Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

Journal of Pharmaceutical Sciences

Volumn 91, Issue 5, 2002, Pages 1358-1370

  Poulin, Patrick ^a   Theil, Frank Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Animal alternatives; Disposition; Drug discovery; In silico; Metabolism; Pharmacokinetics; Physiologically based pharmacokinetic (PBPK) modeling; Quantitative structure activity relationships (QSAR); Toxicokinetics

Indexed keywords

DIAZEPAM; ETHENZAMIDE; GENERIC DRUG; PROPRANOLOL;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DOSE LIVER FUNCTION RELATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; FEMALE; HYDROPHILICITY; IN VIVO STUDY; LIPOPHILICITY; LIVER CLEARANCE; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; RAT; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL;

EID: 0036075799     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10128     Document Type: Article

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