5761
, pp. 622-627
-
-
Nel, A.1
Xia, T.2
Madler, L.3
Li, N.4
-
37
-
-
0004113167
-
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1977. Drinking Water and Health, Vol. 1. Washington, DC: National Academy Press.
-
(1977)
Drinking Water and Health
, vol.1
-
-
-
38
-
-
0004048290
-
Complex Mixtures: Methods for In Vivo Toxicity Testing
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1988. Complex Mixtures: Methods for In Vivo Toxicity Testing. Washington, DC: National Academy Press.
-
(1988)
-
-
-
39
-
-
34250205752
-
Toxicity Testing for Assessment of Environmental Agents: Interim Report
-
Washington, DC: The National Academies Press.
-
NRC (National Research Council). 2006. Toxicity Testing for Assessment of Environmental Agents: Interim Report. Washington, DC: The National Academies Press.
-
(2006)
-
-
-
40
-
-
21244433540
-
Overview of inhalation exposure techniques: Strengths and weaknesses
-
Pauluhn, J. 2005. Overview of inhalation exposure techniques: Strengths and weaknesses. Exp. Toxicol. Pathol. 57(Suppl. 1):111-128.
-
(2005)
Exp. Toxicol. Pathol.
, vol.57
, pp. 111-128
-
-
Pauluhn, J.1
-
41
-
-
23844468413
-
A tiered approach to comparative genomics
-
Ptacek, T., and S.M. Sell. 2005. A tiered approach to comparative genomics. Brief Funct. Genomic Proteomic. 4(2):178-185.
-
(2005)
Brief Funct. Genomic Proteomic.
, vol.4
, Issue.2
, pp. 178-185
-
-
Ptacek, T.1
Sell, S.M.2
-
42
-
-
0034837087
-
High-throughput screening approaches for investigating drug metabolism and pharmacokinetics
-
Roberts, S.A. 2001. High-throughput screening approaches for investigating drug metabolism and pharmacokinetics. Xenobiotica 31(8-9):557-589.
-
(2001)
Xenobiotica
, vol.31
, Issue.8-9
, pp. 557-589
-
-
Roberts, S.A.1
-
43
-
-
0037399647
-
Nuclear receptors: Integration of multiple signaling pathways through phosphorylation
-
Rochette-Egly, C. 2003. Nuclear receptors: Integration of multiple signaling pathways through phosphorylation. Cell. Signal. 15(4):355-366.
-
(2003)
Cell. Signal.
, vol.15
, Issue.4
, pp. 355-366
-
-
Rochette-Egly, C.1
-
45
-
-
24644513538
-
Predicting the risk of developmental toxicity from in vitro assays
-
Spielmann, H. 2005. Predicting the risk of developmental toxicity from in vitro assays. Toxicol. Appl. Pharmacol. 207(Suppl. 2):375-380.
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.207
, pp. 375-380
-
-
Spielmann, H.1
-
46
-
-
32544449005
-
Safety assessment of high fructose corn syrup (HFCS) as an ingredient added to cigarette tobacco
-
Stavanja, M.S., P.H. Ayres, D.R. Meckley, E.R. Bombick, M.F. Borgerding, M.J. Morton, C.D. Garner, D.H. Pence, and J.E. Swauger. 2006. Safety assessment of high fructose corn syrup (HFCS) as an ingredient added to cigarette tobacco. Exp. Toxicol. Pathol. 57(4):267-281.
-
(2006)
Exp. Toxicol. Pathol.
, vol.57
, Issue.4
, pp. 267-281
-
-
Stavanja, M.S.1
Ayres, P.H.2
Meckley, D.R.3
Bombick, E.R.4
Borgerding, M.F.5
Morton, M.J.6
Garner, C.D.7
Pence, D.H.8
Swauger, J.E.9
-
47
-
-
33645029027
-
Advances in systems biology: Measurement, modeling and representation
-
Stephens, S.M., and J. Rung. 2006. Advances in systems biology: Measurement, modeling and representation. Curr. Opin. Drug Discov. Devel. 9(2):240-250.
-
(2006)
Curr. Opin. Drug Discov. Devel.
, vol.9
, Issue.2
, pp. 240-250
-
-
Stephens, S.M.1
Rung, J.2
-
48
-
-
0036006595
-
Ecdysone-regulated puff genes 2000
-
Thummel, C.S. 2002. Ecdysone-regulated puff genes 2000. Insect Biochem. Mol. Biol. 32(2):113-120.
-
(2002)
Insect Biochem. Mol. Biol.
, vol.32
, Issue.2
, pp. 113-120
-
-
Thummel, C.S.1
-
49
-
-
84989264154
-
Support of Science-Based Decisions Concerning the Evaluation of the Toxicology of Mixtures: A New Beginning
-
February 16-17, 2005, Atlanta, GA, Society in Toxicology Sponsored Meeting: Contemporary Concepts In Toxicology, [accessed Feb. 9, 2007].
-
Teuschler, L., J. Klaunig, E. Carney, J. Chambers, R. Conolly, C. Gennings, J. Giesy, R. Hertzberg, C. Klaassen, R. Kode, D. Paustenbach, and R. Yang. 2005. Support of Science-Based Decisions Concerning the Evaluation of the Toxicology of Mixtures: A New Beginning. Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment, February 16-17, 2005, Atlanta, GA, Society in Toxicology Sponsored Meeting: Contemporary Concepts In Toxicology [online]. Available: http:// www.toxicology.org/ai/meet/MixturesWhitePapers.doc [accessed Feb. 9, 2007].
-
(2005)
Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment
-
-
Teuschler, L.1
Klaunig, J.2
Carney, E.3
Chambers, J.4
Conolly, R.5
Gennings, C.6
Giesy, J.7
Hertzberg, R.8
Klaassen, C.9
Kode, R.10
Paustenbach, D.11
Yang, R.12
-
50
-
-
0347379850
-
Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line
-
Xiao, G.G., M. Wang, N. Li, J.A. Loo, and A.E. Nel. 2003. Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. J. Biol. Chem. 278(50):50781-50790.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.50
, pp. 50781-50790
-
-
Xiao, G.G.1
Wang, M.2
Li, N.3
Loo, J.A.4
Nel, A.E.5
-
51
-
-
11344292119
-
Tiered chemical testing: A value of information approach
-
Yokota, F., G. Gray, J.K. Hammitt, and K.M. Thompson. 2004. Tiered chemical testing: A value of information approach. Risk Anal. 24(6):1625-1639.
-
(2004)
Risk Anal
, vol.24
, Issue.6
, pp. 1625-1639
-
-
Yokota, F.1
Gray, G.2
Hammitt, J.K.3
Thompson, K.M.4
-
52
-
-
34447554398
-
Non-hematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally-induced asthma
-
Abdala-Valencia, H., J. Earwood, S. Bansal, M. Jansen, G. Babcock, B. Garvy, M. Wills-Karp, and J.M. Cook-Mills. 2007. Non-hematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally-induced asthma. Am. J. Physiol. Lung Cell Mol. Physiol. 292(5):L1111-L1125.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.292
, Issue.5
, pp. L1111-L1125
-
-
Abdala-Valencia, H.1
Earwood, J.2
Bansal, S.3
Jansen, M.4
Babcock, G.5
Garvy, B.6
Wills-Karp, M.7
Cook-Mills, J.M.8
-
54
-
-
33746892695
-
Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
-
Andrew, A.S., J.L. Burgess, M.M. Meza, E. Demidenko, M.G. Waugh, J.W. Hamilton, and M.R. Karagas. 2006. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ. Health Perspect. 114(8):1193-1198.
-
(2006)
Environ. Health Perspect.
, vol.114
, Issue.8
, pp. 1193-1198
-
-
Andrew, A.S.1
Burgess, J.L.2
Meza, M.M.3
Demidenko, E.4
Waugh, M.G.5
Hamilton, J.W.6
Karagas, M.R.7
-
55
-
-
0034957480
-
Nuclear hormone receptors and gene expression
-
Aranda, A., and A. Pascual. 2001. Nuclear hormone receptors and gene expression. Physiol. Rev. 81(3):1269-1304.
-
(2001)
Physiol. Rev.
, vol.81
, Issue.3
, pp. 1269-1304
-
-
Aranda, A.1
Pascual, A.2
-
56
-
-
34249950410
-
Modeling self-assembly and phase behavior in complex mixtures
-
Balazs, A.C. 2007. Modeling self-assembly and phase behavior in complex mixtures. Annu. Rev. Phys. Chem. 58:211-233.
-
(2007)
Annu. Rev. Phys. Chem.
, vol.58
, pp. 211-233
-
-
Balazs, A.C.1
-
57
-
-
77954022084
-
-
EPA Contract Number 68-W-01-023, Work Assignment 2-3. Prepared for U.S. Environmental Protection Agency, by Battelle, Columbus, OH. August 1, 2002.
-
Battelle. 2002. Evaluation of SAR Predictions of Estrogen Receptor Binding Affinity. EPA Contract Number 68-W-01-023, Work Assignment 2-3. Prepared for U.S. Environmental Protection Agency, by Battelle, Columbus, OH. August 1, 2002.
-
(2002)
Evaluation of SAR Predictions of Estrogen Receptor Binding Affinity
-
-
-
58
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
-
Bhalla, U.S., P.T. Ram, and R. Iyengar. 2002. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297(5583):1018-1023.
-
(2002)
Science
, vol.297
, Issue.5583
, pp. 1018-1023
-
-
Bhalla, U.S.1
Ram, P.T.2
Iyengar, R.3
-
59
-
-
0029976187
-
Population toxicokinetics of tetrachloroethylene
-
Bois, F.Y., A. Gelman, J. Jiang, D.R. Maszle, L. Zeise, and G. Alexeef. 1996. Population toxicokinetics of tetrachloroethylene. Arch Toxicol 70(6):347-355.
-
(1996)
Arch Toxicol
, vol.70
, Issue.6
, pp. 347-355
-
-
Bois, F.Y.1
Gelman, A.2
Jiang, J.3
Maszle, D.R.4
Zeise, L.5
Alexeef, G.6
-
60
-
-
33749543675
-
The potential risks of nanomaterials: A review carried out for ECETOC
-
Borm, P.J., D. Robbins, S. Haubold, T. Kuhlbusch, H. Fissan, K. Donaldson, R. Schins, W. Kreyling, J. Lademann, J. Krutmann, D. Warheit, and E. Oberdorster. 2006. The potential risks of nanomaterials: A review carried out for ECETOC. Part. Fibre Toxicol. 3:11.
-
(2006)
Part. Fibre Toxicol.
, vol.3
, pp. 11
-
-
Borm, P.J.1
Robbins, D.2
Haubold, S.3
Kuhlbusch, T.4
Fissan, H.5
Donaldson, K.6
Schins, R.7
Kreyling, W.8
Lademann, J.9
Krutmann, J.10
Warheit, D.11
Oberdorster, E.12
-
61
-
-
0003893348
-
-
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, [accessed July 25, 2006].
-
CDC (Centers for Disease Control and Prevention). 2001. National Report on Human Exposure to Environmental Chemicals. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA [online]. Available: http://www.noharm.org/details.cfm?ID=745&type= document [accessed July 25, 2006].
-
(2001)
National Report on Human Exposure to Environmental Chemicals
-
-
-
62
-
-
0013202598
-
-
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, [accessed July 25, 2006].
-
CDC (Centers for Disease Control and Prevention). 2003. Second National Report on Human Exposure to Environmental Chemicals. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA [online]. Available: http://www.serafin.ch/toxicreport.pdf [accessed July 25, 2006].
-
(2003)
Second National Report on Human Exposure to Environmental Chemicals
-
-
-
63
-
-
27744543374
-
-
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, [accessed July 25, 2006].
-
CDC (Centers for Disease Control and Prevention). 2005. Third National Report on Human Exposure to Environmental Chemicals. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA [online]. Available: http://www.cdc.gov/exposurereport/pdf/ third_report_chemicals.pdf [accessed July 25, 2006].
-
(2005)
Third National Report on Human Exposure to Environmental Chemicals
-
-
-
64
-
-
33746520807
-
Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation
-
Chan, R.C., M. Wang, N. Li, Y. Yanagawa, K. Onoe, J.J. Lee, and A.E. Nel. 2006. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. J. Allergy Clin. Immunol. 118(2):455-465.
-
(2006)
J. Allergy Clin. Immunol.
, vol.118
, Issue.2
, pp. 455-465
-
-
Chan, R.C.1
Wang, M.2
Li, N.3
Yanagawa, Y.4
Onoe, K.5
Lee, J.J.6
Nel, A.E.7
-
65
-
-
0242574987
-
Investigations into the analysis and modeling of the TNFa-mediated NF-?B-signaling pathway
-
Cho, K.H., S.Y. Shin, H.W. Lee, and O. Wolkenhauer. 2003. Investigations into the analysis and modeling of the TNFa-mediated NF-?B-signaling pathway. Genome Res. 13(11):2413-2422.
-
(2003)
Genome Res
, vol.13
, Issue.11
, pp. 2413-2422
-
-
Cho, K.H.1
Shin, S.Y.2
Lee, H.W.3
Wolkenhauer, O.4
-
66
-
-
11344264355
-
Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment
-
Clark, L.H., R.W. Setzer, and H.A. Barton. 2004. Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Anal. 24(6): 1697-1717.
-
(2004)
Risk Anal
, vol.24
, Issue.6
, pp. 1697-1717
-
-
Clark, L.H.1
Setzer, R.W.2
Barton, H.A.3
-
67
-
-
21844454441
-
Evaluation of physiologically based pharmacokinetic models in risk assessment: An example with perchloroethylene
-
Clewell, H.J., P.R. Gentry, J.E. Kester, and M.E. Andersen. 2005. Evaluation of physiologically based pharmacokinetic models in risk assessment: An example with perchloroethylene. Crit. Rev. Toxicol. 35(5):413-433.
-
(2005)
Crit. Rev. Toxicol.
, vol.35
, Issue.5
, pp. 413-433
-
-
Clewell, H.J.1
Gentry, P.R.2
Kester, J.E.3
Andersen, M.E.4
-
68
-
-
22844438986
-
Toxicokinetics and metabolism
-
Coecke, S., B.J. Blaauboer, G. Elaut, S. Freeman, A. Freidig, N. Gensmantel, P. Hoet, V.M. Kapoulas, B. Ladstetter, G. Langley, D. Leahy, G. Mannens, A. Meneguz, M. Monshouwer, B. Nemery, O. Pelkonen, W. Pfaller, P. Prieto, N. Proctor, V. Rogiers, A. Rostami-Hodjegan, E. Sabbioni, W. Steiling, and J.J. van de Sandt. 2005. Toxicokinetics and metabolism. Altern. Lab. Anim. 33(Suppl. 1):147-175.
-
(2005)
Altern. Lab. Anim.
, vol.33
, pp. 147-175
-
-
Coecke, S.1
Blaauboer, B.J.2
Elaut, G.3
Freeman, S.4
Freidig, A.5
Gensmantel, N.6
Hoet, P.7
Kapoulas, V.M.8
Ladstetter, B.9
Langley, G.10
Leahy, D.11
Mannens, G.12
Meneguz, A.13
Monshouwer, M.14
Nemery, B.15
Pelkonen, O.16
Pfaller, W.17
Prieto, P.18
Proctor, N.19
Rogiers, V.20
Rostami-Hodjegan, A.21
Sabbioni, E.22
Steiling, W.23
van de Sandt, J.J.24
more..
-
69
-
-
33644870082
-
Metabolism: A bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
-
Coecke, S., H. Ahr, B.J. Blaauboer, S. Bremer, S. Casati, J. Castell, R. Combes, R. Corvi, C.L. Crespi, M.L. Cunningham, G. Elaut, B. Eletti, A. Freidig, A. Gennari, J.F. Ghersi-Egea, A. Guillouzo, T. Hartung, P. Hoet, M. Ingelman- Sundberg, S. Munn, W. Janssens, B. Ladstetter, D. Leahy, A. Long, A. Meneguz, M. Monshouwer, S. Morath, F. Nagelkerke, O. Pelkonen, J. Ponti, P. Prieto, L. Richert, E. Sabbioni, B. Schaack, W. Steiling, E. Testai, J.A. Vericat, and A. Worth. 2006. Metabolism: A bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern. Lab Anim. 34(1):49-84.
-
(2006)
Altern. Lab Anim.
, vol.34
, Issue.1
, pp. 49-84
-
-
Coecke, S.1
Ahr, H.2
Blaauboer, B.J.3
Bremer, S.4
Casati, S.5
Castell, J.6
Combes, R.7
Corvi, R.8
Crespi, C.L.9
Cunningham, M.L.10
Elaut, G.11
Eletti, B.12
Freidig, A.13
Gennari, A.14
Ghersi-Egea, J.F.15
Guillouzo, A.16
Hartung, T.17
Hoet, P.18
Ingelman-Sundberg, M.19
Munn, S.20
Janssens, W.21
Ladstetter, B.22
Leahy, D.23
Long, A.24
Meneguz, A.25
Monshouwer, M.26
Morath, S.27
Nagelkerke, F.28
Pelkonen, O.29
Ponti, J.30
Prieto, P.31
Richert, L.32
Sabbioni, E.33
Schaack, B.34
Steiling, W.35
Testai, E.36
Vericat, J.A.37
Worth, A.38
more..
-
70
-
-
0141618447
-
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat
-
Conolly, R.B., J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller. 2003. Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol. Sci. 75(2):432-447.
-
(2003)
Toxicol. Sci.
, vol.75
, Issue.2
, pp. 432-447
-
-
Conolly, R.B.1
Kimbell, J.S.2
Janszen, D.3
Schlosser, P.M.4
Kalisak, D.5
Preston, J.6
Miller, F.J.7
-
71
-
-
0029803319
-
Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicology interaction between carbon tetrachloride and kepone
-
el-Masri, H.A., R.S. Thomas, G.R. Sabados, J.K. Phillips, A.A. Constan, S.A. Benjamin, M.E. Andersen, H.M. Mehendale, and R.S. Yang. 1996. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicology interaction between carbon tetrachloride and kepone. Arch. Toxicol. 70(11):704-713.
-
(1996)
Arch. Toxicol.
, vol.70
, Issue.11
, pp. 704-713
-
-
el-Masri, H.A.1
Thomas, R.S.2
Sabados, G.R.3
Phillips, J.K.4
Constan, A.A.5
Benjamin, S.A.6
Andersen, M.E.7
Mehendale, H.M.8
Yang, R.S.9
-
72
-
-
14544280668
-
Surviving heat shock: Control strategies for robustness and performance
-
El-Samad, H., H. Kurata, J.C. Doyle, C.A. Gross, and M. Khammash. 2005. Surviving heat shock: Control strategies for robustness and performance. Proc. Natl. Acad. Sci. U.S.A. 102(8):2736-2841.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, Issue.8
, pp. 2736-2841
-
-
El-Samad, H.1
Kurata, H.2
Doyle, J.C.3
Gross, C.A.4
Khammash, M.5
-
73
-
-
1042286444
-
Do mouse models of allergic asthma mimic clinical disease?
-
Epstein, M.M. 2004. Do mouse models of allergic asthma mimic clinical disease? Int. Arch. Allergy Immunol. 133(1):84-100.
-
(2004)
Int. Arch. Allergy Immunol.
, vol.133
, Issue.1
, pp. 84-100
-
-
Epstein, M.M.1
-
74
-
-
0035796891
-
Quantitative structurepharmacokinetic relationship modeling
-
Fouchecourt, M.O., M. Beliveau, and K. Krishnan. 2001. Quantitative structurepharmacokinetic relationship modeling. Sci. Total Environ. 274(1-3):125-135.
-
(2001)
Sci. Total Environ.
, vol.274
, Issue.1-3
, pp. 125-135
-
-
Fouchecourt, M.O.1
Beliveau, M.2
Krishnan, K.3
-
75
-
-
0023790133
-
Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes
-
Gargas, M.L., P.G. Seybold, and M.E. Andersen. 1988. Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes. Toxicol. Lett. 43(1-3):235-256.
-
(1988)
Toxicol. Lett.
, vol.43
, Issue.1-3
, pp. 235-256
-
-
Gargas, M.L.1
Seybold, P.G.2
Andersen, M.E.3
-
76
-
-
0024524118
-
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
-
Gargas, M.L., R.J. Burgess, D.E.Voisard, G.H. Cason, and M.E. Andersen. 1989. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol 98(1):87-99.
-
(1989)
Toxicol. Appl. Pharmacol
, vol.98
, Issue.1
, pp. 87-99
-
-
Gargas, M.L.1
Burgess, R.J.2
Voisard, D.E.3
Cason, G.H.4
Andersen, M.E.5
-
77
-
-
33947237432
-
How to compute isomerization energies of organic molecules with quantum chemical methods
-
Grimme, S., M. Steinmetz, and M. Korth. 2007. How to compute isomerization energies of organic molecules with quantum chemical methods. J. Org. Chem. 72(6):2118-2126.
-
(2007)
J. Org. Chem.
, vol.72
, Issue.6
, pp. 2118-2126
-
-
Grimme, S.1
Steinmetz, M.2
Korth, M.3
-
78
-
-
33845346100
-
Nanoparticles: Health effects-pros and cons
-
Gwinn, M.R., and V. Vallyathan. 2006. Nanoparticles: Health effects-pros and cons. Environ. Health Perspect. 114(12):1818-1825.
-
(2006)
Environ. Health Perspect
, vol.114
, Issue.12
, pp. 1818-1825
-
-
Gwinn, M.R.1
Vallyathan, V.2
-
79
-
-
9944265844
-
Regulatory network of lipid-sensing nuclear receptors: Roles for CAR, PXR, LXR, and FXR
-
Handschin, C., and U.A. Meyer. 2005. Regulatory network of lipid-sensing nuclear receptors: Roles for CAR, PXR, LXR, and FXR. Arch. Biochem. Biophys. 433(2):387-396.
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, Issue.2
, pp. 387-396
-
-
Handschin, C.1
Meyer, U.A.2
-
80
-
-
33344476520
-
Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action
-
Harrington, W.R., S.H. Kim, C.C. Funk, Z. Madak-Erdogan, R. Schiff, J.A. Katzenellenbogen, and B.S. Katzenellenbogen. 2006. Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol. Endocrinol. 20(3):491-502.
-
(2006)
Mol. Endocrinol.
, vol.20
, Issue.3
, pp. 491-502
-
-
Harrington, W.R.1
Kim, S.H.2
Funk, C.C.3
Madak-Erdogan, Z.4
Schiff, R.5
Katzenellenbogen, J.A.6
Katzenellenbogen, B.S.7
-
81
-
-
33748740824
-
The impact of aryl hydrocarbon receptor signaling on matrix metabolism: Implications for development and disease
-
Hillegass, J.M., K.A. Murphy, C.M. Villano, and L.A. White. 2006. The impact of aryl hydrocarbon receptor signaling on matrix metabolism: Implications for development and disease. Biol Chem. 387(9):1159-1173.
-
(2006)
Biol Chem.
, vol.387
, Issue.9
, pp. 1159-1173
-
-
Hillegass, J.M.1
Murphy, K.A.2
Villano, C.M.3
White, L.A.4
-
82
-
-
33745246032
-
Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phophodiesterase type 4 variant 4
-
Ho, S.M., W.Y. Tang, J. Belmonte de Frausto, and G.S. Prins. 2006. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phophodiesterase type 4 variant 4. Cancer Res. 66(11):5624-5632.
-
(2006)
Cancer Res.
, vol.66
, Issue.11
, pp. 5624-5632
-
-
Ho, S.M.1
Tang, W.Y.2
Belmonte de Frausto, J.3
Prins, G.S.4
-
83
-
-
0037044575
-
The IκB-NF-κB signaling module: Temporal control and selective gene activation
-
Hoffmann, A., A. Levchenko, M.L. Scott, and D. Baltimore. 2002. The IκB-NF-κB signaling module: Temporal control and selective gene activation. Science 298(5596):1241-1245.
-
(2002)
Science
, vol.298
, Issue.5596
, pp. 1241-1245
-
-
Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
-
84
-
-
0036939548
-
Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring
-
Hubbs, A.F., L.A. Battelli, W.T. Goldsmith, D.W. Porter, D. Frazer, S. Friend, D. Schwegler-Berry, R.R. Mercer, J.S. Reynolds, A. Grote, V. Castranova, G. Kullman, J.S. Fedan, J. Dowdy, and W.G. Jones. 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185(2):128-135.
-
(2002)
Toxicol. Appl. Pharmacol.
, vol.185
, Issue.2
, pp. 128-135
-
-
Hubbs, A.F.1
Battelli, L.A.2
Goldsmith, W.T.3
Porter, D.W.4
Frazer, D.5
Friend, S.6
Schwegler-Berry, D.7
Mercer, R.R.8
Reynolds, J.S.9
Grote, A.10
Castranova, V.11
Kullman, G.12
Fedan, J.S.13
Dowdy, J.14
Jones, W.G.15
-
85
-
-
29144455476
-
Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms
-
Iarmarcovai, G., I. Sari-Minodier, F. Chaspoul, C. Botta, M. De Meo, T. Orsiere, J.L. Berge-Lefranc, P. Gallice, and A. Botta. 2005. Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms. Mutagenesis 20(6):425-432.
-
(2005)
Mutagenesis
, vol.20
, Issue.6
, pp. 425-432
-
-
Iarmarcovai, G.1
Sari-Minodier, I.2
Chaspoul, F.3
Botta, C.4
De Meo, M.5
Orsiere, T.6
Berge-Lefranc, J.L.7
Gallice, P.8
Botta, A.9
-
86
-
-
84990888517
-
Implications of Nanotechnology for Environmental Health Research
-
Washington, DC: The National Academies Press.
-
IOM (Institute of Medicine). 2005. Implications of Nanotechnology for Environmental Health Research. Washington, DC: The National Academies Press.
-
(2005)
-
-
-
87
-
-
84988666676
-
The Future of Drug Safety: Promoting and Protecting the Health of the Public
-
Washington, DC: The National Academies Press.
-
IOM (Institute of Medicine). 2007. The Future of Drug Safety: Promoting and Protecting the Health of the Public. Washington, DC: The National Academies Press.
-
(2007)
-
-
-
88
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for CuI3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi, A., M.I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, T. Chiba, K. Igarashi, and M. Yamamoto. 2004. Oxidative stress sensor Keap1 functions as an adaptor for CuI3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell. Biol. 24(16):7130-7139.
-
(2004)
Mol. Cell. Biol.
, vol.24
, Issue.16
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
89
-
-
33748052967
-
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
-
Kobayashi, M., and M. Yamamoto. 2006. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 46:113-140.
-
(2006)
Adv. Enzyme Regul.
, vol.46
, pp. 113-140
-
-
Kobayashi, M.1
Yamamoto, M.2
-
90
-
-
0036682184
-
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant
-
Kreiss, K., A. Gomaa, G. Kullman, K. Fedan, E.J. Simoes, and P.L. Enright. 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347(5):330-338.
-
(2002)
N. Engl. J. Med.
, vol.347
, Issue.5
, pp. 330-338
-
-
Kreiss, K.1
Gomaa, A.2
Kullman, G.3
Fedan, K.4
Simoes, E.J.5
Enright, P.L.6
-
91
-
-
18844459369
-
Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure
-
Lee, C.T., J. Ylostalo, M. Friedman, and G.W. Hoyle. 2005. Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure. Toxicol. Appl. Pharmacol. 205(1):53-64.
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.205
, Issue.1
, pp. 53-64
-
-
Lee, C.T.1
Ylostalo, J.2
Friedman, M.3
Hoyle, G.W.4
-
92
-
-
0030221452
-
A biologically-based dose-response model for developmental toxicology
-
Leroux, B.G., W.M. Leisenring, S.H. Moolgavkar, and E.M. Faustman. 1996. A biologically-based dose-response model for developmental toxicology. Risk Anal. 16(4):449-458.
-
(1996)
Risk Anal.
, vol.16
, Issue.4
, pp. 449-458
-
-
Leroux, B.G.1
Leisenring, W.M.2
Moolgavkar, S.H.3
Faustman, E.M.4
-
93
-
-
15244362887
-
Drug withdrawals from the Canadian market for safety reasons, 1963-2004
-
Lexchin, J. 2005. Drug withdrawals from the Canadian market for safety reasons, 1963-2004. CMAJ 172(6):765-767.
-
(2005)
CMAJ
, vol.172
, Issue.6
, pp. 765-767
-
-
Lexchin, J.1
-
94
-
-
33846886738
-
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine
-
Li, T., W. Chen, and J.Y. Chiang. 2006. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J. Lipid Res. 48(2):373-384.
-
(2006)
J. Lipid Res.
, vol.48
, Issue.2
, pp. 373-384
-
-
Li, T.1
Chen, W.2
Chiang, J.Y.3
-
95
-
-
0000082467
-
Bronchiolits obliterans in the food flavoring manufacturing industry
-
Lockey, J., R. Mckay, E. Barth, J. Dahlsten, and R. Baughman. 2002. Bronchiolits obliterans in the food flavoring manufacturing industry. Am. J. Respir. Crit. Care Med. 165:A461.
-
(2002)
Am. J. Respir. Crit. Care Med.
, vol.165
, pp. A461
-
-
Lockey, J.1
Mckay, R.2
Barth, E.3
Dahlsten, J.4
Baughman, R.5
-
96
-
-
13544270930
-
Vagus nerve participates in regulation of the airways: Inflammatory response and hyperreactivity induced by occupational asthmogens
-
Lutz, W., and W.J. Sulkowski. 2004. Vagus nerve participates in regulation of the airways: Inflammatory response and hyperreactivity induced by occupational asthmogens. Int. J. Occup. Med. Environ. Health 17(4):417-431.
-
(2004)
Int. J. Occup. Med. Environ. Health
, vol.17
, Issue.4
, pp. 417-431
-
-
Lutz, W.1
Sulkowski, W.J.2
-
97
-
-
0036181314
-
The pathophysiology of asthma
-
Maddox, L., and D.A. Schwartz. 2002. The pathophysiology of asthma. Annu. Rev. Med. 53:477-498.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 477-498
-
-
Maddox, L.1
Schwartz, D.A.2
-
98
-
-
0142246636
-
In vivo heat-shock response in the brain: Signaling pathway and transcription factor activation
-
Maroni, P., P. Bendinelli, L. Tiberio, F. Rovetta, R. Piccoletti, and L. Schiaffonati. 2003. In vivo heat-shock response in the brain: Signaling pathway and transcription factor activation. Brain Res. Mol. Brain Res. 119(1):90-99.
-
(2003)
Brain Res. Mol. Brain Res.
, vol.119
, Issue.1
, pp. 90-99
-
-
Maroni, P.1
Bendinelli, P.2
Tiberio, L.3
Rovetta, F.4
Piccoletti, R.5
Schiaffonati, L.6
-
99
-
-
33747728194
-
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: A two-site interaction model for the Nrf2-Keap1 complex
-
McMahon, M., N. Thomas, K. Itoh, M. Yamamoto, and J.D. Hayes. 2006. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: A two-site interaction model for the Nrf2-Keap1 complex. J. Biol. Chem. 281(34):24756-24768.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.34
, pp. 24756-24768
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
100
-
-
0025141187
-
Two-event model for carcinogenesis: Biological, mathematical, and statistical considerations
-
Moolgavkar, S.H. and G. Luebeck. 1990. Two-event model for carcinogenesis: Biological, mathematical, and statistical considerations. Risk Anal. 10(2):323-341.
-
(1990)
Risk Anal.
, vol.10
, Issue.2
, pp. 323-341
-
-
Moolgavkar, S.H.1
Luebeck, G.2
-
101
-
-
7244253081
-
Nrf2-Keap1 defines a physiologically important stress response mechanism
-
Motohashi, H., and M. Yamamoto. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10(11):549-557.
-
(2004)
Trends Mol. Med.
, vol.10
, Issue.11
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
102
-
-
33947210941
-
Role of cytokines in allergic airway inflammation
-
Nakajima, H., and K. Takatsu. 2006. Role of cytokines in allergic airway inflammation. Int. Arch. Allergy Immunol. 142(4):265-273.
-
(2006)
Int. Arch. Allergy Immunol.
, vol.142
, Issue.4
, pp. 265-273
-
-
Nakajima, H.1
Takatsu, K.2
-
103
-
-
0028040226
-
Drug-metabolizing enzymes in ligand-modulated transcription
-
Nebert, D.W. 1994. Drug-metabolizing enzymes in ligand-modulated transcription. Biochem. Pharmacol. 47(1):25-37.
-
(1994)
Biochem. Pharmacol.
, vol.47
, Issue.1
, pp. 25-37
-
-
Nebert, D.W.1
-
104
-
-
31944451232
-
Toxic potential of materials at the nanolevel
-
Nel, A., T. Xia, L. Madler, and N. Li. 2006. Toxic potential of materials at the nanolevel. Science 311(5761):622-627.
-
(2006)
Science
, vol.311
, Issue.5761
, pp. 622-627
-
-
Nel, A.1
Xia, T.2
Madler, L.3
Li, N.4
-
105
-
-
34247098314
-
Genome instability and DNA damage accumulation in gene-targeted mice
-
Nordstrand L.M., J. Ringvoll, E. Larsen, and A. Klungland. 2007. Genome instability and DNA damage accumulation in gene-targeted mice. Neuroscience 145(4):1309-1317.
-
(2007)
Neuroscience
, vol.145
, Issue.4
, pp. 1309-1317
-
-
Nordstrand, L.M.1
Ringvoll, J.2
Larsen, E.3
Klungland, A.4
-
106
-
-
84967539788
-
Hormonally Active Agents in the Environment
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1999. Hormonally Active Agents in the Environment. Washington, DC: National Academy Press.
-
(1999)
-
-
-
107
-
-
84967537993
-
Scientific Frontiers in Developmental Toxicology and Risk Assessment
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 2000. Scientific Frontiers in Developmental Toxicology and Risk Assessment. Washington, DC: National Academy Press.
-
(2000)
-
-
-
108
-
-
34250205752
-
Toxicity Testing for Assessment of Environmental Agents: Interim Report
-
Washington, DC: The National Academies Press.
-
NRC (National Research Council). 2006a. Toxicity Testing for Assessment of Environmental Agents: Interim Report. Washington, DC: The National Academies Press.
-
(2006)
-
-
-
109
-
-
85011385846
-
Human Biomonitoring for Environmental Chemicals
-
Washington, DC: The National Academies Press.
-
NRC (National Research Council). 2006b. Human Biomonitoring for Environmental Chemicals. Washington, DC: The National Academies Press.
-
(2006)
-
-
-
110
-
-
33750486521
-
Prediction of activation energies for hydrogen abstraction by cytochrome p450
-
Olsen, L., P. Rydberg, T.H. Rod, and U. Ryde. 2006. Prediction of activation energies for hydrogen abstraction by cytochrome p450. J. Med. Chem. 49(22):6489-6499.
-
(2006)
J. Med. Chem.
, vol.49
, Issue.22
, pp. 6489-6499
-
-
Olsen, L.1
Rydberg, P.2
Rod, T.H.3
Ryde, U.4
-
111
-
-
0038580375
-
Animal models for asthma: Controversial aspects and unsolved problems
-
Pabst, R. 2002. Animal models for asthma: Controversial aspects and unsolved problems. Pathobiology 70(5):252-254.
-
(2002)
Pathobiology
, vol.70
, Issue.5
, pp. 252-254
-
-
Pabst, R.1
-
112
-
-
0036175013
-
Diesel exhaust and asthma: Hypotheses and molecular mechanisms of action
-
Pandya, R.J., G. Solomon, A. Kinner, and J.R. Balmes. 2002. Diesel exhaust and asthma: Hypotheses and molecular mechanisms of action. Environ. Health Perspect. 110(Suppl. 1):103-112.
-
(2002)
Environ. Health Perspect.
, vol.110
, pp. 103-112
-
-
Pandya, R.J.1
Solomon, G.2
Kinner, A.3
Balmes, J.R.4
-
113
-
-
0036075799
-
Prediction of pharmacokinetics prior to in vivo studies, II. Generic physiologically based pharmacokinetic models of drug disposition
-
Poulin, P., and F.P. Theil. 2002. Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J. Pharm. Sci. 91(5):1358-1370.
-
(2002)
J. Pharm. Sci.
, vol.91
, Issue.5
, pp. 1358-1370
-
-
Poulin, P.1
Theil, F.P.2
-
114
-
-
33645219531
-
Nanomaterial health effects-Part 1: Background and current knowledge
-
Powell, M.C., and M.S. Kanarek. 2006. Nanomaterial health effects-Part 1: Background and current knowledge. WMJ 105(2):16-20.
-
(2006)
WMJ
, vol.105
, Issue.2
, pp. 16-20
-
-
Powell, M.C.1
Kanarek, M.S.2
-
115
-
-
0025133542
-
Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling
-
Reitz, R.H., A.L. Mendrala, R.A. Corley, J.F. Quast, M.L. Gargas, M.E. Andersen, D.A. Staats, and R.B. Conolly. 1990. Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. Toxicol. Appl. Pharmacol. 105(3):443-459.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.105
, Issue.3
, pp. 443-459
-
-
Reitz, R.H.1
Mendrala, A.L.2
Corley, R.A.3
Quast, J.F.4
Gargas, M.L.5
Andersen, M.E.6
Staats, D.A.7
Conolly, R.B.8
-
116
-
-
21244495733
-
Mathematical modeling of the eukaryotic heat-shock response: Dynamics of the hsp70 promoter
-
Rieger, T.R., R.I. Morimoto, and V. Hatzimanikatis. 2005. Mathematical modeling of the eukaryotic heat-shock response: Dynamics of the hsp70 promoter. Biophys. J. 88(3):1646-1658.
-
(2005)
Biophys. J.
, vol.88
, Issue.3
, pp. 1646-1658
-
-
Rieger, T.R.1
Morimoto, R.I.2
Hatzimanikatis, V.3
-
117
-
-
0036300635
-
Dose-response modeling of cytochrome p450 induction by rats by octamethylcyclotetrasiloxane
-
Sarangapani, R., J. Teeguarden, K.P. Plotzke, J.M. McKim, Jr., and M.E. Andersen. 2002. Dose-response modeling of cytochrome p450 induction by rats by octamethylcyclotetrasiloxane. Toxicol. Sci. 67(2):159-172.
-
(2002)
Toxicol. Sci.
, vol.67
, Issue.2
, pp. 159-172
-
-
Sarangapani, R.1
Teeguarden, J.2
Plotzke, K.P.3
McKim, J.M.4
Andersen, M.E.5
-
118
-
-
33645468875
-
Ochratoxin A: Potential epigenetic mechanisms of toxicity and carcinogenicity
-
Schilter, B., M. Marin-Kuan, T. Delatour, S. Nestler, P. Mantle, and C. Cavin. 2006. Ochratoxin A: Potential epigenetic mechanisms of toxicity and carcinogenicity. Food Addit. Contam. 22(Suppl. 1):88-93.
-
(2006)
Food Addit. Contam.
, vol.22
, pp. 88-93
-
-
Schilter, B.1
Marin-Kuan, M.2
Delatour, T.3
Nestler, S.4
Mantle, P.5
Cavin, C.6
-
119
-
-
0033990288
-
Role of Gadd45 in apoptosis
-
Sheikh, M.S., M.C. Hollander, and A.J. Fornance, Jr. 2000. Role of Gadd45 in apoptosis. Biochem. Pharmacol. 59(1):43-45.
-
(2000)
Biochem. Pharmacol.
, vol.59
, Issue.1
, pp. 43-45
-
-
Sheikh, M.S.1
Hollander, M.C.2
Fornance, A.J.3
-
120
-
-
39049190270
-
Genetic and epigenetic changes induced by chronic low dose exposure to arsenic of mouse testicular Leydig cells
-
Singh, K.P., and J.W. DuMond, Jr. 2007. Genetic and epigenetic changes induced by chronic low dose exposure to arsenic of mouse testicular Leydig cells. Int. J. Oncol. 30(1):253-260.
-
(2007)
Int. J. Oncol.
, vol.30
, Issue.1
, pp. 253-260
-
-
Singh, K.P.1
DuMond, J.W.2
-
121
-
-
33646266987
-
Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome, Peroxisome-toendoplasmic reticulum translocation of a phospholipase C
-
Subramanya, S., and K. Mensa-Wilmot. 2006. Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome. Peroxisome-toendoplasmic reticulum translocation of a phospholipase C. FEBS J. 273(10):2110-2126.
-
(2006)
FEBS J.
, vol.273
, Issue.10
, pp. 2110-2126
-
-
Subramanya, S.1
Mensa-Wilmot, K.2
-
122
-
-
0037452445
-
Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
-
Theil, F.P., T.W. Guentert, S. Haddad, and P. Poulin. 2003. Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol. Lett. 138(1-2):29-49.
-
(2003)
Toxicol. Lett.
, vol.138
, Issue.1-2
, pp. 29-49
-
-
Theil, F.P.1
Guentert, T.W.2
Haddad, S.3
Poulin, P.4
-
123
-
-
33847024555
-
CAR and PXR: The xenobiotic-sensing receptors
-
Timsit, Y.E. and M. Negishi. 2006. CAR and PXR: The xenobiotic-sensing receptors. Steroids 72(3):231-246.
-
(2006)
Steroids
, vol.72
, Issue.3
, pp. 231-246
-
-
Timsit, Y.E.1
Negishi, M.2
-
124
-
-
0033928677
-
Response of Saccharomyces cerevisiae to sever osmotic stress: Evidence for a novel activation mechanism of the HOG MAP kinase pathway
-
Van Wuytswinkel, O., V. Reiser, M. Siderius, M.C. Kelders, G. Ammerer, H. Ruis, and W.H. Mager. 2000. Response of Saccharomyces cerevisiae to sever osmotic stress: Evidence for a novel activation mechanism of the HOG MAP kinase pathway. Mol. Microbiol. 37(2):382-397.
-
(2000)
Mol. Microbiol.
, vol.37
, Issue.2
, pp. 382-397
-
-
Van Wuytswinkel, O.1
Reiser, V.2
Siderius, M.3
Kelders, M.C.4
Ammerer, G.5
Ruis, H.6
Mager, W.H.7
-
125
-
-
11144284714
-
Knowledge-based algorithms for chemical structure and property analysis
-
Volarath, P., H. Wang, H. Fu, and R. Harrison. 2004. Knowledge-based algorithms for chemical structure and property analysis. Conf. Proc. IEEE Eng. Med. Biol. Soc. 4:3011-3014.
-
(2004)
Conf. Proc. IEEE Eng. Med. Biol. Soc.
, vol.4
, pp. 3011-3014
-
-
Volarath, P.1
Wang, H.2
Fu, H.3
Harrison, R.4
-
126
-
-
33845297317
-
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redoxdependent activation of nrf2 by cancer chemotherapeutic agents
-
Wang, X.J., J.D. Hayes, and C.R. Wolf. 2006. Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redoxdependent activation of nrf2 by cancer chemotherapeutic agents. Cancer Res. 66(22):10983-10994.
-
(2006)
Cancer Res.
, vol.66
, Issue.22
, pp. 10983-10994
-
-
Wang, X.J.1
Hayes, J.D.2
Wolf, C.R.3
-
127
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman, D.J. 1999. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 369(1):11-23.
-
(1999)
Arch. Biochem. Biophys.
, vol.369
, Issue.1
, pp. 11-23
-
-
Waxman, D.J.1
-
128
-
-
22144456709
-
Personalized exposure assessment: Promising approaches for human environmental health research
-
Weis, B.K., D. Balshaw, J.R. Barr, D. Brown, M. Ellisman, P. Lioy, G. Omenn, J.D. Potter, M.T. Smith, L. Sohn, W.A. Suk, S. Sumner, J. Swenberg, D.R. Walt, S. Watkins, C. Thompson, and S.H. Wilson. 2005. Personalized exposure assessment: Promising approaches for human environmental health research. Environ. Health Perspect. 113(7):840-848.
-
(2005)
Environ. Health Perspect.
, vol.113
, Issue.7
, pp. 840-848
-
-
Weis, B.K.1
Balshaw, D.2
Barr, J.R.3
Brown, D.4
Ellisman, M.5
Lioy, P.6
Omenn, G.7
Potter, J.D.8
Smith, M.T.9
Sohn, L.10
Suk, W.A.11
Sumner, S.12
Swenberg, J.13
Walt, D.R.14
Watkins, S.15
Thompson, C.16
Wilson, S.H.17
-
129
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for diseases of protein conformation
-
Westerheide, S.D., and R.I. Morimoto. 2005. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J. Biol. Chem. 280(39):33097-33100.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.39
, pp. 33097-33100
-
-
Westerheide, S.D.1
Morimoto, R.I.2
-
130
-
-
1842429727
-
Trends in environmentally related childhood illnesses
-
Woodruff, T.J., D.A. Axelrad, A.D. Kyle, O. Nweke, G.G. Miller, and B.J. Hurley. 2004. Trends in environmentally related childhood illnesses. Pediatrics 113(Suppl. 4):1133-1140.
-
(2004)
Pediatrics
, vol.113
, pp. 1133-1140
-
-
Woodruff, T.J.1
Axelrad, D.A.2
Kyle, A.D.3
Nweke, O.4
Miller, G.G.5
Hurley, B.J.6
-
131
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
Zhang, D.D. 2006. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 38(4):769-789.
-
(2006)
Drug Metab Rev.
, vol.38
, Issue.4
, pp. 769-789
-
-
Zhang, D.D.1
-
132
-
-
84989225999
-
GeneChip Arrays. Affymetrix Corporation
-
[accessed March 27, 2007].
-
Affymetrix Corporation. 2007. GeneChip Arrays. Affymetrix Corporation. [online]. Available: http://www.affymetrix.com/products/arrays/specific/ hgu133plus.affx [accessed March 27, 2007].
-
(2007)
-
-
-
133
-
-
0000005079
-
A system for identifying genetic networks from gene expression patterns produced by gene disruption and overexpressions
-
Akutsu, T., S. Kuhara, O. Maruyama, and S. Miyano. 1998. A system for identifying genetic networks from gene expression patterns produced by gene disruption and overexpressions. Genome Inform. Ser. Workshop Genome Inform. 9:151-160.
-
(1998)
Genome Inform. Ser. Workshop Genome Inform.
, vol.9
, pp. 151-160
-
-
Akutsu, T.1
Kuhara, S.2
Maruyama, O.3
Miyano, S.4
-
134
-
-
33750533388
-
Physicochemical modeling of cell signaling pathways
-
Aldridge, B.B., J.M. Burke, D.A. Lauffenburger, and P.K. Sorger. 2006. Physicochemical modeling of cell signaling pathways. Nat. Cell Biol. 8(11):1195-1203.
-
(2006)
Nat. Cell Biol.
, vol.8
, Issue.11
, pp. 1195-1203
-
-
Aldridge, B.B.1
Burke, J.M.2
Lauffenburger, D.A.3
Sorger, P.K.4
-
135
-
-
0036989983
-
Molecular circuits, biological switches, and nonlinear dose-response relationships
-
Andersen, M.E., R.S. Yang, C.T. French, L.S. Chubb, and J.E. Dennison. 2002. Molecular circuits, biological switches, and nonlinear dose-response relationships. Environ. Health Perspect. 110(Suppl. 6):971-978.
-
(2002)
Environ. Health Perspect.
, vol.110
, pp. 971-978
-
-
Andersen, M.E.1
Yang, R.S.2
French, C.T.3
Chubb, L.S.4
Dennison, J.E.5
-
136
-
-
13944283866
-
New directions in incidence dose-response modeling
-
Andersen, M.E., J.E. Dennison, R.S. Thomas, and R.B. Conolly. 2005a. New directions in incidence dose-response modeling. Trends Biotechnol. 23(3):122-127.
-
(2005)
Trends Biotechnol
, vol.23
, Issue.3
, pp. 122-127
-
-
Andersen, M.E.1
Dennison, J.E.2
Thomas, R.S.3
Conolly, R.B.4
-
137
-
-
15944383395
-
Doseresponse modeling in reproductive toxicology in the systems biology era
-
Andersen, M.E., R.S. Thomas, K.W. Gaido, and R.B. Conolly. 2005b. Doseresponse modeling in reproductive toxicology in the systems biology era. Reprod. Toxicol. 19(3):327-337.
-
(2005)
Reprod. Toxicol
, vol.19
, Issue.3
, pp. 327-337
-
-
Andersen, M.E.1
Thomas, R.S.2
Gaido, K.W.3
Conolly, R.B.4
-
138
-
-
0036854505
-
The state of the world's pharmacy: A portrait of the pharmacy profession
-
Anderson, S. 2002. The state of the world's pharmacy: A portrait of the pharmacy profession. J. Interprof. Care 16(4):391-404.
-
(2002)
J. Interprof. Care
, vol.16
, Issue.4
, pp. 391-404
-
-
Anderson, S.1
-
139
-
-
33645807414
-
Rational design approaches to chemical libraries for hit identification
-
Balakin, K.V., A.V. Kozintsev, A.S. Kiselyov, and N.P. Savchuk. 2006. Rational design approaches to chemical libraries for hit identification. Curr. Drug Discov. Technol. 3(1):49-65.
-
(2006)
Curr. Drug Discov. Technol.
, vol.3
, Issue.1
, pp. 49-65
-
-
Balakin, K.V.1
Kozintsev, A.V.2
Kiselyov, A.S.3
Savchuk, N.P.4
-
140
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabasi, A.L., and Z.N. Oltvai. 2004. Network biology: Understanding the cell's functional organization. Nat. Rev. Genet. 5(2):101-113.
-
(2004)
Nat. Rev. Genet.
, vol.5
, Issue.2
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
141
-
-
23644438904
-
Computational pharmacokinetics during developmental windows of susceptibility
-
Barton, H.A. 2005. Computational pharmacokinetics during developmental windows of susceptibility. J. Toxicol. Environ. Health A 68(11-12):889-900.
-
(2005)
J. Toxicol. Environ. Health A
, vol.68
, Issue.11-12
, pp. 889-900
-
-
Barton, H.A.1
-
142
-
-
2142809738
-
Chemical structure of mutagens and carcinogens and the relationship with biological activity
-
Benigni, R. 2004. Chemical structure of mutagens and carcinogens and the relationship with biological activity. J. Exp. Clin. Cancer Res. 23(1):5-8.
-
(2004)
J. Exp. Clin. Cancer Res.
, vol.23
, Issue.1
, pp. 5-8
-
-
Benigni, R.1
-
143
-
-
33749859175
-
Structure-activity models of chemical carcinogens: State of the art, and new directions
-
Benigni, R., and C. Bossa. 2006. Structure-activity models of chemical carcinogens: State of the art, and new directions. Ann. Ist Super Sanita. 42(2):118-126.
-
(2006)
Ann. Ist Super Sanita.
, vol.42
, Issue.2
, pp. 118-126
-
-
Benigni, R.1
Bossa, C.2
-
144
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K., E.M. Hijmans, J. Mullenders, T.R. Brummelkamp, A. Velds, M. Heimerikx, R.M. Kerkhoven, M. Madiredjo, W. Nijkamp, B. Weigelt, R. Agami, W. Ge, G. Cavet, P.S. Linsley, R.L. Beijersbergen, and R. Bernards. 2004. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428(6981):431-437.
-
(2004)
Nature
, vol.428
, Issue.6981
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madiredjo, M.8
Nijkamp, W.9
Weigelt, B.10
Agami, R.11
Ge, W.12
Cavet, G.13
Linsley, P.S.14
Beijersbergen, R.L.15
Bernards, R.16
-
145
-
-
4143118798
-
Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways
-
Bhalla, U.S. 2004a. Signaling in small subcellular volumes. I. Stochastic and diffusion effects on individual pathways. Biophys J. 87(2):733-744.
-
(2004)
Biophys J
, vol.87
, Issue.2
, pp. 733-744
-
-
Bhalla, U.S.1
-
146
-
-
4143144113
-
Signaling in small subcellular volumes. II. Stochastic and diffusion effects on synaptic network properties
-
Bhalla, U.S. 2004b. Signaling in small subcellular volumes. II. Stochastic and diffusion effects on synaptic network properties. Biophys. J. 87(2):745-753.
-
(2004)
Biophys. J
, vol.87
, Issue.2
, pp. 745-753
-
-
Bhalla, U.S.1
-
147
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen activated protein kinase signaling network
-
Bhalla, U.S., P.T. Ram, and R. Iyengar. 2002. MAP kinase phosphatase as a locus of flexibility in a mitogen activated protein kinase signaling network. Science 297(5583):1018-1023.
-
(2002)
Science
, vol.297
, Issue.5583
, pp. 1018-1023
-
-
Bhalla, U.S.1
Ram, P.T.2
Iyengar, R.3
-
148
-
-
0032827970
-
Recent advances in retrometabolic design approaches
-
Bodor, N. 1999. Recent advances in retrometabolic design approaches. J. Control. Release 62(1-2):209-222.
-
(1999)
J. Control. Release
, vol.62
, Issue.1-2
, pp. 209-222
-
-
Bodor, N.1
-
149
-
-
0029092057
-
Modeling human interindividual variability in metabolism and risk: The example of 4-aminobiphenyl
-
Bois, F.Y., G. Krowech, and L. Zeise. 1995. Modeling human interindividual variability in metabolism and risk: The example of 4-aminobiphenyl. Risk Anal. 15(2):205-213.
-
(1995)
Risk Anal.
, vol.15
, Issue.2
, pp. 205-213
-
-
Bois, F.Y.1
Krowech, G.2
Zeise, L.3
-
150
-
-
0034614598
-
Genomic biology
-
Brent, R. 2000. Genomic biology. Cell 100(1):169-183.
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 169-183
-
-
Brent, R.1
-
151
-
-
1042302103
-
Early prediction of drug metabolism and toxicity: Systems biology approach and modeling
-
Bugrim, A., T. Nikolskaya, and Y. Nikolsky. 2004. Early prediction of drug metabolism and toxicity: Systems biology approach and modeling. Drug Discov. Today 9(3):127-135.
-
(2004)
Drug Discov. Today
, vol.9
, Issue.3
, pp. 127-135
-
-
Bugrim, A.1
Nikolskaya, T.2
Nikolsky, Y.3
-
152
-
-
0142059834
-
Genome-scale functional profiling of the mammalian AP-1signaling pathway
-
Chanda, S.K., S. White, A.P. Orth, R. Reisdorph, L. Miraglia, R.S. Thomas, P. DeJesus, D.E. Mason, Q. Huang, R. Vega, D.H. Yu, C.G. Nelson, B.M. Smith, R. Terry, A.S. Linford, Y. Yu, G.W. Chirn, C. Song, M.A. Labow, D. Cohen, F.J. King, E.C. Peters, P.G. Schultz, P.K. Vogt, J.B. Hogenesch, and J.S. Caldwell. 2003. Genome-scale functional profiling of the mammalian AP-1signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 100(21):12153-12158.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, Issue.21
, pp. 12153-12158
-
-
Chanda, S.K.1
White, S.2
Orth, A.P.3
Reisdorph, R.4
Miraglia, L.5
Thomas, R.S.6
DeJesus, P.7
Mason, D.E.8
Huang, Q.9
Vega, R.10
Yu, D.H.11
Nelson, C.G.12
Smith, B.M.13
Terry, R.14
Linford, A.S.15
Yu, Y.16
Chirn, G.W.17
Song, C.18
Labow, M.A.19
Cohen, D.20
King, F.J.21
Peters, E.C.22
Schultz, P.G.23
Vogt, P.K.24
Hogenesch, J.B.25
Caldwell, J.S.26
more..
-
153
-
-
3042541905
-
Correlation between structure and transfection efficiency: A study of DC-Chol-- DOPE/DNA complexes
-
Congiu, A., D. Pozzi, C. Esposito, C. Castellano, and G. Mossa. 2004. Correlation between structure and transfection efficiency: A study of DC-Chol-- DOPE/DNA complexes. Colloids Surf. B Biointerfaces. 36(1):43-48.
-
(2004)
Colloids Surf. B Biointerfaces.
, vol.36
, Issue.1
, pp. 43-48
-
-
Congiu, A.1
Pozzi, D.2
Esposito, C.3
Castellano, C.4
Mossa, G.5
-
154
-
-
0037184865
-
The use of biologically based modeling in risk assessment
-
Conolly, R.B. 2002. The use of biologically based modeling in risk assessment. Toxicology 27:181-182; 275-279.
-
(2002)
Toxicology
, vol.27
, Issue.181-182
, pp. 275-279
-
-
Conolly, R.B.1
-
155
-
-
8444227400
-
Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset
-
Conolly, R.B., J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller. 2004. Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicol. Sci. 82(1):279-296.
-
(2004)
Toxicol. Sci.
, vol.82
, Issue.1
, pp. 279-296
-
-
Conolly, R.B.1
Kimbell, J.S.2
Janszen, D.3
Schlosser, P.M.4
Kalisak, D.5
Preston, J.6
Miller, F.J.7
-
156
-
-
0036975618
-
The current status and future applicability of quantitative structure-activity relationships (QSARs) in predicting toxicity
-
Cronin, M.T. 2002. The current status and future applicability of quantitative structure-activity relationships (QSARs) in predicting toxicity. Altern. Lab. Anim. 30(Suppl. 2):81-84.
-
(2002)
Altern. Lab. Anim.
, vol.30
, pp. 81-84
-
-
Cronin, M.T.1
-
157
-
-
15944417084
-
A systems biology approach to developmental toxicology
-
Cummings, A., and R. Kavlock. 2005. A systems biology approach to developmental toxicology. Reprod. Toxicol. 19(3):281-290.
-
(2005)
Reprod. Toxicol.
, vol.19
, Issue.3
, pp. 281-290
-
-
Cummings, A.1
Kavlock, R.2
-
158
-
-
0031106196
-
Advances in understanding mechanisms of toxicity and implications for risk assessment
-
Daston, G.P. 1997. Advances in understanding mechanisms of toxicity and implications for risk assessment. Reprod. Toxicol. 11(2-3):389-396.
-
(1997)
Reprod. Toxicol.
, vol.11
, Issue.2-3
, pp. 389-396
-
-
Daston, G.P.1
-
159
-
-
30144443169
-
Systems-ADME/Tox: Resources and network applications
-
Ekins, S. 2006. Systems-ADME/Tox: Resources and network applications. J. Pharmacol. Toxicol. Methods 53(1):38-66.
-
(2006)
J. Pharmacol. Toxicol. Methods
, vol.53
, Issue.1
, pp. 38-66
-
-
Ekins, S.1
-
160
-
-
15944425080
-
Techniques: Applications of systems biology to absorption, distribution, metabolism, excretion and toxicity
-
Ekins, S., Y. Nikolsky, and T. Nikolskaya. 2005. Techniques: Applications of systems biology to absorption, distribution, metabolism, excretion and toxicity. Trends Pharmacol. Sci. 26(4):202-209.
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, Issue.4
, pp. 202-209
-
-
Ekins, S.1
Nikolsky, Y.2
Nikolskaya, T.3
-
161
-
-
9644274131
-
Computational approaches for modeling regulatory cellular networks
-
Eungdamrong, N.J., and R. Iyengar. 2004. Computational approaches for modeling regulatory cellular networks. Trends Cell Biol. 14(12):661-669.
-
(2004)
Trends Cell Biol.
, vol.14
, Issue.12
, pp. 661-669
-
-
Eungdamrong, N.J.1
Iyengar, R.2
-
162
-
-
0034713376
-
A simple model for the prediction of blood-brain partitioning
-
Feher, M., E. Sourial, and J.M. Schmidt. 2000. A simple model for the prediction of blood-brain partitioning. Int. J. Pharm. 201(2):239-247.
-
(2000)
Int. J. Pharm.
, vol.201
, Issue.2
, pp. 239-247
-
-
Feher, M.1
Sourial, E.2
Schmidt, J.M.3
-
163
-
-
33947183899
-
Membrane lipids as signaling molecules
-
Fernandis, A.Z, and M.R. Wenk. 2007. Membrane lipids as signaling molecules. Curr. Opin. Lipidol. 18(2):121-128.
-
(2007)
Curr. Opin. Lipidol.
, vol.18
, Issue.2
, pp. 121-128
-
-
Fernandis, A.Z.1
Wenk, M.R.2
-
164
-
-
27144548985
-
Towards quantitative biology: Integration of biological information to elucidate disease pathways and to guide drug discovery
-
Fischer, H.P. 2005. Towards quantitative biology: Integration of biological information to elucidate disease pathways and to guide drug discovery. Biotechnol. Annu. Rev. 11:1-68.
-
(2005)
Biotechnol. Annu. Rev.
, vol.11
, pp. 1-68
-
-
Fischer, H.P.1
-
165
-
-
33745480519
-
Translating genomic biomarkers into clinically useful diagnostics
-
Ginsburg, G.S., and S.B. Haga. 2006. Translating genomic biomarkers into clinically useful diagnostics. Expert Rev. Mol. Diagn. 6(2):179-191.
-
(2006)
Expert Rev. Mol. Diagn.
, vol.6
, Issue.2
, pp. 179-191
-
-
Ginsburg, G.S.1
Haga, S.B.2
-
166
-
-
30144438595
-
Protecting more than animals
-
Goldberg, A.M., and T. Hartung. 2006. Protecting more than animals. Sci Am. 294(1):84-91.
-
(2006)
Sci Am.
, vol.294
, Issue.1
, pp. 84-91
-
-
Goldberg, A.M.1
Hartung, T.2
-
167
-
-
0041386827
-
Role of ADME characteristics in drug discovery and their in silico evaluation: In silico screening of chemicals for their metabolic stability
-
Gombar, V.K., I.S. Silver, and Z. Zhao. 2003. Role of ADME characteristics in drug discovery and their in silico evaluation: In silico screening of chemicals for their metabolic stability. Curr. Top. Med. Chem. 3(11):1205-1225.
-
(2003)
Curr. Top. Med. Chem.
, vol.3
, Issue.11
, pp. 1205-1225
-
-
Gombar, V.K.1
Silver, I.S.2
Zhao, Z.3
-
168
-
-
26944441255
-
Dicing and slicing: The core machinery of the RNA interference pathway
-
Hammond, S.M. 2005. Dicing and slicing: The core machinery of the RNA interference pathway. FEBS Lett. 579(26):5822-5829.
-
(2005)
FEBS Lett.
, vol.579
, Issue.26
, pp. 5822-5829
-
-
Hammond, S.M.1
-
169
-
-
0037062951
-
RNA interference
-
Hannon, G.J. 2002. RNA interference. Nature 418(6894):244-251.
-
(2002)
Nature
, vol.418
, Issue.6894
, pp. 244-251
-
-
Hannon, G.J.1
-
170
-
-
0025003870
-
Uncertainties in pharmacokinetic modeling for perchloroethylene, I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors
-
Hattis, D., P. White, L. Marmorstein, and P. Koch. 1990. Uncertainties in pharmacokinetic modeling for perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors. Risk Anal. 10(3):449-458.
-
(1990)
Risk Anal.
, vol.10
, Issue.3
, pp. 449-458
-
-
Hattis, D.1
White, P.2
Marmorstein, L.3
Koch, P.4
-
171
-
-
33644844520
-
Microarray technology: Beyond transcript profiling and genotype analysis
-
Hoheisel, J.D. 2006. Microarray technology: Beyond transcript profiling and genotype analysis. Nat. Rev. Genet. 7(3):200-210.
-
(2006)
Nat. Rev. Genet.
, vol.7
, Issue.3
, pp. 200-210
-
-
Hoheisel, J.D.1
-
172
-
-
33747603487
-
Integrated mechanistic and data driven modeling for multivariate analysis of signaling pathways
-
Hua, F., S. Hautaniemi, R. Yokoo, and D.A. Lauffenburger. 2006. Integrated mechanistic and data driven modeling for multivariate analysis of signaling pathways. J. R. Soc. Interface. 3(9):515-526.
-
(2006)
J. R. Soc. Interface.
, vol.3
, Issue.9
, pp. 515-526
-
-
Hua, F.1
Hautaniemi, S.2
Yokoo, R.3
Lauffenburger, D.A.4
-
173
-
-
1542513776
-
Identification of p53 regulators by genome-wide functional analysis
-
Huang, Q., A. Raya, P. DeJesus, S.H. Chao, K.C. Quon, J.S. Caldwell, S.K. Chanda, J.C. Izpisua-Belmonte, and P.G. Schultz. 2004. Identification of p53 regulators by genome-wide functional analysis. Proc. Natl. Acad. Sci. USA 101(10):3456-3461.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.10
, pp. 3456-3461
-
-
Huang, Q.1
Raya, A.2
DeJesus, P.3
Chao, S.H.4
Quon, K.C.5
Caldwell, J.S.6
Chanda, S.K.7
Izpisua-Belmonte, J.C.8
Schultz, P.G.9
-
174
-
-
0037107022
-
Expanding the HTS paradigm
-
Inglese, J. 2002. Expanding the HTS paradigm. Drug Discov. Today 7(Suppl. 18):S105-S106.
-
(2002)
Drug Discov. Today
, vol.7
, pp. S105-S106
-
-
Inglese, J.1
-
175
-
-
33746789921
-
Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
-
Inglese, J., D.S. Auld, A. Jadhav, R.L. Johnson, A. Simeonov, A. Yasgar, W. Zheng, and C.P. Austin. 2006. Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. U.S.A. 103(31):11473-11478.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, Issue.31
, pp. 11473-11478
-
-
Inglese, J.1
Auld, D.S.2
Jadhav, A.3
Johnson, R.L.4
Simeonov, A.5
Yasgar, A.6
Zheng, W.7
Austin, C.P.8
-
176
-
-
33645961885
-
Bioinformatics for cancer management in the post-genome era
-
Katoh, M., and M. Katoh. 2006. Bioinformatics for cancer management in the post-genome era. Technol. Cancer Res. Treat. 5(2):169-175.
-
(2006)
Technol. Cancer Res. Treat.
, vol.5
, Issue.2
, pp. 169-175
-
-
Katoh, M.1
Katoh, M.2
-
177
-
-
0035384515
-
Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment
-
Kedderis, G.L, and J.C. Lipscomb. 2001. Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment. Toxicol. Ind. Health 17(5-10):315-321.
-
(2001)
Toxicol. Ind. Health
, vol.17
, Issue.5-10
, pp. 315-321
-
-
Kedderis, G.L.1
Lipscomb, J.C.2
-
178
-
-
33746927955
-
International alliance for quantitative modeling in systems biology
-
0007 [accessed March 27, 2007]
-
Kitano, H. 2005. International alliance for quantitative modeling in systems biology. Mol. Syst. Biol. 1(1):2005.0007 [online]. Available: http://www.nature. com/msb/journal/v1/n1/pdf/msb4100011.pdf [accessed March 27, 2007].
-
(2005)
Mol. Syst. Biol
, vol.1
, Issue.1
, pp. 2005
-
-
Kitano, H.1
-
179
-
-
77954010363
-
Introducing computational systems biology
-
Boston: Elsevier Academic Press.
-
Kriete, A., and R. Eils. 2006. Introducing computational systems biology. Pp. 1-14 in: Computational System Biology. Boston: Elsevier Academic Press.
-
(2006)
Computational System Biology
, pp. 1-14
-
-
Kriete, A.1
Eils, R.2
-
180
-
-
0034628834
-
Genomics: Journey to the center of biology
-
Lander, E.S., and R.A. Weinberg. 2000. Genomics: Journey to the center of biology. Science 287(5459):1777-1782.
-
(2000)
Science
, vol.287
, Issue.5459
, pp. 1777-1782
-
-
Lander, E.S.1
Weinberg, R.A.2
-
181
-
-
33751248731
-
High-throughput human metabolism and toxicity analysis
-
Lee, M.Y., and J.S. Dordick. 2006. High-throughput human metabolism and toxicity analysis. Curr. Opin. Biotechnol. 17(6):619-627.
-
(2006)
Curr. Opin. Biotechnol.
, vol.17
, Issue.6
, pp. 619-627
-
-
Lee, M.Y.1
Dordick, J.S.2
-
182
-
-
84878615936
-
-
Sudbury, MA: Jones and Bartlett Pub.
-
Lewin, B., L. Cassimeris, V.R. Lingappa, and G. Plopper. 2007. Cells. Sudbury, MA: Jones and Bartlett Pub.
-
(2007)
Cells
-
-
Lewin, B.1
Cassimeris, L.2
Lingappa, V.R.3
Plopper, G.4
-
183
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
Lum, L., S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, M. Nirenberg, and P.A. Beachy. 2003. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299(5615): 2039-2045.
-
(2003)
Science
, vol.299
, Issue.5615
, pp. 2039-2045
-
-
Lum, L.1
Yao, S.2
Mozer, B.3
Rovescalli, A.4
Von Kessler, D.5
Nirenberg, M.6
Beachy, P.A.7
-
184
-
-
0035031472
-
In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery
-
Masimirembwa, C.M., R. Thompson, and T.B. Andersson. 2001. In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery. Comb. Chem. High Throughput Screen. 4(3):245-263.
-
(2001)
Comb. Chem. High Throughput Screen.
, vol.4
, Issue.3
, pp. 245-263
-
-
Masimirembwa, C.M.1
Thompson, R.2
Andersson, T.B.3
-
185
-
-
0033935598
-
The practice of structure activity relationships (SAR) in toxicology
-
McKinney, J.D., A. Richard, C. Waller, M.C. Newman, and F. Gerberick. 2000. The practice of structure activity relationships (SAR) in toxicology. Toxicol. Sci. 56(1):8-17.
-
(2000)
Toxicol. Sci.
, vol.56
, Issue.1
, pp. 8-17
-
-
McKinney, J.D.1
Richard, A.2
Waller, C.3
Newman, M.C.4
Gerberick, F.5
-
186
-
-
4644223259
-
Mechanisms of gene slicing by double-stranded RNA
-
Meister, G., and T. Tuschl. 2004. Mechanisms of gene slicing by double-stranded RNA. Nature 431(7006):343-349.
-
(2004)
Nature
, vol.431
, Issue.7006
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
187
-
-
4644336023
-
Revealing the world of RNA interference
-
Mello, C.C., and D. Conte, Jr. 2004. Revealing the world of RNA interference. Nature 431(7006):338-342.
-
(2004)
Nature
, vol.431
, Issue.7006
, pp. 338-342
-
-
Mello, C.C.1
Conte, D.2
-
188
-
-
0036842503
-
Arrayed adenoviral expression libraries for functional screening
-
Michiels, F., H. van Es, L. van Rompaey, P. Merchiers, B. Francken, K. Pittois, J. van der Schueren, R. Brys, J. Vandersmissen, F. Beirinckx, S. Herman, K. Dokic, H. Klaassen, E. Narinx, A. Hagers, W. Laenen, I. Piest, H. Pavliska, Y. Rombout, E. Langemeijer, L. Ma, C. Schipper, M.D. Raeymaeker, S. Schweicher, M. Jans, K. van Beeck, I.R. Tsang, O. van de Stolpe, P. Tomme, G.J. Arts, and J. Donker. 2002. Arrayed adenoviral expression libraries for functional screening. Nat. Biotechnol. 20(11):1154-1157.
-
(2002)
Nat. Biotechnol.
, vol.20
, Issue.11
, pp. 1154-1157
-
-
Michiels, F.1
van Es, H.2
van Rompaey, L.3
Merchiers, P.4
Francken, B.5
Pittois, K.6
van der Schueren, J.7
Brys, R.8
Vandersmissen, J.9
Beirinckx, F.10
Herman, S.11
Dokic, K.12
Klaassen, H.13
Narinx, E.14
Hagers, A.15
Laenen, W.16
Piest, I.17
Pavliska, H.18
Rombout, Y.19
Langemeijer, E.20
Ma, L.21
Schipper, C.22
Raeymaeker, M.D.23
Schweicher, S.24
Jans, M.25
van Beeck, K.26
Tsang, I.R.27
van de Stolpe, O.28
Tomme, P.29
Arts, G.J.30
Donker, J.31
more..
-
189
-
-
39049177797
-
In vitro cytotoxicity assessment
-
O'Brien, P., and J.R. Haskins. 2007. In vitro cytotoxicity assessment. Methods Mol. Biol. 356: 415-425.
-
(2007)
Methods Mol. Biol.
, vol.356
, pp. 415-425
-
-
O'Brien, P.1
Haskins, J.R.2
-
190
-
-
84989258278
-
Three-dimensional structures in target drug discovery and validation
-
6th Ed, D. Leon, and S. Markel, eds. Boca Raton, FL: CRC Press.
-
O'Donoghue, S.I., R.B. Russell, and A. Schafferhans. 2006. Three-dimensional structures in target drug discovery and validation. Pp. 285-308 in In Silico Technologies in Drug Target Identification and Validation, 6th Ed, D. Leon, and S. Markel, eds. Boca Raton, FL: CRC Press.
-
(2006)
In Silico Technologies in Drug Target Identification and Validation
, pp. 285-308
-
-
O'Donoghue, S.I.1
Russell, R.B.2
Schafferhans, A.3
-
191
-
-
29144435996
-
Computational modeling of the receptor-tyrosine-kinase-activated MAPK pathway
-
Orton, R.J., O.E. Sturm, V. Vyshemirsky, M. Calder, D.R. Gilbert, and W. Kolch. 2005. Computational modeling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem. J. 392(Pt. 2):249-261.
-
(2005)
Biochem. J.
, vol.392
, pp. 249-261
-
-
Orton, R.J.1
Sturm, O.E.2
Vyshemirsky, V.3
Calder, M.4
Gilbert, D.R.5
Kolch, W.6
-
192
-
-
0033790956
-
Positron emission tomography in drug development and drug evaluation
-
Paans, A.M., and W. Vaalburg. 2000. Positron emission tomography in drug development and drug evaluation. Curr. Pharm. Des. 6(16): 1583-1591.
-
(2000)
Curr. Pharm. Des.
, vol.6
, Issue.16
, pp. 1583-1591
-
-
Paans, A.M.1
Vaalburg, W.2
-
193
-
-
0032421339
-
Testing strategies in immunotoxicology
-
Pallardy, M., S. Kerdine, and H. Lebrec. 1998. Testing strategies in immunotoxicology. Toxicol. Lett. 102-103:257-260.
-
(1998)
Toxicol. Lett
, vol.102-103
, pp. 257-260
-
-
Pallardy, M.1
Kerdine, S.2
Lebrec, H.3
-
194
-
-
33645106173
-
A search for thresholds and other nonlinearities in the relationship between hexavalent chromium and lung cancer
-
Park, R.M., and L.T. Stayner. 2006. A search for thresholds and other nonlinearities in the relationship between hexavalent chromium and lung cancer. Risk Anal. 26(1):79-88.
-
(2006)
Risk Anal.
, vol.26
, Issue.1
, pp. 79-88
-
-
Park, R.M.1
Stayner, L.T.2
-
195
-
-
23244453897
-
Growing applications and advancements in microarray technology and analysis tools
-
Peeters, J.K., and P.J. Van der Spek. 2005. Growing applications and advancements in microarray technology and analysis tools. Cell Biochem. Biophys. 43(1):149-166.
-
(2005)
Cell Biochem. Biophys.
, vol.43
, Issue.1
, pp. 149-166
-
-
Peeters, J.K.1
Van der Spek, P.J.2
-
196
-
-
0028883920
-
Interest and limits of human tissue and cell use in pharmacotoxicology
-
Potier, M., B. Lakhdar, D. Merlet, and J. Cambar. 1995. Interest and limits of human tissue and cell use in pharmacotoxicology. Cell Biol Toxicol. 11(3- 4):133-139.
-
(1995)
Cell Biol Toxicol.
, vol.11
, Issue.3-4
, pp. 133-139
-
-
Potier, M.1
Lakhdar, B.2
Merlet, D.3
Cambar, J.4
-
197
-
-
13844319702
-
Molecular imaging of antiangiogenic agents
-
Rehmann, S., and G.C. Jayson. 2005. Molecular imaging of antiangiogenic agents. Oncologist. 10(2):92-103.
-
(2005)
Oncologist.
, vol.10
, Issue.2
, pp. 92-103
-
-
Rehmann, S.1
Jayson, G.C.2
-
198
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
Sachs, K., O. Perez, D. Pe'er, D.A. Lauffenburger, and G.P. Nolan. 2005. Causal protein-signaling networks derived from multiparameter single-cell data. Science 308(5721):523-529.
-
(2005)
Science
, vol.308
, Issue.5721
, pp. 523-529
-
-
Sachs, K.1
Perez, O.2
Pe'er, D.3
Lauffenburger, D.A.4
Nolan, G.P.5
-
199
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
Santos, S.D., P.J. Verveer, and P.I. Bastiaens. 2007. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9(3):324-330.
-
(2007)
Nat. Cell Biol.
, vol.9
, Issue.3
, pp. 324-330
-
-
Santos, S.D.1
Verveer, P.J.2
Bastiaens, P.I.3
-
200
-
-
3242797413
-
Development of an in vitro model for vascular injury with human endothelial cells
-
Schleger, C., S.J. Platz, and U. Deschl. 2004. Development of an in vitro model for vascular injury with human endothelial cells. ALTEX 21(Suppl. 3):12-19.
-
(2004)
ALTEX
, vol.21
, pp. 12-19
-
-
Schleger, C.1
Platz, S.J.2
Deschl, U.3
-
201
-
-
0034678865
-
Health effects related structure-toxicity relationships: A paradigm for the first decade of the new millennium
-
Schultz, T.W., and J.R. Seward. 2000. Health effects related structure-toxicity relationships: A paradigm for the first decade of the new millennium. Sci. Total Environ. 249(1-3):73-84.
-
(2000)
Sci. Total Environ.
, vol.249
, Issue.1-3
, pp. 73-84
-
-
Schultz, T.W.1
Seward, J.R.2
-
202
-
-
0000639465
-
QSAR in aquatic toxicology: A mechanism of action approach comparing toxic potency to Pimephales pro-melas, Tetrahymena pyriformis, and Vibrio fischeri
-
ed. London: Taylor and Francis.
-
Schultz, T.W., G.D. Sinks, and A.P. Bearden. 1998. QSAR in aquatic toxicology: A mechanism of action approach comparing toxic potency to Pimephales pro-melas, Tetrahymena pyriformis, and Vibrio fischeri. Pp. 51-110 in Comparative QSAR, J. Devillers, ed. London: Taylor and Francis.
-
(1998)
Comparative QSAR, J. Devillers
, pp. 51-110
-
-
Schultz, T.W.1
Sinks, G.D.2
Bearden, A.P.3
-
203
-
-
0033403326
-
Technologies for detecting genetic polymorphisms in pharmacogenomics
-
Shi, M.M., M.R. Bleavins, and F.A. de la Iglesia. 1999. Technologies for detecting genetic polymorphisms in pharmacogenomics. Mol. Diagn. 4(4):343-351.
-
(1999)
Mol. Diagn.
, vol.4
, Issue.4
, pp. 343-351
-
-
Shi, M.M.1
Bleavins, M.R.2
de la Iglesia, F.A.3
-
204
-
-
33745191450
-
Use of computerassisted prediction of toxic effects of chemical substances
-
Simon-Hettich, B., A. Rothfuss, and T. Steger-Hartmann. 2006. Use of computerassisted prediction of toxic effects of chemical substances. Toxicology 224(1-2):156-162.
-
(2006)
Toxicology
, vol.224
, Issue.1-2
, pp. 156-162
-
-
Simon-Hettich, B.1
Rothfuss, A.2
Steger-Hartmann, T.3
-
205
-
-
9944240752
-
Dosedependent transitions in mechanisms of toxicity: Case studies
-
Slikker, W., Jr., M.E. Andersen, M.S. Bogdanffy, J.S. Bus, S.D. Cohen, R.B. Conolly, R.M. David, N.G. Doerrer, D.C. Dorman, D.W. Gaylor, D. Hattis, J.M. Rogers, R.W. Setzer, J.A. Swenberg, and K. Wallace. 2004a. Dosedependent transitions in mechanisms of toxicity: Case studies. Toxicol. Appl. Pharmacol. 201(3):226-294.
-
(2004)
Toxicol. Appl. Pharmacol
, vol.201
, Issue.3
, pp. 226-294
-
-
Slikker, W.1
Andersen, M.E.2
Bogdanffy, M.S.3
Bus, J.S.4
Cohen, S.D.5
Conolly, R.B.6
David, R.M.7
Doerrer, N.G.8
Dorman, D.C.9
Gaylor, D.W.10
Hattis, D.11
Rogers, J.M.12
Setzer, R.W.13
Swenberg, J.A.14
Wallace, K.15
-
206
-
-
6344251467
-
Dose-dependent transitions in mechanisms of toxicity
-
Slikker, W., Jr., M.E. Andersen, M.S. Bogdanffy, J.S. Bus, S.D. Cohen, R.B. Conolly, R.M. David, N.G. Doerrer, D.C. Dorman, D.W. Gaylor, D. Hattis, J.M. Rogers, R. Woodrow Setzer, J.A. Swenberg, and K. Wallace. 2004b. Dose-dependent transitions in mechanisms of toxicity. Toxicol. Appl. Pharmacol. 201(3):203-225.
-
(2004)
Toxicol. Appl. Pharmacol
, vol.201
, Issue.3
, pp. 203-225
-
-
Slikker, W.1
Andersen, M.E.2
Bogdanffy, M.S.3
Bus, J.S.4
Cohen, S.D.5
Conolly, R.B.6
David, R.M.7
Doerrer, N.G.8
Dorman, D.C.9
Gaylor, D.W.10
Hattis, D.11
Rogers, J.M.12
Woodrow Setzer, R.13
Swenberg, J.A.14
Wallace, K.15
-
207
-
-
15944363065
-
Application of a systems biology approach to developmental neurotoxicology
-
Slikker, W., Z. Xu, and C. Wang. 2005. Application of a systems biology approach to developmental neurotoxicology. Reprod. Toxicol. 19(3):305-319.
-
(2005)
Reprod. Toxicol.
, vol.19
, Issue.3
, pp. 305-319
-
-
Slikker, W.1
Xu, Z.2
Wang, C.3
-
208
-
-
33749608410
-
Comparative assessment of performance and genome dependence among phylogenetic profiling methods
-
Snitkin, E.S., A.M. Gustafson, J. Mellor, J. Wu, and C. DeLisi. 2006. Comparative assessment of performance and genome dependence among phylogenetic profiling methods. BMC Bioinformatics 7:420.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 420
-
-
Snitkin, E.S.1
Gustafson, A.M.2
Mellor, J.3
Wu, J.4
DeLisi, C.5
-
209
-
-
0034819395
-
Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity
-
Soffers, A.E., M.G. Boersma, W.H. Vaes, J. Vervoort, B. Tyrakowska, J.L. Hermens, I.M. Rietjens. 2001. Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity. Toxicol. In Vitro 15(4- 5):539-551.
-
(2001)
Toxicol. In Vitro
, vol.15
, Issue.4-5
, pp. 539-551
-
-
Soffers, A.E.1
Boersma, M.G.2
Vaes, W.H.3
Vervoort, J.4
Tyrakowska, B.5
Hermens, J.L.6
Rietjens, I.M.7
-
210
-
-
0034824347
-
Lessons learned from validation of in vitro toxicity test: From failure to acceptance into regulatory practice
-
Spielmann, H., and M. Liebsch. 2001. Lessons learned from validation of in vitro toxicity test: From failure to acceptance into regulatory practice. Toxicol. In Vitro 15(4-5):585-590.
-
(2001)
Toxicol. In Vitro
, vol.15
, Issue.4-5
, pp. 585-590
-
-
Spielmann, H.1
Liebsch, M.2
-
211
-
-
77953976774
-
The role of mutagenicity in describing formaldehydeinduced carcinogenicity: Possible inferences using the ciit model
-
Baltimore, MD, Dec. 3-6
-
Subramaniam, R.P., K.S. Crump, C. Chen, P. White, C. Van Landingham, J.F. Fox, P. Schlosser, T.R. Covington, D. DeVoney, J.J. Vandenberg, P. Preuss, and J. Whalan. 2006. The role of mutagenicity in describing formaldehydeinduced carcinogenicity: Possible inferences using the ciit model. Presented at the Society of Risk Analysis Annual Meeting, Dec. 3-6, 2006, Baltimore, MD.
-
(2006)
Presented at the Society of Risk Analysis Annual Meeting
, vol.2006
-
-
Subramaniam, R.P.1
Crump, K.S.2
Chen, C.3
White, P.4
Van Landingham, C.5
Fox, J.F.6
Schlosser, P.7
Covington, T.R.8
DeVoney, D.9
Vandenberg, J.J.10
Preuss, P.11
Whalan, J.12
-
212
-
-
39049174047
-
Establishment and therapeutic use of human embryonic stem cell lines
-
Suemori, H. 2006. Establishment and therapeutic use of human embryonic stem cell lines. Hum. Cell. 19(2):65-70.
-
(2006)
Hum. Cell.
, vol.19
, Issue.2
, pp. 65-70
-
-
Suemori, H.1
-
213
-
-
39049193821
-
Loss of integrin alpha3 expression is associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells
-
Suzuki, N., A. Higashiguchi, Y. Hasegawa, H. Matsumoto, S. Oie, K. Orikawa, S. Ezawa, N. Susumu, K. Miyashita, and D. Aoki. 2005. Loss of integrin alpha3 expression is associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells. Hum. Cell. 8(3):147-155.
-
(2005)
Hum. Cell.
, vol.8
, Issue.3
, pp. 147-155
-
-
Suzuki, N.1
Higashiguchi, A.2
Hasegawa, Y.3
Matsumoto, H.4
Oie, S.5
Orikawa, K.6
Ezawa, S.7
Susumu, N.8
Miyashita, K.9
Aoki, D.10
-
214
-
-
0142121263
-
Structure-activity relationship approaches and applications
-
Tong, W., W.J. Welsh, L. Shi, H. Fang, and R. Perkins. 2003. Structure-activity relationship approaches and applications. Environ. Toxicol. Chem. 22(8): 1680-1695.
-
(2003)
Environ. Toxicol. Chem.
, vol.22
, Issue.8
, pp. 1680-1695
-
-
Tong, W.1
Welsh, W.J.2
Shi, L.3
Fang, H.4
Perkins, R.5
-
215
-
-
0024320509
-
Lipophilic analogues of sparsomycin as strong inhibitors of protein synthesis and tumor growth: A structure-activity relationship study
-
van den Broek, L.A., E. Lazaro, Z. Zylicz, P.J. Fennis, F.A. Missler, P. Lelieveld, M. Garzotto, D.J. Wagener, J.P. Ballesta, and H.C. Ottenheijm. 1989. Lipophilic analogues of sparsomycin as strong inhibitors of protein synthesis and tumor growth: A structure-activity relationship study. J. Med. Chem. 32(8):2002-2015.
-
(1989)
J. Med. Chem.
, vol.32
, Issue.8
, pp. 2002-2015
-
-
van den Broek, L.A.1
Lazaro, E.2
Zylicz, Z.3
Fennis, P.J.4
Missler, F.A.5
Lelieveld, P.6
Garzotto, M.7
Wagener, D.J.8
Ballesta, J.P.9
Ottenheijm, H.C.10
-
216
-
-
0032449610
-
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for human and wildlife
-
Van der Berg, M., L. Birnbaum, A.T. Bosveld, B. Brunstrom, P. Cook, M. Feeley, J.P. Giesy, A. Hanberg, R. Hasegawa, S.W. Kennedy, T. Kubiak, J.C. Larsen, F.X. van Leeuwen, A.K. Liem, C. Nolt, R.E. Peterson, L. Poellinger, S. Safe, D. Schrenk, D. Tillitt, M. Tysklind, M. Younes, F. Waern, and T. Zacharewski. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for human and wildlife. Environ. Health Perspect. 106(12):775-792.
-
(1998)
Environ. Health Perspect.
, vol.106
, Issue.12
, pp. 775-792
-
-
Van der Berg, M.1
Birnbaum, L.2
Bosveld, A.T.3
Brunstrom, B.4
Cook, P.5
Feeley, M.6
Giesy, J.P.7
Hanberg, A.8
Hasegawa, R.9
Kennedy, S.W.10
Kubiak, T.11
Larsen, J.C.12
van Leeuwen, F.X.13
Liem, A.K.14
Nolt, C.15
Peterson, R.E.16
Poellinger, L.17
Safe, S.18
Schrenk, D.19
Tillitt, D.20
Tysklind, M.21
Younes, M.22
Waern, F.23
Zacharewski, T.24
more..
-
217
-
-
0033475010
-
Replacing animal testing by virtual experiments: A challenge in computational biology
-
Vedani, A. 1999. Replacing animal testing by virtual experiments: A challenge in computational biology. Chimia 53(5):227-228.
-
(1999)
Chimia
, vol.53
, Issue.5
, pp. 227-228
-
-
Vedani, A.1
-
218
-
-
0037923585
-
Quantitative cationic-activity relationships for predicting toxicity of metals
-
Walker, J.D., M. Enache, and J.C. Dearden. 2003. Quantitative cationic-activity relationships for predicting toxicity of metals. Environ. Toxicol. Chem. 22(8):1916-1935.
-
(2003)
Environ. Toxicol. Chem.
, vol.22
, Issue.8
, pp. 1916-1935
-
-
Walker, J.D.1
Enache, M.2
Dearden, J.C.3
-
219
-
-
0142089686
-
Guidelines for developing and using quantitative structure-activity relationships
-
Walker, J.D., J. Jaworska, M.H. Comber, T.W. Schultz, and J.C. Dearden. 2003b. Guidelines for developing and using quantitative structure-activity relationships. Environ. Toxicol. Chem. 22(8):1653-1665.
-
(2003)
Environ. Toxicol. Chem
, vol.22
, Issue.8
, pp. 1653-1665
-
-
Walker, J.D.1
Jaworska, J.2
Comber, M.H.3
Schultz, T.W.4
Dearden, J.C.5
-
220
-
-
84989256240
-
Quantitative Structure-Activity Relationships for Pollution Prevention, Toxicity Screening, Risk Assessment, and Web Applications (QSAR II)
-
Pensacola, FL: SETAC Press.
-
Walker, J.D., ed. 2004. Quantitative Structure-Activity Relationships for Pollution Prevention, Toxicity Screening, Risk Assessment, and Web Applications (QSAR II). Pensacola, FL: SETAC Press.
-
(2004)
-
-
Walker, J.D.1
-
221
-
-
33749637181
-
Microarray analysis of geneexpression profile in hepatocellular carcinoma cell, BEL-7402, with stable suppression of hLRH-1 via a DNA vector-based RNA interference
-
Wang, S.L., F.H. Lan, Y.P. Zhuang, H.Z. Li, L.H. Huang, D.Z. Zheng, J. Zeng, L.H. Dong, Z.Y. Zhu, and J.L. Fu. 2006. Microarray analysis of geneexpression profile in hepatocellular carcinoma cell, BEL-7402, with stable suppression of hLRH-1 via a DNA vector-based RNA interference. Yi Chuan Xue Bao. 33(10):881-891.
-
(2006)
Yi Chuan Xue Bao.
, vol.33
, Issue.10
, pp. 881-891
-
-
Wang, S.L.1
Lan, F.H.2
Zhuang, Y.P.3
Li, H.Z.4
Huang, L.H.5
Zheng, D.Z.6
Zeng, J.7
Dong, L.H.8
Zhu, Z.Y.9
Fu, J.L.10
-
222
-
-
0034040368
-
The impact of genomics based technologies on drug safety evaluation
-
Waring, J.F., and R.G. Ulrich. 2000. The impact of genomics based technologies on drug safety evaluation. Annu. Rev. Pharmacol. Toxicol. 40:335-352.
-
(2000)
Annu. Rev. Pharmacol. Toxicol.
, vol.40
, pp. 335-352
-
-
Waring, J.F.1
Ulrich, R.G.2
-
224
-
-
26444490100
-
Studying cellular processes and detecting disease with protein microarrays
-
Zangar, R.C., S.M. Varnum, and N. Bollinger. 2005. Studying cellular processes and detecting disease with protein microarrays. Drug Metab. Rev. 37(3): 473-487.
-
(2005)
Drug Metab. Rev.
, vol.37
, Issue.3
, pp. 473-487
-
-
Zangar, R.C.1
Varnum, S.M.2
Bollinger, N.3
-
225
-
-
33846918010
-
The principles of weight of evidence validation of test methods and testing strategie, The report and recommendations of ECVAM workshop 58.
-
Balls, M., P. Amcoff, S. Bremer, S. Casati, S. Coecke, R. Clothier, R. Combes, R. Corvi, R. Curren, C. Eskes, J. Fentem, L. Gribaldo, M. Halder, T. Hartung, S. Hoffmann, L. Schectman, L. Scott, H. Spielmann, W. Stokes, R. Tice, D. Wagner, and V. Zuang. 2006. The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58. Altern. Lab. Anim. 34(6):603-620.
-
(2006)
Altern. Lab. Anim.
, vol.34
, Issue.6
, pp. 603-620
-
-
Balls, M.1
Amcoff, P.2
Bremer, S.3
Casati, S.4
Coecke, S.5
Clothier, R.6
Combes, R.7
Corvi, R.8
Curren, R.9
Eskes, C.10
Fentem, J.11
Gribaldo, L.12
Halder, M.13
Hartung, T.14
Hoffmann, S.15
Schectman, L.16
Scott, L.17
Spielmann, H.18
Stokes, W.19
Tice, R.20
Wagner, D.21
Zuang, V.22
more..
-
226
-
-
33845317579
-
Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States
-
Blount, B.C., J.L. Pirkle, J.D. Osterloh, L. Valentin-Blasini, and K.L. Caldwell. 2006. Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ. Health Perspect. 114(12):1865-1871.
-
(2006)
Environ. Health Perspect.
, vol.114
, Issue.12
, pp. 1865-1871
-
-
Blount, B.C.1
Pirkle, J.L.2
Osterloh, J.D.3
Valentin-Blasini, L.4
Caldwell, K.L.5
-
227
-
-
18344396568
-
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
-
Brazma, A., P. Hingamp, J. Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C.A. Ball, H.C. Causton, T. Gaasterland, P. Glenisson, F.C. Holstege, I.F. Kim, V. Markowitz, C. Matese, H. Parkinson, A. Robinson, U. Sarkans, S. Schulze-Kremer, J. Stewart, R. Taylor, J. Vilo, and M. Vingron. 2001. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 29(4):365-371.
-
(2001)
Nat. Genet.
, vol.29
, Issue.4
, pp. 365-371
-
-
Brazma, A.1
Hingamp, P.2
Quackenbush, J.3
Sherlock, G.4
Spellman, P.5
Stoeckert, C.6
Aach, J.7
Ansorge, W.8
Ball, C.A.9
Causton, H.C.10
Gaasterland, T.11
Glenisson, P.12
Holstege, F.C.13
Kim, I.F.14
Markowitz, V.15
Matese, C.16
Parkinson, H.17
Robinson, A.18
Sarkans, U.19
Schulze-Kremer, S.20
Stewart, J.21
Taylor, R.22
Vilo, J.23
Vingron, M.24
more..
-
228
-
-
33644777676
-
Meeting report: Validation of toxicogenomics-based test systems: ECVAMICCVAM/ NICEATM considerations for regulatory use
-
Corvi, R., H.J. Ahr, S. Albertini, D.H. Blakey, L. Clerici, S. Coecke, G.R. Douglas, L. Gribaldo, J.P. Groten, B. Haase, K. Hamernik, T. Hartung, T. Inoue, I. Indans, D. Maurici, G. Orphanides, D. Rembges, S.A. Sansone, J.R. Snape, E. Toda, W. Tong, J.H. van Delft, B. Weis, and L.M. Schechtman. 2006. Meeting report: Validation of toxicogenomics-based test systems: ECVAMICCVAM/ NICEATM considerations for regulatory use. Environ Health Perspect. 114(3):420-429.
-
(2006)
Environ Health Perspect.
, vol.114
, Issue.3
, pp. 420-429
-
-
Corvi, R.1
Ahr, H.J.2
Albertini, S.3
Blakey, D.H.4
Clerici, L.5
Coecke, S.6
Douglas, G.R.7
Gribaldo, L.8
Groten, J.P.9
Haase, B.10
Hamernik, K.11
Hartung, T.12
Inoue, T.13
Indans, I.14
Maurici, D.15
Orphanides, G.16
Rembges, D.17
Sansone, S.A.18
Snape, J.R.19
Toda, E.20
Tong, W.21
van Delft, J.H.22
Weis, B.23
Schechtman, L.M.24
more..
-
229
-
-
84989267791
-
Science and Research Budgets for the U.S. Environmental Protection Agency for Fiscal Year 2007; An Advisory Report by the Science Advisory Board. EPA-SAB-ADV-06-003
-
Washington DC. March 30, 2006 [accessed April 4, 2007].
-
EPA (U.S. Environmental Protection Agency). 2006. Science and Research Budgets for the U.S. Environmental Protection Agency for Fiscal Year 2007; An Advisory Report by the Science Advisory Board. EPA-SAB-ADV-06- 003. U.S. Environmental Protection Agency, Washington DC. March 30, 2006 [online]. Available: http://yosemite.epa.gov/sab/sabproduct.nsf/36a1ca3f683ae57a85256ce9006a32d0/0EDAAECA1096A5B085257145007 2E33E/$File/sab-adv-06-003.pdf [accessed April 4, 2007].
-
(2006)
U.S. Environmental Protection Agency
-
-
-
230
-
-
84989220650
-
Comments on EPA's Strategic Research Directions and Research Budget for FY 2008, An Advisory Report of the U.S. Environmental Protection Agency Science Advisory Board
-
Washington DC. March 13, 2007 [accessed April 7, 2007].
-
EPA (U.S. Environmental Protection Agency). 2007. Comments on EPA's Strategic Research Directions and Research Budget for FY 2008, An Advisory Report of the U.S. Environmental Protection Agency Science Advisory Board. EPA-SAB-ADV-07-004. U.S. Environmental Protection Agency, Washington DC. March 13, 2007 [online]. Available: http://yosemite.epa.gov/sab/sabproduct.nsf/997517EFA5FC48798525729F0073B4D4/$File/sab-07-004.pdf [accessed April 7, 2007].
-
(2007)
EPA-SAB-ADV-07-004. U.S. Environmental Protection Agency
-
-
-
231
-
-
27744549344
-
ICCVAM Guidelines for the Nomination and Submission of New, Revised, and Alternative Test Methods
-
National Institute of Environmental Health Sciences, National Institutes of Health.
-
ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods) and NICEATM (National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicolgical Methods). 2003. ICCVAM Guidelines for the Nomination and Submission of New, Revised, and Alternative Test Methods. NIH Publication No. 03-4508. National Institute of Environmental Health Sciences, National Institutes of Health.
-
(2003)
NIH Publication No. 03-4508
-
-
-
232
-
-
33746789921
-
Quantitative high-throughput screening: A titrationbased approach that efficiently identifies biological activities in large chemical libraries
-
Inglese, J., D.S. Auld, A. Jadhav, R.L. Johnson, A. Simeonov, A. Yasgar, W. Zheng, and C.P. Austin. 2006. Quantitative high-throughput screening: A titrationbased approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. U.S.A. 103(31):11473-11478.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, Issue.31
, pp. 11473-11478
-
-
Inglese, J.1
Auld, D.S.2
Jadhav, A.3
Johnson, R.L.4
Simeonov, A.5
Yasgar, A.6
Zheng, W.7
Austin, C.P.8
-
233
-
-
0022499545
-
Cost-effectiveness of short-term tests for carcinogenicity
-
Lave, L.B., and G.S. Omenn. 1986. Cost-effectiveness of short-term tests for carcinogenicity. Nature 324(6092):29-34.
-
(1986)
Nature
, vol.324
, Issue.6092
, pp. 29-34
-
-
Lave, L.B.1
Omenn, G.S.2
-
234
-
-
0024289475
-
Information value of the rodent bioassay
-
Lave, L.B., F.K. Ennever, H.S. Rosenkranz, and G.S. Omenn. 1988. Information value of the rodent bioassay. Nature 336(6200):631-633.
-
(1988)
Nature
, vol.336
, Issue.6200
, pp. 631-633
-
-
Lave, L.B.1
Ennever, F.K.2
Rosenkranz, H.S.3
Omenn, G.S.4
-
235
-
-
84967537993
-
Scientific Frontiers in Developmental Toxicology and Risk Assessment
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 2000. Scientific Frontiers in Developmental Toxicology and Risk Assessment. Washington, DC: National Academy Press.
-
(2000)
-
-
-
236
-
-
84987973312
-
Review of the Department of Energy's Genomics: GTL Program.
-
Washington, DC: The National Academies Press.
-
NRC (National Research Council). 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press.
-
(2006)
-
-
-
237
-
-
84989271717
-
Current Directions and Evolving Strategies
-
National Institutes of Health, Research Triangle Park, NC [accessed April 4, 2007].
-
NTP (National Toxicology Program). 2006. Current Directions and Evolving Strategies. National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC[online]. Available: http://ntp.niehs.nih.gov/files/NTP_CurrDir2006.pdf [accessed April 4, 2007].
-
(2006)
National Toxicology Program, National Institute of Environmental Health Sciences
-
-
-
238
-
-
66949181171
-
Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment
-
Organisation for Economic Co-operation and Development, Paris [accessed April 4, 2007].
-
OECD (Organisation for Economic Co-operation and Development). 2005. Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment. OECD Series on Testing and Assessment No. 34. ENV/JM/Mono(2005)14. Organisation for Economic Co-operation and Development, Paris [online]. Available: http://appli1.oecd.org/olis/2005doc.nsf/linkto/env-jm-mono(2005)14 [accessed April 4, 2007].
-
(2005)
OECD Series on Testing and Assessment No. 34. ENV/JM/Mono(2005)14
-
-
-
239
-
-
77954020157
-
A Primer on Health Risk Communication Principles and Practices
-
Agency for Toxic Substances and Disease Registry, Division of Health Education, Atlanta, GA [accessed March 20, 2007].
-
ATSDR (Agency for Toxic Substances and Disease Registry). 2007. A Primer on Health Risk Communication Principles and Practices. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Division of Health Education, Atlanta, GA [online]. Available: http://www.atsdr.cdc.gov/risk/ riskprimer/index.html [accessed March 20, 2007].
-
(2007)
U.S. Department of Health and Human Services
-
-
-
240
-
-
84989225023
-
Public Health Goal for Arsenic in Drinking Water
-
April 2004 [accessed March 20, 2007].
-
CalEPA (California Environmental Protection Agency). 2004. Public Health Goal for Arsenic in Drinking Water. Office of Environmental Health Hazard As-sessment, California Environmental Protection Agency. April 2004 [online]. Available: http://www.oehha.ca.gov/water/phg/pdf/asfinal.pdf [accessed March 20, 2007].
-
(2004)
Office of Environmental Health Hazard As-sessment, California Environmental Protection Agency
-
-
-
241
-
-
33644870082
-
Metabolism: A bottleneck in in vitro toxicological test developmen, The report and recommendations of ECVM Workshop 54
-
Coecke, S., H. Ahr, B.J. Blaauboer, S. Bremer, S. Casati, J. Castell, R. Combes, R. Corvi, C.L. Crespi, M.L. Cunningham, G. Elaut, B. Eletti, A. Freidig, A. Gennari, J.F. Ghersi-Egea, A. Guillouzo, T. Hartung, P. Hoet, M. Ingelman- Sundberg, S. Munn, W. Janssens, B. Ladstetter, D. Leahy, A. Long, A. Meneguz, M. Monshouwer, S. Morath, F. Nagelkerke, O. Pelkonen, J. Ponti, P. Prieto, L. Richert, E. Sabbioni, B. Schaack, W. Steiling, E. Testai, J.A. Vericat, and A. Worth. 2006. Metabolism: A bottleneck in in vitro toxicological test development. The report and recommendations of ECVM Workshop 54. ATLA 34(1):49-84.
-
(2006)
ATLA
, vol.34
, Issue.1
, pp. 49-84
-
-
Coecke, S.1
Ahr, H.2
Blaauboer, B.J.3
Bremer, S.4
Casati, S.5
Castell, J.6
Combes, R.7
Corvi, R.8
Crespi, C.L.9
Cunningham, M.L.10
Elaut, G.11
Eletti, B.12
Freidig, A.13
Gennari, A.14
Ghersi-Egea, J.F.15
Guillouzo, A.16
Hartung, T.17
Hoet, P.18
Ingelman-Sundberg, M.19
Munn, S.20
Janssens, W.21
Ladstetter, B.22
Leahy, D.23
Long, A.24
Meneguz, A.25
Monshouwer, M.26
Morath, S.27
Nagelkerke, F.28
Pelkonen, O.29
Ponti, J.30
Prieto, P.31
Richert, L.32
Sabbioni, E.33
Schaack, B.34
Steiling, W.35
Testai, E.36
Vericat, J.A.37
Worth, A.38
more..
-
242
-
-
84989238573
-
Guidelines for Developmental Toxicity Risk Assessment. EPA/600/FR-91/001
-
Washington, DC [accessed March 7, 2007].
-
EPA (U.S. Environmental Protection Agency). 1991. Guidelines for Developmental Toxicity Risk Assessment. EPA/600/FR-91/001. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/NCEA/raf/pdfs/devtox.pdf [accessed March 7, 2007].
-
(1991)
Risk Assessment Forum, U.S. Environmental Protection Agency
-
-
-
243
-
-
84989219074
-
Guidelines for Reproductive Toxicity Risk Assessment. EPA/630/R-96/009
-
Washington, DC [accessed July 27, 2006].
-
EPA (U.S. Environmental Protection Agency). 1996. Guidelines for Reproductive Toxicity Risk Assessment. EPA/630/R-96/009. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http:://www.epa.gov/ncea/raf/pdfs/repro51.pdf [accessed July 27, 2006].
-
(1996)
Risk Assessment Forum, U.S. Environmental Protection Agency
-
-
-
244
-
-
84989219075
-
Guidelines for Neurotoxicity Risk Assessment. EPA/630/R-95/001F
-
Washington, DC [accessed March 7, 2007].
-
EPA (U.S. Environmental Protection Agency). 1998a. Guidelines for Neurotoxicity Risk Assessment. EPA/630/R-95/001F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/ncea/raf/pdfs/neurotox.pdf [accessed March 7, 2007].
-
(1998)
Risk Assessment Forum, U.S. Environmental Protection Agency
-
-
-
245
-
-
85043306443
-
Health Effects Test Guidelines: OPPTS 870.4300 Combined Chronic Toxicity/Carcinogenicity. EPA 712-C-98-212.
-
U.S. Environmental Protection Agency, Washington, DC [accessed March 20, 2007].
-
EPA (U.S. Environmental Protection Agency). 1998b. Health Effects Test Guidelines: OPPTS 870.4300 Combined Chronic Toxicity/Carcinogenicity. EPA 712-C-98-212. Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/opptsfrs/publications/OPPTS_Harmon ized/870_Health_Effects_Test_Guidelines/Series/870-4300.pdf [accessed March 20, 2007].
-
(1998)
Office of Prevention, Pesticides and Toxic Substances
-
-
-
246
-
-
30344443429
-
Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F
-
Washington, DC [accessed July 27, 2006].
-
EPA (U.S. Environmental Protection Agency). 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/iris/cancer032505.pdf [accessed July 27, 2006].
-
(2005)
Risk Assessment Forum, U.S. Environmental Protection Agency
-
-
-
247
-
-
84989225033
-
Pesticides: Science and Policy
-
[accessed March 21, 2007].
-
EPA (U.S. Environmental Protection Agency). 2006. Pesticides: Science and Policy. Office of Pesticides, U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/pesticides/science/index.htm [accessed March 21, 2007].
-
(2006)
Office of Pesticides, U.S. Environmental Protection Agency
-
-
-
248
-
-
33748277108
-
Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide
-
Lyon, France: IARC Press.
-
IARC (International Agency for Research on Cancer). 2006. Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 86. Lyon, France: IARC Press.
-
(2006)
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
, vol.86
-
-
-
249
-
-
84989238587
-
Glossary of IRIS Terms. Integrated Risk Information System
-
[accessed March 20, 2007].
-
IRIS (Integrated Risk Information System). 2007. Glossary of IRIS Terms. Integrated Risk Information System, U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/iris/gloss8.htm [accessed March 20, 2007].
-
(2007)
U.S. Environmental Protection Agency
-
-
-
250
-
-
0002470112
-
Principles of toxicology
-
4th Ed., M.O. Amdur, J. Doull, and C.D. Klaassen, eds. New York: Pergamon Press.
-
Klaassen, C.D., and D.L. Eaton. 1991. Principles of toxicology. Pp. 12-49 in Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th Ed., M.O. Amdur, J. Doull, and C.D. Klaassen, eds. New York: Pergamon Press.
-
(1991)
Casarett and Doull's Toxicology: The Basic Science of Poisons
, pp. 12-49
-
-
Klaassen, C.D.1
Eaton, D.L.2
-
251
-
-
33747609152
-
Public perception of population health risks in Canada: Health hazards and sources of information
-
Krewski, D., L. Lemyre, M.C. Turner, J.E.C. Lee, C. Dallaire, L. Bouchard, K. Brand, and P. Mercier. 2006. Public perception of population health risks in Canada: Health hazards and sources of information. Hum. Ecol. Risk Assess. 12(4):626-644.
-
(2006)
Hum. Ecol. Risk Assess.
, vol.12
, Issue.4
, pp. 626-644
-
-
Krewski, D.1
Lemyre, L.2
Turner, M.C.3
Lee, J.E.C.4
Dallaire, C.5
Bouchard, L.6
Brand, K.7
Mercier, P.8
-
252
-
-
0010275746
-
In the Chamber of Risks: Understanding Risk Controversies
-
Montreal: McGill-Queen's University Press.
-
Leiss, W. 2001. In the Chamber of Risks: Understanding Risk Controversies. Montreal: McGill-Queen's University Press.
-
(2001)
-
-
Leiss, W.1
-
253
-
-
33745804081
-
Towards an understanding of the role of forces in carcinogenesis: A perspective with therapeutic implications
-
Lieber, M.M. 2006. Towards an understanding of the role of forces in carcinogenesis: A perspective with therapeutic implications. Riv. Biol. 99(1):131-160.
-
(2006)
Riv. Biol.
, vol.99
, Issue.1
, pp. 131-160
-
-
Lieber, M.M.1
-
254
-
-
9144238300
-
A framework for human relevance analysis of information on carcinogenic modes of action
-
Meek, M.E., J.R. Bucher, S.M. Cohen, V. Dellarco, R.N. Hill, L.D. Lehman- McKeeman, D.G. Longfellow, T. Pastoor, J. Seed, and D. Patton. 2003. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33(6):591-653.
-
(2003)
Crit. Rev. Toxicol.
, vol.33
, Issue.6
, pp. 591-653
-
-
Meek, M.E.1
Bucher, J.R.2
Cohen, S.M.3
Dellarco, V.4
Hill, R.N.5
Lehman-McKeeman, L.D.6
Longfellow, D.G.7
Pastoor, T.8
Seed, J.9
Patton, D.10
-
255
-
-
0004239573
-
Improving Risk Communication
-
Washington, DC: National Academy Press.
-
NRC (National Research Council). 1989. Improving Risk Communication. Washington, DC: National Academy Press.
-
(1989)
-
-
-
256
-
-
84989238571
-
Report on Carcinogens, 11th Ed. U.S. Department of Health and Human Services
-
[accessed March 20, 2007].
-
NTP (National Toxicology Program). 2005. Report on Carcinogens, 11th Ed. U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program [online]. Available: http://ntpserver.niehs.nih. gov/ntp/roc/toc11.html [accessed March 20, 2007].
-
(2005)
Public Health Service, National Toxicology Program
-
-
-
257
-
-
0041379637
-
Risk characterization of chemicals in food and diet
-
Renwick, A.G., S.M Barlow, I. Hertz-Picciotto, A.R. Boobis, E. Dybing, L. Edler, G. Eisenbrand, J.B. Greig, J. Kleiner, J. Lambe, D.J. Muller, M.R. Smith, A. Tritscher, S. Tuijtelaars, P.A. van den Brandt, R. Walter, and R. Kroes. 2003. Risk characterization of chemicals in food and diet. Food Chem. Toxicol. 41(9):1211-1271.
-
(2003)
Food Chem. Toxicol.
, vol.41
, Issue.9
, pp. 1211-1271
-
-
Renwick, A.G.1
S.M, Barlow2
Hertz-Picciotto, I.3
Boobis, A.R.4
Dybing, E.5
Edler, L.6
Eisenbrand, G.7
Greig, J.B.8
Kleiner, J.9
Lambe, J.10
Muller, D.J.11
Smith, M.R.12
Tritscher, A.13
Tuijtelaars, S.14
van den Brandt, P.A.15
Walter, R.16
Kroes, R.17
-
258
-
-
14744275129
-
Ecological risk assessment: History and fundamentals
-
D.J. Paustenbach, ed. New York: John Wiley and Sons.
-
Sergeant, A. 2002. Ecological risk assessment: History and fundamentals. Pp. 369- 442 in Human and Ecological Risk Assessment: Theory and Practice, D.J. Paustenbach, ed. New York: John Wiley and Sons.
-
(2002)
Human and Ecological Risk Assessment: Theory and Practice
, pp. 369-442
-
-
Sergeant, A.1
|