Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

Archives of Toxicology

Volumn 70, Issue 11, 1996, Pages 704-713

  El Masri, Hisham A ^a   Thomas, Russell S ^a   Sabados, G Rob ^a   Phillips, Jenny K ^a   Constan, Alexander A ^a   Benjamin, Stephen A ^a   Andersen, Melvin E ^b   Mehendale, Harihara M ^c   Yang, Raymond S H ^a  

^a Department of Ecosystem Science and Sustainability   (United States)

^b ICF INTERNATIONAL   (United States)

^c UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

CCl4; Kepone; Mixtures; PBPK PD

Indexed keywords

CARBON TETRACHLORIDE; CHLORDECONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENTIATION; LD 50; LETHALITY; LIVER INJURY; LIVER REGENERATION; LIVER TOXICITY; MALE; MORTALITY; NONHUMAN; PHAGOCYTOSIS; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ANIMALS; CARBON TETRACHLORIDE; CHLORDECONE; DRUG SYNERGISM; MALE; MODELS, CHEMICAL; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0029803319     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050331     Document Type: Article

References (32)

1. Bungay PM, Dedrick RL, Matthews HB (1981) Enteric transport of chlordecone (Kepone) in the rat. J Pharmacokinet Biopharmaceut 9: 309-341
2. Carlson DA, Konyha KD, Wheeler WB, Marshall GP, Zaylskie RG (1976) Mirex in the environment: its degradation to Kepone and related compounds. Science 194: 939-941
3. Curtis LR, Mehendale HM (1979) The effects of Kepone pretreatment on biliary excretion of xenobiotics in the male rat. Toxicol Appl Pharmacol 47: 295-303
4. Curtis LR, Williams WL, Mehendale HM (1979) Potentiation of hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (Kepone) in the male rat. Toxicol Appl Pharmacol 51: 283-293
5. Dallas CE, Gallo JM, Raghupathy R, Srinivasa M, Bruckner JV (1991) Physiologically based pharmacokinetic modeling of inhaled trichlorocthylene in rats. Toxicol Appl Pharmacol 110: 303-314
6. EPA (1988) Reference physiological parameters in pharmacokinetic modeling. EPA-600/S6-88-004. Environmental Protection Agency Washington DC
7. Gargas ML, Burgess DE, Voisard ED, Cason GH, Andersen ME (1989) Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol Appl Pharmacol 98: 87-99
8. Gosselin RE, Gleason MN (1976) Clinical toxicology of commercial products acute poisoning. 4th edn. Williams and Wilkins, Baltimore
9. Glende EA Jr (1972) On the mechanism of carbon tetrachloride toxicily coincidence of loss of drug metabolizing activity with peroxidation of microsomal lipid. Biochem Pharmacol 21: 2131-2138
10. Guild WR, Young JV, Merrill JP (1958) Anuria due to carbon tetrachloride intoxication. Ann Int Med 48: 1221-1227
11. Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karbcr method for estimating median lethal concentrations in loxicity bioassays. Environ Sci Technol 11: 714-719
12. 4 lethality by chlordecone. Toxicol Lett 11: 149-154
13. 4 hepatotoxicity. Biochem Pharmacol 40: 859-866
14. 1. Exp Mol Pathol 39: 230-245
15. 2. Exp Mol Pathol 39: 246-255
16. Mehendale HM (1984) Potentiation of halomethane hepatotoxicity: chlordecone and carbon tetrachloride. Fundam Appl Toxicol 4: 295-308
17. Mehendale HM (1990) Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism. Med Hypoth 33: 289-299
18. Mehendale HM (1991) Role of hepatocellular regencration and hepatolobular healing in the final outcome of liver injury. Biochem Pharmacol 42: 1155-1162
19. Mehendale HM (1994) Mechanism of the interactive amplification of halomethane hepatotoxicity and lethality by other chemicals. In: Van RSH (ed) Toxicology of chemical mixtures: case studies, mechanisms, and novel Approaches. Academic Press, San Diego, pp 299-329
20. Naylor T, Balintfy J, Burdick D, Chu K (1968) Computer simulation techniques. John Wiley, New York
21. NCl (1976) Bioassay of carbon tetrachloride for possible carcinogenicily. Tech. Rep. No. 86. National Cancer Institute, Washington DC
22. Paustenbach DJ, Clewell HJ, Gargas ML, Andersen ME (1988) A physiologically based pharmacokinetic model for inhaled carbon tetrachloride. Toxicol Appl Pharmacol 96: 191-211
23. Portier CJ, Kaplan NL (1989) Variability of safe dose estimates when using complicated models of the carcinogenic process. Fundam Appl Toxicol 13: 533-544
24. Ramsey JC, Andersen ME (1984) A physiologically based description of the inhalation pharmacokinetics of styrene in rats and man. Toxicol Appl Pharmacol 73: 159-175
25. Recknagel RO (1967) Carbon tetrachloride hepatotoxicity. Pharmacol Rev 19: 145-208
26. Recknagel RO, Glende EA Jr, Ugazio G, Koch RR, Srinivasan S (1974) New data in support of the lipid peroxidation theory for carbon tetrachloride liver injury. Isr J Med Sci 10: 301-311
27. Reitz RH, Mendrala AL, Corley RA, Quasi JF, Gargas ML, Andersen ME, Staats DA, Conolly RB (1990) Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. Toxicol Appl Pharmacol 105: 443-459
28. Soni MG, Mehendale HM (1993) Hepatic failure leads to lethality of chlordecone-amplified hepatotoxicity of carbon tetrachloride. Fundam Appl Toxicol 21: 442-450
29. 4 hepatotoxicity and lethality. J Hepatol 20: 267-274
30. Thomas RS, Lytle WE, Keffe TJ, Constan AA, Yang RSH (1996) Incorporation of Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method. Fundam Appl Toxicol (in press)
31. Umiker W, Pearce J (1953) Nature and genesis of pulmonary alterations in carbon tetrachloride poisoning. Arch Pathol 55: 203-217
32. von Oettingen WF (1964) The halogenated hydrocarbons of industrial and loxicological importance. In: Browning E. (ed.) Elsevier monographs on toxic agents. Elsevier, New York