High-throughput human metabolism and toxicity analysis

Current Opinion in Biotechnology

Volumn 17, Issue 6, 2006, Pages 619-627

  Lee, Moo Yeal ^a   Dordick, Jonathan S ^b  

^a Solidus Biosciences Inc   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; HUMAN ENGINEERING; OPTIMIZATION; SCREENING; TOXICITY;

DRUG DISCOVERY; HUMAN METABOLISM; PHARMACEUTICAL INDUSTRY;

METABOLISM;

AMINO ACID; ANTINEOPLASTIC AGENT; BENOXAPROFEN; BENZOQUINONE; BROMFENAC; CYCLOPHOSPHAMIDE; CYTOCHROME P450; DRUG METABOLIZING ENZYME; GLUTATHIONE; LIVER ENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; TEGAFUR; XENOBIOTIC AGENT;

ACETYLATION; CATALYSIS; CHO CELL; CRYOPRESERVATION; DRUG CLEARANCE; DRUG COST; DRUG ELIMINATION; DRUG INDUSTRY; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DRUG TRANSFORMATION; ELECTROPHORESIS; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME INDUCTION; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IC 50; IN VIVO STUDY; LIVER; LIVER TOXICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SULFATION; ULTRAVIOLET IRRADIATION;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PHYSIOLOGY; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HUMANS; METABOLISM; ROBOTICS; TOXICITY TESTS;

EID: 33751248731     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2006.09.003     Document Type: Review

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