-
1
-
-
33646713469
-
Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR
-
Kodama S., and Negishi M. Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR. Drug Metab Rev 38 (2006) 75-87
-
(2006)
Drug Metab Rev
, vol.38
, pp. 75-87
-
-
Kodama, S.1
Negishi, M.2
-
2
-
-
0035038008
-
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
-
Sueyoshi T., and Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41 (2001) 123-143
-
(2001)
Annu Rev Pharmacol Toxicol
, vol.41
, pp. 123-143
-
-
Sueyoshi, T.1
Negishi, M.2
-
3
-
-
13544258619
-
Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells
-
Swales K., Kakizaki S., Yamamoto Y., Inoue K., Kobayashi K., and Negishi M. Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. J Biol Chem 280 (2005) 3458-3466
-
(2005)
J Biol Chem
, vol.280
, pp. 3458-3466
-
-
Swales, K.1
Kakizaki, S.2
Yamamoto, Y.3
Inoue, K.4
Kobayashi, K.5
Negishi, M.6
-
4
-
-
14244270349
-
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism
-
Qatanani M., Zhang J., and Moore D.D. Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology 146 (2005) 995-1002
-
(2005)
Endocrinology
, vol.146
, pp. 995-1002
-
-
Qatanani, M.1
Zhang, J.2
Moore, D.D.3
-
5
-
-
2442485772
-
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction
-
Maglich J.M., Watson J., McMillen P.J., Goodwin B., Willson T.M., and Moore J.T. The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem 279 (2004) 19832-19838
-
(2004)
J Biol Chem
, vol.279
, pp. 19832-19838
-
-
Maglich, J.M.1
Watson, J.2
McMillen, P.J.3
Goodwin, B.4
Willson, T.M.5
Moore, J.T.6
-
6
-
-
0035042684
-
CYP3A regulation: from pharmacology to nuclear receptors
-
Quattrochi L.C., and Guzelian P.S. CYP3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos 29 (2001) 615-622
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 615-622
-
-
Quattrochi, L.C.1
Guzelian, P.S.2
-
7
-
-
33744962967
-
Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α
-
Miao J., Fang S., Bae Y., and Kemper J.K. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α. J Biol Chem 281 (2006) 14537-14546
-
(2006)
J Biol Chem
, vol.281
, pp. 14537-14546
-
-
Miao, J.1
Fang, S.2
Bae, Y.3
Kemper, J.K.4
-
8
-
-
4444246000
-
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
-
Kodama S., Koike C., Negishi M., and Yamamoto Y. Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol 24 (2004) 7931-7940
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7931-7940
-
-
Kodama, S.1
Koike, C.2
Negishi, M.3
Yamamoto, Y.4
-
9
-
-
0021850197
-
Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects
-
Lahtela J.T., Arranto A.J., and Sotaniemi E.A. Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects. Diabetes 34 (1985) 911-916
-
(1985)
Diabetes
, vol.34
, pp. 911-916
-
-
Lahtela, J.T.1
Arranto, A.J.2
Sotaniemi, E.A.3
-
10
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger J.L., Goodwin B., Jones S.A., Hawkins-Brown D., MacKenzie K.I., LaTour A., et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98 (2001) 3369-3374
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
-
11
-
-
0035853057
-
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
-
Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98 (2001) 3375-3380
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-Pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
-
12
-
-
0037422578
-
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
-
Goodwin B., Gauthier K.C., Umetani M., Watson M.A., Lochansky M.I., Collins J.L., et al. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci USA 100 (2003) 223-228
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 223-228
-
-
Goodwin, B.1
Gauthier, K.C.2
Umetani, M.3
Watson, M.A.4
Lochansky, M.I.5
Collins, J.L.6
-
13
-
-
13844306334
-
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
-
Sonoda J., Chong L.W., Downes M., Barish G.D., Coulter S., Liddle C., et al. Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc Natl Acad Sci USA 102 (2005) 2198-2203
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2198-2203
-
-
Sonoda, J.1
Chong, L.W.2
Downes, M.3
Barish, G.D.4
Coulter, S.5
Liddle, C.6
-
15
-
-
10344224570
-
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
-
Zhang J., Huang W., Qatanani M., Evans R.M., and Moore D.D. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 279 (2004) 49517-49522
-
(2004)
J Biol Chem
, vol.279
, pp. 49517-49522
-
-
Zhang, J.1
Huang, W.2
Qatanani, M.3
Evans, R.M.4
Moore, D.D.5
-
16
-
-
0037931737
-
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
-
Maglich J.M., Parks D.J., Moore L.B., Collins J.L., Goodwin B., Billin A.N., et al. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 278 (2003) 17277-17283
-
(2003)
J Biol Chem
, vol.278
, pp. 17277-17283
-
-
Maglich, J.M.1
Parks, D.J.2
Moore, L.B.3
Collins, J.L.4
Goodwin, B.5
Billin, A.N.6
-
17
-
-
0033999734
-
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
-
Tzameli I., Pissios P., Schuetz E.G., and Moore D.D. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol 20 (2000) 2951-2958
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2951-2958
-
-
Tzameli, I.1
Pissios, P.2
Schuetz, E.G.3
Moore, D.D.4
-
20
-
-
0036799870
-
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
-
Kliewer S.A., Goodwin B., and Willson T.M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 23 (2002) 687-702
-
(2002)
Endocr Rev
, vol.23
, pp. 687-702
-
-
Kliewer, S.A.1
Goodwin, B.2
Willson, T.M.3
-
21
-
-
28844498056
-
Localization of the nuclear receptor CAR at the cell membrane of mouse liver
-
Koike C., Moore R., and Negishi M. Localization of the nuclear receptor CAR at the cell membrane of mouse liver. FEBS Lett 579 (2005) 6733-6736
-
(2005)
FEBS Lett
, vol.579
, pp. 6733-6736
-
-
Koike, C.1
Moore, R.2
Negishi, M.3
-
22
-
-
22444448890
-
Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor
-
Choi E., Lee S., Yeom S.Y., Kim G.H., Lee J.W., and Kim S.W. Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor. Mol Endocrinol 19 (2005) 1711-1719
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1711-1719
-
-
Choi, E.1
Lee, S.2
Yeom, S.Y.3
Kim, G.H.4
Lee, J.W.5
Kim, S.W.6
-
23
-
-
0032230234
-
Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2
-
Kim H.J., Lee S.K., Na S.Y., Choi H.S., and Lee J.W. Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2. Mol Endocrinol 12 (1998) 1038-1047
-
(1998)
Mol Endocrinol
, vol.12
, pp. 1038-1047
-
-
Kim, H.J.1
Lee, S.K.2
Na, S.Y.3
Choi, H.S.4
Lee, J.W.5
-
24
-
-
0037135532
-
Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo
-
Min G., Kemper J.K., and Kemper B. Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. J Biol Chem 277 (2002) 26356-26363
-
(2002)
J Biol Chem
, vol.277
, pp. 26356-26363
-
-
Min, G.1
Kemper, J.K.2
Kemper, B.3
-
25
-
-
0035310906
-
Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1
-
Muangmoonchai R., Smirlis D., Wong S.C., Edwards M., Phillips I.R., and Shephard E.A. Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1. Biochem J 355 (2001) 71-78
-
(2001)
Biochem J
, vol.355
, pp. 71-78
-
-
Muangmoonchai, R.1
Smirlis, D.2
Wong, S.C.3
Edwards, M.4
Phillips, I.R.5
Shephard, E.A.6
-
26
-
-
0038514189
-
Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor γ coactivator-1αṡ A possible link between xenobiotic response and nutritional state
-
Shiraki T., Sakai N., Kanaya E., and Jingami H. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor γ coactivator-1αṡ A possible link between xenobiotic response and nutritional state. J Biol Chem 278 (2003) 11344-11350
-
(2003)
J Biol Chem
, vol.278
, pp. 11344-11350
-
-
Shiraki, T.1
Sakai, N.2
Kanaya, E.3
Jingami, H.4
-
27
-
-
33747169939
-
Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics
-
Inoue K., Borchers C.H., and Negishi M. Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. Biochem J 398 (2006) 125-133
-
(2006)
Biochem J
, vol.398
, pp. 125-133
-
-
Inoue, K.1
Borchers, C.H.2
Negishi, M.3
-
28
-
-
0032766430
-
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
-
Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., and Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19 (1999) 6318-6322
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6318-6322
-
-
Kawamoto, T.1
Sueyoshi, T.2
Zelko, I.3
Moore, R.4
Washburn, K.5
Negishi, M.6
-
29
-
-
0030744682
-
An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures
-
Sidhu J.S., and Omiecinski C.J. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J Pharmacol Exp Ther 282 (1997) 1122-1129
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1122-1129
-
-
Sidhu, J.S.1
Omiecinski, C.J.2
-
30
-
-
0032032380
-
Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes
-
Honkakoski P., and Negishi M. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem J 330 (1998) 889-895
-
(1998)
Biochem J
, vol.330
, pp. 889-895
-
-
Honkakoski, P.1
Negishi, M.2
-
31
-
-
0035076197
-
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
-
Zelko I., Sueyoshi T., Kawamoto T., Moore R., and Negishi M. The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol Cell Biol 21 (2001) 2838-2846
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2838-2846
-
-
Zelko, I.1
Sueyoshi, T.2
Kawamoto, T.3
Moore, R.4
Negishi, M.5
-
32
-
-
0142210183
-
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells
-
Kobayashi K., Sueyoshi T., Inoue K., Moore R., and Negishi M. Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol Pharmacol 64 (2003) 1069-1075
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1069-1075
-
-
Kobayashi, K.1
Sueyoshi, T.2
Inoue, K.3
Moore, R.4
Negishi, M.5
-
33
-
-
0042236405
-
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
-
Yoshinari K., Kobayashi K., Moore R., Kawamoto T., and Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett 548 (2003) 17-20
-
(2003)
FEBS Lett
, vol.548
, pp. 17-20
-
-
Yoshinari, K.1
Kobayashi, K.2
Moore, R.3
Kawamoto, T.4
Negishi, M.5
-
34
-
-
33645109954
-
Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor
-
Hosseinpour F., Moore R., Negishi M., and Sueyoshi T. Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. Mol Pharmacol 69 (2006) 1095-1102
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1095-1102
-
-
Hosseinpour, F.1
Moore, R.2
Negishi, M.3
Sueyoshi, T.4
-
35
-
-
14844299331
-
Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation
-
Xia J., and Kemper B. Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. J Biol Chem 280 (2005) 7285-7293
-
(2005)
J Biol Chem
, vol.280
, pp. 7285-7293
-
-
Xia, J.1
Kemper, B.2
-
36
-
-
24644488771
-
Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity
-
Jia Y., Guo G.L., Surapureddi S., Sarkar J., Qi C., Guo D., et al. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci USA 102 (2005) 12531-12536
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12531-12536
-
-
Jia, Y.1
Guo, G.L.2
Surapureddi, S.3
Sarkar, J.4
Qi, C.5
Guo, D.6
-
37
-
-
8344219885
-
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
-
Squires E.J., Sueyoshi T., and Negishi M. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem 279 (2004) 49307-49314
-
(2004)
J Biol Chem
, vol.279
, pp. 49307-49314
-
-
Squires, E.J.1
Sueyoshi, T.2
Negishi, M.3
-
38
-
-
28144459680
-
The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges
-
Orans J., Teotico D.G., and Redinbo M.R. The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Mol Endocrinol 19 (2005) 2891-2900
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2891-2900
-
-
Orans, J.1
Teotico, D.G.2
Redinbo, M.R.3
-
39
-
-
13244291443
-
Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase A signal transduction pathway
-
Ding X., and Staudinger J.L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase A signal transduction pathway. J Pharmacol Exp Ther 312 (2005) 849-856
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 849-856
-
-
Ding, X.1
Staudinger, J.L.2
-
40
-
-
13844253850
-
Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C
-
Ding X., and Staudinger J.L. Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. Biochem Pharmacol 69 (2005) 867-873
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 867-873
-
-
Ding, X.1
Staudinger, J.L.2
-
41
-
-
0033652116
-
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
-
Kawamoto T., Kakizaki S., Yoshinari K., and Negishi M. Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol Endocrinol 14 (2000) 1897-1905
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1897-1905
-
-
Kawamoto, T.1
Kakizaki, S.2
Yoshinari, K.3
Negishi, M.4
-
42
-
-
0036259008
-
Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR
-
Ueda A., Kakizaki S., Negishi M., and Sueyoshi T. Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. Mol Pharmacol 61 (2002) 1284-1288
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1284-1288
-
-
Ueda, A.1
Kakizaki, S.2
Negishi, M.3
Sueyoshi, T.4
-
43
-
-
20544458355
-
Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR
-
Ueda A., Matsui K., Yamamoto Y., Pedersen L.C., Sueyoshi T., and Negishi M. Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. Biochem J 388 (2005) 623-630
-
(2005)
Biochem J
, vol.388
, pp. 623-630
-
-
Ueda, A.1
Matsui, K.2
Yamamoto, Y.3
Pedersen, L.C.4
Sueyoshi, T.5
Negishi, M.6
-
44
-
-
0036311095
-
A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity
-
Dussault I., Lin M., Hollister K., Fan M., Termini J., Sherman M.A., et al. A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity. Mol Cell Biol 22 (2002) 5270-5280
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5270-5280
-
-
Dussault, I.1
Lin, M.2
Hollister, K.3
Fan, M.4
Termini, J.5
Sherman, M.A.6
-
45
-
-
4043173466
-
Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs
-
Frank C., Molnar F., Matilainen M., Lempiainen H., and Carlberg C. Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs. J Biol Chem 279 (2004) 33558-33566
-
(2004)
J Biol Chem
, vol.279
, pp. 33558-33566
-
-
Frank, C.1
Molnar, F.2
Matilainen, M.3
Lempiainen, H.4
Carlberg, C.5
-
46
-
-
14044269562
-
Amino acids important for ligand specificity of the human constitutive androstane receptor
-
Jyrkkarinne J., Windshugel B., Makinen J., Ylisirnio M., Perakyla M., Poso A., et al. Amino acids important for ligand specificity of the human constitutive androstane receptor. J Biol Chem 280 (2005) 5960-5971
-
(2005)
J Biol Chem
, vol.280
, pp. 5960-5971
-
-
Jyrkkarinne, J.1
Windshugel, B.2
Makinen, J.3
Ylisirnio, M.4
Perakyla, M.5
Poso, A.6
-
47
-
-
19944372389
-
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer
-
Xu R.X., Lambert M.H., Wisely B.B., Warren E.N., Weinert E.E., Waitt G.M., et al. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Mol Cell 16 (2004) 919-928
-
(2004)
Mol Cell
, vol.16
, pp. 919-928
-
-
Xu, R.X.1
Lambert, M.H.2
Wisely, B.B.3
Warren, E.N.4
Weinert, E.E.5
Waitt, G.M.6
-
48
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski A.M., Pike A.C., Dauter Z., Hubbard R.E., Bonn T., Engstrom O., et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389 (1997) 753-758
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
Hubbard, R.E.4
Bonn, T.5
Engstrom, O.6
-
49
-
-
0032568527
-
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
-
Tanenbaum D.M., Wang Y., Williams S.P., and Sigler P.B. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc Natl Acad Sci USA 95 (1998) 5998-6003
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5998-6003
-
-
Tanenbaum, D.M.1
Wang, Y.2
Williams, S.P.3
Sigler, P.B.4
-
50
-
-
10944250224
-
The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization
-
Suino K., Peng L., Reynolds R., Li Y., Cha J.Y., Repa J.J., et al. The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell 16 (2004) 893-905
-
(2004)
Mol Cell
, vol.16
, pp. 893-905
-
-
Suino, K.1
Peng, L.2
Reynolds, R.3
Li, Y.4
Cha, J.Y.5
Repa, J.J.6
-
51
-
-
10944229118
-
Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism
-
Shan L., Vincent J., Brunzelle J.S., Dussault I., Lin M., Ianculescu I., et al. Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Mol Cell 16 (2004) 907-917
-
(2004)
Mol Cell
, vol.16
, pp. 907-917
-
-
Shan, L.1
Vincent, J.2
Brunzelle, J.S.3
Dussault, I.4
Lin, M.5
Ianculescu, I.6
-
52
-
-
0036707613
-
Insights from a three-dimensional model into ligand binding to constitutive active receptor
-
Xiao L., Cui X., Madison V., White R.E., and Cheng K.C. Insights from a three-dimensional model into ligand binding to constitutive active receptor. Drug Metab Dispos 30 (2002) 951-956
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 951-956
-
-
Xiao, L.1
Cui, X.2
Madison, V.3
White, R.E.4
Cheng, K.C.5
-
53
-
-
33746924066
-
Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies
-
Poso A., and Honkakoski P. Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies. Mini Rev Med Chem 6 (2006) 937-947
-
(2006)
Mini Rev Med Chem
, vol.6
, pp. 937-947
-
-
Poso, A.1
Honkakoski, P.2
-
54
-
-
33847043360
-
Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity
-
Windshugel B., Jyrkkarinne J., Vanamo J., Poso A., Honkakoski P., and Sippl W. Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. J Mol Graph Model (2006)
-
(2006)
J Mol Graph Model
-
-
Windshugel, B.1
Jyrkkarinne, J.2
Vanamo, J.3
Poso, A.4
Honkakoski, P.5
Sippl, W.6
-
55
-
-
0036240393
-
Structural insights into the promiscuity and function of the human pregnane X receptor
-
Watkins R.E., Noble S.M., and Redinbo M.R. Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Dev 5 (2002) 150-158
-
(2002)
Curr Opin Drug Discov Dev
, vol.5
, pp. 150-158
-
-
Watkins, R.E.1
Noble, S.M.2
Redinbo, M.R.3
-
56
-
-
0035933511
-
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
-
Watkins R.E., Wisely G.B., Moore L.B., Collins J.L., Lambert M.H., Williams S.P., et al. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292 (2001) 2329-2333
-
(2001)
Science
, vol.292
, pp. 2329-2333
-
-
Watkins, R.E.1
Wisely, G.B.2
Moore, L.B.3
Collins, J.L.4
Lambert, M.H.5
Williams, S.P.6
-
57
-
-
17844396881
-
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
-
Chrencik J.E., Orans J., Moore L.B., Xue Y., Peng L., Collins J.L., et al. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol 19 (2005) 1125-1134
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1125-1134
-
-
Chrencik, J.E.1
Orans, J.2
Moore, L.B.3
Xue, Y.4
Peng, L.5
Collins, J.L.6
-
58
-
-
0037501542
-
2.1 Å crystal structure of human PXR in complex with the St. John's Wort compound hyperforin
-
Watkins R.E., Maglich J.M., Moore L.B., Wisely G.B., Noble S.M., Davis-Searles P.R., et al. 2.1 Å crystal structure of human PXR in complex with the St. John's Wort compound hyperforin. Biochemistry 42 (2003) 1430-1438
-
(2003)
Biochemistry
, vol.42
, pp. 1430-1438
-
-
Watkins, R.E.1
Maglich, J.M.2
Moore, L.B.3
Wisely, G.B.4
Noble, S.M.5
Davis-Searles, P.R.6
-
59
-
-
0043168030
-
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
-
Watkins R.E., Davis-Searles P.R., Lambert M.H., and Redinbo M.R. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 331 (2003) 815-828
-
(2003)
J Mol Biol
, vol.331
, pp. 815-828
-
-
Watkins, R.E.1
Davis-Searles, P.R.2
Lambert, M.H.3
Redinbo, M.R.4
-
60
-
-
17844366538
-
The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion
-
Masuyama H., Suwaki N., Tateishi Y., Nakatsukasa H., Segawa T., and Hiramatsu Y. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol 19 (2005) 1170-1180
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1170-1180
-
-
Masuyama, H.1
Suwaki, N.2
Tateishi, Y.3
Nakatsukasa, H.4
Segawa, T.5
Hiramatsu, Y.6
-
61
-
-
18144399332
-
The human glucocorticoid receptor: one gene, multiple proteins and diverse responses
-
Zhou J., and Cidlowski J.A. The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70 (2005) 407-417
-
(2005)
Steroids
, vol.70
, pp. 407-417
-
-
Zhou, J.1
Cidlowski, J.A.2
-
62
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S., Endoh H., Masuhiro Y., Kitamoto T., Uchiyama S., Sasaki H., et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270 (1995) 1491-1494
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
Kitamoto, T.4
Uchiyama, S.5
Sasaki, H.6
-
63
-
-
0023663885
-
Functional domains of the human estrogen receptor
-
Kumar V., Green S., Stack G., Berry M., Jin J.R., and Chambon P. Functional domains of the human estrogen receptor. Cell 51 (1987) 941-951
-
(1987)
Cell
, vol.51
, pp. 941-951
-
-
Kumar, V.1
Green, S.2
Stack, G.3
Berry, M.4
Jin, J.R.5
Chambon, P.6
-
64
-
-
18144424777
-
Gene regulation by the glucocorticoid receptor: structure:function relationship
-
Kumar R., and Thompson E.B. Gene regulation by the glucocorticoid receptor: structure:function relationship. J Steroid Biochem Mol Biol 94 (2005) 383-394
-
(2005)
J Steroid Biochem Mol Biol
, vol.94
, pp. 383-394
-
-
Kumar, R.1
Thompson, E.B.2
-
65
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau A.K., Barstad D., Loria P.M., Cheng L., Kushner P.J., Agard D.A., et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95 (1998) 927-937
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
-
66
-
-
0036234964
-
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
-
Shiau A.K., Barstad D., Radek J.T., Meyers M.J., Nettles K.W., Katzenellenbogen B.S., et al. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat Struct Biol 9 (2002) 359-364
-
(2002)
Nat Struct Biol
, vol.9
, pp. 359-364
-
-
Shiau, A.K.1
Barstad, D.2
Radek, J.T.3
Meyers, M.J.4
Nettles, K.W.5
Katzenellenbogen, B.S.6
-
67
-
-
3242876293
-
Structure and function of the glucocorticoid receptor ligand binding domain
-
Bledsoe R.K., Stewart E.L., and Pearce K.H. Structure and function of the glucocorticoid receptor ligand binding domain. Vitamin Horm 68 (2004) 49-91
-
(2004)
Vitamin Horm
, vol.68
, pp. 49-91
-
-
Bledsoe, R.K.1
Stewart, E.L.2
Pearce, K.H.3
-
68
-
-
33746081681
-
Human PXR forms a tryptophan zipper-mediated homodimer
-
Noble S.M., Carnahan V.E., Moore L.B., Luntz T., Wang H., Ittoop O.R., et al. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry 45 (2006) 8579-8589
-
(2006)
Biochemistry
, vol.45
, pp. 8579-8589
-
-
Noble, S.M.1
Carnahan, V.E.2
Moore, L.B.3
Luntz, T.4
Wang, H.5
Ittoop, O.R.6
-
69
-
-
33745821260
-
The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion
-
Oxelmark E., Roth J.M., Brooks P.C., Braunstein S.E., Schneider R.J., and Garabedian M.J. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol 26 (2006) 5205-5213
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5205-5213
-
-
Oxelmark, E.1
Roth, J.M.2
Brooks, P.C.3
Braunstein, S.E.4
Schneider, R.J.5
Garabedian, M.J.6
-
70
-
-
29244464699
-
Repressive domain of unliganded human estrogen receptor α associates with Hsc70
-
Ogawa S., Oishi H., Mezaki Y., Kouzu-Fujita M., Matsuyama R., Nakagomi M., et al. Repressive domain of unliganded human estrogen receptor α associates with Hsc70. Genes Cells 10 (2005) 1095-1102
-
(2005)
Genes Cells
, vol.10
, pp. 1095-1102
-
-
Ogawa, S.1
Oishi, H.2
Mezaki, Y.3
Kouzu-Fujita, M.4
Matsuyama, R.5
Nakagomi, M.6
-
71
-
-
0141592432
-
Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling
-
Oxelmark E., Knoblauch R., Arnal S., Su L.F., Schapira M., and Garabedian M.J. Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling. J Biol Chem 278 (2003) 36547-36555
-
(2003)
J Biol Chem
, vol.278
, pp. 36547-36555
-
-
Oxelmark, E.1
Knoblauch, R.2
Arnal, S.3
Su, L.F.4
Schapira, M.5
Garabedian, M.J.6
-
72
-
-
0033585002
-
Caveolin-1 potentiates estrogen receptor α (ERα) signaling. Caveolin-1 drives ligand-independent nuclear translocation and activation of ERα
-
Schlegel A., Wang C., Katzenellenbogen B.S., Pestell R.G., and Lisanti M.P. Caveolin-1 potentiates estrogen receptor α (ERα) signaling. Caveolin-1 drives ligand-independent nuclear translocation and activation of ERα. J Biol Chem 274 (1999) 33551-33556
-
(1999)
J Biol Chem
, vol.274
, pp. 33551-33556
-
-
Schlegel, A.1
Wang, C.2
Katzenellenbogen, B.S.3
Pestell, R.G.4
Lisanti, M.P.5
-
73
-
-
0032915424
-
Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction
-
Knoblauch R., and Garabedian M.J. Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol 19 (1999) 3748-3759
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3748-3759
-
-
Knoblauch, R.1
Garabedian, M.J.2
-
74
-
-
0032230245
-
Interaction and dissociation by ligands of estrogen receptor and Hsp90: the antiestrogen RU 58668 induces a protein synthesis-dependent clustering of the receptor in the cytoplasm
-
Devin-Leclerc J., Meng X., Delahaye F., Leclerc P., Baulieu E.E., and Catelli M.G. Interaction and dissociation by ligands of estrogen receptor and Hsp90: the antiestrogen RU 58668 induces a protein synthesis-dependent clustering of the receptor in the cytoplasm. Mol Endocrinol 12 (1998) 842-854
-
(1998)
Mol Endocrinol
, vol.12
, pp. 842-854
-
-
Devin-Leclerc, J.1
Meng, X.2
Delahaye, F.3
Leclerc, P.4
Baulieu, E.E.5
Catelli, M.G.6
-
75
-
-
0027985633
-
Heat shock protein 90 strongly stimulates the binding of purified estrogen receptor to its responsive element
-
Inano K., Curtis S.W., Korach K.S., Omata S., and Horigome T. Heat shock protein 90 strongly stimulates the binding of purified estrogen receptor to its responsive element. J Biochem (Tokyo) 116 (1994) 759-766
-
(1994)
J Biochem (Tokyo)
, vol.116
, pp. 759-766
-
-
Inano, K.1
Curtis, S.W.2
Korach, K.S.3
Omata, S.4
Horigome, T.5
-
76
-
-
0037643416
-
Molecular mechanisms of glucocorticoid action and resistance
-
Schaaf M.J., and Cidlowski J.A. Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol 83 (2002) 37-48
-
(2002)
J Steroid Biochem Mol Biol
, vol.83
, pp. 37-48
-
-
Schaaf, M.J.1
Cidlowski, J.A.2
-
77
-
-
18144392361
-
Requirements for estrogen receptor alpha membrane localization and function
-
Evinger III A.J., and Levin E.R. Requirements for estrogen receptor alpha membrane localization and function. Steroids 70 (2005) 361-363
-
(2005)
Steroids
, vol.70
, pp. 361-363
-
-
Evinger III, A.J.1
Levin, E.R.2
-
78
-
-
12344307170
-
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
-
Thomas P., Pang Y., Filardo E.J., and Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 (2005) 624-632
-
(2005)
Endocrinology
, vol.146
, pp. 624-632
-
-
Thomas, P.1
Pang, Y.2
Filardo, E.J.3
Dong, J.4
-
79
-
-
14844343093
-
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
-
Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., and Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307 (2005) 1625-1630
-
(2005)
Science
, vol.307
, pp. 1625-1630
-
-
Revankar, C.M.1
Cimino, D.F.2
Sklar, L.A.3
Arterburn, J.B.4
Prossnitz, E.R.5
-
80
-
-
33747841976
-
Nature of functional estrogen receptors at the plasma membrane
-
Pedram A., Razandi M., and Levin E.R. Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol 20 (2006) 1996-2009
-
(2006)
Mol Endocrinol
, vol.20
, pp. 1996-2009
-
-
Pedram, A.1
Razandi, M.2
Levin, E.R.3
-
81
-
-
0042815093
-
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
-
Brychzy A., Rein T., Winklhofer K.F., Hartl F.U., Young J.C., and Obermann W.M. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J 22 (2003) 3613-3623
-
(2003)
EMBO J
, vol.22
, pp. 3613-3623
-
-
Brychzy, A.1
Rein, T.2
Winklhofer, K.F.3
Hartl, F.U.4
Young, J.C.5
Obermann, W.M.6
-
82
-
-
33751552134
-
Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, DNA, and coregulators associated with alterations in estrogen and tamoxifen activity
-
Likhite V.S., Stossi F., Kim K., Katzenellenbogen B.S., and Katzenellenbogen J.A. Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, DNA, and coregulators associated with alterations in estrogen and tamoxifen activity. Mol Endocrinol (2006)
-
(2006)
Mol Endocrinol
-
-
Likhite, V.S.1
Stossi, F.2
Kim, K.3
Katzenellenbogen, B.S.4
Katzenellenbogen, J.A.5
-
83
-
-
33344475383
-
Antagonist-induced, activation function-2-independent estrogen receptor α phosphorylation
-
Lipfert L., Fisher J.E., Wei N., Scafonas A., Su Q., Yudkovitz J., et al. Antagonist-induced, activation function-2-independent estrogen receptor α phosphorylation. Mol Endocrinol 20 (2006) 516-533
-
(2006)
Mol Endocrinol
, vol.20
, pp. 516-533
-
-
Lipfert, L.1
Fisher, J.E.2
Wei, N.3
Scafonas, A.4
Su, Q.5
Yudkovitz, J.6
-
84
-
-
0036318571
-
Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation
-
Lee H., and Bai W. Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Mol Cell Biol 22 (2002) 5835-5845
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5835-5845
-
-
Lee, H.1
Bai, W.2
-
85
-
-
0025775736
-
Identification of phosphorylated sites in the mouse glucocorticoid receptor
-
Bodwell J.E., Orti E., Coull J.M., Pappin D.J., Smith L.I., and Swift F. Identification of phosphorylated sites in the mouse glucocorticoid receptor. J Biol Chem 266 (1991) 7549-7555
-
(1991)
J Biol Chem
, vol.266
, pp. 7549-7555
-
-
Bodwell, J.E.1
Orti, E.2
Coull, J.M.3
Pappin, D.J.4
Smith, L.I.5
Swift, F.6
-
86
-
-
0029093343
-
Role of acidic and phosphorylated residues in gene activation by the glucocorticoid receptor
-
Almlof T., Wright A.P., and Gustafsson J.A. Role of acidic and phosphorylated residues in gene activation by the glucocorticoid receptor. J Biol Chem 270 (1995) 17535-17540
-
(1995)
J Biol Chem
, vol.270
, pp. 17535-17540
-
-
Almlof, T.1
Wright, A.P.2
Gustafsson, J.A.3
-
87
-
-
0033523006
-
Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton
-
Galigniana M.D., Housley P.R., DeFranco D.B., and Pratt W.B. Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton. J Biol Chem 274 (1999) 16222-16227
-
(1999)
J Biol Chem
, vol.274
, pp. 16222-16227
-
-
Galigniana, M.D.1
Housley, P.R.2
DeFranco, D.B.3
Pratt, W.B.4
-
88
-
-
0037450436
-
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
-
Pascussi J.M., Gerbal-Chaloin S., Drocourt L., Maurel P., and Vilarem M.J. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 1619 (2003) 243-253
-
(2003)
Biochim Biophys Acta
, vol.1619
, pp. 243-253
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Drocourt, L.3
Maurel, P.4
Vilarem, M.J.5
-
89
-
-
0035659943
-
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor
-
Pascussi J.M., Drocourt L., Gerbal-Chaloin S., Fabre J.M., Maurel P., and Vilarem M.J. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 268 (2001) 6346-6358
-
(2001)
Eur J Biochem
, vol.268
, pp. 6346-6358
-
-
Pascussi, J.M.1
Drocourt, L.2
Gerbal-Chaloin, S.3
Fabre, J.M.4
Maurel, P.5
Vilarem, M.J.6
-
90
-
-
0029871817
-
Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose
-
Agrawal A.K., and Shapiro B.H. Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. Mol Pharmacol 49 (1996) 523-531
-
(1996)
Mol Pharmacol
, vol.49
, pp. 523-531
-
-
Agrawal, A.K.1
Shapiro, B.H.2
-
91
-
-
0030835437
-
Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley rats
-
Chang T.K.H., Anderson M.D., Bandiera S.M., and Bellward G.D. Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley rats. Drug Metab Dispos 25 (1997) 994-1000
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 994-1000
-
-
Chang, T.K.H.1
Anderson, M.D.2
Bandiera, S.M.3
Bellward, G.D.4
-
92
-
-
0035132641
-
Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers
-
Yoshinari K., Sueyoshi T., Moore R., and Negishi M. Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers. Mol Pharmacol 59 (2001) 278-284
-
(2001)
Mol Pharmacol
, vol.59
, pp. 278-284
-
-
Yoshinari, K.1
Sueyoshi, T.2
Moore, R.3
Negishi, M.4
-
93
-
-
0037072887
-
Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators
-
Min G., Kim H., Bae Y., Petz L., and Kemper J.K. Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. J Biol Chem 277 (2002) 34626-34633
-
(2002)
J Biol Chem
, vol.277
, pp. 34626-34633
-
-
Min, G.1
Kim, H.2
Bae, Y.3
Petz, L.4
Kemper, J.K.5
-
94
-
-
0033061636
-
Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers
-
Ganem L.G., Trottier E., Anderson A., and Jefcoate C.R. Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers. Toxicol Appl Pharmacol 155 (1999) 32-42
-
(1999)
Toxicol Appl Pharmacol
, vol.155
, pp. 32-42
-
-
Ganem, L.G.1
Trottier, E.2
Anderson, A.3
Jefcoate, C.R.4
-
95
-
-
0033039910
-
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension
-
Kietzmann T., Hirsch-Ernst K.I., Kahl G.F., and Jungermann K. Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension. Mol Pharmacol 56 (1999) 46-53
-
(1999)
Mol Pharmacol
, vol.56
, pp. 46-53
-
-
Kietzmann, T.1
Hirsch-Ernst, K.I.2
Kahl, G.F.3
Jungermann, K.4
-
96
-
-
1642454578
-
Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region
-
Bauer D., Wolfram N., Kahl G.F., and Hirsch-Ernst K.I. Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region. Mol Pharmacol 65 (2004) 172-180
-
(2004)
Mol Pharmacol
, vol.65
, pp. 172-180
-
-
Bauer, D.1
Wolfram, N.2
Kahl, G.F.3
Hirsch-Ernst, K.I.4
-
97
-
-
4644240254
-
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance
-
Assenat E., Gerbal-Chaloin S., Larrey D., Saric J., Fabre J.M., Maurel P., et al. Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 40 (2004) 951-960
-
(2004)
Hepatology
, vol.40
, pp. 951-960
-
-
Assenat, E.1
Gerbal-Chaloin, S.2
Larrey, D.3
Saric, J.4
Fabre, J.M.5
Maurel, P.6
-
98
-
-
31144440344
-
Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration
-
Thasler W.E., Dayoub R., Muhlbauer M., Hellerbrand C., Singer T., Grabe A., et al. Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration. J Pharmacol Exp Ther 316 (2006) 822-829
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 822-829
-
-
Thasler, W.E.1
Dayoub, R.2
Muhlbauer, M.3
Hellerbrand, C.4
Singer, T.5
Grabe, A.6
-
99
-
-
0034637122
-
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
-
Pascussi J.M., Gerbal-Chaloin S., Pichard-Garcia L., Daujat M., Fabre J.M., Maurel P., et al. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 274 (2000) 707-713
-
(2000)
Biochem Biophys Res Commun
, vol.274
, pp. 707-713
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Pichard-Garcia, L.3
Daujat, M.4
Fabre, J.M.5
Maurel, P.6
-
100
-
-
30944463481
-
Gadd45β is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia
-
Columbano A., Ledda-Columbano G.M., Pibiri M., Cossu C., Menegazzi M., Moore D.D., et al. Gadd45β is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology 42 (2005) 1118-1126
-
(2005)
Hepatology
, vol.42
, pp. 1118-1126
-
-
Columbano, A.1
Ledda-Columbano, G.M.2
Pibiri, M.3
Cossu, C.4
Menegazzi, M.5
Moore, D.D.6
-
101
-
-
0036144190
-
Ligands have various potential effects on the degradation of pregnane X receptor by proteasome
-
Masuyama H., Inoshita H., Hiramatsu Y., and Kudo T. Ligands have various potential effects on the degradation of pregnane X receptor by proteasome. Endocrinology 143 (2002) 55-61
-
(2002)
Endocrinology
, vol.143
, pp. 55-61
-
-
Masuyama, H.1
Inoshita, H.2
Hiramatsu, Y.3
Kudo, T.4
-
102
-
-
0033636597
-
Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
-
Chen D., Riedl T., Washbrook E., Pace P.E., Coombes R.C., Egly J.M., et al. Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. Mol Cell 6 (2000) 127-137
-
(2000)
Mol Cell
, vol.6
, pp. 127-137
-
-
Chen, D.1
Riedl, T.2
Washbrook, E.3
Pace, P.E.4
Coombes, R.C.5
Egly, J.M.6
-
103
-
-
0037051987
-
MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor α
-
Lu Q., Ebling H., Mittler J., Baur W.E., and Karas R.H. MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor α. FEBS Lett 516 (2002) 1-8
-
(2002)
FEBS Lett
, vol.516
, pp. 1-8
-
-
Lu, Q.1
Ebling, H.2
Mittler, J.3
Baur, W.E.4
Karas, R.H.5
-
104
-
-
0036794281
-
Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
-
Itoh M., Adachi M., Yasui H., Takekawa M., Tanaka H., and Imai K. Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation. Mol Endocrinol 16 (2002) 2382-2392
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2382-2392
-
-
Itoh, M.1
Adachi, M.2
Yasui, H.3
Takekawa, M.4
Tanaka, H.5
Imai, K.6
-
105
-
-
0026406078
-
Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors
-
DeFranco D.B., Qi M., Borror K.C., Garabedian M.J., and Brautigan D.L. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol Endocrinol 5 (1991) 1215-1228
-
(1991)
Mol Endocrinol
, vol.5
, pp. 1215-1228
-
-
DeFranco, D.B.1
Qi, M.2
Borror, K.C.3
Garabedian, M.J.4
Brautigan, D.L.5
-
106
-
-
28144439277
-
CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha
-
Fan M., Park A., and Nephew K.P. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Mol Endocrinol 19 (2005) 2901-2914
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2901-2914
-
-
Fan, M.1
Park, A.2
Nephew, K.P.3
-
107
-
-
0037351881
-
Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling
-
Reid G., Hubner M.R., Metivier R., Brand H., Denger S., Manu D., et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Mol Cell 11 (2003) 695-707
-
(2003)
Mol Cell
, vol.11
, pp. 695-707
-
-
Reid, G.1
Hubner, M.R.2
Metivier, R.3
Brand, H.4
Denger, S.5
Manu, D.6
-
108
-
-
19944428232
-
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor
-
Tateishi Y., Kawabe Y., Chiba T., Murata S., Ichikawa K., Murayama A., et al. Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J 23 (2004) 4813-4823
-
(2004)
EMBO J
, vol.23
, pp. 4813-4823
-
-
Tateishi, Y.1
Kawabe, Y.2
Chiba, T.3
Murata, S.4
Ichikawa, K.5
Murayama, A.6
-
109
-
-
33750338745
-
Turning off estrogen receptor β-mediated transcription requires estrogen-dependent receptor proteolysis
-
Tateishi Y., Sonoo R., Sekiya Y.I., Sunahara N., Kawano M., Wayama M., et al. Turning off estrogen receptor β-mediated transcription requires estrogen-dependent receptor proteolysis. Mol Cell Biol (2006)
-
(2006)
Mol Cell Biol
-
-
Tateishi, Y.1
Sonoo, R.2
Sekiya, Y.I.3
Sunahara, N.4
Kawano, M.5
Wayama, M.6
-
110
-
-
0035146685
-
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
-
Connell P., Ballinger C.A., Jiang J., Wu Y., Thompson L.J., Hohfeld J., et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 3 (2001) 93-96
-
(2001)
Nat Cell Biol
, vol.3
, pp. 93-96
-
-
Connell, P.1
Ballinger, C.A.2
Jiang, J.3
Wu, Y.4
Thompson, L.J.5
Hohfeld, J.6
-
111
-
-
0035900780
-
Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids
-
Wallace A.D., and Cidlowski J.A. Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J Biol Chem 276 (2001) 42714-42721
-
(2001)
J Biol Chem
, vol.276
, pp. 42714-42721
-
-
Wallace, A.D.1
Cidlowski, J.A.2
-
112
-
-
0028786089
-
Distinct functions of the 90 kDa heat-shock protein (hsp90) in oestrogen and mineralocorticosteroid receptor activity: effects of hsp90 deletion mutants
-
Binart N., Lombes M., and Baulieu E.E. Distinct functions of the 90 kDa heat-shock protein (hsp90) in oestrogen and mineralocorticosteroid receptor activity: effects of hsp90 deletion mutants. Biochem J 311 (1995) 797-804
-
(1995)
Biochem J
, vol.311
, pp. 797-804
-
-
Binart, N.1
Lombes, M.2
Baulieu, E.E.3
-
113
-
-
2442537231
-
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
-
Pratt W.B., Galigniana M.D., Harrell J.M., and DeFranco D.B. Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. Cell Signal 16 (2004) 857-872
-
(2004)
Cell Signal
, vol.16
, pp. 857-872
-
-
Pratt, W.B.1
Galigniana, M.D.2
Harrell, J.M.3
DeFranco, D.B.4
-
114
-
-
0037085381
-
A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
-
Davies T.H., Ning Y.M., and Sanchez E.R. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem 277 (2002) 4597-4600
-
(2002)
J Biol Chem
, vol.277
, pp. 4597-4600
-
-
Davies, T.H.1
Ning, Y.M.2
Sanchez, E.R.3
-
115
-
-
22344454972
-
G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
-
Kino T., Tiulpakov A., Ichijo T., Chheng L., Kozasa T., and Chrousos G.P. G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J Cell Biol 169 (2005) 885-896
-
(2005)
J Cell Biol
, vol.169
, pp. 885-896
-
-
Kino, T.1
Tiulpakov, A.2
Ichijo, T.3
Chheng, L.4
Kozasa, T.5
Chrousos, G.P.6
-
116
-
-
2342447986
-
Importin 7 and importin α/importin β are nuclear import receptors for the glucocorticoid receptor
-
Freedman N.D., and Yamamoto K.R. Importin 7 and importin α/importin β are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell 15 (2004) 2276-2286
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2276-2286
-
-
Freedman, N.D.1
Yamamoto, K.R.2
-
117
-
-
0035825129
-
Calreticulin is a receptor for nuclear export
-
Holaska J.M., Black B.E., Love D.C., Hanover J.A., Leszyk J., and Paschal B.M. Calreticulin is a receptor for nuclear export. J Cell Biol 152 (2001) 127-140
-
(2001)
J Cell Biol
, vol.152
, pp. 127-140
-
-
Holaska, J.M.1
Black, B.E.2
Love, D.C.3
Hanover, J.A.4
Leszyk, J.5
Paschal, B.M.6
-
118
-
-
0141844466
-
Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin
-
Walther R.F., Lamprecht C., Ridsdale A., Groulx I., Lee S., Lefebvre Y.A., et al. Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin. J Biol Chem 278 (2003) 37858-37864
-
(2003)
J Biol Chem
, vol.278
, pp. 37858-37864
-
-
Walther, R.F.1
Lamprecht, C.2
Ridsdale, A.3
Groulx, I.4
Lee, S.5
Lefebvre, Y.A.6
-
119
-
-
0038152840
-
Protein 14-3-3σ interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway
-
Kino T., Souvatzoglou E., De Martino M.U., Tsopanomihalu M., Wan Y., and Chrousos G.P. Protein 14-3-3σ interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. J Biol Chem 278 (2003) 25651-25656
-
(2003)
J Biol Chem
, vol.278
, pp. 25651-25656
-
-
Kino, T.1
Souvatzoglou, E.2
De Martino, M.U.3
Tsopanomihalu, M.4
Wan, Y.5
Chrousos, G.P.6
-
120
-
-
0033534727
-
Ligand-independent activation of the glucocorticoid receptor by β2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells
-
Eickelberg O., Roth M., Lorx R., Bruce V., Rudiger J., Johnson M., et al. Ligand-independent activation of the glucocorticoid receptor by β2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 274 (1999) 1005-1010
-
(1999)
J Biol Chem
, vol.274
, pp. 1005-1010
-
-
Eickelberg, O.1
Roth, M.2
Lorx, R.3
Bruce, V.4
Rudiger, J.5
Johnson, M.6
-
121
-
-
0029899120
-
Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import
-
Carey K.L., Richards S.A., Lounsbury K.M., and Macara I.G. Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import. J Cell Biol 133 (1996) 985-996
-
(1996)
J Cell Biol
, vol.133
, pp. 985-996
-
-
Carey, K.L.1
Richards, S.A.2
Lounsbury, K.M.3
Macara, I.G.4
|