Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat

Toxicological Sciences

Volumn 75, Issue 2, 2003, Pages 432-447

  Conolly, Rory B ^c   Kimbell, Julia S ^c   Janszen, Derek ^a,c   Schlosser, Paul M ^c   Kalisak, Darin ^c   Preston, Julian ^b,c   Miller, Frederick J ^c  

^a PFIZER INC   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Clonal growth; Computational modeling; DNA protein cross links; Dose response; F344 rat; Formaldehyde; Regenerative cellular proliferation; Risk assessment; Squamos cell carcinoma

Indexed keywords

CARCINOGEN; FORMALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENICITY; CELL DIVISION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DATA BASE; DOSE RESPONSE; GENE MUTATION; INHALATION; MATHEMATICAL COMPUTING; MAXIMUM LIKELIHOOD METHOD; MUTAGENICITY; NONHUMAN; NOSE CARCINOMA; PROTEIN DNA INTERACTION; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; REVIEW; SENSITIVITY ANALYSIS; SQUAMOUS CELL CARCINOMA; STATISTICAL PARAMETERS;

ADMINISTRATION, INHALATION; ANIMALS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; HUMANS; MODELS, BIOLOGICAL; NOSE NEOPLASMS; RATS; RATS, INBRED F344; RISK ASSESSMENT;

ANIMALIA; RODENTIA;

EID: 0141618447     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg182     Document Type: Review

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