Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

Biochemical Journal

Volumn 392, Issue 2, 2005, Pages 249-261

  Orton, Richard J ^a   Sturm, Oliver E ^a   Vyshemirsky, Vladislav ^a   Calder, Muffy ^a   Gilbert, David R ^a   Kolch, Walter ^b,c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Computational modelling; Extracellular signal regulated kinase (ERK); Mitogen activated protein kinase (MAPK); Receptor tyrosine kinase; Signalling network; Systems biology

Indexed keywords

CELLS; COMPUTATIONAL METHODS; COMPUTER SIMULATION; DRUG DOSAGE; IMMUNOLOGY; MATHEMATICAL MODELS; TUMORS;

COMPUTATIONAL MODELING; EXTRACELLULAR-SIGNAL-REGULATED KINASE (ERK); MITOGEN-ACTIVATED PROTEIN KINASE (MAPK); RECEPTOR TYROSINE KINASE; SIGNALLING NETWORK; SYSTEMS BIOLOGY;

ENZYMES;

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

COMPUTER PROGRAM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; MATHEMATICAL MODEL; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SIMULATION; VALIDATION PROCESS;

ANIMALS; COMPUTER SIMULATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 29144435996     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050908     Document Type: Review

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