메뉴 건너뛰기




Volumn 11, Issue 19-20, 2006, Pages 889-894

High-content screening moves to the front of the line

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIBODY; G PROTEIN COUPLED RECEPTOR; PROTEIN INHIBITOR; REAGENT; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXO;

EID: 33748742351     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2006.08.015     Document Type: Review
Times cited : (102)

References (54)
  • 1
    • 23144461838 scopus 로고    scopus 로고
    • Inflammatory pathway analysis using a high content screening platform
    • Bertelsen M., and Sanfridson A. Inflammatory pathway analysis using a high content screening platform. Assay Drug Dev. Technol. 3 (2005) 261-271
    • (2005) Assay Drug Dev. Technol. , vol.3 , pp. 261-271
    • Bertelsen, M.1    Sanfridson, A.2
  • 2
    • 20544442929 scopus 로고    scopus 로고
    • High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells
    • Borchert K.M., et al. High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells. Assay Drug Dev. Technol. 3 (2005) 133-141
    • (2005) Assay Drug Dev. Technol. , vol.3 , pp. 133-141
    • Borchert, K.M.1
  • 3
    • 10244229793 scopus 로고    scopus 로고
    • A quantitative cell-based high-content screening assay for the epidermal growth factor receptor-specific activation of mitogen-activated protein kinase
    • Ghosh R.N., et al. A quantitative cell-based high-content screening assay for the epidermal growth factor receptor-specific activation of mitogen-activated protein kinase. Assay Drug Dev. Technol. 2 (2004) 473-481
    • (2004) Assay Drug Dev. Technol. , vol.2 , pp. 473-481
    • Ghosh, R.N.1
  • 4
    • 0035450462 scopus 로고    scopus 로고
    • Micronuclei assay by laser scanning cytometry
    • Smolewski P., et al. Micronuclei assay by laser scanning cytometry. Cytometry 45 (2001) 19-26
    • (2001) Cytometry , vol.45 , pp. 19-26
    • Smolewski, P.1
  • 5
    • 0347480490 scopus 로고    scopus 로고
    • Ligand-selective signaling and high-content screening for GPCR drugs
    • Gurwitz D., and Haring R. Ligand-selective signaling and high-content screening for GPCR drugs. Drug Discov. Today 8 (2003) 1108-1109
    • (2003) Drug Discov. Today , vol.8 , pp. 1108-1109
    • Gurwitz, D.1    Haring, R.2
  • 6
    • 3543069879 scopus 로고    scopus 로고
    • Seventeen-colour flow cytometry: unravelling the immune system
    • Perfetto S.P., et al. Seventeen-colour flow cytometry: unravelling the immune system. Nat. Rev. Immunol. 4 (2004) 648-655
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 648-655
    • Perfetto, S.P.1
  • 7
    • 21344452806 scopus 로고    scopus 로고
    • Use of high-content analysis for compound screening and target selection
    • Rausch O. Use of high-content analysis for compound screening and target selection. IDrugs 8 (2005) 573-577
    • (2005) IDrugs , vol.8 , pp. 573-577
    • Rausch, O.1
  • 8
    • 22544448136 scopus 로고    scopus 로고
    • High content screening-Emerging importance of novel reagents/probes and pathway analysis
    • Comley J. High content screening-Emerging importance of novel reagents/probes and pathway analysis. Drug Discovery World 6 (2005) 31-54
    • (2005) Drug Discovery World , vol.6 , pp. 31-54
    • Comley, J.1
  • 9
    • 33645464806 scopus 로고    scopus 로고
    • Cellular imaging in drug discovery
    • Lang P., et al. Cellular imaging in drug discovery. Nat. Rev. Drug Discov. 5 (2006) 343-356
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 343-356
    • Lang, P.1
  • 10
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang J.-H., et al. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4 (1999) 67-73
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.-H.1
  • 11
    • 4544237524 scopus 로고    scopus 로고
    • Visualization of molecular activities inside living cells with fluorescent labels
    • Bunt G., and Wouters F.S. Visualization of molecular activities inside living cells with fluorescent labels. Int. Rev. Cytol. 237 (2004) 205-277
    • (2004) Int. Rev. Cytol. , vol.237 , pp. 205-277
    • Bunt, G.1    Wouters, F.S.2
  • 12
    • 0029924379 scopus 로고    scopus 로고
    • Automated cell cycle analysis with fluorescence microscopy and image analysis
    • Bocker W., et al. Automated cell cycle analysis with fluorescence microscopy and image analysis. Phys. Med. Biol. 41 (1996) 523-537
    • (1996) Phys. Med. Biol. , vol.41 , pp. 523-537
    • Bocker, W.1
  • 13
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121 (2005) 335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1
  • 14
    • 28544448518 scopus 로고    scopus 로고
    • Rheumatic diseases: the effects of inflammation on bone
    • Walsh N.C., et al. Rheumatic diseases: the effects of inflammation on bone. Immunol. Rev. 208 (2005) 228-251
    • (2005) Immunol. Rev. , vol.208 , pp. 228-251
    • Walsh, N.C.1
  • 15
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak R.E., and Griffin W.S. Glia and their cytokines in progression of neurodegeneration. Neurobiol. Aging 26 (2005) 349-354
    • (2005) Neurobiol. Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 16
    • 0035995230 scopus 로고    scopus 로고
    • Molecular aspects of neurodegeneration in Alzheimer's disease
    • Russo C., et al. Molecular aspects of neurodegeneration in Alzheimer's disease. Funct. Neurol. 17 (2002) 65-70
    • (2002) Funct. Neurol. , vol.17 , pp. 65-70
    • Russo, C.1
  • 17
    • 33748752341 scopus 로고    scopus 로고
    • Lapan, P. et al. Single cell analysis by high content screening improves the analysis of protein function using RNAi, as well as in unperturbed cells. in preparation
  • 18
    • 0035753427 scopus 로고    scopus 로고
    • RNA-mediated interference as a tool for identifying drug targets
    • O'Neil N.J., et al. RNA-mediated interference as a tool for identifying drug targets. Am. J. Pharmacogenomics 1 (2001) 45-53
    • (2001) Am. J. Pharmacogenomics , vol.1 , pp. 45-53
    • O'Neil, N.J.1
  • 19
    • 84926974821 scopus 로고    scopus 로고
    • Haney, S.A. et al. RNAi in the drug discovery process, in RNA Interference Technology: From Basic Science to Drug Development, K. Appasani, Editor. 2005. Cambridge University Press, p. 331-346
  • 20
    • 9144226019 scopus 로고    scopus 로고
    • Oncology studies using siRNA libraries: the dawn of RNAi-based genomics
    • Sachse C., and Echeverri C.J. Oncology studies using siRNA libraries: the dawn of RNAi-based genomics. Oncogene 23 (2004) 8384-8391
    • (2004) Oncogene , vol.23 , pp. 8384-8391
    • Sachse, C.1    Echeverri, C.J.2
  • 21
    • 9144273977 scopus 로고    scopus 로고
    • RNAi and HTS: exploring cancer by systematic loss-of-function
    • Willingham A.T., et al. RNAi and HTS: exploring cancer by systematic loss-of-function. Oncogene 23 (2004) 8392-8400
    • (2004) Oncogene , vol.23 , pp. 8392-8400
    • Willingham, A.T.1
  • 22
    • 33646187810 scopus 로고    scopus 로고
    • High-throughput RNAi screening in cultured cells: a user's guide
    • Echeverri C.J., and Perrimon N. High-throughput RNAi screening in cultured cells: a user's guide. Nat. Rev. Genet. 7 (2006) 373-384
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 373-384
    • Echeverri, C.J.1    Perrimon, N.2
  • 24
    • 4744373229 scopus 로고    scopus 로고
    • Noise amidst the silence: off-target effects of siRNAs?
    • Jackson A.L., and Linsley P.S. Noise amidst the silence: off-target effects of siRNAs?. Trends Genet. 20 (2004) 521-524
    • (2004) Trends Genet. , vol.20 , pp. 521-524
    • Jackson, A.L.1    Linsley, P.S.2
  • 25
    • 33646188259 scopus 로고    scopus 로고
    • 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A., et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods 3 (2006) 199-204
    • (2006) Nat. Methods , vol.3 , pp. 199-204
    • Birmingham, A.1
  • 26
    • 24044461406 scopus 로고    scopus 로고
    • RNAi versus small molecules: Different mechanisms and specificities can lead to different outcomes
    • Fitzgerald K. RNAi versus small molecules: Different mechanisms and specificities can lead to different outcomes. Curr. Opin. Drug Discov. Devel. 8 (2005) 557-566
    • (2005) Curr. Opin. Drug Discov. Devel. , vol.8 , pp. 557-566
    • Fitzgerald, K.1
  • 27
    • 11344255740 scopus 로고    scopus 로고
    • Defining and Assaying RNAi in Mammalian Cells
    • Huppi K., et al. Defining and Assaying RNAi in Mammalian Cells. Mol. Cell 17 (2005) 1-10
    • (2005) Mol. Cell , vol.17 , pp. 1-10
    • Huppi, K.1
  • 28
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson A.L., et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21 (2003) 635-637
    • (2003) Nat. Biotechnol. , vol.21 , pp. 635-637
    • Jackson, A.L.1
  • 29
    • 29444457543 scopus 로고    scopus 로고
    • RNAi and high-content screening in target identification and validation
    • Haney S.A. RNAi and high-content screening in target identification and validation. IDrugs 8 (2005) 997-1001
    • (2005) IDrugs , vol.8 , pp. 997-1001
    • Haney, S.A.1
  • 30
    • 19944430064 scopus 로고    scopus 로고
    • High-throughput RNA interference strategies for target discovery and validation by using synthetic short interfering RNAs: functional genomics investigations of biological pathways
    • Sachse C., et al. High-throughput RNA interference strategies for target discovery and validation by using synthetic short interfering RNAs: functional genomics investigations of biological pathways. Methods Enzymol. 392 (2005) 242-277
    • (2005) Methods Enzymol. , vol.392 , pp. 242-277
    • Sachse, C.1
  • 31
    • 33646033137 scopus 로고    scopus 로고
    • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    • Moffat J., et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124 (2006) 1283-1298
    • (2006) Cell , vol.124 , pp. 1283-1298
    • Moffat, J.1
  • 32
    • 10744230287 scopus 로고    scopus 로고
    • RNAi microarray analysis in cultured mammalian cells
    • Mousses S., et al. RNAi microarray analysis in cultured mammalian cells. Genome Res. 13 (2003) 2341-2347
    • (2003) Genome Res. , vol.13 , pp. 2341-2347
    • Mousses, S.1
  • 33
    • 15844431376 scopus 로고    scopus 로고
    • Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
    • Sonnichsen B., et al. Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434 (2005) 462-469
    • (2005) Nature , vol.434 , pp. 462-469
    • Sonnichsen, B.1
  • 34
    • 0347747970 scopus 로고    scopus 로고
    • A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells
    • Kau T.R., et al. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 4 (2003) 463-476
    • (2003) Cancer Cell , vol.4 , pp. 463-476
    • Kau, T.R.1
  • 35
    • 8444223104 scopus 로고    scopus 로고
    • Automatic identification of subcellular phenotypes on human cell arrays
    • Perlman Z.E., et al. Automatic identification of subcellular phenotypes on human cell arrays. Science 306 (2004) 1194-1198
    • (2004) Science , vol.306 , pp. 1194-1198
    • Perlman, Z.E.1
  • 36
    • 28144449723 scopus 로고    scopus 로고
    • The progress and promise of molecular imaging probes in oncologic drug development
    • Kelloff G.J., et al. The progress and promise of molecular imaging probes in oncologic drug development. Clin. Cancer Res. 11 (2005) 7967-7985
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7967-7985
    • Kelloff, G.J.1
  • 37
    • 33644867837 scopus 로고    scopus 로고
    • Pharmacogenomics and clinical biomarkers in drug discovery and development
    • Ross J.S., et al. Pharmacogenomics and clinical biomarkers in drug discovery and development. Am. J. Clin. Pathol. 124 (2005) S29-S41
    • (2005) Am. J. Clin. Pathol. , vol.124
    • Ross, J.S.1
  • 38
    • 31544452152 scopus 로고    scopus 로고
    • Fine needle aspiration cytology of adult perineal rhabdomyosarcoma: a case report
    • Meng M.V., et al. Fine needle aspiration cytology of adult perineal rhabdomyosarcoma: a case report. Acta Cytol. 50 (2006) 88-92
    • (2006) Acta Cytol. , vol.50 , pp. 88-92
    • Meng, M.V.1
  • 39
    • 20344400638 scopus 로고    scopus 로고
    • Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review
    • Singhal S., et al. Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review. Clin. Cancer Res. 11 (2005) 3974-3986
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3974-3986
    • Singhal, S.1
  • 40
    • 25144453872 scopus 로고    scopus 로고
    • Turning all the lights on: quantum dots in cellular assays
    • Bruchez M.P. Turning all the lights on: quantum dots in cellular assays. Curr. Opin. Chem. Biol. 9 (2005) 533-537
    • (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 533-537
    • Bruchez, M.P.1
  • 41
    • 4444283084 scopus 로고    scopus 로고
    • Potentials and pitfalls of fluorescent quantum dots for biological imaging
    • Jaiswal J.K., and Simon S.M. Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol. 14 (2004) 497-504
    • (2004) Trends Cell Biol. , vol.14 , pp. 497-504
    • Jaiswal, J.K.1    Simon, S.M.2
  • 42
    • 18844403391 scopus 로고    scopus 로고
    • High content screening for G protein-coupled receptors using cell-based protein translocation assays
    • Granas C., et al. High content screening for G protein-coupled receptors using cell-based protein translocation assays. Comb. Chem. High Throughput Screen. 8 (2005) 301-309
    • (2005) Comb. Chem. High Throughput Screen. , vol.8 , pp. 301-309
    • Granas, C.1
  • 43
    • 30944457170 scopus 로고    scopus 로고
    • Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells
    • Wadsworth P., et al. Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells. Nat. Methods 2 (2005) 981-987
    • (2005) Nat. Methods , vol.2 , pp. 981-987
    • Wadsworth, P.1
  • 44
    • 21844440569 scopus 로고    scopus 로고
    • Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
    • Pelkmans L., et al. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 436 (2005) 78-86
    • (2005) Nature , vol.436 , pp. 78-86
    • Pelkmans, L.1
  • 45
    • 32844460056 scopus 로고    scopus 로고
    • Identification of a Small Molecule That Induces Mitotic Arrest Using a Simplified High-Content Screening Assay and Data Analysis Method
    • Wilson C.J., et al. Identification of a Small Molecule That Induces Mitotic Arrest Using a Simplified High-Content Screening Assay and Data Analysis Method. J. Biomol. Screen. 11 (2006) 21-28
    • (2006) J. Biomol. Screen. , vol.11 , pp. 21-28
    • Wilson, C.J.1
  • 46
    • 21744448078 scopus 로고    scopus 로고
    • An unbiased cell morphology-based screen for new, biologically active small molecules
    • Tanaka M., et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 3 (2005) e128
    • (2005) PLoS Biol. , vol.3
    • Tanaka, M.1
  • 47
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer T.U., et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286 (1999) 971-974
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1
  • 48
    • 1242338653 scopus 로고    scopus 로고
    • High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole
    • Giuliano K.A. High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole. J. Biomol. Screen. 8 (2003) 125-135
    • (2003) J. Biomol. Screen. , vol.8 , pp. 125-135
    • Giuliano, K.A.1
  • 49
    • 17044431370 scopus 로고    scopus 로고
    • High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs
    • Giuliano K.A., et al. High-content screening with siRNA optimizes a cell biological approach to drug discovery: defining the role of P53 activation in the cellular response to anticancer drugs. J. Biomol. Screen. 9 (2004) 557-568
    • (2004) J. Biomol. Screen. , vol.9 , pp. 557-568
    • Giuliano, K.A.1
  • 50
    • 12344288635 scopus 로고    scopus 로고
    • Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
    • Eggert U.S., et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2 (2004) e379
    • (2004) PLoS Biol. , vol.2
    • Eggert, U.S.1
  • 51
    • 33644966531 scopus 로고    scopus 로고
    • A computerized cellular imaging system for high content analysis in Monastrol suppressor screens
    • Zhou X., et al. A computerized cellular imaging system for high content analysis in Monastrol suppressor screens. J. Biomed. Inform. 39 (2005) 115-125
    • (2005) J. Biomed. Inform. , vol.39 , pp. 115-125
    • Zhou, X.1
  • 52
    • 0033107620 scopus 로고    scopus 로고
    • A review of US EPA and FDA requirements for electronic records, electronic signatures, and electronic submissions
    • Keatley K.L. A review of US EPA and FDA requirements for electronic records, electronic signatures, and electronic submissions. Qual. Assur. 7 (1999) 77-89
    • (1999) Qual. Assur. , vol.7 , pp. 77-89
    • Keatley, K.L.1
  • 53
    • 0037418911 scopus 로고    scopus 로고
    • Informatics and quantitative analysis in biological imaging
    • Swedlow J.R., et al. Informatics and quantitative analysis in biological imaging. Science 300 (2003) 100-102
    • (2003) Science , vol.300 , pp. 100-102
    • Swedlow, J.R.1
  • 54
    • 18344396568 scopus 로고    scopus 로고
    • Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
    • Brazma A., et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 29 (2001) 365-371
    • (2001) Nat. Genet. , vol.29 , pp. 365-371
    • Brazma, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.