Towards quantitative biology: Integration of biological information to elucidate disease pathways and to guide drug discovery

Biotechnology Annual Review

Volumn 11, Issue SUPPL., 2005, Pages 1-68

  Fischer, Hans Peter ^a  

^a GENEDATA AG   (Switzerland)

Author keywords

omics technologies; 2D gels; Anti microbial; Antibiotics; Assay development; Bioinformatics; Biomedical research; Cancer research; Chemotherapy; COG; Comparative genomics; Composite elements; Compound evaluation; Compound screening; Computational biology; Computational methods; Data analysis; Data integration; Diagnostics; Disease hypothesis; DNA chips; Drug development; Drug discovery; Efficacy studies; Expression analysis; Expression profiling; Fluxomics; Functional genomics; Fusion protein analysis; GC MS; Gene neighbourhood analysis; Gene prediction; gene regulation; Genome analysis; Genome comparisons; Genomics; High throughput screening; In silico; LC MS; Marker genes; Mass spectrometry; Mechanism of action; Metabolic flux; metabolic pathways; Metabolomics; Microarray data; MOA; Mode of action; MS MS; Oligonucleotide chips; Oncogenomics; Oncology; Operon prediction; Pathway dynamics; Pathway modelling; Pathway reconstruction; Pathway simulations; Pharmacogenomics; Phylogenetic footprinting; Phylogenetic profiling; position weight matrix; Promoter analysis; Promoter modules; Protein interactions; Proteomics; Quantitative biology; Regulatory elements; Regulatory modules; Regulatory network; Regulatory pathways; Reporter assays; Research management system; Sequence analysis; Signalling pathways; Systems biology; Target identification; Target validation; TFBS; Tissue expression; Tissue profiling; Toxicity studies; Toxicogenomics; Transcription factor binding site prediction; Transcriptomics; Whole genome sequences; Yeast two hybrid

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; DNA; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; JANUS KINASE; MESSENGER RNA; NEW DRUG; OLIGONUCLEOTIDE; STAT PROTEIN; TRANSCRIPTION FACTOR;

BINDING SITE; BIOINFORMATICS; CANCER RESEARCH; COMPARATIVE GENE MAPPING; COMPUTER MODEL; COMPUTER NETWORK; COMPUTER SIMULATION; DNA FINGERPRINTING; DNA MICROARRAY; DRUG RESEARCH; DRUG TARGETING; FUNCTIONAL GENOMICS; GAS CHROMATOGRAPHY; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MARKER GENE; MASS SPECTROMETRY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEDICAL RESEARCH; METABOLOMICS; MOLECULAR EVOLUTION; NONHUMAN; OPEN READING FRAME; OPERON; PHYLOGENY; PREDICTION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN INTERACTION; PROTEOMICS; RECOMBINANT DNA TECHNOLOGY; REGULATORY MECHANISM; REVIEW; RNA INTERFERENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS; TWO HYBRID SYSTEM; VALIDATION PROCESS;

ANIMALS; BIOTECHNOLOGY; DRUG INDUSTRY; GENOMICS; HUMANS; MODELS, BIOLOGICAL; PROTEOMICS; SYSTEMS BIOLOGY; TECHNOLOGY, PHARMACEUTICAL;

EID: 27144548985     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(05)11001-1     Document Type: Review

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