Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Toxicology Letters

Volumn 138, Issue 1-2, 2003, Pages 29-49

  Theil, Frank Peter ^a   Guentert, Theodor W ^a   Haddad, Sami ^a   Poulin, Patrick ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Drug development; Drug discovery; Partition coefficients; PBPK modeling; Pharmacokinetics; QSAR; Toxicokinetics

Indexed keywords

PROPANOL;

ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TISSUE LEVEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METABOLIC CLEARANCE RATE; MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIMULATION; TECHNIQUE;

ANIMALS; DRUG EVALUATION; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; HUMANS; MODELS, BIOLOGICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SOLUBILITY; SPECIES SPECIFICITY;

EID: 0037452445     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00374-0     Document Type: Article

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