Quantitative cationic-activity relationships for predicting toxicity of metals

Environmental Toxicology and Chemistry

Volumn 22, Issue 8, 2003, Pages 1916-1935

  Walker, John D ^a   Enache, Monica ^b   Dearden, John C ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Inorganic chemicals; Metals; Quantitive structure activity relationships; Toxicity

Indexed keywords

BINDING ENERGY; COMPLEXATION; CORRELATION METHODS; POSITIVE IONS;

CATIONIC ACTIVITY;

TOXICITY;

ALUMINUM; ARSENIC; CALMODULIN; CATION; HEAVY METAL; MERCURY; ION; METAL;

ACUTE TOXICITY; BINDING AFFINITY; HEAVY METAL POISONING; IONIZATION; LC 50; LD 50; LIGAND BINDING; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; TOXICITY TESTING; ANIMAL; BIOASSAY; CHEMISTRY; FORECASTING; HUMAN; MAMMAL; METHODOLOGY; POLLUTANT; THEORETICAL MODEL;

ANIMALIA; MAMMALIA;

ANIMALS; BIOLOGICAL ASSAY; CHEMISTRY, PHYSICAL; ENVIRONMENTAL POLLUTANTS; FORECASTING; HUMANS; IONS; MAMMALS; METALS; MODELS, THEORETICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037923585     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/02-568     Document Type: Review

References (128)

1. Chang LW, Cockerham LG. 1994. Toxic metals in the environment. In Cockerham LG, Shane BS, eds, Basic Environmental Toxicology. CRC, Boca Raton, FL, USA, pp 109-132.
2. Gough LP, Shacklette HT, Case AA. 1979. Element concentrations toxic to plants, animals, and man. Bulletin 1466. U.S. Geology Survey, Reston, VA.
3. Luckey TD, Venugopal B. 1977. Metal Toxicity in Mammals, Vol 1-Physiologic and Chemical Basis for Metal Toxicity. Plenum, New York, NY, USA.
4. Venugopal B, Luckey TD. 1978. Metal Toxicity in Mammals, Vol 2-Chemical Toxicity of Metals and Metalloids. Plenum, New York, NY, USA.
5. Krantzberg G. 1989. Accumulation of essential and nonessential metals by Chironomid larvae in relation to physical and chemical properties of the elements. Can J Fish Aquat Sci 46:1755-1761.
6. Walker JD. 2003. QSARs for pollution prevention, toxicity screening, risk assessment and web applications-future challenges, Chapter 17. In Walker JD, ed, QSARs for Pollution Prevention, Toxicity Screening, Risk Assessment and Web Applications. SETAC, Pensacola, FL, USA (in press).
7. Pearson RG. 1963. Physical and inorganic chemistry. J Am Chem Soc 85:3533-3539.
8. Pearson RG. 1966. Acids and bases. Science 151:172-177.
9. Pearson RG. 1967. Hard and soft acids and bases. Chem Br 3:103-107.
10. Pearson RG. 1968. Hard and soft acids and bases, HSAB, Part I. Fundamental principles. J Chem Educ 45:581-587.
11. Pearson RG. 1968. Hard and soft acids and bases, HSAB, Part II. Underlying theories. J Chem Educ 45:643-648.
12. Reedijk J. 1996. Polymer-Metal Complexes in Living Systems. In Ciardelli F, Tsuchida E, Wöhrle D, eds, Macromolecule-Metal Complexes. Springer-Verlag, Heidelberg, Germany, pp 131-151.
13. Irving H, Williams RJP. 1948. Order of stability of metal complexes. Nature 162:746.
14. Irving HM, Williams RJP. 1953. Stability of transitional metal complexes. J Chem Soc 3192-3210.
15. Shaw WHR. 1961. Cation toxicity and the stability of transition-metal complexes. Nature 192:754-755.
16. Gorsuch JW, Janssen CR, Lee CM, Reiley MC, eds. 2002. The biotic ligand model for metals-current research, future directions, regulatory implications. Comp Biochem Physiol 133:1-343.
17. Kleinberg J, Angersinger WJ Jr, Griswold E. 1960. Inorganic Chemistry. DC Heath, Boston, MA, USA.
18. Dearden JC. 1991. The QSAR prediction of melting point, a property of environmental relevance. In Hermens JLM, Opperhuizen A, eds, QSAR in Environmental Toxicology - IV. Elsevier, Amsterdam, The Netherlands, pp 59-69.
19. Dearden JC. 1999. The prediction of melting point. Advances in Quantitative Structure Property Relationships 2:127-175.
20. Dearden JC. 2003. Quantitative structure-activity relationships for prediction of boiling point, vapor pressure and melting point. Enviro Toxicol Chem 22:1696-1709.
21. Jacobson KB, Turner JE. 1980. The interaction of cadmium and certain other metal ions with proteins and nucleic acids. Toxicology 16:1-37.
22. Jørgensen CK. 1975. Continuum effects indicated by hard and soft antibases (Lewis acids) and bases. Top Curr Chem 56:1-66.
23. Dearden JC. 1990. Physico-chemical descriptors. In Karcher W, Devillers I, eds, Practical Applications of Quantitative Structure-Activity Relationships (QSAR) in Environmental Chemistry and Toxicology. Kluwer Academic, Dordrecht, The Netherlands, pp 25-59.
24. Hoeschele JD, Turner JE, England MW. 1991. Inorganic concepts relevant to metal binding, activity, and toxicity in a biological system. In Hermens JLM, Opperhuizen A, eds, QSAR in Environmental Toxicology - IV. Elsevier, The Netherlands, pp 477-492.
25. Rossotti FJC. 1960. The thermodynamics of metal ion complex formation in solution. In Lewis J, Wilkins RG, eds, Modern Coordination Chemistry. Principles and Methods. Interscience, New York, NY, USA, pp 1-77.
26. Yatsimirskii KB. 1994. Electronic structure, energy of hydration, and stability of metal aquo ions. Theor Exp Chem 30:1-9.
27. Kaiser KLE. 1980. Correlation and prediction of metal toxicity to aquatic biota. Can J Fish Aquat Sci 37:211-218.
28. Filov VA, Golubev AA, Liublina EI, Tolokontsev NA. 1978. Quantitative Toxicology. Wiley-Interscience, New York, NY, USA.
29. Botkin S. 1885. Zur Frage über den Zusammenhang der physiologischen Wirkung mit den chemischen Eigenschaften der Alkali-metalle der ersten Gruppe nach Mendelejeff. Centralbl Med Wiss 48:849-864.
30. Nieboer E, Richardson DHS. 1980. The replacement of the nondescript term "heavy metals" by a biologically and chemically significant classification of metal ions. Environ Pollut Ser B 1:3-26.
31. Nieboer E, McBryde WAE. 1973. Free-energy relationships in coordination chemistry. III. A comprehensive index to complex stability. Can J Chem 51:2512-2524.
32. Turner DR, Whitfield M, Dickson AG. 1981. The equilibrium speciation of dissolved components in freshwater and seawater at 25°C and 1 atm pressure. Geochim Cosmochim Acta 45:855-881.
33. Newman MC, McCloskey JT. 1996. Predicting relative toxicity and interactions of divalent metal ions: Microtox® bioluminescence assay. Environ Toxicol Chem 15:275-281.
34. Klopman G. 1968. Chemical reactivity and the concept of charge- and frontier-controlled reactions. J Am Chem Soc 90:223-234.
35. McCloskey JT, Newman MC, Clark SB. 1996. Predicting the relative toxicity of metal-ions using ion characteristics: Microtox® bioluminescence assay. Environ Toxicol Chem 15:1730-1737.
36. Baes CF Jr, Mesmer RE. 1976. The Hydrolysis of Cations. John Wiley, New York, NY, USA.
37. Turner JE, Williams MW, Hingerty BE, Hayden TL. 1987. Multiparameter correlations between properties of metal ions and their acute toxicity in mice. In Kaiser KLE, Reidel D, eds, QSAR in Environmental Toxicology - II. Dordrecht, The Netherlands, pp 375-383.
38. Brezonik PL, King SO, March CE. 1991. The influence of water chemistry on trace metal bioavailability and toxicity to aquatic organisms. In Newman MC, McIntosh AW, eds, Metal Ecotoxicology: Concepts and Applications. Lewis, Boca Raton, FL, USA, pp 1-31.
39. Newman MC, Jagoe CH. 1994. Ligands and the bioavailability of metals in aquatic environments. In Hamelink JL, Landrum PF, Bergman HL, Benson WH, eds. Bioavailability: Physical, Chemical and Biological Interactions. CRC, Boca Raton, FL, USA, pp 39-61.
40. Pearson RG, Mawby RJ. 1967. The nature of metal-halogen bonds. In Gutmann V, ed, Halogen Chemistry, Vol 3. Academic, London, UK, pp 55-84.
41. Ahrland S. 1968. Scales of softness for acceptors and donors. Chem Phys Lett 2:303-306.
42. Blake J. 1839. Mémoire sur les effets de diverses substances salines injectées dans le système circulatoire. Arch Gen Med Chem 6:289-300.
43. Kahlenberg L, True RH. 1896. On the toxic action of dissolved salts and their electrolytic dissociation. Bot Gaz 12:81-124.
44. Heald FD. 1896. On the toxic effect of dilute solutions of acids and salts upon plants. Bot Gaz 22:125-153.
45. Krönig B, Paul T. 1897. Die chemischen Grundlagen der Lehre von der Giftwirkung und Desinfection. In Koch R, Flügge C, eds, Zeitschrift für Hygiene und Infectionskrankheiten. Verlag von Veit, Leipzig, Germany, pp 1-113.
46. Mathews AP. 1902. The nature of nerve stimulation and of changes in irritability. Science 15:492-498.
47. Lillie RS. 1904. The relation of ions to ciliary movement. Am J Physiol 10:419-443.
48. Loeb J. 1902. Studies on the physiological effects of the valency and possibly the electrical charges of ions. I. The toxic and antitoxic effects of ions as a function of their valency and possibly their electrical charge. Am J Physiol 6:411-433.
49. Richet C. 1881. De la toxicité comparée des différents métaux. CR Acad Sci Paris 93:649-651.
50. Richet C. 1882. De l'action chimique des différents métaux sur le coeur de la grenouille. CR Acad Sci Paris 94:742-743.
51. Binet P. 1892. Sur la toxicité comparée des mètaux alcalins et alcalino-terreux. CR Acad Sci Paris 115:251-253.
52. Blake J. 1884. On the connection between physiological action and chemical constitution. J Physiol 5:35-44.
53. Mathews AP. 1903. The nature of nerve irritability and of chemical and electrical stimulation. Part II. Science 17:729-733.
54. Mathews AP. 1904. The relation between solution tension atomic volume and the physiological action of the elements. Am J Physiol 10:290-323.
55. Mathews AP. 1905. The toxic and anti-toxic action of salts. Am J Physiol 12:419-443.
56. McGuigan H. 1904. The relation between the decomposition-tension of salts and their antifermentative properties. Am J Physiol 10:444-451.
57. Woodruff LL, Bunzel HH. 1909. The relative toxicity of various salts and acids toward Paramecium. Am J Physiol 25:190-194.
58. Jones JRE. 1939. The relation between the electrolytic solution pressures of the metals and their toxicity to the stickleback (Gasterosteus aculeatus L.). J Exp Biol 16:425-437.
59. Jones JRE. 1940. A further study of the relation between toxicity and solution pressure with Polycelis nigra as test animal. J Exp Biol 17:408-415.
60. Danielli JF. 1950. Cell Physiology and Pharmacology. Elsevier, Amsterdam, The Netherlands, pp 30-32.
61. Joseph DR, Meltzer SJ. 1909. The comparative toxicity of the chlorides of magnesium, calcium, potassium, and sodium. J Pharmacol 1:1-26.
62. True RH. 1930. The toxicity of molecules and ions. Proc Am Philos Soc 69:231-245.
63. Seifriz W. 1949. Toxicity and the chemical properties of ions. Science 110:193-196.
64. Danielli JF, Davis JT. 1951. Reactions at interfaces in relation to biological problems. Advan Enzymol Relat Subj Biochem 11:35-89.
65. Fildes P. 1947. The mechanism of the anti-bacterial action of mercury. Br J Exp Pathol 67-73.
66. Barron SG, Kalnitsky JJ. 1947. The inhibition of succinoxidase by heavy metals and its reactivation with dithiols. Biochem J 41:346-51.
67. Shaw WHR. 1954. The inhibition of urease by various metal ions. J Am Chem Soc 76:2160-2163.
68. Shaw WHR. 1954. Toxicity of cations toward living systems. Science 120:361-363.
69. Grushkin B. 1956. Some Effects of Metals on Living Systems. MS thesis. The University of Texas, Austin, TX, USA.
70. Shaw WHR, Grushkin B. 1957. The toxicity of metal ions to aquatic organisms. Arch Biochem Biophys 67:447-452.
71. Khangarot BS, Ray PK. 1989. Investigation of correlation between physico-chemical properties of metals and their toxicity to the water flea Daphnia magna Straus. Ecotoxicol Environ Saf 18:109-120.
72. Somers E. 1959. Fungitoxicity of metal ions. Nature 184:475-476.
73. Ahrland S, Chatt J, Davies NR. 1958. The relative affinities of ligand atoms for acceptor molecules and ions. Q Rev Chem Soc Lond 12:265-276.
74. Bienvenu P, Nofre C, Cier A. 1963. Toxicité géné rale comparée des ions métalliques. Comptes rendus de l'Académie des Sciences 256:1043-1044.
75. Nofre C, Dufour H, Cier A. 1963. Toxicité générale comparée des anions minéraux chez la souris. CR Acad Sci Paris 257:791-794.
76. Saccardo P. 1955. Rappresentaz periòdica e tossicològica degli elementi. Chimica 31:411-414.
77. Tichy M, Krivucova M. 1976. Use of structure-activity relationships to estimate toxicity of inorganic cations. In Tichy M, ed, Quantitative Structure-Activity Relationships. Akademiai Kiado, Budapest, Hungary, pp 83-84.
78. Biesinger KL, Christensen GM. 1972. Effects of various metals on survival growth reproduction and metabolism of Daphnia magna. J Fish Res Board Can 29:1691-1700.
79. Venugopal B, Luckey TD. 1975. Toxicology of nonradioactive heavy metals and their salts. In Luckey TP, ed, Heavy Metal Toxicity Safety and Hormology. Thieme Stuttgart, Germany, pp 4-73.
80. Jones MM, Vaughn WK. 1978. HSAB theory and acute metal ion toxicity and detoxification processes. J Inorg Nucl Chem 40:2081-2088.
81. Williams MW, Turner JE. 1981. Comments on softness parameters and metal ion toxicity. J Inorg Nucl Chem 43:1689-1691.
82. Hoeschele JD, Williams MW, Turner JE, Jacobson KB, Christie NT 1980. Analysis of softness parameters as potential numerical indices of acute metal ion toxicity. Abstr Pap Am Chem Soc 180:48-INOR.
83. Williams MW, Hoeschele JD, Turner JE, Jacobson KB, Christie NT, Paton CL, Smith LH, Witschi HR, Lee EH. 1982. Chemical softness and acute metal toxicity in mice and Drosophila. Toxicol Appl Pharmacol 63:461-469.
84. Williams RJP, Hale JD. 1966. The classification of acceptors and donors in inorganic reactions. Struct Bond 1:249-281.
85. Jacobson KB, Opresko L, Owenby RR, Christie NT. 1981. Effects of cadmium on Drosophila: Toxicity proteins and transfer RNAs. Toxicol Appl Pharmacol 60:368-378.
86. Jacobson KB, Turner JE, Christie NT, Owenby RK. 1983. Toxic and biochemical effects of divalent metal ions in Drosophila: Correlations to effects in mice and to chemical softness parameters. Sci Total Environ 28:355-366.
87. Turner JE, Lee EH, Jacobson KB, Christie NT, Williams MW, Hoeschele JD. 1983. Investigation of correlations between chemical parameters of metal ions and acute toxicity in mice and Drosophila. Sci Total Environ 28:343-354.
88. Turner JE, England MW, Hingerty BE, Hayden TL. 1988. Correlations between pairs of physicochemical parameters of metal ions and acute toxicity in mice. In Turner JE, England MW, Schultz TW, Kwaak NJ, eds, Proceedings, 3rd International Workshop Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology. CONF-880520-9DE88013180. U.S. Department of Energy, Washington, DC, USA, pp 215-216.
89. Bláha K Jr, Tichý M, Cikrt M, Havrdová J, Horákoá L. 1985. Effect of chelating agents on Cd distribution: QSAR study. In Tichý M, ed. QSAR in Toxicology and Xenobiochemistry. Elsevier Science, Amsterdam, The Netherlands, pp 183-190.
90. Eybl V, Skora J, Koutenský J, Mertl F, Jones MM. 1985. Interaction of some chelating agents with cadmium in vivo and the molecular connectivity. In Tichý M, ed, QSAR in Toxicology and Xenobiochemistry. Elsevier Science, Amsterdam, The Netherlands, pp 179-183.
91. England MW, Turner JE, Jacobson KB. 1988. Extrapolation of metal-ion toxicities across species to man. In Turner JE, England MW, Schultz TW, Kwaak NJ, eds, Proceedings, 3rd International Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology. CONF-880520-9DE88013180. National Technical Information Service, Springfield, VA, USA, pp 175-178.
92. Tan E-L, Williams MW, Schenley RL, Perdue SW, Hayden TL, Turner JE, Hsie AW. 1984. The toxicity of sixteen metallic compounds in Chinese hamster ovary cells. Toxicol Appl Pharmacol 74:330-336.
93. Turner JE, Williams MW, Jacobson KB, Hingerty BE. 1985. Correlations of acute toxicity of metal ions and the covalent/ ionic character of their bonds. In Tichy M, ed, QSAR in Toxicology and Xenobiochemistry. Elsevier, Amsterdam, The Netherlands, pp 171-178.
94. Babich H, Puerner JA, Borenfreund E. 1986. In vitro cytotoxicity of metal to bluegill (BF-2) cells. Arch Environ Contam Toxicol 15:31-37.
95. Magwood S, George S. 1996. In-vitro alternatives to whole animal testing-comparative cytotoxicity studies of divalent metals in established cell-lines derived from tropical and temperate water fish species in a neutral red assay. Mar Environ Res 42:37-40.
96. Segner H, Lenz D, Hanke W, Schüürmann G. 1994. Cytotoxicity of metals toward rainbow trout R1 cell-line. Environ Toxiicol Water Qual 9:273-279.
97. Sauvant MP, Pepin D, Bohatier J, Groliere CA, Guillot J. 1997. Toxicity assessment of 16 inorganic environmental pollutants by six bioassays. Ecotoxicol Environ Saf 37:131-140.
98. Cox JL, Harrison SD Jr. 1983. Correlation of metal toxicity with in vitro calmodulin inhibition. Biochem Biophys Res Commun 115:106-111.
99. Williams MW, Turner JE, Hsie AW. 1987. Calmodulin inhibition: A possible predictor of metal-ion toxicity. In Kaiser KLE, Reidel D, eds, QSAR in Environmental Toxicology - II. Dordrecht, The Netherlands, pp 401-405.
100. Kaiser KLE. 1984. Organic comtaminants in the environment: Research progress and needs. Environ Int 10:241-250.
101. Kaiser KLE. 1985. Correlation of metal ion toxicities to mice. Sci Total Environ 46:113-119.
102. Lithner G. 1989. Some fundamental relationships between metal toxicity in freshwater physico-chemical properties and background levels. Sci Total Environ 87/88:365-380.
103. Svanberg O, Lithner G. 1978. Evaluation of Harmful Effects of Heavy Metals on Aquatic Organisms. Seminar on Heavy Metals. Technological Methods for the Limitation of Discharges. Under the Convention on the Protection of the Marine Environment of the Baltic Sea Area, Copenhagen, Denmark. NBL Rep. 75. Swedish Environmental Protection Board.
104. Fisher NS. 1986. On the reactivity of metals for marine phytoplankton. Limnol Oceanogr 31:443-449.
105. Tatara CP, Newman MC, McCloskey JT, Williams PL. 1997. Predicting relative metal toxicity with ion characteristics: Caenorhabditis elegans LC50. Aquat Toxicol 39:279-290.
106. Tatara CP, Newman MC, McCloskey JT, Williams PL. 1998. Use of ion characteristics to predict relative toxicity of mono-, di-, and trivalent metal ions: Caenorhabditis elegans LC50. Aquat Toxicol. 42:255-269.
107. Newman MC, McCloskey JT, Tatara CP. 1998. Using metal-ligand binding characteristics to predict metal toxicity: Quantitative ion character-activity relationships (QICARs). Environ Health Perspect (Suppl. 6) 106:1419-1425.
108. Ownby DR, Newman MC. 2003. Advances in quantitative ion character-activity relationships (QICARs): Using metal-ligand binding characteristics to predict metal toxicity. QSAR Comb Sci 22:241-246.
109. Lewis DFV, Dobrota M, Taylor MG, Parke DV. 1999. Metal toxicity in two rodent species and redox potential: Evaluation of quantitative structure-activity relationships. Environ Toxicol Chem 18:2199-2204.
110. Sax NI, Lewis RJ. 1989. Dangerous Properties of Industrial Materials. Reinhold, New York, NY, USA.
111. Serrano ML, Barceló AR. 1996. Effect of metal ions on peroxidase activity from grapevine cells. Plant Physiol Biochem 34:827-832.
112. Enache M, Palit P, Dearden JC, Lepp NW. 1999. Evaluation of cation toxicities to sunflower: a study related to the assessment of environmental. Extended Abstracts, 5th International Conference on the Biogeochemistry of Trace Elements, Vol 2. Vienna, Austria, July 11-15, pp 1120-1121.
113. Enache M, Palit P, Dearden JC, Lepp NW. 2000. Correlation of physico-chemical parameters with toxicity of metal ions to plants. Pesticide Management Science 56:821-824.
114. Enache M, Dearden JC, Walker JD. 2003. QSAR analysis of metal ion toxicity data in sunflower callus cultures (Helianthus annuus, Sunspot). QSAR Comb Sci 22:239-240.
115. Walker JD, Hickey JP. 2000. QSARs for metals-fact or fiction? In Centeno JA, Colleery P, Vernet G, Finkelman RB, Gibb H, Etienne JC, eds, Metal Ions in Biology and Medicine. John Libbey Eurotext, Montrouge France, pp 401-405.
116. Cotton FA, Wilkinson G. 1980. Advanced Inorganic Chemisty: A Comprehensive Text, 4th ed. John Wiley, New York, NY, USA.
117. Greenwood NN, Earnshaw A. 1980. Chemistry of the Elements. Pergamon, New York, NY, USA.
118. Pearson RG. 1987. Recent advances in the concept of hard and soft acids and bases. J Chem Educ 64:561-567.
119. Pearson RG. 1993. The principle of maximum hardness. Accounts of Chemical Research 26:250-255.
120. Vouk V. 1979. General chemistry of metals. In Friberg L, Nordberg GF, Vouk VB, eds, Handbook on the Toxicology of Metals. Elsevier, Amsterdam, The Netherlands, pp 15-30.
121. Canada, Parliament. 1999. Canadian Environmental Protection Act, Chapter 33. Minister of Supply and Services Canada. Ottawa, ON, Canada.
122. MacDonald D, Breton R, Sutcliffe R, Walker JD. 2002. Uses and limitations of quantitative structure-activity relationships (QSARs) to categorize substances on the Canadian domestic substance list as persistent and/or bioaccumulative, and inherently toxic to nonhuman organisms. SAR/QSAR Environ Res 13:43-55.
123. Inorganic Working Group. 2001. Categorization of Inorganic Substances on the Domestic Substances List (DSL): Findings and Recommendations of the Inorganic Working Group (IWG). IWG Secretariat, Environment Canada, Hull, QC, Canada, p 29.
124. Shannon RD. 1976. Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Acta Cryst A32:751-767.
125. Shannon RD, Prewitt CT. 1969. Effective ionic radii in oxides and fluorides. Acta Crystallogr Sect B 25:925-946.
126. Shannon RD, Prewitt CT. 1970. Revised values of effective ionic radii. Acta Cryst B 26:1046-1048.
127. Levina EN. 1972. On relationships between solubility of metal compounds and their toxicity, distribution, and elimination from the body. Gig Tr Prof Zabo 1:40-43.
128. Misono M, Saito Y. 1970. Evaluation of softness from the stability constants of metal-ion complexes. Bull Chem Soc Japan 43:3680-3684.